IronCircuit said:
This is an awesome post, as it’s something I’ve wondered about. Although daily administration is the norm, studies suggest EOD administration can be effective as well.
This same question comes up in the secretogoblin debate. Sure, you can use a 5-on/2-off schedule and still get results, but your cumulative GH/IGF-1 exposure will presumably be lower than with daily administration.
My question has always revolved around lipolysis. My understanding is that much of the acute lipolytic effect is driven by the GH response itself. So on days you don’t administer GH, or tesamorelin, for that matter, you’re missing that additional GH-driven lipolytic stimulus, even though endogenous GH secretion and baseline lipolysis obviously continue.
Therefore, if fat loss is the primary goal, it would seem that daily administration would make more sense than intentionally taking days off.
Click to expand...