Just received glutathione 600 and NAD 500

[Gr33dyOctopus]

How many ml of bac water should I use for each one ideally? Also, what's the dosing schedule? I've never used either before and have definitely done some reading, but I'd like to hear what my glp friends have to say right now.

 

[MikeyMike]

Gluta: I inject 100mg intramuscularly 3x weekly, though doses range between 100-300mg. Recently I picked up some Korean pink Gluta 1200 and intend to begin at 200 mg 3x per week.

NAD: the suggested approach is 25mg 3x per week for weeks 1-2, then 50mg 3x per week for weeks 3-4, then 100mg 3x per week. Going above 300mg weekly isn't advised. Personally I favor daily dosing at 50mg. Both IM and subQ have been options for me; subQ is my preference.

 

[Gr33dyOctopus]

MikeyMike said:

Gluta: I inject 100mg intramuscularly 3x weekly, though doses range between 100-300mg. Recently I picked up some Korean pink Gluta 1200 and intend to begin at 200 mg 3x per week.

NAD: the suggested approach is 25mg 3x per week for weeks 1-2, then 50mg 3x per week for weeks 3-4, then 100mg 3x per week. Going above 300mg weekly isn't advised. Personally I favor daily dosing at 50mg. Both IM and subQ have been options for me; subQ is my preference.

awesome! so how many mg per ml is your mix?

 

[Skidude]

Gr33dyOctopus said:

How many ml of bac water should I use for each one ideally? Also, what's the dosing schedule? I've never used either before and have definitely done some reading, but I'd like to hear what my glp friends have to say right now.

Glutathione tends to have a bit of a sting, and when I used my pink Korean one it ended up taking up more volume compared to standard peps

1.75ml ended up giving roughly 2ml of volume

At first I ran the detox dose: 600mg 2x per week, then switched to 3x weekly

https://pep-pedia.org/peptides/glutathione


As for the NAD+

I went with 100mg 5 days a week

Pretty sure I mixed it as 500mg/2.5ml, and each dose was 100mg/.5ml

 

[Gt3294a]

Gr33dyOctopus said:

How many ml of bac water should I use for each one ideally? Also, what's the dosing schedule? I've never used either before and have definitely done some reading, but I'd like to hear what my glp friends have to say right now.

What made you go with these 2? I'm looking to begin a different protocol myself. Right now NAD is something I only use orally.

 

[Gr33dyOctopus]

Gt3294a said:

Gr33dyOctopus said:

How many ml of bac water should I use for each one ideally? Also, what's the dosing schedule? I've never used either before and have definitely done some reading, but I'd like to hear what my glp friends have to say right now.

What made you go with these 2? I'm looking to begin a different protocol myself. Right now NAD is something I only use orally.

Nope, they aren't mine. I'm only testing the vials for some other folks, haha.

 

[Sukuna]

I combined my NAD+500 with 3ml of bac water. At the moment I'm using 60iu disposable pens since setting the dose is really straightforward. I picked up bac NS not long ago, and up to now I've only used it for mots c, which has been fine. If it turns out well, I may give it a go with NAD too.

 

[ftv10hb]

Gr33dyOctopus said:

How many ml of bac water should I use for each one ideally? Also, what's the dosing schedule? I've never used either before and have definitely done some reading, but I'd like to hear what my glp friends have to say right now.

For the NAD, I use 5mL — that way I can shift my dose among 50, 75, or 100mg based on how I'm feeling that day and what's on my plate, without needing to do mental math first thing in the morning or grab another syringe lol. At that concentration, it barely stings for me. As for the glutathione, I go with 3mL since I'm injecting 200mg subq and I don't want the shot to exceed 1mL.

 

[Mochizuki0124]

Beginners dose for me was 250mg MWF, later switching to 300mg on alternate days. Each 1500mg batch covers 10 days, reconstituted with 5ml of BAC.

Injections go IM with 27g 1in.

 

[eidos]

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

 

[miameow]

How much discomfort you're willing to put up with matters here, as does your choice between SQ and IM. If you go SQ, keep the BAC volume low so each shot stays at or under 1mL. Going IM gives you more dilution leeway, and that can take some of the sting out.

Gluta: 600mg vial gets 3 mL of BAC (use 6 mL if the vial is 1200mg), then pull 1mL to hit a 200mg dose. IM, 24g, 1".

NAD+: 500mg vial gets 5 mL of BAC, then pull 0.25mL to hit a 25mg dose. Anything above 25mg of NAD+ is more than I can handle, and it only works for me when paired with MOTS-c at the same time; on its own I crash. SQ, 29~30g, 1/2".

 

[miameow]

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

 

[eidos]

miameow said:

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

I appreciate you being straightforward. Feeling an improvement from the boost is fine.

So we're on the same page that this isn't a matter of bioavailability or going past a regulated biological threshold, correct?

 

[miameow]

eidos said:

miameow said:

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

I appreciate you being straightforward. Feeling an improvement from the boost is fine.

So we're on the same page that this isn't a matter of bioavailability or going past a regulated biological threshold, correct?

I don't agree, and that's unfortunate. One key factor here is bioavailability. Even if the body eventually regulates these compounds, the route of administration can lead to markedly different peak levels and immediate effects. Such pharmacokinetic distinctions are relevant for every compound.

 

[eidos]

miameow said:

eidos said:

miameow said:

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

I appreciate you being straightforward. Feeling an improvement from the boost is fine.

So we're on the same page that this isn't a matter of bioavailability or going past a regulated biological threshold, correct?

I don't agree, and that's unfortunate. One key factor here is bioavailability. Even if the body eventually regulates these compounds, the route of administration can lead to markedly different peak levels and immediate effects. Such pharmacokinetic distinctions are relevant for every compound.

Like you mentioned, kinetics is what's at play here. When we talk about availability, that's tied to concentrations, which means it's largely about dynamics.

Put another way, what changes is how soon the initial peak arrives.

Think of it as flooring it the moment the light goes green: pointless if there's a cap on how fast you can go later.

 

[miameow]

You're correct that pharmacodynamic effects are ultimately shaped by concentration, and correct too that a faster peak doesn't by itself make an intervention more beneficial — it depends on the compound in question.

eidos said:

miameow said:

eidos said:

miameow said:

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

I appreciate you being straightforward. Feeling an improvement from the boost is fine.

So we're on the same page that this isn't a matter of bioavailability or going past a regulated biological threshold, correct?

I don't agree, and that's unfortunate. One key factor here is bioavailability. Even if the body eventually regulates these compounds, the route of administration can lead to markedly different peak levels and immediate effects. Such pharmacokinetic distinctions are relevant for every compound.

Like you mentioned, kinetics is what's at play here. When we talk about availability, that's tied to concentrations, which means it's largely about dynamics.

Put another way, what changes is how soon the initial peak arrives.

Think of it as flooring it the moment the light goes green: pointless if there's a cap on how fast you can go later.

The point I'd push back on is the idea that bioavailability is consequently "mainly a matter of (pharmaco)dynamics,"

eidos said:

miameow said:

eidos said:

miameow said:

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

I appreciate you being straightforward. Feeling an improvement from the boost is fine.

So we're on the same page that this isn't a matter of bioavailability or going past a regulated biological threshold, correct?

I don't agree, and that's unfortunate. One key factor here is bioavailability. Even if the body eventually regulates these compounds, the route of administration can lead to markedly different peak levels and immediate effects. Such pharmacokinetic distinctions are relevant for every compound.

Like you mentioned, kinetics is what's at play here. When we talk about availability, that's tied to concentrations, which means it's largely about dynamics.

Put another way, what changes is how soon the initial peak arrives.

Think of it as flooring it the moment the light goes green: pointless if there's a cap on how fast you can go later.

as well as the framing that narrows route differences down to how soon the first peak arrives.

To be clear: bioavailability belongs to pharmacokinetics, not pharmacodynamics. It covers both the rate and the extent to which a compound becomes available — not merely the "concentration."

Keep in mind that the route of administration can shape every one of these:

• Tmax: how quickly the peak occurs
  
• Cmax: how high the peak is
  
• AUC: total systemic exposure over time
  
• The overall concentration-time curve
  
• The duration of exposure

eidos said:

miameow said:

eidos said:

miameow said:

eidos said:

Injecting glutathione and NAD — I really don't get why this has become a thing.

With NAC and vitamin C, oral bioavailability isn't a problem. Same goes for B3, more or less. NR does spare me the stomach upset that niacin gives me, sure, but beyond that there's nothing to it.

Take them on a regular basis and your body lands at the proper biological levels just fine. On top of that, the digestive system has its own checks in place so you can't overload on these things.

So that's 2 shots of spicy stuff that I've got no real need for.

Saving money isn't the reason either, as far as I can tell.

Or is it just that you want something fresh to experiment with?

For a good while I followed the precursor supplementation route, and that was long before peptides and injections gained such widespread popularity.

That said, precursor supplementation and direct administration don't map onto each other perfectly. When you administer directly, the effect can come on more acutely, since certain conversion steps get skipped.

From my own experience, out of every compound I've experimented with, glutathione is genuinely my top pick, mainly because the immediate lift I get from it is something precursors by themselves have never matched for me.

Is injecting glutathione or NAD necessary? No. Endogenous glutathione production can be supported with NAC and glycine, while niacin, nicotinamide, NR, or NMN can support NAD synthesis. The broader antioxidant system can also be supported by vitamin C.

Still.. I go with the injections purely because I feel far better using them. On top of that, I'd rather take two shots than keep adding 4+ oral supplements to my stack. My pill box will burst.

I wrote a similar but more detailed comment on this subject previously : FYI

I appreciate you being straightforward. Feeling an improvement from the boost is fine.

So we're on the same page that this isn't a matter of bioavailability or going past a regulated biological threshold, correct?

I don't agree, and that's unfortunate. One key factor here is bioavailability. Even if the body eventually regulates these compounds, the route of administration can lead to markedly different peak levels and immediate effects. Such pharmacokinetic distinctions are relevant for every compound.

Like you mentioned, kinetics is what's at play here. When we talk about availability, that's tied to concentrations, which means it's largely about dynamics.

Put another way, what changes is how soon the initial peak arrives.

Think of it as flooring it the moment the light goes green: pointless if there's a cap on how fast you can go later.

Your traffic light analogy would only hold if all routes ended up producing identical results across every item listed above. In practice they frequently don't, and those gaps are meaningful.

Worth remembering: no single route is right, wrong, better, or worse. What matters is the compound, the goal, tolerability, and sometimes simply personal preference. That's why I lean toward injections here, while others may feel differently — and that's completely okay.

 

[FartfulCodger]

If I've got this right — when what I'm after is overall systemic exposure, oral supplements could get me to those same serum levels (?). Possibly needing a bigger dose, so the liver doesn't ruin things?

I'm already injecting plenty of stuff, and my guess is going oral costs far less. Could be less risky too, given that I trust the Western organizations doing the certifying.

 

[miameow]

FartfulCodger said:

If I've got this right — when what I'm after is overall systemic exposure, oral supplements could get me to those same serum levels (?). Possibly needing a bigger dose, so the liver doesn't ruin things?

I'm already injecting plenty of stuff, and my guess is going oral costs far less. Could be less risky too, given that I trust the Western organizations doing the certifying.

Regarding effects:

It's true that oral supplements can deliver systemic exposure, yet there's no way to work backwards from an injection's serum peak to figure out what oral dose would match it. And like I mentioned before, the peak isn't the only factor—what really counts is the full area under the curve. So I wouldn't jump to the conclusion that upping the oral amount puts both methods on equal footing.

Regarding price:

I also doubt that oral ends up being the cheaper option when you care about quality. Just a decent NMN supplement costs about $65 per month. Then you'd need vitamin C, glycine, liposomal NAD+, and other items.. That already adds up to hundreds.

Regarding quality:

Things like NMN and liposomal NAD+ aren't medicines, so they aren't held to the same standards as pharmaceutical-grade products. A lot of worthless supplements are on the market, and much of the raw material is still produced in China, India, or Eastern Europe regardless.

For my part, I'd prefer injectable glutathione made by a Korean pharmaceutical company and third-party-tested NAD+ from my Chinese vendor over anything available on Amazon.



Suggestion:

Give the oral method a try first, then move to injectables later if the orals don't have much effect for you. That's the same path I took.