No change on the scale for 2 weeks — vial issue or normal stall?

[amosmylove]

Hi everyone. I'm pretty new to GLP1s. I've been using grey Tirz for 9 weeks now. Yesterday I took my 2nd dose at 7.5mg. My starting dose 9 weeks back was 2.5mg. Over the first 7 weeks I dropped 19lbs, and the side effects stayed manageable. Burping and diarrhea were the main problems.

But for roughly 2 weeks now, my weight hasn't moved at all. I figured moving up to 7.5mg would finally get things going. On top of that, during these last 2 weeks I've felt hungrier and less full when I eat.

The thing that stands out most is that my switch to 7.5 happened at the same time I opened a new 60mg vial of Tirz. Both vials came from the same website, though the first one was 30mg. Could the 60mg vial be weaker? Or maybe the first vial carried more endotoxins, which is why my gut acted up more back then? With this new vial I've had zero stomach trouble, no burping, no loose stools.

So I'm asking what you'd do if you were me. Raise the dose, or add a midweek shot to kick something off?

I was steadily dropping around 2.5lbs per week, and now there's been nothing for over 2 weeks. I haven't eaten badly or too much at all. I'm still in a calorie deficit and I fast for most of the day. I have been pretty inactive. Energy has been a real struggle, which might be from the weight I lost in earlier months.

Starting weight 207, current weight 189.

I also just wrapped up a BPC/TB stack cycle last week. Plus a DSIP cycle.

Is it normal for nothing to change, or did I get a bad vial?

 

[cheaperseeker]

The complete effects of tirz generally need 4 weeks to emerge, and for some people it can take 5 or 6. Before moving up to a stronger dose or deciding whether it is doing anything, you ought to give it no less than that amount of time. Staying on the smallest dose that works leaves you somewhere to go if tolerance develops later. There is another benefit to holding a dose for 4 weeks: it can keep side effects from appearing or make them milder.

A pause of several weeks on the scale is also expected once you have dropped a decent amount of weight. That is simply your body recalibrating.

My suggestion would be to stay at 7.5mg for at least 2 more weeks.

 

[wileyhorse]

The odds that a vial has gone “bad” are quite low. Guidance is to remain at any given dose for no less than 4 weeks, and a stall or plateau isn’t really a thing until you’ve gone 4 weeks without losing. Dropping 19lbs across 7 weeks is extremely fast, so your body is probably just catching up. Keep at 7.5 for the next 2 weeks at minimum; if the scale still hasn’t budged after that, that’s when I’d consider moving the dose up.

 

[amosmylove]

cheaperseeker said:

The complete effects of tirz generally need 4 weeks to emerge, and for some people it can take 5 or 6. Before moving up to a stronger dose or deciding whether it is doing anything, you ought to give it no less than that amount of time. Staying on the smallest dose that works leaves you somewhere to go if tolerance develops later. There is another benefit to holding a dose for 4 weeks: it can keep side effects from appearing or make them milder.

A pause of several weeks on the scale is also expected once you have dropped a decent amount of weight. That is simply your body recalibrating.

My suggestion would be to stay at 7.5mg for at least 2 more weeks.

Right away I was pretty sure it was working great for me. The only difference is that after I switched to another vial, everything changed. It feels almost as if I'm getting only half of what I used to.

When you mention needing 4 weeks, or 5 or 6, before the 'full effects of tirz' show up, do you mean 4-6 weeks on one particular dose? If it's supposed to take longer than that, why do clinical guidelines recommend moving up every 4 weeks? Though maybe I'm just not following what you mean.

What I can't figure out is why 2.5/5mg worked so well for me, but once I moved to 7.5 it flatlined. That doesn't make sense to me. Unless the vial is weaker or no good. That's the point when things shifted.

 

[cheaperseeker]

Another point: going most of the day without eating is probably why you're low on energy.

Do you identify as female? I heard recently that the research showing fasting is beneficial was conducted on men, and for women it may not be as helpful since their bodies react more strongly to how much energy is available. So if your system thinks food is scarce, it might cling to the weight as a "reserve".

Even for a man, cutting calories too aggressively can send that same scarcity signal.

Have something to eat at least 3 times a day and be sure you're taking in enough calories. Honestly, I'd suggest skipping calorie counting altogether and simply eating whenever you feel hungry. Once you stop stressing and allow the tirz to do its thing, the number on the scale might surprise you.

 

[amosmylove]

wileyhorse said:

The odds that a vial has gone “bad” are quite low. Guidance is to remain at any given dose for no less than 4 weeks, and a stall or plateau isn’t really a thing until you’ve gone 4 weeks without losing. Dropping 19lbs across 7 weeks is extremely fast, so your body is probably just catching up. Keep at 7.5 for the next 2 weeks at minimum; if the scale still hasn’t budged after that, that’s when I’d consider moving the dose up.

Staying at 7.5 is fine with me. I figure that since I bumped the dose up and still feel nothing at all, it must not be doing anything. I'm not a fan of diarrhea, but back when I had it, at least I had proof the glp1 was active! LOL

Patience is what I need more of. I assumed the weight would keep coming off without interruption, so going 2 weeks and counting with zero movement threw me off.

 

[FlowerFairy]

amosmylove said:

cheaperseeker said:

The complete effects of tirz generally need 4 weeks to emerge, and for some people it can take 5 or 6. Before moving up to a stronger dose or deciding whether it is doing anything, you ought to give it no less than that amount of time. Staying on the smallest dose that works leaves you somewhere to go if tolerance develops later. There is another benefit to holding a dose for 4 weeks: it can keep side effects from appearing or make them milder.

A pause of several weeks on the scale is also expected once you have dropped a decent amount of weight. That is simply your body recalibrating.

My suggestion would be to stay at 7.5mg for at least 2 more weeks.

Right away I was pretty sure it was working great for me. The only difference is that after I switched to another vial, everything changed. It feels almost as if I'm getting only half of what I used to.

When you mention needing 4 weeks, or 5 or 6, before the 'full effects of tirz' show up, do you mean 4-6 weeks on one particular dose? If it's supposed to take longer than that, why do clinical guidelines recommend moving up every 4 weeks? Though maybe I'm just not following what you mean.

What I can't figure out is why 2.5/5mg worked so well for me, but once I moved to 7.5 it flatlined. That doesn't make sense to me. Unless the vial is weaker or no good. That's the point when things shifted.

Plateaus happen. That isn't about the medication or how much you're taking — your body is just pausing to recalibrate.

On top of that, how are you doing on protein? Hitting those targets plays a role in how quickly you lose.

One more thing — have you had your kits tested, or looked into a group test? You can't rely on what a vendor reports. I'm not saying the kit is bad, but with no testing there's simply no way to tell.

 

[amosmylove]

cheaperseeker said:

Another point: going most of the day without eating is probably why you're low on energy.

Do you identify as female? I heard recently that the research showing fasting is beneficial was conducted on men, and for women it may not be as helpful since their bodies react more strongly to how much energy is available. So if your system thinks food is scarce, it might cling to the weight as a "reserve".

Even for a man, cutting calories too aggressively can send that same scarcity signal.

Have something to eat at least 3 times a day and be sure you're taking in enough calories. Honestly, I'd suggest skipping calorie counting altogether and simply eating whenever you feel hungry. Once you stop stressing and allow the tirz to do its thing, the number on the scale might surprise you.

Yes, I'm female. I don't log anything, but I'm confident I'm in a deficit — years of watching what I eat and how the scale reacts taught me that. Around 1800-2000k keeps my weight steady, and dropping below 1500 cals makes me lose. Right now I'm well beneath that 1500 line.

Generally, I haven't been eating 3x per day. My first meal tends to be dinner, then a snack before bed. Occasionally I'll have something in the late morning.

Most days my food is salmon or chicken.

I'll need to be more intentional about eating on a more frequent schedule so I don't end up overtired.

 

[amosmylove]

FlowerFairy said:

amosmylove said:

cheaperseeker said:

The complete effects of tirz generally need 4 weeks to emerge, and for some people it can take 5 or 6. Before moving up to a stronger dose or deciding whether it is doing anything, you ought to give it no less than that amount of time. Staying on the smallest dose that works leaves you somewhere to go if tolerance develops later. There is another benefit to holding a dose for 4 weeks: it can keep side effects from appearing or make them milder.

A pause of several weeks on the scale is also expected once you have dropped a decent amount of weight. That is simply your body recalibrating.

My suggestion would be to stay at 7.5mg for at least 2 more weeks.

Right away I was pretty sure it was working great for me. The only difference is that after I switched to another vial, everything changed. It feels almost as if I'm getting only half of what I used to.

When you mention needing 4 weeks, or 5 or 6, before the 'full effects of tirz' show up, do you mean 4-6 weeks on one particular dose? If it's supposed to take longer than that, why do clinical guidelines recommend moving up every 4 weeks? Though maybe I'm just not following what you mean.

What I can't figure out is why 2.5/5mg worked so well for me, but once I moved to 7.5 it flatlined. That doesn't make sense to me. Unless the vial is weaker or no good. That's the point when things shifted.

Plateaus happen. That isn't about the medication or how much you're taking — your body is just pausing to recalibrate.

On top of that, how are you doing on protein? Hitting those targets plays a role in how quickly you lose.

One more thing — have you had your kits tested, or looked into a group test? You can't rely on what a vendor reports. I'm not saying the kit is bad, but with no testing there's simply no way to tell.

I'm hoping that's the only thing going on. Thanks for sharing that!

 

[FlowerFairy]

amosmylove said:

cheaperseeker said:

Another point: going most of the day without eating is probably why you're low on energy.

Do you identify as female? I heard recently that the research showing fasting is beneficial was conducted on men, and for women it may not be as helpful since their bodies react more strongly to how much energy is available. So if your system thinks food is scarce, it might cling to the weight as a "reserve".

Even for a man, cutting calories too aggressively can send that same scarcity signal.

Have something to eat at least 3 times a day and be sure you're taking in enough calories. Honestly, I'd suggest skipping calorie counting altogether and simply eating whenever you feel hungry. Once you stop stressing and allow the tirz to do its thing, the number on the scale might surprise you.

Yes, I'm female. I don't log anything, but I'm confident I'm in a deficit — years of watching what I eat and how the scale reacts taught me that. Around 1800-2000k keeps my weight steady, and dropping below 1500 cals makes me lose. Right now I'm well beneath that 1500 line.

Generally, I haven't been eating 3x per day. My first meal tends to be dinner, then a snack before bed. Occasionally I'll have something in the late morning.

Most days my food is salmon or chicken.

I'll need to be more intentional about eating on a more frequent schedule so I don't end up overtired.

Hmm. Is your food intake sufficient? Tracking what you eat is genuinely important. Apps such as My Fitness Pal cost nothing and let you log calories, protein, and more. Hitting your protein target doesn't just fight tiredness — it also stops the hair shedding lots of people get while losing weight.

 

[cheaperseeker]

amosmylove said:

cheaperseeker said:

The complete effects of tirz generally need 4 weeks to emerge, and for some people it can take 5 or 6. Before moving up to a stronger dose or deciding whether it is doing anything, you ought to give it no less than that amount of time. Staying on the smallest dose that works leaves you somewhere to go if tolerance develops later. There is another benefit to holding a dose for 4 weeks: it can keep side effects from appearing or make them milder.

A pause of several weeks on the scale is also expected once you have dropped a decent amount of weight. That is simply your body recalibrating.

My suggestion would be to stay at 7.5mg for at least 2 more weeks.

Right away I was pretty sure it was working great for me. The only difference is that after I switched to another vial, everything changed. It feels almost as if I'm getting only half of what I used to.

When you mention needing 4 weeks, or 5 or 6, before the 'full effects of tirz' show up, do you mean 4-6 weeks on one particular dose? If it's supposed to take longer than that, why do clinical guidelines recommend moving up every 4 weeks? Though maybe I'm just not following what you mean.

What I can't figure out is why 2.5/5mg worked so well for me, but once I moved to 7.5 it flatlined. That doesn't make sense to me. Unless the vial is weaker or no good. That's the point when things shifted.

Yes, each dose should be held for 4-6 weeks.

Your stall lining up with a new vial may be nothing more than coincidence. That said, as wileyhorse pointed out, a true stall generally means staying at the same weight for 4 weeks or longer, since weight loss commonly plateaus now and then. Besides, you dropped that weight quite quickly. Losing 0.5 - 2 pounds weekly is considered a "healthy" pace. Even so, going back over your reconstitution and dosing calculations would be a sensible extra step.

The guidelines likely recommend 4 weeks because by then most people's levels have nearly reached the full amount, and a standard protocol was wanted that could be applied to everyone without weekly blood work for each patient. Everyone differs somewhat, though. For me, I've found it takes about 5 weeks before the effects feel complete and steady.

Getting protein in is great, but be sure you're also taking in some healthy carbs and fats.

 

[deleted.user.16]

Whenever someone posts about the scale not moving, the response is always the same: eat more. More food, more carbs, pile on more of everything. That advice is completely backwards.

I'm not trying to come off harsh, but that's simply not how any of this functions. What actually helps is more salad, more soup, more veggies, more movement, and fewer calories. Skipping a meal is fine, it won't hurt you. If you'd rather not skip, that's your call, but a healthy overweight adult won't suffer any damage from it. Pushing yourself to eat 3 meals daily when you have no appetite goes against every bit of common sense.

 

[cheaperseeker]

To give you a rough sense of how levels build during the initial weeks on a new dose, here's a GLP-1 plotter:

GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator



This tool graphs and calculates levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) using dose & half-life.

Image unavailable


glp1plotter.com

 

[amosmylove]

@FlowerFairy

I keep attempting to reply, but it seems like anything I write gets flagged as possible spam.

 

[amosmylove]

cheaperseeker said:

amosmylove said:

cheaperseeker said:

The complete effects of tirz generally need 4 weeks to emerge, and for some people it can take 5 or 6. Before moving up to a stronger dose or deciding whether it is doing anything, you ought to give it no less than that amount of time. Staying on the smallest dose that works leaves you somewhere to go if tolerance develops later. There is another benefit to holding a dose for 4 weeks: it can keep side effects from appearing or make them milder.

A pause of several weeks on the scale is also expected once you have dropped a decent amount of weight. That is simply your body recalibrating.

My suggestion would be to stay at 7.5mg for at least 2 more weeks.

Right away I was pretty sure it was working great for me. The only difference is that after I switched to another vial, everything changed. It feels almost as if I'm getting only half of what I used to.

When you mention needing 4 weeks, or 5 or 6, before the 'full effects of tirz' show up, do you mean 4-6 weeks on one particular dose? If it's supposed to take longer than that, why do clinical guidelines recommend moving up every 4 weeks? Though maybe I'm just not following what you mean.

What I can't figure out is why 2.5/5mg worked so well for me, but once I moved to 7.5 it flatlined. That doesn't make sense to me. Unless the vial is weaker or no good. That's the point when things shifted.

Yes, each dose should be held for 4-6 weeks.

Your stall lining up with a new vial may be nothing more than coincidence. That said, as wileyhorse pointed out, a true stall generally means staying at the same weight for 4 weeks or longer, since weight loss commonly plateaus now and then. Besides, you dropped that weight quite quickly. Losing 0.5 - 2 pounds weekly is considered a "healthy" pace. Even so, going back over your reconstitution and dosing calculations would be a sensible extra step.

The guidelines likely recommend 4 weeks because by then most people's levels have nearly reached the full amount, and a standard protocol was wanted that could be applied to everyone without weekly blood work for each patient. Everyone differs somewhat, though. For me, I've found it takes about 5 weeks before the effects feel complete and steady.

Getting protein in is great, but be sure you're also taking in some healthy carbs and fats.

I mixed my 60mg vial using 2ml of bac water, and for 7.5mg I draw 25 units on a 100unit syringe. That's what my calculator tells me.

 

[cheaperseeker]

deleted.user.16 said:

Whenever someone posts about the scale not moving, the response is always the same: eat more. More food, more carbs, pile on more of everything. That advice is completely backwards.

I'm not trying to come off harsh, but that's simply not how any of this functions. What actually helps is more salad, more soup, more veggies, more movement, and fewer calories. Skipping a meal is fine, it won't hurt you. If you'd rather not skip, that's your call, but a healthy overweight adult won't suffer any damage from it. Pushing yourself to eat 3 meals daily when you have no appetite goes against every bit of common sense.

To shed pounds and remain in good health, you definitely must take in a set number of calories.

A few main takeaways from the piece linked below (and plenty of other credible articles and studies echo the same idea):

When calories are cut too drastically, the body undergoes metabolic adaptation — it responds by reducing its metabolic rate and holding onto energy, which is what brings weight loss to a halt. On top of that, such a pattern can cause muscle wasting, overwhelming tiredness, stronger food cravings, and disrupted hormones, all of which make keeping weight off over the long term much tougher.~

Why Eating Too Little Can Stall Weight Loss



Undereating doesn't accelerate fat loss — it actually decelerates it. Your metabolism requires fuel to work properly, and proper nutrition is what makes lasting progress possible. More details are available in this article.

www.weightkidneycare.com

 

[amosmylove]

cheaperseeker said:

To give you a rough sense of how levels build during the initial weeks on a new dose, here's a GLP-1 plotter:



View attachment 10876



GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator



This tool graphs and calculates levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) using dose & half-life.

Image unavailable


glp1plotter.com

A few weeks back I had been using that! I'll pick it up again. Appreciate it!

 

[amosmylove]

cheaperseeker said:

deleted.user.16 said:

Whenever someone posts about the scale not moving, the response is always the same: eat more. More food, more carbs, pile on more of everything. That advice is completely backwards.

I'm not trying to come off harsh, but that's simply not how any of this functions. What actually helps is more salad, more soup, more veggies, more movement, and fewer calories. Skipping a meal is fine, it won't hurt you. If you'd rather not skip, that's your call, but a healthy overweight adult won't suffer any damage from it. Pushing yourself to eat 3 meals daily when you have no appetite goes against every bit of common sense.

To shed pounds and remain in good health, you definitely must take in a set number of calories.

A few main takeaways from the piece linked below (and plenty of other credible articles and studies echo the same idea):

When calories are cut too drastically, the body undergoes metabolic adaptation — it responds by reducing its metabolic rate and holding onto energy, which is what brings weight loss to a halt. On top of that, such a pattern can cause muscle wasting, overwhelming tiredness, stronger food cravings, and disrupted hormones, all of which make keeping weight off over the long term much tougher.~



View attachment 10877



Why Eating Too Little Can Stall Weight Loss



Undereating doesn't accelerate fat loss — it actually decelerates it. Your metabolism requires fuel to work properly, and proper nutrition is what makes lasting progress possible. More details are available in this article.

View attachment 10878


www.weightkidneycare.com

Unhealthy weight loss is something I'm very familiar with. Several years back, major depression hit me hard. I dropped 40lbs over 3 months, and it wasn't intentional — it was purely the depression. After that, I lost nearly all my hair, which sent me into an even deeper depression. As a woman, that was absolutely awful. My hair has fully returned since then, but the experience led me to start wearing wigs.

 

[cheaperseeker]

amosmylove said:

cheaperseeker said:

deleted.user.16 said:

Whenever someone posts about the scale not moving, the response is always the same: eat more. More food, more carbs, pile on more of everything. That advice is completely backwards.

I'm not trying to come off harsh, but that's simply not how any of this functions. What actually helps is more salad, more soup, more veggies, more movement, and fewer calories. Skipping a meal is fine, it won't hurt you. If you'd rather not skip, that's your call, but a healthy overweight adult won't suffer any damage from it. Pushing yourself to eat 3 meals daily when you have no appetite goes against every bit of common sense.

To shed pounds and remain in good health, you definitely must take in a set number of calories.

A few main takeaways from the piece linked below (and plenty of other credible articles and studies echo the same idea):

When calories are cut too drastically, the body undergoes metabolic adaptation — it responds by reducing its metabolic rate and holding onto energy, which is what brings weight loss to a halt. On top of that, such a pattern can cause muscle wasting, overwhelming tiredness, stronger food cravings, and disrupted hormones, all of which make keeping weight off over the long term much tougher.~



View attachment 10877



Why Eating Too Little Can Stall Weight Loss



Undereating doesn't accelerate fat loss — it actually decelerates it. Your metabolism requires fuel to work properly, and proper nutrition is what makes lasting progress possible. More details are available in this article.

View attachment 10878


www.weightkidneycare.com

Unhealthy weight loss is something I'm very familiar with. Several years back, major depression hit me hard. I dropped 40lbs over 3 months, and it wasn't intentional — it was purely the depression. After that, I lost nearly all my hair, which sent me into an even deeper depression. As a woman, that was absolutely awful. My hair has fully returned since then, but the experience led me to start wearing wigs.

That's a rough situation all around. I really hope you managed to get through it and that things have been looking up for you recently.

 

[amosmylove]

cheaperseeker said:

amosmylove said:

cheaperseeker said:

deleted.user.16 said:

Whenever someone posts about the scale not moving, the response is always the same: eat more. More food, more carbs, pile on more of everything. That advice is completely backwards.

I'm not trying to come off harsh, but that's simply not how any of this functions. What actually helps is more salad, more soup, more veggies, more movement, and fewer calories. Skipping a meal is fine, it won't hurt you. If you'd rather not skip, that's your call, but a healthy overweight adult won't suffer any damage from it. Pushing yourself to eat 3 meals daily when you have no appetite goes against every bit of common sense.

To shed pounds and remain in good health, you definitely must take in a set number of calories.

A few main takeaways from the piece linked below (and plenty of other credible articles and studies echo the same idea):

When calories are cut too drastically, the body undergoes metabolic adaptation — it responds by reducing its metabolic rate and holding onto energy, which is what brings weight loss to a halt. On top of that, such a pattern can cause muscle wasting, overwhelming tiredness, stronger food cravings, and disrupted hormones, all of which make keeping weight off over the long term much tougher.~



View attachment 10877



Why Eating Too Little Can Stall Weight Loss



Undereating doesn't accelerate fat loss — it actually decelerates it. Your metabolism requires fuel to work properly, and proper nutrition is what makes lasting progress possible. More details are available in this article.

View attachment 10878


www.weightkidneycare.com

Unhealthy weight loss is something I'm very familiar with. Several years back, major depression hit me hard. I dropped 40lbs over 3 months, and it wasn't intentional — it was purely the depression. After that, I lost nearly all my hair, which sent me into an even deeper depression. As a woman, that was absolutely awful. My hair has fully returned since then, but the experience led me to start wearing wigs.

That's a rough situation all around. I really hope you managed to get through it and that things have been looking up for you recently.

Things are better now — that was a rough patch in my marriage, but we got through it. Thanks for the kind words