INTRO Greetings from a Veteran GLP-1 User Who Began Reta This Week

[sandwhich]

Hi, I'm Sandwhich, writing from the good ol 'USA.

For more than 2 years, I bounced up and down on GLP-1. Things got to the point where only much larger doses would produce any effect for me, yet those larger doses came with side effects that were truly awful, which made it really tough to keep going.

I only began Reta this week, and I'm eager to see for myself just how much better it works.

Can't wait to get to know all of you.

 

[mamallama]

Hi Sandwich. Another person from the USA here—the good old one. GLP medications have been part of my life for several years now, though I only recently came across this site. My search for every bit of info I could dig up online is what led me here.

When I got a type 2 DM diagnosis more than 2 years back, that's when Ozempic entered the picture, and I went all the way up through the dosing levels. Keeping things steady became more and more of a struggle, so the switch to Monjaro happened. At this point I'm checking out the grey zone, since after a year and a half on Tirz the food noise has gotten awful, I've gained 17 lbs, and the sugar cravings are out of control. Honestly, I feel stuck. Whether I messed something up, I can't say for certain.

Venturing into grey peptides and giving Reta a shot feels like the next step, because I remember how well it worked back when it was effective. The side effects of diabetes are something I truly want to avoid. So my reason for being here is to figure out my choices and get myself educated.

When you made the move to Reta, how did you do it? Did the Reta get taken at the point your next tirz dose was scheduled, or was it handled differently? What's your condition like at the moment?

 

[sandwhich]

jumped over tirz and went right to reta. first shot was 1mg, mainly to check my response. but i'll bump it up to 2mg for the next one since the 1mg hasn't done anything for me so far

 

[mamallama]

sandwhich said:

jumped over tirz and went right to reta. first shot was 1mg, mainly to check my response. but i'll bump it up to 2mg for the next one since the 1mg hasn't done anything for me so far

I'd love to hear updates on how it affects you

 

[deleted.user.15]

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

 

[upnorth8]

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I attempted a swap, yet the reta had no effect on the food noise, and because of how the ramp-up works, reaching that point would take weeks or even months. So I dose both, split. My reta ramp-up has moved extremely slowly (nearly 3 months in and I'm still taking 3mg every 5 days). The reason I wanted to change over was the metabolism boost people talk about. I'm still dropping weight, though it's slow at this point.

 

[mamallama]

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I joined to pick up exactly this kind of knowledge. Having spent a few years at the maximum tirs dose, the results just aren't what they used to be for me. So at this point I'm weighing my options for what comes next.

 

[deleted.user.15]

upnorth8 said:

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I attempted a swap, yet the reta had no effect on the food noise, and because of how the ramp-up works, reaching that point would take weeks or even months. So I dose both, split. My reta ramp-up has moved extremely slowly (nearly 3 months in and I'm still taking 3mg every 5 days). The reason I wanted to change over was the metabolism boost people talk about. I'm still dropping weight, though it's slow at this point.

I appreciate you laying it all out.

After 4 months of reta, food noise is still present for me, yet my body seems to be undergoing recomposition — I believe that's the correct word. Fat is going down while muscle mass goes up. The 2 years I spent on Tirz before did reshape my eating habits, but once I read what you went through, that food noise returned!!! When hunger or cravings hit, I tried tactics like sipping more green tea or taking a walk.

What makes this community so valuable is that we swap our stories, and whether people believe it or not, that helps folks in my position who have no way to discuss this with families that judge. They hardly even notice I've dropped over 50lbs, but the 1 time I brought up GLPs, out poured the negativity — opinions built on hearsay and zero information. All of which is my way of saying I'm grateful you shared your experience so openly. I might pick up some extra T as a backup now.

 

[emsjustin]

welcome!

It's wonderful that knowledgeable veterans are here to share what they know.

Has reta started to take effect for you yet? Are you noticing a major contrast between reta and other glp1?

 

[ultima thule]

I'd like to know too — how does Reta compare with a plain GLP-1? I've only just begun reta, yet I'm already planning ahead: once I hit my target and decide to come off reta, how do I do it sensibly? My thought is to switch over to a GLP-1 only for maintenance... though that's probably far off, and things could look different by then. Time will tell, as always.

 

[upnorth8]

ultima thule said:

I'd like to know too — how does Reta compare with a plain GLP-1? I've only just begun reta, yet I'm already planning ahead: once I hit my target and decide to come off reta, how do I do it sensibly? My thought is to switch over to a GLP-1 only for maintenance... though that's probably far off, and things could look different by then. Time will tell, as always.

The way reta affects me isn't pleasant. It leaves me exhausted, and occasionally on edge as well, and on top of that it did nothing for the food noise. Everything goes into Shotsy so I can monitor where I stand with both medications.

 

[chonkkk]

upnorth8 said:

ultima thule said:

I'd like to know too — how does Reta compare with a plain GLP-1? I've only just begun reta, yet I'm already planning ahead: once I hit my target and decide to come off reta, how do I do it sensibly? My thought is to switch over to a GLP-1 only for maintenance... though that's probably far off, and things could look different by then. Time will tell, as always.

The way reta affects me isn't pleasant. It leaves me exhausted, and occasionally on edge as well, and on top of that it did nothing for the food noise. Everything goes into Shotsy so I can monitor where I stand with both medications.

What's your current dose?

 

[lluna45469]

Keen to hear how things go for you.

 

[nambo]

mamallama said:

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I joined to pick up exactly this kind of knowledge. Having spent a few years at the maximum tirs dose, the results just aren't what they used to be for me. So at this point I'm weighing my options for what comes next.

For the past year I've used tirz, but about four months back I hit a plateau. My current split dose is 5mg every 4 days, which works out to roughly 10 mg/week — so I'm not actually at the maximum. I've held off on going to 15 mg/week because the STEP-1 RCT reported 22.5% weight loss at 15mg versus 21.4% at 10mg, meaning higher doses bring steep diminishing returns.

Across different trials, tirz 15mg produced weight loss anywhere from 20.2% (surmount-5) up to 25.5% (redefine-4). If I switched to max-dose reta, the weight loss range would be 24.2% to 28.7%, depending on the trial (triumph-4, redefine-4, etc.). That's not a huge improvement over tirz, yet the cost rises considerably.

Adding cagrilintide is what I'm considering, because it looks the most promising. A Lancet study pitted sema 2.4mg against cagri 2.4mg and the two together; weight loss came out to 5.1%, 8.1%, and 15.6% respectively. Stacking cagri's distinct MOA onto tirz really does appear likely to deliver bigger weight loss than making the switch to reta. And I'm not buying the claims about reta having muscle recomp advantages over tirz — that's purely anecdotal and no trial backs it up.

 

[upnorth8]

chonkkk said:

upnorth8 said:

ultima thule said:

I'd like to know too — how does Reta compare with a plain GLP-1? I've only just begun reta, yet I'm already planning ahead: once I hit my target and decide to come off reta, how do I do it sensibly? My thought is to switch over to a GLP-1 only for maintenance... though that's probably far off, and things could look different by then. Time will tell, as always.

The way reta affects me isn't pleasant. It leaves me exhausted, and occasionally on edge as well, and on top of that it did nothing for the food noise. Everything goes into Shotsy so I can monitor where I stand with both medications.

What's your current dose?

3mg taken on a 5-day cycle, so a 4.2 weekly average.

 

[chonkkk]

upnorth8 said:

chonkkk said:

upnorth8 said:

ultima thule said:

I'd like to know too — how does Reta compare with a plain GLP-1? I've only just begun reta, yet I'm already planning ahead: once I hit my target and decide to come off reta, how do I do it sensibly? My thought is to switch over to a GLP-1 only for maintenance... though that's probably far off, and things could look different by then. Time will tell, as always.

The way reta affects me isn't pleasant. It leaves me exhausted, and occasionally on edge as well, and on top of that it did nothing for the food noise. Everything goes into Shotsy so I can monitor where I stand with both medications.

What's your current dose?

3mg taken on a 5-day cycle, so a 4.2 weekly average.

Yeah, there's certainly plenty of room to increase. I'm amazed it isn't doing much for you.

 

[mamallama]

nambo said:

mamallama said:

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I joined to pick up exactly this kind of knowledge. Having spent a few years at the maximum tirs dose, the results just aren't what they used to be for me. So at this point I'm weighing my options for what comes next.

For the past year I've used tirz, but about four months back I hit a plateau. My current split dose is 5mg every 4 days, which works out to roughly 10 mg/week — so I'm not actually at the maximum. I've held off on going to 15 mg/week because the STEP-1 RCT reported 22.5% weight loss at 15mg versus 21.4% at 10mg, meaning higher doses bring steep diminishing returns.

Across different trials, tirz 15mg produced weight loss anywhere from 20.2% (surmount-5) up to 25.5% (redefine-4). If I switched to max-dose reta, the weight loss range would be 24.2% to 28.7%, depending on the trial (triumph-4, redefine-4, etc.). That's not a huge improvement over tirz, yet the cost rises considerably.

Adding cagrilintide is what I'm considering, because it looks the most promising. A Lancet study pitted sema 2.4mg against cagri 2.4mg and the two together; weight loss came out to 5.1%, 8.1%, and 15.6% respectively. Stacking cagri's distinct MOA onto tirz really does appear likely to deliver bigger weight loss than making the switch to reta. And I'm not buying the claims about reta having muscle recomp advantages over tirz — that's purely anecdotal and no trial backs it up.

I appreciate you sharing this! I’ve been soaking up whatever I can, and it definitely gives me a lot to think over. I was thinking about splitting my dose and lowering it slightly just to observe how my body responds. Perhaps I ought to look into Cagri.

 

[Smiter]

mamallama said:

nambo said:

mamallama said:

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I joined to pick up exactly this kind of knowledge. Having spent a few years at the maximum tirs dose, the results just aren't what they used to be for me. So at this point I'm weighing my options for what comes next.

For the past year I've used tirz, but about four months back I hit a plateau. My current split dose is 5mg every 4 days, which works out to roughly 10 mg/week — so I'm not actually at the maximum. I've held off on going to 15 mg/week because the STEP-1 RCT reported 22.5% weight loss at 15mg versus 21.4% at 10mg, meaning higher doses bring steep diminishing returns.

Across different trials, tirz 15mg produced weight loss anywhere from 20.2% (surmount-5) up to 25.5% (redefine-4). If I switched to max-dose reta, the weight loss range would be 24.2% to 28.7%, depending on the trial (triumph-4, redefine-4, etc.). That's not a huge improvement over tirz, yet the cost rises considerably.

Adding cagrilintide is what I'm considering, because it looks the most promising. A Lancet study pitted sema 2.4mg against cagri 2.4mg and the two together; weight loss came out to 5.1%, 8.1%, and 15.6% respectively. Stacking cagri's distinct MOA onto tirz really does appear likely to deliver bigger weight loss than making the switch to reta. And I'm not buying the claims about reta having muscle recomp advantages over tirz — that's purely anecdotal and no trial backs it up.

I appreciate you sharing this! I’ve been soaking up whatever I can, and it definitely gives me a lot to think over. I was thinking about splitting my dose and lowering it slightly just to observe how my body responds. Perhaps I ought to look into Cagri.

For me, glutamine powder has been useful in keeping my sweet cravings in check. Honestly, that craving is a beast. If archaeologists studying Megalodon saw my sweet tooth, they'd try to figure out what kind of frightening creature it came from.

 

[CharlieBrown]

Smiter said:

mamallama said:

nambo said:

mamallama said:

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I joined to pick up exactly this kind of knowledge. Having spent a few years at the maximum tirs dose, the results just aren't what they used to be for me. So at this point I'm weighing my options for what comes next.

For the past year I've used tirz, but about four months back I hit a plateau. My current split dose is 5mg every 4 days, which works out to roughly 10 mg/week — so I'm not actually at the maximum. I've held off on going to 15 mg/week because the STEP-1 RCT reported 22.5% weight loss at 15mg versus 21.4% at 10mg, meaning higher doses bring steep diminishing returns.

Across different trials, tirz 15mg produced weight loss anywhere from 20.2% (surmount-5) up to 25.5% (redefine-4). If I switched to max-dose reta, the weight loss range would be 24.2% to 28.7%, depending on the trial (triumph-4, redefine-4, etc.). That's not a huge improvement over tirz, yet the cost rises considerably.

Adding cagrilintide is what I'm considering, because it looks the most promising. A Lancet study pitted sema 2.4mg against cagri 2.4mg and the two together; weight loss came out to 5.1%, 8.1%, and 15.6% respectively. Stacking cagri's distinct MOA onto tirz really does appear likely to deliver bigger weight loss than making the switch to reta. And I'm not buying the claims about reta having muscle recomp advantages over tirz — that's purely anecdotal and no trial backs it up.

I appreciate you sharing this! I’ve been soaking up whatever I can, and it definitely gives me a lot to think over. I was thinking about splitting my dose and lowering it slightly just to observe how my body responds. Perhaps I ought to look into Cagri.

For me, glutamine powder has been useful in keeping my sweet cravings in check. Honestly, that craving is a beast. If archaeologists studying Megalodon saw my sweet tooth, they'd try to figure out what kind of frightening creature it came from.

Ohhhh, 100% with you on that. No alcohol, no cigarettes for me; not ever.

Still, there's never been a cake that I turned down

 

[Smiter]

CharlieBrown said:

Smiter said:

mamallama said:

nambo said:

mamallama said:

GeeB5 said:

Hi everyone,

I'd like to know what drives your decision to switch things up, and how you figure out the right moment to adjust your dose. Is there some kind of schedule you stick to? Or do you simply trust your gut?

Thanks so much ahead of time.

I joined to pick up exactly this kind of knowledge. Having spent a few years at the maximum tirs dose, the results just aren't what they used to be for me. So at this point I'm weighing my options for what comes next.

For the past year I've used tirz, but about four months back I hit a plateau. My current split dose is 5mg every 4 days, which works out to roughly 10 mg/week — so I'm not actually at the maximum. I've held off on going to 15 mg/week because the STEP-1 RCT reported 22.5% weight loss at 15mg versus 21.4% at 10mg, meaning higher doses bring steep diminishing returns.

Across different trials, tirz 15mg produced weight loss anywhere from 20.2% (surmount-5) up to 25.5% (redefine-4). If I switched to max-dose reta, the weight loss range would be 24.2% to 28.7%, depending on the trial (triumph-4, redefine-4, etc.). That's not a huge improvement over tirz, yet the cost rises considerably.

Adding cagrilintide is what I'm considering, because it looks the most promising. A Lancet study pitted sema 2.4mg against cagri 2.4mg and the two together; weight loss came out to 5.1%, 8.1%, and 15.6% respectively. Stacking cagri's distinct MOA onto tirz really does appear likely to deliver bigger weight loss than making the switch to reta. And I'm not buying the claims about reta having muscle recomp advantages over tirz — that's purely anecdotal and no trial backs it up.

I appreciate you sharing this! I’ve been soaking up whatever I can, and it definitely gives me a lot to think over. I was thinking about splitting my dose and lowering it slightly just to observe how my body responds. Perhaps I ought to look into Cagri.

For me, glutamine powder has been useful in keeping my sweet cravings in check. Honestly, that craving is a beast. If archaeologists studying Megalodon saw my sweet tooth, they'd try to figure out what kind of frightening creature it came from.

Ohhhh, 100% with you on that. No alcohol, no cigarettes for me; not ever.

Still, there's never been a cake that I turned down

Ugh! I used to smoke like crazy. These days I vape just as badly.

A word to anyone who smokes: whatever you do, avoid India. And if you somehow end up there, stay far away from Gold Flake Kings cigarettes. Believe me, after those, every other cigarette will only disgust you.