MOTS-c Potency Loss

[ftv10hb]

Yesterday I fell down a research rabbit hole and found an AI reference to a finding stating that once reconstituted, MOTS-C exposed to room temperature for 2-3 hours might lose 80-90% of its potency. Digging a bit deeper, its sequence does contain methionine and tryptophan, which are apparently 2 of the 3 peptides most susceptible to oxidation at room temperature.

I lack anything close to the scientific background needed to assess whether that is valid, and I also don't have the interest to go through the sequences of every other common peptide out there. Still, I'm curious whether those who know better have a view on this, or a recommendation based on it about which other peptides would be most vulnerable to this. I travel frequently, and although I have an insulated case with a solid ice pack that works well, sometimes too much time passes before I can reach a fridge, and my peps occasionally sit at or near room temperature for a while. I'd really like to know which ones would be better left at home lol.

Could this also account for some of the variation in experiences people have had with MOTS-C? For anyone who hasn't felt much or anything while using it, is it possible it was at room temperature for a while and that could be the reason? If a couple hours loses 80-90%, I'd imagine even 30-40 minutes would have some significant effect, especially if dosing was already on the lower end

 

[Chili777]

ftv10hb said:

Yesterday I fell down a research rabbit hole and found an AI reference to a finding stating that once reconstituted, MOTS-C exposed to room temperature for 2-3 hours might lose 80-90% of its potency. Digging a bit deeper, its sequence does contain methionine and tryptophan, which are apparently 2 of the 3 peptides most susceptible to oxidation at room temperature.

I lack anything close to the scientific background needed to assess whether that is valid, and I also don't have the interest to go through the sequences of every other common peptide out there. Still, I'm curious whether those who know better have a view on this, or a recommendation based on it about which other peptides would be most vulnerable to this. I travel frequently, and although I have an insulated case with a solid ice pack that works well, sometimes too much time passes before I can reach a fridge, and my peps occasionally sit at or near room temperature for a while. I'd really like to know which ones would be better left at home lol.

Could this also account for some of the variation in experiences people have had with MOTS-C? For anyone who hasn't felt much or anything while using it, is it possible it was at room temperature for a while and that could be the reason? If a couple hours loses 80-90%, I'd imagine even 30-40 minutes would have some significant effect, especially if dosing was already on the lower end

According to what I've come across, once Mots-C is mixed it ought to be finished off within a 30-day window, and that's with cold storage. A paper floating around online reports roughly 7% breakdown around the 30-day mark, with the figure climbing as more time passes. Compared with most other peptides, that shelf life is noticeably shorter. I haven't managed to locate the source the AI was drawing from, and the number strikes me as on the high side, yet given that study I mentioned, it wouldn't shock me entirely. When it comes to peptides, LLMs remain a bit dubious in my view, though Gemini 3.0 seems to be improving, so tracking down something that backs it up would be my suggestion.

 

[ftv10hb]

Chili777 said:

ftv10hb said:

Yesterday I fell down a research rabbit hole and found an AI reference to a finding stating that once reconstituted, MOTS-C exposed to room temperature for 2-3 hours might lose 80-90% of its potency. Digging a bit deeper, its sequence does contain methionine and tryptophan, which are apparently 2 of the 3 peptides most susceptible to oxidation at room temperature.

I lack anything close to the scientific background needed to assess whether that is valid, and I also don't have the interest to go through the sequences of every other common peptide out there. Still, I'm curious whether those who know better have a view on this, or a recommendation based on it about which other peptides would be most vulnerable to this. I travel frequently, and although I have an insulated case with a solid ice pack that works well, sometimes too much time passes before I can reach a fridge, and my peps occasionally sit at or near room temperature for a while. I'd really like to know which ones would be better left at home lol.

Could this also account for some of the variation in experiences people have had with MOTS-C? For anyone who hasn't felt much or anything while using it, is it possible it was at room temperature for a while and that could be the reason? If a couple hours loses 80-90%, I'd imagine even 30-40 minutes would have some significant effect, especially if dosing was already on the lower end

According to what I've come across, once Mots-C is mixed it ought to be finished off within a 30-day window, and that's with cold storage. A paper floating around online reports roughly 7% breakdown around the 30-day mark, with the figure climbing as more time passes. Compared with most other peptides, that shelf life is noticeably shorter. I haven't managed to locate the source the AI was drawing from, and the number strikes me as on the high side, yet given that study I mentioned, it wouldn't shock me entirely. When it comes to peptides, LLMs remain a bit dubious in my view, though Gemini 3.0 seems to be improving, so tracking down something that backs it up would be my suggestion.

Yeah, there was a citation linked to it, but I never followed it through — I figured at that hour the science would be more than my interest could handle, ha. The way it came across, it sounded like this might be an unusual case as far as peptides go. Still, I'd like to know what kind of potency loss is typical for other peptides after a few hours at room temperature, since if I'm really losing a meaningful amount on long travel days, I'd rather either shift my pin schedule so I can leave some behind at home, or put money into one of those electric insulin travel coolers instead of sticking with my insulated ice pack carrier.

 

[Chili777]

ftv10hb said:


Yea it had a citation link for it but I didn’t click through, I expected it would be a little too much science for the interest I had at that time of night lol. From my impression it did seem to imply it was something of an outlier among peptides, but I would be curious to know what a more common potency loss for a few hours at room temp is for other peptides, because if I’m losing something significant when I have long travel days then I would rather either adjust my pin schedule to leave some at home or invest in one of those electric insulin travel coolers as an upgrade over my insulated ice pack carrier.

Click to expand...

When traveling briefly, an insulated insulin case paired with freezer packs should be sufficient in the majority of situations. That's what I rely on, though my accommodations are usually suite-style hotels that include refrigerators. Should neither be available, an electric cooler might be the better choice.

Regarding other peptides, my approach would be to input them into Gemini and then examine the references it provides. From what I've come across, Tirz appears to be the most resilient among them, but I haven't looked into the more frequently used ones. A handful of hours probably won't cause any meaningful impact, but that's something I'd look into further.

Typo