New Here — Coming Back to GLP-1s from the Northeast US

Calgon

Calgon

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Aug 11, 2026
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Hey everyone. I'm returning to GLPs after taking some time off.

My history with GLP-1s spans more than a year. I began with sema, then switched to tirz and titrated up to 10mg. That got me down 30-40 lbs and I felt like I was in a solid place. Circumstances forced me to stop for roughly six months, and during that stretch I regained 20+ lbs. It's a humbling experience, although based on what I've been reading around here, it seems like the usual pattern once you quit. I'm back on tirz at a reduced dose now. My initial milestone is returning to 207, the weight I held before the pause. The ultimate aim is 175. Since insurance cut off coverage, I'm covering the cost myself, which makes me take it pretty seriously. I'm here to pick up what I can from folks who've played the long game with this instead of a short sprint. Happy to be part of the group.
 
You’re not wrong about the out-of-pocket costs, lol. What was the reason you had to stop taking it for a stretch? I’m on Reta and doing whatever I can to overhaul my eating patterns while using it, hoping I’ll end up as one of the people it works out for. Only time will show.
 
Welcome! I'm in this community because insurance never would cover it for me, and paying out of pocket simply wasn't possible, so joining lets me take the less expensive path. Nice work on dropping so much, and yeah, I figure the real challenge for everyone is knowing when our bodies' set point will at last settle down in the 100s rather than trying to drag us back up past 200.

With this medicine, I'm curious whether they'll ever be able to determine when or if that set point shift truly occurs.
 
Heavytruck said:

You’re not wrong about the out-of-pocket costs, lol. What was the reason you had to stop taking it for a stretch? I’m on Reta and doing whatever I can to overhaul my eating patterns while using it, hoping I’ll end up as one of the people it works out for. Only time will show.
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During a stretch of several months without a job, GLPs dropped down my list of priorities fast, behind the basics I had to cover. These days my situation has stabilized, though shelling out full self-pay costs for the name-brand options isn't exactly enjoyable.
 
Nyx_Zen said:

Welcome! I'm in this community because insurance never would cover it for me, and paying out of pocket simply wasn't possible, so joining lets me take the less expensive path. Nice work on dropping so much, and yeah, I figure the real challenge for everyone is knowing when our bodies' set point will at last settle down in the 100s rather than trying to drag us back up past 200.

With this medicine, I'm curious whether they'll ever be able to determine when or if that set point shift truly occurs.
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Glad to have you here! It's a real shame that so few insurance plans pay for these, and some are actually dropping the coverage they had. Fingers crossed that access will improve down the road — in the meantime, best of luck to you!
 
My guess is that the real problem is that everyone is going to have to come down gradually.

If reaching the highest dose required 12 months, then it stands to reason that coming off could also require 12 months before things settle.

Not many people have been in a position to try that out, so we will just have to wait and see.

One thing that seems clear: stopping abruptly is a bad idea. In the best case, it seems to leave you stuck in some kind of glp limbo once you attempt to start up again.
 
Calgon said:


I was out of work for several months and GLPs quickly lost priority over other essentials. Everything is good now, but paying out of pocket prices for the branded versions is not fun.

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I get it completely. For a moment there, I figured maybe illness had hit you or something along those lines.
 
Just A Cat said:

My guess is that the real problem is that everyone is going to have to come down gradually.

If reaching the highest dose required 12 months, then it stands to reason that coming off could also require 12 months before things settle.

Not many people have been in a position to try that out, so we will just have to wait and see.

One thing that seems clear: stopping abruptly is a bad idea. In the best case, it seems to leave you stuck in some kind of glp limbo once you attempt to start up again.
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I'm with you on that. I've got an agent that logs my numbers, how things are going, and what I intend to do. It came back with one observation: during that first stretch on glp, fat took the place of the muscle I lost, and that's now playing an active role in this plateau.

Most days I get in 2-3 miles of walking at a fairly brisk pace, but resistance training has to become part of the routine. My work schedule is working directly against that, yet I still have to come up with a solution.
 
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