Ok, so that was indeed too much B12

turlian

turlian

New member
Joined
Aug 19, 2026
Messages
16
Reaction score
0
Location
Imported archive
I've been on daily Omeprazole and Semaglutide for about 18 months (just switch to Tirz two weeks ago, but kinda irrelevant). My gastroenterologist, following some blood work, had me on a B12 supplement once a day.

Well my B12 went from 270 to 1,792 pg/ml since February (normal range is up to 1,100). My PCP said "OK, time to ramp down on the B12". I've been using the Costco B12, which is (no joke) 208,333% of your daily dosage - as it's so hard to absorb B12.

I was kinda surprised to see that an oral vitamin actually did something.
 
turlian said:


I've been on daily Omeprazole and GLP1 for about 18 months (just switch to GLP2 two weeks ago, but kinda irrelevant). My gastroenterologist, following some blood work, had me on a B12 supplement once a day.

Well my B12 went from 270 to 1,792 pg/ml since February (normal range is up to 1,100). My PCP said "OK, time to ramp down on the B12". I've been using the Costco B12, which is (no joke) 208,333% of your daily dosage - as it's so hard to absorb B12.

I was kinda surprised to see that an oral vitamin actually did something.

Click to expand...
Click to expand...
OMG! I had the exact same thing happen, also from the Costco "Mature" multi! My b12 has never been so high!

I immediately ditched them and bought one with a more normal level of B12, but interestingly my doc wasn't concerned at all. He said people losing a lot of weight NEED extra B12, but I think he confused GLP weight loss with bariatric, which is a malabsorption issue. (He's an idiot, I fired him shortly after 🤣).
 
Happened to me too! Naturopath put me on B supplements and my level went way high so now I only take B on every other day or every two days. Much better!
 
turlian said:


I've been on daily Omeprazole and GLP1 for about 18 months (just switch to GLP2 two weeks ago, but kinda irrelevant).

Click to expand...
Click to expand...
Curious which GLP-2 agonist you're taking, teduglutide, glepaglutide, apraglutide, dapiglutide, or elsiglutide?

There are substantial differences between GLP-1 and GLP-2 agonists, as they target completely different hormones and are designed to treat completely different conditions, so definitely not irrelavent.
 
ZippityDooDah said:


Curious which GLP-2 agonist you're taking, teduglutide, glepaglutide, apraglutide, dapiglutide, or elsiglutide?

There are substantial differences between GLP-1 and GLP-2 agonists, as they target completely different hormones and are designed to treat completely different conditions, so definitely not irrelavent.

Click to expand...
Click to expand...
Sorry, misspoke (based off confusing labeling) - not a GLP-2, but Tirzepatide. My source incorrectly uses a 2 identifier for this.
 
turlian said:


I've been on daily Omeprazole and Semaglutide for about 18 months (just switch to Tirz two weeks ago, but kinda irrelevant). My gastroenterologist, following some blood work, had me on a B12 supplement once a day.

Well my B12 went from 270 to 1,792 pg/ml since February (normal range is up to 1,100). My PCP said "OK, time to ramp down on the B12". I've been using the Costco B12, which is (no joke) 208,333% of your daily dosage - as it's so hard to absorb B12.

I was kinda surprised to see that an oral vitamin actually did something.

Click to expand...
Click to expand...
There are studies that show that oral (both tablet and sublingual) B12 is more effective than injections. I wouldn’t lose any sleep over your pg/ml. Medically there is no “normal range” for B12 as well there is no established serums levels where it is toxic to humans. There is evidence of markers present in certain disease states, but it is generally seen as a marker, not a cause. BTW, I’m not gpt, just a biochemist with 20+ years in the medical field working in research, marketing, even some implementations of the very drugs we talk about here 🙂
 
turlian said:


Sorry, misspoke (based off confusing labeling) - not a GLP-2, but Tirzepatide. My source incorrectly uses a 2 identifier for this.

Click to expand...
Click to expand...
Tell me you are buying from a US single vial seller without telling me... 😎

...just razzing you!...GL with the B12 stuff 🙂
 
turlian said:


I've been on daily Omeprazole and Semaglutide for about 18 months (just switch to Tirz two weeks ago, but kinda irrelevant). My gastroenterologist, following some blood work, had me on a B12 supplement once a day.

Well my B12 went from 270 to 1,792 pg/ml since February (normal range is up to 1,100). My PCP said "OK, time to ramp down on the B12". I've been using the Costco B12, which is (no joke) 208,333% of your daily dosage - as it's so hard to absorb B12.

I was kinda surprised to see that an oral vitamin actually did something.

Click to expand...
Click to expand...
wait, you are serious with the daily dosage % or is that hyperbole. made me laugh out loud
 
bamagirl26 said:


wait, you are serious with the daily dosage % or is that hyperbole. made me laugh out loud

Click to expand...
Click to expand...





598e9088fd82f250f1cb3d3536bd045d7e5e20f1efba957da62a8fe79e7cc20b.webp
 
Today in "things I didn't know that I needed to know" is ...

Watch out when on high dose multi-B vitamins. While it is true that most of them are safe, there is one exception that everyone needs to be aware of.

While vitamin B6 is a water-soluble nutrient critical for metabolic functions and safely consumed through whole foods, ONE synthetic form, the cheap to manufacture synthetic pyridoxine HCl can accumulate to toxic levels in the body.

Use of other forms of B6 is safe. This is specific to the B6-HCl.

Search B6 paradox for more info. There is also a link below.

The vitamin B6 paradox refers to the counterintuitive phenomenon where taking high doses of synthetic pyridoxine HCl (the inactive form of vitamin B6 found in many supplements) actually induces a functional vitamin B6 deficiency and neurotoxicity in peripheral tissues

Click to expand...
Click to expand...
 
Back
Top