RETA: Weekly Injection Compared to Daily Injection

[rixsternaz]

BNLFL said:

myboysherman said:

BNLFL said:

myboysherman said:

I split my dose into 2x per week, and when I increased it I moved to every 3 days, because side effects had me nervous. Taking on too much at once wasn't something I wanted to risk. Down the road I plan to push the dose higher than needed and then switch to a single weekly shot, but at the dose I'm on now, the results haven't made me feel sure enough to do that.

The adverse reactions haven't been awful. Nausea never showed up for us; what we did notice was a bit of heartburn when lying down for the night, though managing it is simple. It fades before the following tiration, and by this point even if it does occur, it isn't severe. Those are the only things that come to mind.

That's a fair point, and I do see it the same way. My concern, though, was arrhythmia of the heart. I'm already jittery as it is. Things became quite rough for about 2 days following my 3rd dose, so I paused, reduced the amount, and then built it back up gradually. As far as the heart goes, electrolytes appear to have resolved it.

For AFIB that started 3.5 years ago, I take Metoprolol 50mg along with Lisinopril 10mg. The AFIB came after a severe case of pneumonia that landed me in the ICU for 2 weeks, plus another 1 week before they agreed to discharge me.

If you have heart problems, particularly A-fib, using Reta demands serious caution. Reta has a reputation for raising heart rate, and that effect may disrupt your heart's normal rhythm, potentially landing you in the E.R.

 

[RubbaDubba1]

myboysherman said:

BNLFL said:

myboysherman said:

I split my dose into 2x per week, and when I increased it I moved to every 3 days, because side effects had me nervous. Taking on too much at once wasn't something I wanted to risk. Down the road I plan to push the dose higher than needed and then switch to a single weekly shot, but at the dose I'm on now, the results haven't made me feel sure enough to do that.

The adverse reactions haven't been awful. Nausea never showed up for us; what we did notice was a bit of heartburn when lying down for the night, though managing it is simple. It fades before the following tiration, and by this point even if it does occur, it isn't severe. Those are the only things that come to mind.

That's a fair point, and I do see it the same way. My concern, though, was arrhythmia of the heart. I'm already jittery as it is. Things became quite rough for about 2 days following my 3rd dose, so I paused, reduced the amount, and then built it back up gradually. As far as the heart goes, electrolytes appear to have resolved it.

A lot of people suggest pairing Taurine with Reta. Here's what an AI had to say:

Taurine is an amino acid that's found in high amounts in the heart, where it plays a role in keeping heartbeat steady, managing calcium signaling, and regulating blood pressure. Research indicates that supplementing with taurine may lower heart rate by roughly 3.6 bpm and cut down premature contractions (PACs/PVCs) by 50%. It's usually regarded as safe and helpful for heart rhythm and function. Heart Rhythm Regulation: Taurine contributes to a consistent, regular heartbeat, lowering the occurrence of arrhythmia, especially premature contractions.

Every GLP-1 has the potential to elevate resting heart rate, though Reta clearly stands out as the most potent. These days I take 2000mg of Taurine every day; back when I was on 4mg per week of Reta and losing weight, I took 4000mg. At present I only use 1mg each of Tirz & Reta weekly. Even the Nutricost brand of Taurine does the job—I monitored my BPM together with my BP for a period and it did help lower it. From what I understand, for most people the elevated BPM tends to come down after several months on Reta, if anyone else can confirm that.

 

[BNLFL]

rixsternaz said:

BNLFL said:

myboysherman said:

BNLFL said:

myboysherman said:

I split my dose into 2x per week, and when I increased it I moved to every 3 days, because side effects had me nervous. Taking on too much at once wasn't something I wanted to risk. Down the road I plan to push the dose higher than needed and then switch to a single weekly shot, but at the dose I'm on now, the results haven't made me feel sure enough to do that.

The adverse reactions haven't been awful. Nausea never showed up for us; what we did notice was a bit of heartburn when lying down for the night, though managing it is simple. It fades before the following tiration, and by this point even if it does occur, it isn't severe. Those are the only things that come to mind.

That's a fair point, and I do see it the same way. My concern, though, was arrhythmia of the heart. I'm already jittery as it is. Things became quite rough for about 2 days following my 3rd dose, so I paused, reduced the amount, and then built it back up gradually. As far as the heart goes, electrolytes appear to have resolved it.

For AFIB that started 3.5 years ago, I take Metoprolol 50mg along with Lisinopril 10mg. The AFIB came after a severe case of pneumonia that landed me in the ICU for 2 weeks, plus another 1 week before they agreed to discharge me.

If you have heart problems, particularly A-fib, using Reta demands serious caution. Reta has a reputation for raising heart rate, and that effect may disrupt your heart's normal rhythm, potentially landing you in the E.R.

It was the pneumonia that brought it on, and the only reason he still has me on this medication is that I get no side effects whatsoever from it, plus it serves as a precaution given that I used to put away a lot of beer. Some time ago I had a nuclear stress test — no problems found, no blockages. As it happens, I see him on Monday. An EKG is done at every visit. My BP tends to sit around 125/75, which I check myself at home. My HR runs maybe 4-6 BPM higher, and only at certain times. While I'm asleep it averages 55. O2 stays at 98-100% consistently. I appreciate the concern.

 

[yota96]

RubbaDubba1 said:

Taking it daily is likely too much, though splitting into 2 doses per week isn't rare and may smooth out serum concentrations. That could mean reduced food noise and possibly fewer heart-rate spikes. I tried an every-other-day schedule previously and didn't notice any upside. For me, 1mg Tirz plus 1mg Reta spaced 84 hours apart each week keeps me at maintenance and does the job well.

What's the reason behind combining Tirz and Reta?

 

[RubbaDubba1]

Why not both? Plenty of people here are already doing that, and for maintenance it works really well — Tirz gives you enough appetite suppression while Reta delivers enough caloric burn. My labs look great, and it helps me with some of the bad habits I have.