What do you really gain from low dose HGH?

[timfa]

I notice a lot of folks between 30 and 65 taking 0.5-2iu of hgh daily, and I just can't figure out the point.. the sleep and muscle advantages are hardly there

At that kind of dose (obviously it varies by person, but from what I've observed, most don't feel anything until about 3-4 iu), those who run hgh this low keep saying "it's for skin health and hair health and anti aging" fine, hgh might help with skin elasticity and hair health, but ghkcu does the same thing (at half the cost and half the negative effects) I get the feeling there's something I'm not seeing, so why bother with doses that low?

 

[yrrdead]

timfa said:

I notice a lot of folks between 30 and 65 taking 0.5-2iu of hgh daily, and I just can't figure out the point.. the sleep and muscle advantages are hardly there

At that kind of dose (obviously it varies by person, but from what I've observed, most don't feel anything until about 3-4 iu), those who run hgh this low keep saying "it's for skin health and hair health and anti aging" fine, hgh might help with skin elasticity and hair health, but ghkcu does the same thing (at half the cost and half the negative effects) I get the feeling there's something I'm not seeing, so why bother with doses that low?

As people get older, the dosing curve shifts downward. So it's fair to say there's a piece of the picture you're overlooking.

 

[lessthanhalf]

At 1.5iu/day (I'm 58yo), I had my IGF-1 levels tested. The reading came back at 50nmol/l, where the mean is 20 — roughly 5 standard deviations above normal, which puts it in potential acromegaly territory and 100% not safe to remain at long term. So it's clear that even these low doses can be too high.

 

[blokje Ham]

lessthanhalf said:

At 1.5iu/day (I'm 58yo), I had my IGF-1 levels tested. The reading came back at 50nmol/l, where the mean is 20 — roughly 5 standard deviations above normal, which puts it in potential acromegaly territory and 100% not safe to remain at long term. So it's clear that even these low doses can be too high.

. That only happens once you're running anabolics alongside insulin. For people with HIV, every dose is 18 IU per day as standard. Did they all turn into giants ? No, your take comes from fear. It's only past 8 iu HGH per day that other things start coming into play, together with testosterone supplementation. Without testosterone there's no point taking that much. But acromegaly, no ‍.

 

[WholesomeApril]

lessthanhalf said:

At 1.5iu/day (I'm 58yo), I had my IGF-1 levels tested. The reading came back at 50nmol/l, where the mean is 20 — roughly 5 standard deviations above normal, which puts it in potential acromegaly territory and 100% not safe to remain at long term. So it's clear that even these low doses can be too high.

I had bloodwork done too while on 2iu per day, and it came back at 33nmol/L.

That amount also gave me headaches every day, so I paused it for a while. I plan to restart before long, though probably at just 0.5iu.

Just so it's clear, I'm a woman in my early 40s, and HGH made my hair become lush

About 2 years back I ran several GLOW cycles, but the hair growth improvement I saw from HGH was wayyy more obvious.

That said, for my skin I'd still rate GLOW higher. While on glow I looked so hydrated

 

[littlefire]

lessthanhalf said:

At 1.5iu/day (I'm 58yo), I had my IGF-1 levels tested. The reading came back at 50nmol/l, where the mean is 20 — roughly 5 standard deviations above normal, which puts it in potential acromegaly territory and 100% not safe to remain at long term. So it's clear that even these low doses can be too high.

50 is really on the low end, isn't it? Or is there something I'm not getting... Prior to beginning at age 59, my own level was 100 ng/ml, and the usual reference range is 68 - 247.

 

[WholesomeApril]

littlefire said:

lessthanhalf said:

At 1.5iu/day (I'm 58yo), I had my IGF-1 levels tested. The reading came back at 50nmol/l, where the mean is 20 — roughly 5 standard deviations above normal, which puts it in potential acromegaly territory and 100% not safe to remain at long term. So it's clear that even these low doses can be too high.

50 is really on the low end, isn't it? Or is there something I'm not getting... Prior to beginning at age 59, my own level was 100 ng/ml, and the usual reference range is 68 - 247.

On the other scale, a 50nmol/L reading converts to about 383 ng/mL

 

[UpDownLeftRightAS*]

Off-topic maybe, but when your stack also contains something like Tesamorelin (egrifta), IGF labs become genuinely useful — it pushes those numbers up even further. Like 'Lessthanhalf' mentioned earlier, low doses alone can still drive levels past what's safe over the long haul. The good news is that HGH has been researched to death, so nearly any question you have likely has a study behind it. In my own stack it pairs nicely with Reta; there's some counterbalancing and some synergy happening there....

some ref:



Image unavailable



Human growth hormone (HGH): Does it slow aging?



Is this treatment an anti-aging breakthrough? Know the facts.

Image unavailable


www.mayoclinic.org

https://www.perplexity.ai/search/i-see-so-many-people-ages-30-6-wll_Vtc4Sy.fWVw3JkXTTA

 

[timfa]

yrrdead said:

timfa said:

I notice a lot of folks between 30 and 65 taking 0.5-2iu of hgh daily, and I just can't figure out the point.. the sleep and muscle advantages are hardly there

At that kind of dose (obviously it varies by person, but from what I've observed, most don't feel anything until about 3-4 iu), those who run hgh this low keep saying "it's for skin health and hair health and anti aging" fine, hgh might help with skin elasticity and hair health, but ghkcu does the same thing (at half the cost and half the negative effects) I get the feeling there's something I'm not seeing, so why bother with doses that low?

As people get older, the dosing curve shifts downward. So it's fair to say there's a piece of the picture you're overlooking.

Hmm, that’s news to me—thanks. My assumption had been “a dose like that would only push you to around 400 ng/ml,” but after your reply I checked, and for someone who’s 50 that number is actually huge

 

[JulezZ]

If someone uses it occasionally in a cycle pattern, would there be any positive effect on skin or hair? For example, 8 weeks, 3 times per year?

 

[CNCCurrency]

timfa said:

I notice a lot of folks between 30 and 65 taking 0.5-2iu of hgh daily, and I just can't figure out the point.. the sleep and muscle advantages are hardly there

At that kind of dose (obviously it varies by person, but from what I've observed, most don't feel anything until about 3-4 iu), those who run hgh this low keep saying "it's for skin health and hair health and anti aging" fine, hgh might help with skin elasticity and hair health, but ghkcu does the same thing (at half the cost and half the negative effects) I get the feeling there's something I'm not seeing, so why bother with doses that low?

A solid piece of research looking at older males given small amounts of hgh. https://www.nejm.org/doi/full/10.1056/NEJM199007053230101

 

[Tbagger]

JulezZ said:

If someone uses it occasionally in a cycle pattern, would there be any positive effect on skin or hair? For example, 8 weeks, 3 times per year?

Based on all the reading I've done, that approach usually isn't recommended. This is more of a long-term commitment kind of drug. You won't notice the real payoff until roughly 3-6 months in. On top of that, once you introduce it exogenously, your own output shuts down in about a couple weeks, so running it in cycles can tank you, given how many natural processes depend on GH and IGF1. If long-term support isn't what you're after, my take is you'd do better running Tesa or CJC cycles to boost what your body makes on its own. I don't have any personal anecdotal experience to pull from, just what I've heard from others plus my grasp of the research I've been digging into. My plan is to move off tesa/ipa cycles onto straight HGH therapy the moment my order arrives, which is why I've been researching it so intensely lately.

 

[JulezZ]

Tbagger said:

JulezZ said:

If someone uses it occasionally in a cycle pattern, would there be any positive effect on skin or hair? For example, 8 weeks, 3 times per year?

Based on all the reading I've done, that approach usually isn't recommended. This is more of a long-term commitment kind of drug. You won't notice the real payoff until roughly 3-6 months in. On top of that, once you introduce it exogenously, your own output shuts down in about a couple weeks, so running it in cycles can tank you, given how many natural processes depend on GH and IGF1. If long-term support isn't what you're after, my take is you'd do better running Tesa or CJC cycles to boost what your body makes on its own. I don't have any personal anecdotal experience to pull from, just what I've heard from others plus my grasp of the research I've been digging into. My plan is to move off tesa/ipa cycles onto straight HGH therapy the moment my order arrives, which is why I've been researching it so intensely lately.

Thanks, that clears things up for me!