johnny01
Explorer
I've come across several posts where folks combine these 2 compounds. Since reta already covers what tirzepatide covers, just with an extra effect, wouldn't putting the 2 together be kind of pointless?
Is Stacking Reta With Tirz Actually Noticeable for People?
- Thread starter johnny01
- Start date
chewonmysac
Explorer
The GLP-1 mechanism is stronger in Tirz. The components aren't equivalent.
AllCourtTENNIS
Explorer
A lot of folks who stack the two do it because tirzepatide handles food noise better than reta does. I'm in that group. My journey started with tirz, I climbed to a high dose, hit a stall, and then brought reta in while pulling my tirz dose down. I'm happy with my stack. Since I'm near goal and putting my energy into heavy weight lifting, the pounds come off slowly each week, but comparing month to month I can see the change. Week to week things stay steady. Food noise is gone, appetite is low, and I'm not dealing with side effects.
frizzle-fry
Explorer
The reason I began stacking them is that it cuts down on side effects for me. Reta brought on a high RHR and Anhedonia, while Tirz was more effective against food noise but left me nauseas, so running both at lower doses together looks like the sweet spot in my case. On top of that, I've got a low dose of cagri worked into the mix
Troposphere
Explorer
The other day I came across this chart on a different forum. I can't say how accurate it is, but it seems to line up with what users of each compound report, as well as what people who stack several compounds say.
My thinking is that it might help show how someone can tailor their GLP-1 use to land on whatever balance of receptor agonism suits the researcher best.
If I have this wrong, someone with more knowledge than me should step in and say so, but from what I understand a lower Ki binding value indicates lower affinity for the receptor. Put another way, the smaller the number, the better it works at that receptor.
My thinking is that it might help show how someone can tailor their GLP-1 use to land on whatever balance of receptor agonism suits the researcher best.
If I have this wrong, someone with more knowledge than me should step in and say so, but from what I understand a lower Ki binding value indicates lower affinity for the receptor. Put another way, the smaller the number, the better it works at that receptor.
Spendejo
Explorer
How much of each are you taking? I worked my way up to 15 mg of tirz, then switched over to Reta. Right now I'm on 5mg, and for the past 2 weeks I've been adding 5mg of tirz on top since my appetite is still there. It didn't do anything for me though… I'm still starving. I'm trying to work out if the answer is upping my Reta, upping my tirz, or accepting that maybe Reta just isn't the right fit for me and so on.
Yep. What else? 
All joking aside, each one hits me in a way that feels distinct. They also seem to work together. I've recently thrown a little sema into the mix too. That one has its own distinct feel as well.
Right now I'm on .25 sema (I spent 8 weeks at .13mg), 3mg of reta, and this week I'll bump tirz up to 10mg. I'm roughly 10lbs out from my goal, and I've had nothing or next to nothing in the way of side effects since I began on Jan 23. Since Feb 15 I'm down 75lbs.
I've also dropped 100+ pounds "naturally." On more than one occasion. Every time it was pure white knuckling. These days, managing my weight feels doable and--what's more--something I can keep up.
My strong suggestion is that people try the various medications carefully, so they can fine-tune how well they're able to better their health over the long haul.
All joking aside, each one hits me in a way that feels distinct. They also seem to work together. I've recently thrown a little sema into the mix too. That one has its own distinct feel as well.
Right now I'm on .25 sema (I spent 8 weeks at .13mg), 3mg of reta, and this week I'll bump tirz up to 10mg. I'm roughly 10lbs out from my goal, and I've had nothing or next to nothing in the way of side effects since I began on Jan 23. Since Feb 15 I'm down 75lbs.
I've also dropped 100+ pounds "naturally." On more than one occasion. Every time it was pure white knuckling. These days, managing my weight feels doable and--what's more--something I can keep up.
My strong suggestion is that people try the various medications carefully, so they can fine-tune how well they're able to better their health over the long haul.
Flash-BCR
Explorer
Yep, there's a noticeable difference for sure...and I might add some sema as well, giving me a 3rd GLP pin day each week...I'd toss in a "what a time to be alive" line, but I've probably worn that one out with all the KPV, KLOW, Basic, saline stuff...so I'll skip it...ladyj779 said:
Yep. What else?
All joking aside, each one hits me in a way that feels distinct. They also seem to work together. I've recently thrown a little sema into the mix too. That one has its own distinct feel as well.
Right now I'm on .25 sema (I spent 8 weeks at .13mg), 3mg of reta, and this week I'll bump tirz up to 10mg. I'm roughly 10lbs out from my goal, and I've had nothing or next to nothing in the way of side effects since I began on Jan 23. Since Feb 15 I'm down 75lbs.
I've also dropped 100+ pounds "naturally." On more than one occasion. Every time it was pure white knuckling. These days, managing my weight feels doable and--what's more--something I can keep up.
My strong suggestion is that people try the various medications carefully, so they can fine-tune how well they're able to better their health over the long haul.
At lower doses in particular, I believe Reta tends to increase hunger, since glucagon draws on most of the other agonists to blunt the insulin surge. That's why a small amount of sema added 2 days afterward has genuinely helped level out my appetite, and I'm not food averse at all or uneasy after eating. Low doses of each are working well for me. These days, now that the big weight loss push is behind me, feeling good and at ease (or maybe just not bothered) is the goal I'm after.
Builderman
Explorer
It made a huge difference for me when it came to food noise. I was on roughly 7mg of Reta, then I introduced 3mg tirz, and the results have been excellent. Should the food noise return, I might give cag a shot, but we'll see.
PeppamitCat
Explorer
For the food noise, it's mostly doing the job for me. That side of things is handled better by tirz than by what Reta is giving me. Since I'm still snacking, I've been thinking about working in some sema. It's not at the point of white knuckling, but it is annoying. Right now I'm running 7.5 mg tirz and 3 mg Reta.
Jack Rabbit Slims
Explorer
Anyone using ChatGPT or a similar tool can take this image and ask how those figures tie into the way the three compounds each function. The response gives a reasonably solid rundown of how to interpret the numbers. It isn't simply a matter of one figure being stronger or weaker than another.
In my view, this also makes the figures easier to interpretJack Rabbit Slims said:
Anyone using ChatGPT or a similar tool can take this image and ask how those figures tie into the way the three compounds each function. The response gives a reasonably solid rundown of how to interpret the numbers. It isn't simply a matter of one figure being stronger or weaker than another.
bokonon
Explorer
Are you drawing tirz and reta into one syringe, or are you doing 2 separate injections?
Troposphere
Explorer
That's useful info. I'll check into it.Jack Rabbit Slims said:
Anyone using ChatGPT or a similar tool can take this image and ask how those figures tie into the way the three compounds each function. The response gives a reasonably solid rundown of how to interpret the numbers. It isn't simply a matter of one figure being stronger or weaker than another.
Troposphere
Explorer
I fed this chart to Gemini and ran a handful of pointed questions past it, and from what I can tell, a lower Ki value really does line up with greater potency at that receptor. In your view, where am I going wrong? Or asked differently — what did your own query turn up?Jack Rabbit Slims said:
Anyone using ChatGPT or a similar tool can take this image and ask how those figures tie into the way the three compounds each function. The response gives a reasonably solid rundown of how to interpret the numbers. It isn't simply a matter of one figure being stronger or weaker than another.
johnny01
Explorer
When I first started tirzepatide, the way it silenced food noise was incredible — these days I can eat whatever I want.
I had no intention of being someone who keeps pushing doses upward or of stretching out how long I use it, yet my body seems to have adjusted quickly. Getting a few weeks where food wasn't on my mind was a great feeling.
johnny01
Explorer
It's great to hear this has been so effective in your case. Maybe I should give that kind of experimenting a shot as well, since the food noise has gotten its grip on me once more.ladyj779 said:
Yep. What else?
All joking aside, each one hits me in a way that feels distinct. They also seem to work together. I've recently thrown a little sema into the mix too. That one has its own distinct feel as well.
Right now I'm on .25 sema (I spent 8 weeks at .13mg), 3mg of reta, and this week I'll bump tirz up to 10mg. I'm roughly 10lbs out from my goal, and I've had nothing or next to nothing in the way of side effects since I began on Jan 23. Since Feb 15 I'm down 75lbs.
I've also dropped 100+ pounds "naturally." On more than one occasion. Every time it was pure white knuckling. These days, managing my weight feels doable and--what's more--something I can keep up.
My strong suggestion is that people try the various medications carefully, so they can fine-tune how well they're able to better their health over the long haul.