Tirz vs Reta

drzoid614

drzoid614

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Hi everyone,

I'm just starting out on this path and have a question that I haven't come across in previous discussions.

I'm a woman in my late twenties. I work out at the gym consistently, but the extra weight I'm trying to shed just won't budge, which is why I've joined this community and started looking into GLPs.

My dilemma is whether reta or tirz is the right choice for me. The fast weight loss that comes with reta makes me a bit nervous about loose skin. Tirz appears to work more slowly, but does that also mean my results would be limited? I realize semaglutide is another possibility, though I want to hold onto some muscle.

For someone aiming to drop 10-15kg and planning to pair GLP use with a regular exercise routine, what would you recommend?

Apologies if the answer is obvious, I'd just really appreciate hearing some outside perspectives.

Thanks in advance
 
No matter which one you pick, you'll end up eating less. My appetite is completely gone, yet I still force protein in and stick to a meal plan.

These peptides hand YOU the control!!!!!

One more thing!, keep in mind you mainly drop fat only when you're lifting heavy while on Triz and Reta.

Simply look into whatever fits your budget. And go by the clinical data. After all, they poured millions into those studies....
 
Start with tirz; switch to reta only if progress halts, or if fatigue sets in and won't lift.

My reasoning: tirzepatide works very well for a LOT of people, and it comes with multi-year safety data. Reta is great — I've got a stockpile sitting in my freezer — and my guess is that once its clinical trials wrap up and safety data arrives, it'll turn out to be just as safe. The thing is, I don't actually KNOW that. What I do know: when demand for glp-1's runs this hot, sooner or later something reaches the market that harms or kills people — and we'd have known if more data existed, but it didn't, and people wanted it badly, and people died while we found out it wasn't safe.

I expect that WILL eventually happen with GLP-1's. It isn't tirz, it probably won't be reta, it might not be the next gen one after that, or the one after. But eventually, I think it will, so I always want to begin with the options that carry some degree of long-term proven reasonable safety weighed against great efficacy — and right now, that's tirz.
 
Reta and Tirz each act on GLP and GIP to curb appetite and improve insulin sensitivity. What Reta brings in addition is GCGR, which helps hold onto lean mass and lift base metabolic rate.

With either one, how quickly weight comes off can be steered somewhat through the dose. Personally, fast loss hasn't been a problem for me — I've run things fairly aggressively — yet nausea never showed up at all… when I drift too far from the slope I'm aiming for, I tweak what I eat. Should adverse side effects appear, I'll change my dose.
 
BellyD said:

No matter which one you pick, you'll end up eating less. My appetite is completely gone, yet I still force protein in and stick to a meal plan.

These peptides hand YOU the control!!!!!

One more thing!, keep in mind you mainly drop fat only when you're lifting heavy while on Triz and Reta.

Simply look into whatever fits your budget. And go by the clinical data. After all, they poured millions into those studies....
Click to expand...
Thank you, that's genuinely useful guidance!
 
woundcarping said:

Reta and Tirz each act on GLP and GIP to curb appetite and improve insulin sensitivity. What Reta brings in addition is GCGR, which helps hold onto lean mass and lift base metabolic rate.

With either one, how quickly weight comes off can be steered somewhat through the dose. Personally, fast loss hasn't been a problem for me — I've run things fairly aggressively — yet nausea never showed up at all… when I drift too far from the slope I'm aiming for, I tweak what I eat. Should adverse side effects appear, I'll change my dose.
Click to expand...
Alright, that's really useful information. Thanks — this has helped a lot!
 
randompersonrandom said:

Start with tirz; switch to reta only if progress halts, or if fatigue sets in and won't lift.

My reasoning: tirzepatide works very well for a LOT of people, and it comes with multi-year safety data. Reta is great — I've got a stockpile sitting in my freezer — and my guess is that once its clinical trials wrap up and safety data arrives, it'll turn out to be just as safe. The thing is, I don't actually KNOW that. What I do know: when demand for glp-1's runs this hot, sooner or later something reaches the market that harms or kills people — and we'd have known if more data existed, but it didn't, and people wanted it badly, and people died while we found out it wasn't safe.

I expect that WILL eventually happen with GLP-1's. It isn't tirz, it probably won't be reta, it might not be the next gen one after that, or the one after. But eventually, I think it will, so I always want to begin with the options that carry some degree of long-term proven reasonable safety weighed against great efficacy — and right now, that's tirz.
Click to expand...
I really appreciate how thorough your reply was — it made everything much clearer for me. I'm completely with you on this: choosing the GLP that has long-term testing behind it feels like the smarter move. Wishing you all the best on your own journey!
 
Tirz is my bff. It matches my body and my GLP needs perfectly: it dulls hunger without killing it, silences food noise completely, and brings zero side effects.

That said, after just over a year on it and with a solid read on how my body handles it, I feel good about my current approach of layering in some reta. I've still got about 10lb to go until a happy goal weight, and usually I'd just let that play out. But there's a big company offsite in mid March where I'll be face to face with my whole team for the first time in 2 years, and I'll admit (vainly) that I want to nudge the scale a bit further before then. So by adding reta for now, while trimming my tirz just a bit, I'm after the glucagon assist with direct fat burning. I absolutely get sides with reta (nausea after meals, and feeling colder more often) but since it's only for another 6 weeks, I can handle it.

Then it's back to my tried and true tirz.
 
ThatNextGril said:

Tirz is my bff. It matches my body and my GLP needs perfectly: it dulls hunger without killing it, silences food noise completely, and brings zero side effects.

That said, after just over a year on it and with a solid read on how my body handles it, I feel good about my current approach of layering in some reta. I've still got about 10lb to go until a happy goal weight, and usually I'd just let that play out. But there's a big company offsite in mid March where I'll be face to face with my whole team for the first time in 2 years, and I'll admit (vainly) that I want to nudge the scale a bit further before then. So by adding reta for now, while trimming my tirz just a bit, I'm after the glucagon assist with direct fat burning. I absolutely get sides with reta (nausea after meals, and feeling colder more often) but since it's only for another 6 weeks, I can handle it.

Then it's back to my tried and true tirz.
Click to expand...
I can't wait for that food noise to finally quiet down! Honestly, I get exactly where you're coming from — I'd probably make the same call hahah! If you don't mind me asking, how many pounds have you dropped over the past year?

That's really helpful to hear that stacking reta on top is doing the job for you (aside from the side effects, but that's something you can put up with)! I figure somewhere down the line I'll probably look into it too. So this has been super useful to learn! Thank you !! I'm sure you'll look amazing for the team meeting
 
Tirz has been working really well for me, and I'm happy with it. Roughly a month in, I've dropped close to 10lbs. Unlike what a lot of people mention, nausea never hit me — and I'm genuinely grateful for that.

I plan to introduce additional peptides before long.
 
drzoid614 said:

ThatNextGril said:

Tirz is my bff. It matches my body and my GLP needs perfectly: it dulls hunger without killing it, silences food noise completely, and brings zero side effects.

That said, after just over a year on it and with a solid read on how my body handles it, I feel good about my current approach of layering in some reta. I've still got about 10lb to go until a happy goal weight, and usually I'd just let that play out. But there's a big company offsite in mid March where I'll be face to face with my whole team for the first time in 2 years, and I'll admit (vainly) that I want to nudge the scale a bit further before then. So by adding reta for now, while trimming my tirz just a bit, I'm after the glucagon assist with direct fat burning. I absolutely get sides with reta (nausea after meals, and feeling colder more often) but since it's only for another 6 weeks, I can handle it.

Then it's back to my tried and true tirz.
Click to expand...
I can't wait for that food noise to finally quiet down! Honestly, I get exactly where you're coming from — I'd probably make the same call hahah! If you don't mind me asking, how many pounds have you dropped over the past year?

That's really helpful to hear that stacking reta on top is doing the job for you (aside from the side effects, but that's something you can put up with)! I figure somewhere down the line I'll probably look into it too. So this has been super useful to learn! Thank you !! I'm sure you'll look amazing for the team meeting
Click to expand...

Before tirz, I was on sema for roughly 1.5 years. The total drop was only around 15lb, and I disliked how sema left me feeling overly stuffed after meals—occasionally even while eating. Food noise did go down, though nowhere near the level I've had with tirz.

After switching to tirz, I've shed an additional 20lb. My progress began to flatten out around June of last year. I keep bouncing within about +/- 3 pounds, which is reassuring in that my body seems comfortable at this size, but it's still frustrating because it's genuinely a stall.

I believe tirz will leave you quite pleased. Once you understand how your body responds to it, you'll be able to choose how and when to titrate. I'm confident that if I reallllyyyyy wanted to, I could raise my tirz dose rather than add reta, but given what I know about how tirz affects my hunger and food noise, I doubt that would make any real difference now.

There's no real chance I'd remain on reta for any meaningful stretch. The sides I'm dealing with are irritating, and I'm completely fine with tirz staying in charge over the long haul.
 
With high-dose Tirz (> 10 mg), the side effects hit me hard.

On injection day I'd dose in the evening, and then for 3 days straight it felt like a truck had run me over. Drinking even 1 glass of water was impossible. Eating was impossible too. And despite all that, my weight didn't budge — I was just completely miserable.

Reta, by contrast, gives me none of that. I moved up fast: 2 mg the 1st week, 6 mg by week 6, then 10 mg at week 7 (6 mg injected on shot day plus 4 mg 84 hours afterward), and there's essentially nothing in terms of sides.

For me, Reta is pure magic.
 
Male, 60 years old, 6'0", 170 lb. In 3 months I dropped from 201 down to 170 using 2.5 Zepbound each week. Right around when the tirzapatide stopped working as well, I hit my target. To shed a bit more fat while I keep protein high, I moved over to 2mg retatrutide.

Drop 15 kg and loose skin is inevitable. Compared with tirzapatide, retatrutide holds onto somewhat more muscle. On tirzapatide I shed a huge amount of muscle.

No matter what, begin with the standard weekly dosing schedule and hold off 4 weeks before going up, since that's the time needed to accumulate the full amount of gear. Keep it simple. Let the peptides do their thing.
 
SolidChick said:

Tirz has been working really well for me, and I'm happy with it. Roughly a month in, I've dropped close to 10lbs. Unlike what a lot of people mention, nausea never hit me — and I'm genuinely grateful for that.

I plan to introduce additional peptides before long.
Click to expand...
That's awesome!!! Glad to hear it! Yeah, I'm definitely swaying toward it now
 
ThatNextGril said:

drzoid614 said:

ThatNextGril said:

Tirz is my bff. It matches my body and my GLP needs perfectly: it dulls hunger without killing it, silences food noise completely, and brings zero side effects.

That said, after just over a year on it and with a solid read on how my body handles it, I feel good about my current approach of layering in some reta. I've still got about 10lb to go until a happy goal weight, and usually I'd just let that play out. But there's a big company offsite in mid March where I'll be face to face with my whole team for the first time in 2 years, and I'll admit (vainly) that I want to nudge the scale a bit further before then. So by adding reta for now, while trimming my tirz just a bit, I'm after the glucagon assist with direct fat burning. I absolutely get sides with reta (nausea after meals, and feeling colder more often) but since it's only for another 6 weeks, I can handle it.

Then it's back to my tried and true tirz.
Click to expand...
I can't wait for that food noise to finally quiet down! Honestly, I get exactly where you're coming from — I'd probably make the same call hahah! If you don't mind me asking, how many pounds have you dropped over the past year?

That's really helpful to hear that stacking reta on top is doing the job for you (aside from the side effects, but that's something you can put up with)! I figure somewhere down the line I'll probably look into it too. So this has been super useful to learn! Thank you !! I'm sure you'll look amazing for the team meeting
Click to expand...

Before tirz, I was on sema for roughly 1.5 years. The total drop was only around 15lb, and I disliked how sema left me feeling overly stuffed after meals—occasionally even while eating. Food noise did go down, though nowhere near the level I've had with tirz.

After switching to tirz, I've shed an additional 20lb. My progress began to flatten out around June of last year. I keep bouncing within about +/- 3 pounds, which is reassuring in that my body seems comfortable at this size, but it's still frustrating because it's genuinely a stall.

I believe tirz will leave you quite pleased. Once you understand how your body responds to it, you'll be able to choose how and when to titrate. I'm confident that if I reallllyyyyy wanted to, I could raise my tirz dose rather than add reta, but given what I know about how tirz affects my hunger and food noise, I doubt that would make any real difference now.

There's no real chance I'd remain on reta for any meaningful stretch. The sides I'm dealing with are irritating, and I'm completely fine with tirz staying in charge over the long haul.
Click to expand...
It seems like you've got it dialed in perfectly for yourself! I'm really hoping my own path turns out similar to yours! Appreciate the guidance once more
 
drzoid614 said:

SolidChick said:

Tirz has been working really well for me, and I'm happy with it. Roughly a month in, I've dropped close to 10lbs. Unlike what a lot of people mention, nausea never hit me — and I'm genuinely grateful for that.

I plan to introduce additional peptides before long.
Click to expand...
That's awesome!!! Glad to hear it! Yeah, I'm definitely swaying toward it now
Click to expand...
That's wonderful!

May your journey be a positive one.

One more thing I should mention: right at the start I went with microdosing, and I think that worked in my favor too.

My first 2 weeks were at 1.25 mg, the next 2 weeks at 1.5 mg, then 2 weeks at 2.5mg, and my intention is to remain at 2.5 until progress stops showing.
 
drzoid614 said:

Hi everyone,

I'm just starting out on this path and have a question that I haven't come across in previous discussions.

I'm a woman in my late twenties. I work out at the gym consistently, but the extra weight I'm trying to shed just won't budge, which is why I've joined this community and started looking into GLPs.

My dilemma is whether reta or tirz is the right choice for me. The fast weight loss that comes with reta makes me a bit nervous about loose skin. Tirz appears to work more slowly, but does that also mean my results would be limited? I realize semaglutide is another possibility, though I want to hold onto some muscle.

For someone aiming to drop 10-15kg and planning to pair GLP use with a regular exercise routine, what would you recommend?

Apologies if the answer is obvious, I'd just really appreciate hearing some outside perspectives.

Thanks in advance
Click to expand...
If it were me, I'd pick Tirz—its appetite suppression is fantastic.
 
drzoid614 said:

Hi everyone,

I'm just starting out on this path and have a question that I haven't come across in previous discussions.

I'm a woman in my late twenties. I work out at the gym consistently, but the extra weight I'm trying to shed just won't budge, which is why I've joined this community and started looking into GLPs.

My dilemma is whether reta or tirz is the right choice for me. The fast weight loss that comes with reta makes me a bit nervous about loose skin. Tirz appears to work more slowly, but does that also mean my results would be limited? I realize semaglutide is another possibility, though I want to hold onto some muscle.

For someone aiming to drop 10-15kg and planning to pair GLP use with a regular exercise routine, what would you recommend?

Apologies if the answer is obvious, I'd just really appreciate hearing some outside perspectives.

Thanks in advance
Click to expand...
When I began, Tirzepatide was my choice simply because Retatrutide wasn't on my radar yet, and I ended up filling my freezer with a doomsday-level stockpile.lol…

If I were to do it over, my own 2 cents would be to begin with Tirzepatide. The reason is that, in my head, Tirzepatide carries FDA approval, and I figure that means better long-term safety, so I feel less worry even if something like heart burn comes up…
 
DjJoshua said:

drzoid614 said:

Hi everyone,

I'm just starting out on this path and have a question that I haven't come across in previous discussions.

I'm a woman in my late twenties. I work out at the gym consistently, but the extra weight I'm trying to shed just won't budge, which is why I've joined this community and started looking into GLPs.

My dilemma is whether reta or tirz is the right choice for me. The fast weight loss that comes with reta makes me a bit nervous about loose skin. Tirz appears to work more slowly, but does that also mean my results would be limited? I realize semaglutide is another possibility, though I want to hold onto some muscle.

For someone aiming to drop 10-15kg and planning to pair GLP use with a regular exercise routine, what would you recommend?

Apologies if the answer is obvious, I'd just really appreciate hearing some outside perspectives.

Thanks in advance
Click to expand...
When I began, Tirzepatide was my choice simply because Retatrutide wasn't on my radar yet, and I ended up filling my freezer with a doomsday-level stockpile.lol…

If I were to do it over, my own 2 cents would be to begin with Tirzepatide. The reason is that, in my head, Tirzepatide carries FDA approval, and I figure that means better long-term safety, so I feel less worry even if something like heart burn comes up…
Click to expand...
In my opinion, beginning with Tirz is likely a reasonable choice. Compared with Reta, it remains much more affordable. Sure, plenty of us joke about FDA approval, but for those who care about that sort of thing, Tirz and Sema are solid options.
 
Calling it significantly cheaper feels like a bit much. Bulk Tirz runs about $.20/mg for 1200mg, while Reta comes in near $.48/mg.

At the top doses that have been published from trials, that works out to only $2.76/week more, if you're stocking up to lock in the best rate. For me, $2.76/week is a fair trade to hold onto roughly 6-10lb of lean mass across an 80lb cut, since GCGR helps spare lean tissue and gives steadier energy for lifting.

Even if the scale lands on the same number either way, on Tirz I'd be carrying 6-10lb more fat at that weight than I would on Reta, plus all the time it would take to rebuild that lean fiber.

Anecdotal note on energy for sticking with training:

Day 1 on Reta (no prior meaningful exposure) my exercising walking heart rate averaged 114bpm, while the day before and the day after both averaged 115bmp.

18 days in, doing the same exercise with more incline and less perceived effort, my average heart rate over the last 3 days sits around ~130bmp, with reta at 6-9.2mg (Tirz tapering from 2.5mg down to ~1.7mg).

Tirz never gave me any trouble, and so far I have zero regrets about moving to reta.
 
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