tendency said:
We'll have to disagree on that one chili. There's a internal medicine doc - Kevin Joseph (he's got a number of good YT work and also a nice e-book) - that's been using 20-30 peps in clinical practice for a number of years, including semax/selank, and his experience is that overloading of the BDNF pathways is false and these are safe to run indefinitely. He has not experienced downregulation etc. in his patients.
Apparently they're also widely used long term in Russia.
Virtually all the peptide protocols recommend cycling, however this largely seems to simply be based upon an abundance of caution and hearsay, I'm no longer convinced it's necessary at least for a percentage of them.
Click to expand...
I haven't seen that anywhere in my research. From Russian medical clinics:
In Russian clinical practice, Semax is typically prescribed for short-term courses ranging from 5 to 14 days.
Acute Stroke Recovery: Protocols often utilize doses of 12–18 mg/day for 5 to 10 days within the first 24 hours of an ischemic event.
Cognitive Disorders & Optic Nerve Disease: Standard treatments generally last 10 to 14 days, with some pediatric or minimal brain dysfunction cases extending up to 30 days.
Repeat Cycles: If necessary, treatment may be extended or repeated after a rest period of 1 to 3 months.
Note: Russian clinical applications typically involve courses ranging from 10 to 30 days. These treatment windows emerged from extensive trials involving thousands of stroke patients, individuals with cognitive impairment, and those recovering from brain injuries. The protocols balance therapeutic effect against the need for neurotrophin receptor systems to maintain sensitivity.
Users seeking year-round cognitive support often employ cycling patterns that alternate active periods with rest intervals. A popular approach involves 6 weeks of daily administration followed by 2 weeks off, repeated throughout the year.
For cognitive enhancement purposes outside clinical settings, cycle length considerations become even more relevant. Without the acute pathology present in stroke patients, healthy individuals need to balance ongoing cognitive benefits against the potential for receptor adaptation over time.
I prefer a conservative approach, but it appears even Russian enthusiasts acknowledge the receptor issue, even in long term cycles.
For how long? How did you come with 6mg? Did you see major differences when using 6mg than 0,5-1-2?
