Tirz and stomach inflammation — anyone else?

[Brandon556]

I've got this thing with my stomach where it becomes extremely bloated or inflamed. It doesn't feel like gas — more just inflamed and swollen. What I eat or drink doesn't seem to matter, and my doctors have been worthless on it.

I started tirz 3 weeks ago. For 2-3 days after each dose the inflammation vanishes, my stomach is flat and feels great. I'm hoping a higher dose stretches that out longer. Has anyone else had this? It seems to cause bloating for plenty of people.

I mainly went on tirz because of a fatty liver and visceral fat. At 6'2 205lbs I'm not obese, just slightly overweight. Want to get down to 185 and then start building muscle.

I'm tirating up faster than recommend, with no issues. 1st dose 2.5mg, 2nd 3.5mg, 3rd 4.5mg yesterday. I'm going to take another 500mcg and then hold at 5mg for a few weeks. 5mg is meant to be the starting therapeutic dose.

 

[GrandmaJ]

My stomach problems also improved with Tirz. Around month 3, I introduced KPV at .5mg, and every bit of my stomach trouble disappeared. For the rest of my life, I'll be on Tirz/KPV. Now I'm a changed person — I can leave the house, share meals with friends without checking out where the bathrooms are, and honestly I just feel good all around. I hope things keep going well for you!

 

[Mara_aa]

Brandon556 said:

I've got this thing with my stomach where it becomes extremely bloated or inflamed. It doesn't feel like gas — more just inflamed and swollen. What I eat or drink doesn't seem to matter, and my doctors have been worthless on it.

I started tirz 3 weeks ago. For 2-3 days after each dose the inflammation vanishes, my stomach is flat and feels great. I'm hoping a higher dose stretches that out longer. Has anyone else had this? It seems to cause bloating for plenty of people.

I mainly went on tirz because of a fatty liver and visceral fat. At 6'2 205lbs I'm not obese, just slightly overweight. Want to get down to 185 and then start building muscle.

I'm tirating up faster than recommend, with no issues. 1st dose 2.5mg, 2nd 3.5mg, 3rd 4.5mg yesterday. I'm going to take another 500mcg and then hold at 5mg for a few weeks. 5mg is meant to be the starting therapeutic dose.

It's good that your stomach is doing better, but I think you're titrating too quickly. Week after week, tirzepatide accumulates in your body. Right now you might not notice anything at 4.5mg, yet in a few days the accumulation effect means these doses will reach their true peak. The wisest choice is to hold at 5mg for several weeks, otherwise side effects could suddenly hit you.