308fan
Explorer
I’ve recently begun using NAD, and the area where I inject has been hurting quite a bit. I chose my buttocks for the shot, and now sitting down is really unpleasant. Has anyone else experienced this?
NAD causing soreness at the injection spot
- Thread starter 308fan
- Start date
Calm Logic
Explorer
A few of the standard suggestions involve testing pH, further dilution, or thinking about IM (even though that carries greater risk).
Another option is to dilute just prior to injecting by putting saline, saline BAC, or plain BAC into the syringe.
Another option is to dilute just prior to injecting by putting saline, saline BAC, or plain BAC into the syringe.
CNCCurrency
Explorer
Does it contain a buffer?
308fan
Explorer
The expectation was that it would be
randompersonrandom
Explorer
A few months back, while I was experimenting with the mitochondrial protocol, I used up a couple of vials. The source was a reseller who had gotten it from Uther or PGB or a similar supplier. It was labeled as buffered. Even so, each injection caused pain. On top of that, it did nothing for me. After I bailed out during the MOTS-C part of the protocol, I never touched it again. That MOTS-C gave me huge, hard lumps that lasted for months, and 1 of them is STILL not completely gone.
DustAndDignity
Explorer
What's the MG amount in the vial, and what volume of BAC water was used? My experience was that additional dilution of the NAD was necessary to lower the thickness at the time of injection.
A 29g needle was also what I used, and that appeared to lessen the burning sensation. Finally, the least discomfort came from sub-Q shots into the thigh.
lastresort
Explorer
In my opinion, NAD + shots aren't worth it. If I'm wrong, someone please set me straight, but from what I gathered looking through some clinical studies, there don't seem to be any clear benefits.
308fan
Explorer
The vial contains 500mg. I added 3ml of bac water.
DustAndDignity
Explorer
If the vial is large enough, use 4mL of BAC.
My NAD is supplied in a 10mL vial, so I water it down a lot. After that, I put in extra bac water right before I inject. Oddly enough, sub q hurts less. I inject into the fattiest area of my belly or my thighs, and there's no problem.
Calm Logic
Explorer
For sure, the evidence behind energy-boosting peptides such as NAD+, 5AM, SS-31, and MOTS-c is thinner than ideal, 5AM in particular. And for me, anything that stings and also eats up more of my limited BAC is the first thing to go. MOTS-c isn't even worth attempting.
DustAndDignity
Explorer
Those stinging peptides are the worst!!
I figured I was just being a wimp about the NAD, so it's a relief to find out others are dealing with the same thing.
Diluting it with 5ml in the vial, then drawing extra BAC into the syringe before I inject, rotating where I pin, and warming the solution first — I've run through all of that and none of it helped.
It was sold to me as buffered, though I have my doubts. If that's what buffered feels like, unbuffered must be brutal. KLOW had me nervous to start because I'd heard it was spicy too, but next to the NAD it's a cake walk.
Diluting it with 5ml in the vial, then drawing extra BAC into the syringe before I inject, rotating where I pin, and warming the solution first — I've run through all of that and none of it helped.
It was sold to me as buffered, though I have my doubts. If that's what buffered feels like, unbuffered must be brutal. KLOW had me nervous to start because I'd heard it was spicy too, but next to the NAD it's a cake walk.
Gwynhwyfar
Explorer
I had the same experience — for 500mg of NAD+, I mixed in 3 ml of bac water. Since that happened, I've been injecting just half the dose. For my next vial, though, I'm absolutely going with 6 ml of bac!
Calm Logic
Explorer
Yeah, checking the pH might be a good idea. Should it turn out to be too low, injectable sodium bicarb can be added into the vial.