Has Anyone Switched from Reta to Tirz?

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poundsdownstayfit

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I realize most people seem to move in the other direction, from Tirz over to Reta, but I'm wondering if anyone has done the reverse — gone from Reta to Tirz — and found that Tirz gave them better results for weight loss?

Right now I'm at 6mg of reta, and I've been using it for 6 months, going from 218->198. I also started cjc+ipa no dac, and I've been on that for 5 weeks so far. My body composition has clearly shifted, I've held onto muscle, I watch what i eat and I weight train, but the fat loss still feels extremely slow to me. Could it be that I'm a low responder? I'd be curious to hear if anyone else went through the same thing.
 
Is your goal simply to avoid going up in dose? I began with tirz, though I've since incorporated Reta on a Monday/Friday schedule. Had you been taking the 6 mg for 6 months, or was it Reta for 6 months?
 
bamagirl26 said:

Is your goal simply to avoid going up in dose? I began with tirz, though I've since incorporated Reta on a Monday/Friday schedule. Had you been taking the 6 mg for 6 months, or was it Reta for 6 months?
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6 months on reta now. Began at a low dose and worked through 2-4mg along the way, but the last 2 months have been at 6mg. At 6mg the appetite suppression is still holding up fine. Possibly I'm simply reluctant to move up to 8 because the side effects might get worse. On 6 I get no skin tingling, I sleep fine, and I don't notice my HR going up. Maybe I'm just being impatient.
 
For a lot of people, 8 mg of reta seems to be the point where it really clicks:

Gemini said:


Trials and pharmacological breakdowns show that 8 mg achieves roughly 94% of the maximum weight-loss and metabolic effect of the top dose. For many, this is considered the sweet spot where the glucagon-driven metabolic benefits (like increased energy expenditure and profound liver fat clearance) are nearly fully realized without necessarily pushing to the absolute maximum limit.

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On top of that, 8 mg happens to be where reta on its own delivers its best effect on lowering LDL.
 
Calm Logic said:

For a lot of people, 8 mg of reta seems to be the point where it really clicks:


On top of that, 8 mg happens to be where reta on its own delivers its best effect on lowering LDL.
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I appreciate you replying. It's just disheartening when I see posts about folks dropping 20-30lbs on small reta doses within just 2 months. Still, there's probably an upside to a slower pace of weight loss. I'd rather avoid that loose skin appearance.
 
poundsdownstayfit said:

I appreciate you replying. It's just disheartening when I see posts about folks dropping 20-30lbs on small reta doses within just 2 months. Still, there's probably an upside to a slower pace of weight loss. I'd rather avoid that loose skin appearance.
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I used to put it this way: "Married to 1 mg." Nobody hands out awards based on what dose you take. These are just different notions that might not apply to most people, and certainly not to any one person.
 
Calm Logic said:

I used to put it this way: "Married to 1 mg." Nobody hands out awards based on what dose you take. These are just different notions that might not apply to most people, and certainly not to any one person.
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I understand your point. Fair enough
 
The reason I made the change from Reta over to Tirz was the side effects I was getting on Reta. On top of that, Reta never helped me drop any weight at all. After I made the switch, I've lost roughly 10lbs. The only downside I've run into is some constipation.

On Reta I had worked my way up to 7.5mg, and right now I'm taking 5mg of Tirz.
 
Vash said:

The reason I made the change from Reta over to Tirz was the side effects I was getting on Reta. On top of that, Reta never helped me drop any weight at all. After I made the switch, I've lost roughly 10lbs. The only downside I've run into is some constipation.

On Reta I had worked my way up to 7.5mg, and right now I'm taking 5mg of Tirz.
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Which Reta side effect hit you the hardest, or what symptoms were you dealing with?
 
johnny01 said:

Which Reta side effect hit you the hardest, or what symptoms were you dealing with?
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I dealt with trouble sleeping, reflux, being backed up, sulfur burps, and a resting heart rate that was way too high. There were entire days where my pulse stayed over 100bpm.
 
I spent 6 months on tirz (maxing out at 5mg) and dropped 45lbs. Then FOMO hit and I spent 5 months on reta (maxing out at 9mg), and only dropped 16lbs.

These days I split it: 5mg reta on Monday, then 4mg Tirz on Tuesday. Since I started split dosing, roughly 2 months ago, I've dropped another 15lbs.

For me Tirz comes out ahead, though having some reta glucagon in the mix does seem to leave me less tired.
 
Vash said:

I dealt with trouble sleeping, reflux, being backed up, sulfur burps, and a resting heart rate that was way too high. There were entire days where my pulse stayed over 100bpm.
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For roughly 2 weeks I dealt with insomnia. The other sides never happened to me. Only tingling skin and reduced appetite.
 
Schism said:

I spent 6 months on tirz (maxing out at 5mg) and dropped 45lbs. Then FOMO hit and I spent 5 months on reta (maxing out at 9mg), and only dropped 16lbs.

These days I split it: 5mg reta on Monday, then 4mg Tirz on Tuesday. Since I started split dosing, roughly 2 months ago, I've dropped another 15lbs.

For me Tirz comes out ahead, though having some reta glucagon in the mix does seem to leave me less tired.
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I did think about splitting the dose. Still, my plan is to go up to 8mg before trying that.
 
Knowing your height, age, and goal weight would help a lot here. If your goal weight is close, then slow progress makes more sense than if you still have another 50 pounds to lose. That context is really what decides whether you should adjust the dose or switch compounds. And how fast are you losing right now? Nothing at all? 1lb per week?

Losing 20 lbs over 6 months on a decent reta dose is likely below average. The cjc makes this a bit murkier since it will lead to some fluid retention, and if muscle is being added, the scale will move less. So after starting it, I would figure the numbers on the scale would have slowed.

If I am reading this right, you dealt with skin sensitivity and insomnia as side effects, but at 6mg those are no longer an issue. My hunch is that if reta gives you a somewhat weaker response than most people get, then tirz would be more likely than not to do the same for you, though there is no way to know without trying. Reta does cause more weight loss than tirz, but comes with a slightly higher rate of side effects. The typical reason people move to tirz is reta-specific side effects such as heart rate increases or skin sensory problems, or to quiet food noise, though that last one has never fully added up to me since reta produces more weight loss, meaning it must cut food intake at least as much as tirz, even when you account for reta's glucagon agonism raising energy expenditure.

My advice would be to simply move up to 8mg. If 6mg gave you troublesome side effects that have since calmed down, you could instead step to 7mg for a few weeks so the jump is gentler. If raising the dose is not something you can tolerate, then switching could make sense. Tirz might work out well, but if I had to guess, there is a decent chance you would also need doses above average.
 
Vash said:

I dealt with trouble sleeping, reflux, being backed up, sulfur burps, and a resting heart rate that was way too high. There were entire days where my pulse stayed over 100bpm.
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Right now I'm using tirz, though I'd been thinking about switching over to reta. What holds me back is how it messes with the rhr. Being above 100 the whole day worries me
 
johnny01 said:

Right now I'm using tirz, though I'd been thinking about switching over to reta. What holds me back is how it messes with the rhr. Being above 100 the whole day worries me
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Unless your resting heart rate is already sitting quite high, it's fairly improbable that reta would genuinely cause that. How much reta raises heart rate comes down to the dose you're taking. Often, when someone's heart rate spikes after they begin reta, anxiety plays just as big a role as the medication itself does. That said, if anxiety is something you're prone to, tirz might be the smarter choice regardless. A lot hinges on your reason for wanting to switch — the two drugs are, for the most part, extremely alike. And if you were to stack a small dose of reta on top of tirz, the impact on heart rate would probably be quite minor.

My own heart rate did climb somewhat on reta, but since I was already on beta blockers for cardiac reasons, I simply raised the beta blocker dose slightly to bring the heart rate back down.
 
lessthanhalf said:

Unless your resting heart rate is already sitting quite high, it's fairly improbable that reta would genuinely cause that. How much reta raises heart rate comes down to the dose you're taking. Often, when someone's heart rate spikes after they begin reta, anxiety plays just as big a role as the medication itself does. That said, if anxiety is something you're prone to, tirz might be the smarter choice regardless. A lot hinges on your reason for wanting to switch — the two drugs are, for the most part, extremely alike. And if you were to stack a small dose of reta on top of tirz, the impact on heart rate would probably be quite minor.

My own heart rate did climb somewhat on reta, but since I was already on beta blockers for cardiac reasons, I simply raised the beta blocker dose slightly to bring the heart rate back down.
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Before I began Reta, my resting heart rate sat around 50-52.
 
Calm Logic said:

For a lot of people, 8 mg of reta seems to be the point where it really clicks:


On top of that, 8 mg happens to be where reta on its own delivers its best effect on lowering LDL.
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8mg worked really well for me, and I kept at it for 6 weeks.

poundsdownstayfit said:

I appreciate you replying. It's just disheartening when I see posts about folks dropping 20-30lbs on small reta doses within just 2 months. Still, there's probably an upside to a slower pace of weight loss. I'd rather avoid that loose skin appearance.
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I tend to take those with a grain of salt. Loose skin will catch up with you at some point, depending on how old you are. I've got some on my arms — I've been doing sit ups and lifting light weights. I figured I had it on my belly and love handles too, but that turned out to be fat, and it's gradually going down while my weight holds steady on 6 and 8mg doses. My average worked out to just under 2lbs/week.

Calm Logic said:

I used to put it this way: "Married to 1 mg." Nobody hands out awards based on what dose you take. These are just different notions that might not apply to most people, and certainly not to any one person.
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I suppose dropping a lot of weight on .5 and 1mg is just something I can't wrap my head around.
 
Cjc is almost certainly what's behind the slow weight loss. Once you get closer to goal weight, it's commonly used. I'm fairly confident that if you dropped cjc, you'd lose weight faster, though there could be a downside for muscle gain, even if plenty of people have put on muscle mass while on Reta. There's always a trade off.
 
BNLFL said:

8mg worked really well for me, and I kept at it for 6 weeks.


I tend to take those with a grain of salt. Loose skin will catch up with you at some point, depending on how old you are. I've got some on my arms — I've been doing sit ups and lifting light weights. I figured I had it on my belly and love handles too, but that turned out to be fat, and it's gradually going down while my weight holds steady on 6 and 8mg doses. My average worked out to just under 2lbs/week.


I suppose dropping a lot of weight on .5 and 1mg is just something I can't wrap my head around.
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Claims like that show up constantly in Reddit and FB groups. My guess is the people posting them want someone to ask where the info came from — either so they can earn a commission off whatever they point to, or because they themselves are the source.
 
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