My B12 level went through the roof

[turlian]

Daily Omeprazole and Semaglutide have been my routine for roughly 18 months (I moved to Tirz two weeks back, though that isn't really relevant). After some blood work my gastroenterologist put me on a B12 supplement, once a day.

Since February my B12 has climbed from 270 to 1,792 pg/ml (the normal range tops out at 1,100). My PCP's reaction was "OK, time to ramp down on the B12". The Costco B12 I've been taking is (no joke) 208,333% of your daily dosage - absorbing B12 is just that hard.

An oral vitamin actually doing something came as a bit of a surprise.

 

[spanky2026]

turlian said:

Daily Omeprazole and Semaglutide have been my routine for roughly 18 months (I moved to Tirz two weeks back, though that isn't really relevant). After some blood work my gastroenterologist put me on a B12 supplement, once a day.

Since February my B12 has climbed from 270 to 1,792 pg/ml (the normal range tops out at 1,100). My PCP's reaction was "OK, time to ramp down on the B12". The Costco B12 I've been taking is (no joke) 208,333% of your daily dosage - absorbing B12 is just that hard.

An oral vitamin actually doing something came as a bit of a surprise.

OMG! The same thing happened to me, and mine also came from the Costco "Mature" multi! I've never seen my b12 so high!

I got rid of them straight away and switched to one with a saner B12 level, though oddly enough my doc wasn't worried in the slightest. His claim was that losing a lot of weight means you NEED extra B12, but I suspect he was confusing GLP weight loss with bariatric surgery, where malabsorption is the issue. (He's an idiot, I fired him shortly after ).

 

[Slogger]

Same here! My naturopath had me on B supplements and my level shot up, so these days it's every other day, or every two days at most. Much better!

 

[ZippityDooDah]

turlian said:


I've been on daily Omeprazole and GLP1 for about 18 months (just switch to GLP2 two weeks ago, but kinda irrelevant).

Click to expand...

Which GLP-2 agonist are you on - teduglutide, glepaglutide, apraglutide, dapiglutide, or elsiglutide?

GLP-1 and GLP-2 agonists differ substantially: they act on entirely different hormones and are designed for entirely different conditions, so it definitely is not irrelevant.

 

[turlian]

ZippityDooDah said:

turlian said:


I've been on daily Omeprazole and GLP1 for about 18 months (just switch to GLP2 two weeks ago, but kinda irrelevant).

Click to expand...

Which GLP-2 agonist are you on - teduglutide, glepaglutide, apraglutide, dapiglutide, or elsiglutide?

GLP-1 and GLP-2 agonists differ substantially: they act on entirely different hormones and are designed for entirely different conditions, so it definitely is not irrelevant.

Sorry, that was misspoken (the labelling confused me) - it isn't a GLP-2, it's Tirzepatide. My source wrongly attaches a 2 identifier to it.

 

[gpwdeux]

turlian said:

Daily Omeprazole and Semaglutide have been my routine for roughly 18 months (I moved to Tirz two weeks back, though that isn't really relevant). After some blood work my gastroenterologist put me on a B12 supplement, once a day.

Since February my B12 has climbed from 270 to 1,792 pg/ml (the normal range tops out at 1,100). My PCP's reaction was "OK, time to ramp down on the B12". The Costco B12 I've been taking is (no joke) 208,333% of your daily dosage - absorbing B12 is just that hard.

An oral vitamin actually doing something came as a bit of a surprise.

Studies do exist showing oral B12 (tablet and sublingual both) beating injections. Your pg/ml wouldn't worry me at all. Medically speaking there is no "normal range" for B12, and equally no established serum level at which it turns toxic in humans. Markers do show up in certain disease states, but it's read as a marker rather than a cause. BTW, I'm not gpt - just a biochemist with 20+ years in the medical field, spanning research, marketing, and even some implementation work on the very drugs we discuss here

 

[Flash-BCR]

turlian said:

ZippityDooDah said:

turlian said:


I've been on daily Omeprazole and GLP1 for about 18 months (just switch to GLP2 two weeks ago, but kinda irrelevant).

Click to expand...

Which GLP-2 agonist are you on - teduglutide, glepaglutide, apraglutide, dapiglutide, or elsiglutide?

GLP-1 and GLP-2 agonists differ substantially: they act on entirely different hormones and are designed for entirely different conditions, so it definitely is not irrelevant.

Sorry, that was misspoken (the labelling confused me) - it isn't a GLP-2, it's Tirzepatide. My source wrongly attaches a 2 identifier to it.

Say you buy from a US single vial seller without saying it...

...only teasing you!...GL with the B12 stuff

 

[bamagirl26]

turlian said:

Daily Omeprazole and Semaglutide have been my routine for roughly 18 months (I moved to Tirz two weeks back, though that isn't really relevant). After some blood work my gastroenterologist put me on a B12 supplement, once a day.

Since February my B12 has climbed from 270 to 1,792 pg/ml (the normal range tops out at 1,100). My PCP's reaction was "OK, time to ramp down on the B12". The Costco B12 I've been taking is (no joke) 208,333% of your daily dosage - absorbing B12 is just that hard.

An oral vitamin actually doing something came as a bit of a surprise.

wait, is that daily dosage % actually serious, or were you exaggerating? that made me laugh out loud

 

[turlian]

bamagirl26 said:

turlian said:

Daily Omeprazole and Semaglutide have been my routine for roughly 18 months (I moved to Tirz two weeks back, though that isn't really relevant). After some blood work my gastroenterologist put me on a B12 supplement, once a day.

Since February my B12 has climbed from 270 to 1,792 pg/ml (the normal range tops out at 1,100). My PCP's reaction was "OK, time to ramp down on the B12". The Costco B12 I've been taking is (no joke) 208,333% of your daily dosage - absorbing B12 is just that hard.

An oral vitamin actually doing something came as a bit of a surprise.

wait, is that daily dosage % actually serious, or were you exaggerating? that made me laugh out loud

 

[Troposphere]

The one I take is the same deal at 208,330%! Keen to see what my blood work looks like afterwards.

 

[Just A Cat]

Another entry for "things I didn't know that I needed to know" ...

Be careful with high dose multi-B vitamins. Most of them are safe, but there is one exception everyone should know about.

B6 is water-soluble, critical for metabolic functions, and safe when you get it from whole foods. The problem is ONE synthetic form: the cheap to manufacture pyridoxine HCl, which can build up to toxic levels in the body.

Other forms of B6 are fine. It's the B6-HCl specifically.

Search B6 paradox if you want more. There's a link below as well.

The vitamin B6 paradox refers to the counterintuitive phenomenon where taking high doses of synthetic pyridoxine HCl (the inactive form of vitamin B6 found in many supplements) actually induces a functional vitamin B6 deficiency and neurotoxicity in peripheral tissues

Click to expand...