Morning Hunger Pangs

[Purpletree]

Hi, I'm close to finishing week 1 on 5mg tirz, following 4 weeks at 2.5, and when I wake up in the morning, hunger makes me feel nauseous. Does anyone know why this happens specifically? It only lasts maybe 1 minute and then begins to fade, but it's really annoying.

 

[Skidude]

Purpletree said:

Hi, I'm close to finishing week 1 on 5mg tirz, following 4 weeks at 2.5, and when I wake up in the morning, hunger makes me feel nauseous. Does anyone know why this happens specifically? It only lasts maybe 1 minute and then begins to fade, but it's really annoying.

Just guessing without much to go on, but this could stem from glp1s making the stomach empty more slowly.

Google result:

GLP-1 receptor agonists (such as semaglutide and tirzepatide) slow gastric emptying by reducing stomach muscle contractions and tightening the pyloric valve. This intentional delay keeps food in the stomach longer to prolong fullness and prevent blood sugar spikes, but it can also trigger uncomfortable gastrointestinal side effects

Click to expand...

Maybe you're used to that empty-stomach sensation in the morning, and now you have to cope with digestion that's slower.

That's my guess..

At the start I followed 16/8 fasting, so waking up and not eating until noon was normal for me. (except for black coffee and water).

Dehydration might also be behind your nausea, since it's recognized as a problem early on when both eating and drinking decrease.

I'd kick off the day by drinking 16oz of cold water, chug a lug

 

[Purpletree]

Skidude said:

Purpletree said:

Hi, I'm close to finishing week 1 on 5mg tirz, following 4 weeks at 2.5, and when I wake up in the morning, hunger makes me feel nauseous. Does anyone know why this happens specifically? It only lasts maybe 1 minute and then begins to fade, but it's really annoying.

Just guessing without much to go on, but this could stem from glp1s making the stomach empty more slowly.

Google result:

GLP-1 receptor agonists (such as semaglutide and tirzepatide) slow gastric emptying by reducing stomach muscle contractions and tightening the pyloric valve. This intentional delay keeps food in the stomach longer to prolong fullness and prevent blood sugar spikes, but it can also trigger uncomfortable gastrointestinal side effects

Click to expand...

Maybe you're used to that empty-stomach sensation in the morning, and now you have to cope with digestion that's slower.

That's my guess..

At the start I followed 16/8 fasting, so waking up and not eating until noon was normal for me. (except for black coffee and water).

Dehydration might also be behind your nausea, since it's recognized as a problem early on when both eating and drinking decrease.

I'd kick off the day by drinking 16oz of cold water, chug a lug

Back when my dose was 2.5mg, water was something I wanted without thinking about it — well over 2 liters every day. Since moving up to 5mg, getting down even 1.5 liters has turned into a fight, and on certain days I fall short of that entirely…it’s frustrating….

Hunger is there too, yet every food I look at, smell, or imagine seems repulsive lol. What confuses me is that coke0 and pasta used to be the two things I could never resist before tirz, and now it’s been more than a month since I last had a coke 0, plus the sight of pasta makes me feel sick right away lmao

 

[Skidude]

Purpletree said:

Skidude said:

Purpletree said:

Hi, I'm close to finishing week 1 on 5mg tirz, following 4 weeks at 2.5, and when I wake up in the morning, hunger makes me feel nauseous. Does anyone know why this happens specifically? It only lasts maybe 1 minute and then begins to fade, but it's really annoying.

Just guessing without much to go on, but this could stem from glp1s making the stomach empty more slowly.

Google result:

GLP-1 receptor agonists (such as semaglutide and tirzepatide) slow gastric emptying by reducing stomach muscle contractions and tightening the pyloric valve. This intentional delay keeps food in the stomach longer to prolong fullness and prevent blood sugar spikes, but it can also trigger uncomfortable gastrointestinal side effects

Click to expand...

Maybe you're used to that empty-stomach sensation in the morning, and now you have to cope with digestion that's slower.

That's my guess..

At the start I followed 16/8 fasting, so waking up and not eating until noon was normal for me. (except for black coffee and water).

Dehydration might also be behind your nausea, since it's recognized as a problem early on when both eating and drinking decrease.

I'd kick off the day by drinking 16oz of cold water, chug a lug

Back when my dose was 2.5mg, water was something I wanted without thinking about it — well over 2 liters every day. Since moving up to 5mg, getting down even 1.5 liters has turned into a fight, and on certain days I fall short of that entirely…it’s frustrating….

Hunger is there too, yet every food I look at, smell, or imagine seems repulsive lol. What confuses me is that coke0 and pasta used to be the two things I could never resist before tirz, and now it’s been more than a month since I last had a coke 0, plus the sight of pasta makes me feel sick right away lmao

Things usually improve as time goes on — at 5mg you're reaching a level that lots of people view as a "therapeutic" dose. Once your body gets used to it, it'll handle the peps and the titrations better. Heavy foods are still going to be a problem, but having them in moderations should be okay.

My way of thinking about it is like a chemical gastric bypass: you simply don't require as much, which is why weight comes off, and eating beyond what you need can leave you feeling uncomfortable.

Remember that the thirst trigger and the hunger trigger are quite similar, so if hunger hits, start by trying to drink some water.