NAD+ at high doses?

[tendency]

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

 

[PinKushn]

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

I’ve thought about increasing my intake. While I realize absorption may differ, I previously used 1000mg of TruNiagen daily for an extended period before moving to the peptide form. Currently, I’m on 150mg per day.

Do you inject into the muscle or under the skin? Curious how that “whoosh” sensation came across at such a high amount.

 

[BBA1969]

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

 

[tendency]

PinKushn said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

I’ve thought about increasing my intake. While I realize absorption may differ, I previously used 1000mg of TruNiagen daily for an extended period before moving to the peptide form. Currently, I’m on 150mg per day.

Do you inject into the muscle or under the skin? Curious how that “whoosh” sensation came across at such a high amount.

I used to inject intramuscularly, but these days I go for the glute and it's been working really well

 

[tendency]

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

 

[woundcarping]

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

Is that 2.5ml going SQ into the fat over the glute, or IM straight into the glute?

tendency said:

PinKushn said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

I’ve thought about increasing my intake. While I realize absorption may differ, I previously used 1000mg of TruNiagen daily for an extended period before moving to the peptide form. Currently, I’m on 150mg per day.

Do you inject into the muscle or under the skin? Curious how that “whoosh” sensation came across at such a high amount.

I used to inject intramuscularly, but these days I go for the glute and it's been working really well

Keestering NAD+ is wild.

 

[Calm Logic]

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

What's the needle length?

 

[tendency]

woundcarping said:

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

Is that 2.5ml going SQ into the fat over the glute, or IM straight into the glute?

tendency said:

PinKushn said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

I’ve thought about increasing my intake. While I realize absorption may differ, I previously used 1000mg of TruNiagen daily for an extended period before moving to the peptide form. Currently, I’m on 150mg per day.

Do you inject into the muscle or under the skin? Curious how that “whoosh” sensation came across at such a high amount.

I used to inject intramuscularly, but these days I go for the glute and it's been working really well

Keestering NAD+ is wild.

Calm Logic said:

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

What's the needle length?

It's definitely SubQ in the glute — the needle measures just 1/2" in length. At times I don't even insert it the full way, only about 1/2 of it.

 

[RubbaDubba1]

I've come across reports of individuals using up to 500mg subcutaneously within 1 day when preparing for athletic events. From what I gather, this isn't hugely unlike receiving an IV drip of 750 - 1000mg spread across a few hours at a med spa. The main distinction is the speed at which it takes effect.

 

[BBA1969]

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

I'm definitely not a contortionist — my flexibility could use some work. The only way I can pull off a shot in the glutes without trouble is by using a pen. At the moment that's GHK-CU. And true enough, there's no sting.

Time to start rehearsing with syringes behind my back

 

[FNG33]

When there is stinging, put sodium bicarbonate on a PH test strip. Correct the PH and the stinging goes away.

 

[FartfulCodger]

BBA1969 said:

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

I'm definitely not a contortionist — my flexibility could use some work. The only way I can pull off a shot in the glutes without trouble is by using a pen. At the moment that's GHK-CU. And true enough, there's no sting.

Time to start rehearsing with syringes behind my back

Check with a buddy about whether he'd be up for injecting it into your rear.

 

[RubbaDubba1]

FartfulCodger said:

BBA1969 said:

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

I'm definitely not a contortionist — my flexibility could use some work. The only way I can pull off a shot in the glutes without trouble is by using a pen. At the moment that's GHK-CU. And true enough, there's no sting.

Time to start rehearsing with syringes behind my back

Check with a buddy about whether he'd be up for injecting it into your rear.

Just tagging along, asking for a buddy

 

[Calm Logic]

I worry about the gluteus area because of possible contact with structures such as the sciatic nerve or the superior gluteal artery.

For TRT and glutathione at least, deep subq or IM into the thigh (vastus lateralis) worked well for me. Similar to what Nurse Scott demonstrates on Youtube.

 

[BBA1969]

FartfulCodger said:

BBA1969 said:

tendency said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

I mix a 500mg vial with 5ml BAC, so that works out to a pretty big shot of 2.5ml (I only do a single injection). Still, like I said before, I use the glute and it's no problem.

I don't get any sting.

I'm definitely not a contortionist — my flexibility could use some work. The only way I can pull off a shot in the glutes without trouble is by using a pen. At the moment that's GHK-CU. And true enough, there's no sting.

Time to start rehearsing with syringes behind my back

Check with a buddy about whether he'd be up for injecting it into your rear.

My wife would happily give me the shot, though I think she'd do it more out of spite than any real desire to help.

 

[Such1943]

For my initial SS-31/NAD+/Mots-C cycle, I took NAD+ at 150mg on M/W/F. This summer, I'm taking 100mg every day.

 

[Calm Logic]

If the doses go up, or I end up pinning more often, I'd add TMG orally every day. @Skidude brought this up back in the previous year:




how to NAD+



Anyway, a kit of NAD+ showed up and I'm clueless about how to run it. Whether it's buffered, or even what buffered actually refers to, I couldn't tell you. After watching a few videos, my guess is 5ml for reconstitution, but dosing and timing are still a mystery, and dr.google gives me nothing but contradictions. Somebody help.

GLP1Chat.com

Mine came from Amazon, Nutricost, around $10:


https://a.co/d/05uBVJ6w

 

[LabRatBarbie]

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

Funny you bring this up — I was in a screw-it mood earlier and went the same route. I mixed 500mg with 2ML bac water, then pinned 95 units, which works out to roughly 220mg, and damn it hit hard right away.

 

[ftv10hb]

Today I bumped mine up too, just randomly, though not as much as that lol. For roughly 2 weeks I'd been on 100mg 3x/week, and today I moved to 150mg. Flushing hit me for sure and I had to take a seat haha. No problems for the remainder of the day, but from here on out I figure I'll keep it at 100mg and simply raise how often I do it if needed lol. In case it's useful, I mix 1000mg with 2mL bac water, so my 150mg dose was still only a 30 unit shot, while my 100mg has been 20 units. Pinning hasn't given me any real trouble with stinging or anything else, maybe a tiny brief bit but nothing severe or all that obvious.

 

[BBA1969]

LabRatBarbie said:

BBA1969 said:

tendency said:

For the past 3-3.5 months, I've been dosing NAD+ at 50mg every day. It took roughly a couple of months before a slight energy lift and better mood showed up. Subtle, though I could tell it was there. Nothing major.

Then, purely out of curiosity, I jacked the dose way up — 250mg per day for the last 3 days. And wow, wow. That one lands. Energy goes up in a way that's smooth, steady and carries through the whole day. Mood is noticeably better.

Can anyone else relate? Has anyone else needed a huge dose, or seen a big difference, only when taking a mammoth amount?

Wow, 250mg!

I figured 100mg every so often, after 2 months, was the upper limit for me.

Because NAD+ gives me such good results, I'm very drawn to trying that now!

Still, a few things I'm wondering: how do you handle dilution? My vials are 500mg. To get 250mg into a 1ml syringe, I'd need to mix with 2ml of BAC. Isn't that asking for a huge sting? Assuming I can even draw it from the vial?

Or is it a matter of doing several injections?

Funny you bring this up — I was in a screw-it mood earlier and went the same route. I mixed 500mg with 2ML bac water, then pinned 95 units, which works out to roughly 220mg, and damn it hit hard right away.

What was the injection like? Did you get any soreness or a bump? Also, which spot did you use?