Tossing This Out to Everyone. . . .

Sasquatch

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Once I began Tirz, it cut my cravings down quite a bit. Yet over time, my brain stepped in.

I realize I can't risk eating too much. The fallout is TERRIBLE!

Still, the reality that I've gone 60 years without dropping a single pound means my cravings are just as . . . Intense as before.

A lot of people have seen at least some progress or dealt with ups and downs. But honestly, it never once worked for me. Then. . .well I am shedding weight, but like I said, I suppose I'm just stubborn or something?

Who else out there still craves a cheeseburger or steak, basically at any moment? 15mg and I'm still after hostess (truly gross) apple pies. 🫨
 
What was your titration pace? Ramping dosage quickly tends to backfire.
 
You're handling the toughest piece — pushing through that mental fight while the biology handles its end. That isn't being stubborn, that's incredibly tough. A lot of people would give in; you haven't. Don't stop! Personally, I'm obsessed with ZOLLI POPS !!! sugar free. can somebody tell me how to quit these wicked pops...
 
Perhaps what you're taking isn't the right fit. Or maybe there's just no helping you. Still, I lean toward doubting that. From dose number 1, Reta overhauled how I relate to food entirely. Sema, tirz, cagri, and the rest of the options commonly discussed in this space — I haven't given any of them a shot. What would actually do the trick for you is beyond me, but my sense is that tirz on its own has hit a ceiling in your case. Adding or switching to another option could be worth looking into. My guess is that the combined experience of this community could offer something to sharpen your thinking.
 
What's your time on it, and how many suppliers have you gone through? A few times each year there's garbage product.... give reta a shot, titrate up, and add 1mg of sema. Reta gets your metabolism going. I'm behind the wheel 10 or 12 hours daily, zero cardio, and I do weight training for 30 minutes or less a handful of times per week.... on tirz I dropped 6lbs and that was the end of it. Reta gave me another 15, spread across more than a year... If you aren't in a calorie deficit and aren't burning calories, it moves very very slowly. People who were putting away 4000 calories and tipping the scale at 360 are going to shed 80lbs. If you're 250 and barely eating as it is, not so much.....if nothing else works, check your bp, als and alt, triglcyerides, hdl, ldl, glucose and a1c.... if those numbers got better after 6 months, it's still worth sticking with.
 
Airborne Daddy said:

What's your time on it, and how many suppliers have you gone through? A few times each year there's garbage product.... give reta a shot, titrate up, and add 1mg of sema. Reta gets your metabolism going. I'm behind the wheel 10 or 12 hours daily, zero cardio, and I do weight training for 30 minutes or less a handful of times per week.... on tirz I dropped 6lbs and that was the end of it. Reta gave me another 15, spread across more than a year... If you aren't in a calorie deficit and aren't burning calories, it moves very very slowly. People who were putting away 4000 calories and tipping the scale at 360 are going to shed 80lbs. If you're 250 and barely eating as it is, not so much.....if nothing else works, check your bp, als and alt, triglcyerides, hdl, ldl, glucose and a1c.... if those numbers got better after 6 months, it's still worth sticking with.

That's exactly it. Plus, I actually enjoy getting labwork done. Staring at a scale and hoping it shifts is exhausting on its own.
 
Calm Logic said:

Airborne Daddy said:

What's your time on it, and how many suppliers have you gone through? A few times each year there's garbage product.... give reta a shot, titrate up, and add 1mg of sema. Reta gets your metabolism going. I'm behind the wheel 10 or 12 hours daily, zero cardio, and I do weight training for 30 minutes or less a handful of times per week.... on tirz I dropped 6lbs and that was the end of it. Reta gave me another 15, spread across more than a year... If you aren't in a calorie deficit and aren't burning calories, it moves very very slowly. People who were putting away 4000 calories and tipping the scale at 360 are going to shed 80lbs. If you're 250 and barely eating as it is, not so much.....if nothing else works, check your bp, als and alt, triglcyerides, hdl, ldl, glucose and a1c.... if those numbers got better after 6 months, it's still worth sticking with.

That's exactly it. Plus, I actually enjoy getting labwork done. Staring at a scale and hoping it shifts is exhausting on its own.
For the 1st time in roughly 5 years, my lipids came back on target, along with everything else. I handle the labwork on my own for around a hundred dollars, whereas insurance gets billed 700 and then sticks me with 400.
 
r4000 said:

What was your titration pace? Ramping dosage quickly tends to backfire.
My first experience was with Mounjaro pens. Every pen box included a paper showing the full step-up plan. Because of that, I followed the EL protocol when increasing my dose.
 
Camlbacker said:

Perhaps what you're taking isn't the right fit. Or maybe there's just no helping you. Still, I lean toward doubting that. From dose number 1, Reta overhauled how I relate to food entirely. Sema, tirz, cagri, and the rest of the options commonly discussed in this space — I haven't given any of them a shot. What would actually do the trick for you is beyond me, but my sense is that tirz on its own has hit a ceiling in your case. Adding or switching to another option could be worth looking into. My guess is that the combined experience of this community could offer something to sharpen your thinking.
Gave stacking reta a shot, though I likely didn't raise the dose enough. Considering Tesamorlin. 😊 Thanks
 
Airborne Daddy said:

What's your time on it, and how many suppliers have you gone through? A few times each year there's garbage product.... give reta a shot, titrate up, and add 1mg of sema. Reta gets your metabolism going. I'm behind the wheel 10 or 12 hours daily, zero cardio, and I do weight training for 30 minutes or less a handful of times per week.... on tirz I dropped 6lbs and that was the end of it. Reta gave me another 15, spread across more than a year... If you aren't in a calorie deficit and aren't burning calories, it moves very very slowly. People who were putting away 4000 calories and tipping the scale at 360 are going to shed 80lbs. If you're 250 and barely eating as it is, not so much.....if nothing else works, check your bp, als and alt, triglcyerides, hdl, ldl, glucose and a1c.... if those numbers got better after 6 months, it's still worth sticking with.
That's a curious situation. I stay under 2000 calories without much trouble. Weight is coming off, yet wow, it's wild. Feeling hungry, but not risking eating (a lot). My daily grind takes a lot out of me. During winter, though, it drops to 4 or 5 hours rather than the entire day. This isn't about pumping iron. It's baling hay, operating chainsaws, tending animals.

Oh yeah, labs are good. I'm due in March. Thanks AD!
 
Sasquatch said:

Camlbacker said:

Perhaps what you're taking isn't the right fit. Or maybe there's just no helping you. Still, I lean toward doubting that. From dose number 1, Reta overhauled how I relate to food entirely. Sema, tirz, cagri, and the rest of the options commonly discussed in this space — I haven't given any of them a shot. What would actually do the trick for you is beyond me, but my sense is that tirz on its own has hit a ceiling in your case. Adding or switching to another option could be worth looking into. My guess is that the combined experience of this community could offer something to sharpen your thinking.
Gave stacking reta a shot, though I likely didn't raise the dose enough. Considering Tesamorlin. 😊 Thanks
I've come across information about cagri. From what I gather, it supposedly completely eliminates appetite for a lot of people. I actually have some on hand but haven't given it a try, since I've finally reached my target weight using T and surv. That said, based on what I keep seeing posted here, if the goal is to totally crush appetite (and nothing more), cagri would probably get the job done. ymmv
 
If your cravings happen to be tied to emotions, these peptides might not do much for you. Sure, there's chatter and possibly some evidence (I haven't dug into it much, so anyone who's read up can set me straight) that certain ones influence dopamine release, and that could shape eating that's 100% emotional rather than driven by hunger at all. Still, I've seen plenty of folks with BED or other eating-to-cope struggles say the peptides don't reliably deliver that "food doesn't appeal to me" feeling that the "I'm constantly starving" crowd tends to get relief from.

Personally, I DO have a BED history, and they do help me; but part of that help might just be in my head. I try not to look at that too closely, though.
 
Sasquatch said:

Airborne Daddy said:

What's your time on it, and how many suppliers have you gone through? A few times each year there's garbage product.... give reta a shot, titrate up, and add 1mg of sema. Reta gets your metabolism going. I'm behind the wheel 10 or 12 hours daily, zero cardio, and I do weight training for 30 minutes or less a handful of times per week.... on tirz I dropped 6lbs and that was the end of it. Reta gave me another 15, spread across more than a year... If you aren't in a calorie deficit and aren't burning calories, it moves very very slowly. People who were putting away 4000 calories and tipping the scale at 360 are going to shed 80lbs. If you're 250 and barely eating as it is, not so much.....if nothing else works, check your bp, als and alt, triglcyerides, hdl, ldl, glucose and a1c.... if those numbers got better after 6 months, it's still worth sticking with.
That's a curious situation. I stay under 2000 calories without much trouble. Weight is coming off, yet wow, it's wild. Feeling hungry, but not risking eating (a lot). My daily grind takes a lot out of me. During winter, though, it drops to 4 or 5 hours rather than the entire day. This isn't about pumping iron. It's baling hay, operating chainsaws, tending animals.

Oh yeah, labs are good. I'm due in March. Thanks AD!

Might it be water?

I don't know whether this is true for you, but I found that while I was taking smaller doses and drinking a lot of water—roughly ten gulps—I got a full feeling almost right away. That sensation stuck around for a good while; I wasn't thirsty at all, and drinking didn't seem like a chore.

Still, even at a high dose and without much hunger, sometimes I catch myself (my brain) wanting sugar out of nowhere, for no clear reason.

Most of the time I just go along with it, since it doesn't happen often, and I attempt to keep what I take in as low as possible.
 
I can't say whether any of this applies to you without a lot more background, but here's how I managed to shed the weight: I focused on heading off both severe hunger and the intense rebound hunger that follows, by restricting what I ate and steering clear of anything likely to send blood sugar, brain dopamine, or whatever biochemical switch high-calorie foods flip, soaring — since for me that switch, once it flips back a few hours later, means raging hunger.

The closer your eating patterns sit to binge eating disorder or food addiction, the more this matters. What worked for me was sticking to foods with a maximum energy density of 1.5 kcal per gram, which kept hunger way down and let me eat until I wasn't hungry anymore without racking up too many calories. In practice that means as little fat as I can manage, loads of very lean meat, fruit, vegetables, no high-carb high-glycaemic items such as bread, pasta, or grains, a little low-fat high-protein yoghurt, plus 20 g of dark chocolate once a day — for some odd reason it doesn't set off that extreme hunger response. Plenty of low-fat protein, since per calorie it fills you up more than anything else. A soup made from very lean meat is fantastic.

What's good about eating this way is that it's something you can keep up, it's healthy, and you can eat however much you need to not feel too hungry. Overeating most fruits or vegetables is nearly impossible — even when the sugar content is high, the fiber slows absorption, and putting away 1000 calories of many fruits or veg means 2 kilograms, which is genuinely tough to force down even if you graze slowly all day. You can even eat close to double that and still drop weight. Your palate shifts too, so fruit ends up tasting wonderful and you crave the high-calorie stuff less — though for me it took complete, absolute avoidance of high-calorie highly rewarding foods, and so far that's held for 3 years.

The first 70 kg came off without GLPs, since back then I figured they cost too much. I kept it off for a year, but it was brutal — I was hungry much of the time and almost never satisfied, and metabolic adaptation meant maintaining my weight required roughly 1600-1800 kcal/day.

Then I found that prescription ozempic wasn't terribly pricey in Aus at low doses, so I gave it a year and it helped, though it made me nauseous; still, it took a bit of the edge off the hunger. After that I came across this forum, moved to 15mg tirzepatide, and later added 5mg of retatrutide too when I was still somewhat hungry all the time. Those made a huge difference — I feel full after small meals of about 300 kcal, and cravings for unhealthy food dropped a lot. Over the past 7 months I've gradually shed another 8 kg. Without both the GLP's and the diet approach, I doubt I could have lost the weight or kept it off. I'd reached a normal bmi range before but never managed to stay there beyond a couple of years — though back then I didn't really grasp how different foods triggered my hunger, and glp's didn't exist. For me, dodging all high-calorific-density foods works, and based on what I understand of physiology, it ought to be one of the simplest ways to tolerate a lower calorie intake over the long haul with the least hunger. That said, I think cutting out rich foods entirely is necessary to reset your taste, so plainer foods gradually taste better, and to stop extreme rebound hunger from kicking in if you're prone to it. In some ways it's really tough to maintain, since it means completely avoiding many popular foods, but in other ways it's the easiest — you can eat as much as you need and still lose weight. And GLP's certainly make it easier.
 
randompersonrandom said:

If your cravings happen to be tied to emotions, these peptides might not do much for you. Sure, there's chatter and possibly some evidence (I haven't dug into it much, so anyone who's read up can set me straight) that certain ones influence dopamine release, and that could shape eating that's 100% emotional rather than driven by hunger at all. Still, I've seen plenty of folks with BED or other eating-to-cope struggles say the peptides don't reliably deliver that "food doesn't appeal to me" feeling that the "I'm constantly starving" crowd tends to get relief from.

Personally, I DO have a BED history, and they do help me; but part of that help might just be in my head. I try not to look at that too closely, though.
My plan was to send a private message, but maybe it could be of use to somebody else too?

Phenofibrate has been part of my routine for as long as I can remember. (That's the cholesterol medication.) Not long ago, research came out pointing to side-effects along the lines of being 'over-emotional.' The silliest little things set off the waterworks. I used to sit there asking myself why?

It's possible this is going head-to-head with what another chemical is doing. The only way I'd ever know is by cutting off one or the other. (That won't happen for some time yet.) My gut says it isn't BED. Appreciate you sending me down that rabbit hole. 😁 I'm not sure? I'd still say I'm 'highly functional.' No time to sit and stew. There's a pile of things waiting on me. Honestly, that pile (of things waiting) might be what keeps me afloat. 😇 Thanks Rando!
 
Sasquatch said:

randompersonrandom said:

If your cravings happen to be tied to emotions, these peptides might not do much for you. Sure, there's chatter and possibly some evidence (I haven't dug into it much, so anyone who's read up can set me straight) that certain ones influence dopamine release, and that could shape eating that's 100% emotional rather than driven by hunger at all. Still, I've seen plenty of folks with BED or other eating-to-cope struggles say the peptides don't reliably deliver that "food doesn't appeal to me" feeling that the "I'm constantly starving" crowd tends to get relief from.

Personally, I DO have a BED history, and they do help me; but part of that help might just be in my head. I try not to look at that too closely, though.
My plan was to send a private message, but maybe it could be of use to somebody else too?

Phenofibrate has been part of my routine for as long as I can remember. (That's the cholesterol medication.) Not long ago, research came out pointing to side-effects along the lines of being 'over-emotional.' The silliest little things set off the waterworks. I used to sit there asking myself why?

It's possible this is going head-to-head with what another chemical is doing. The only way I'd ever know is by cutting off one or the other. (That won't happen for some time yet.) My gut says it isn't BED. Appreciate you sending me down that rabbit hole. 😁 I'm not sure? I'd still say I'm 'highly functional.' No time to sit and stew. There's a pile of things waiting on me. Honestly, that pile (of things waiting) might be what keeps me afloat. 😇 Thanks Rando!

glad to share a thing that could come in handy for you or somebody else!
 
Sasquatch said:

Camlbacker said:

Perhaps what you're taking isn't the right fit. Or maybe there's just no helping you. Still, I lean toward doubting that. From dose number 1, Reta overhauled how I relate to food entirely. Sema, tirz, cagri, and the rest of the options commonly discussed in this space — I haven't given any of them a shot. What would actually do the trick for you is beyond me, but my sense is that tirz on its own has hit a ceiling in your case. Adding or switching to another option could be worth looking into. My guess is that the combined experience of this community could offer something to sharpen your thinking.
Gave stacking reta a shot, though I likely didn't raise the dose enough. Considering Tesamorlin. 😊 Thanks

I did some reading on Tesa. From what I gathered, it likely works better once you're nearer to your goal. I'm not sure whether you've hit goal yet. That said, I also came across info saying it may ramp up appetite, and that its main purpose is body fat redistribution rather than dropping pounds. So the moment I saw the appetite increase part, my reaction was, yeah, not happening right now....🤣

Given that tirzepatide worked well for you in terms of appetite suppression, bumping past 15mg is an option. Personally, I'm on roughly 17 or 18mg week to week and haven't had issues. Plenty of anecdotal reports exist of folks at 20mg doing well. Since early December I've been stacking tirzepatide alongside a low dose of semaglutide, and that combo has completely erased the mental food chatter. Honestly, I enjoy how sema feels on injection day and for a few days afterward. It's clearly not the same as tirz.
 
Grogu said:

Sasquatch said:

Camlbacker said:

Perhaps what you're taking isn't the right fit. Or maybe there's just no helping you. Still, I lean toward doubting that. From dose number 1, Reta overhauled how I relate to food entirely. Sema, tirz, cagri, and the rest of the options commonly discussed in this space — I haven't given any of them a shot. What would actually do the trick for you is beyond me, but my sense is that tirz on its own has hit a ceiling in your case. Adding or switching to another option could be worth looking into. My guess is that the combined experience of this community could offer something to sharpen your thinking.
Gave stacking reta a shot, though I likely didn't raise the dose enough. Considering Tesamorlin. 😊 Thanks

I did some reading on Tesa. From what I gathered, it likely works better once you're nearer to your goal. I'm not sure whether you've hit goal yet. That said, I also came across info saying it may ramp up appetite, and that its main purpose is body fat redistribution rather than dropping pounds. So the moment I saw the appetite increase part, my reaction was, yeah, not happening right now....🤣

Given that tirzepatide worked well for you in terms of appetite suppression, bumping past 15mg is an option. Personally, I'm on roughly 17 or 18mg week to week and haven't had issues. Plenty of anecdotal reports exist of folks at 20mg doing well. Since early December I've been stacking tirzepatide alongside a low dose of semaglutide, and that combo has completely erased the mental food chatter. Honestly, I enjoy how sema feels on injection day and for a few days afterward. It's clearly not the same as tirz.
Cagri crossed my mind as well. Sema too, since the price is low. Still, there's a case to be made for keeping things simple. That being said, it's quite plausible Reta ends up taking Tirz's place, after it earns its credentials from that big-name doctor whats-his-nutz. The pace of "grandpa's medicine" is absurdly sluggish. By the time reta finally comes out, the early adopters will already have moved on. Suppose that's nothing new.
 
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