Haha, no need to stress. Give the thread a look — sounds like nothing but an old wives' tale.
Once you reconstitute it, NAD+ ranks among the most fragile compounds around. Amber vials are used for a reason: light degrades it readily, and at room temperature breakdown starts right away. Any batch you left out of the fridge would have gone flat quite a while back. My own routine is fridge storage away from light, 100mg per dose, 3x/week, and I clearly get that clean energy plus a steady sense of being capable and productive all day. I inject only in the AM; as far as I can tell, sleep is unaffected in either direction.
What's your source for that? The vials I received weren't amber. How exactly would it degrade? Within a few minutes after injecting I notice a clear effect, and after sitting in the cabinet for 7 days it doesn't seem any less potent.
Amber vials are the norm, so if yours arrived in something else, that’s worth raising with whoever supplied it. I’ve never come across NAD+ that wasn’t packaged that way, and exposure to light would have degraded it well before the room temperature had any effect. Outcomes differ, and I’m not going to push back on whether you keep going or stop. That said, if a seller shipped you NAD+ in clear vials without even suggesting you wrap them in foil, you’d be justified in being annoyed, since that is unquestionably the standard practice.
Keeping it mostly shut away in the cabinet, away from light, would have worked in its favor. That said, clear vials combined with room-temperature conditions mean you’ve almost certainly shed a meaningful amount of potency. Should you decide to move forward regardless, here’s what I’d recommend: once it’s reconstituted, wrap each vial in foil and store it in the fridge. Then pay attention to whether the next vial feels any different — that might make a bit of a difference.
To be straight with you, none of that sounds credible to me. No hard feelings whatsoever haha, in this space everyone swears by their own routine. Still, I appreciate it — I'll keep it noted for down the road, and I might give the foil trick a shot just out of curiosity.
So mine must be the unbuffered kind. Typical. At least I'm young and my skin tolerates it, haha.
Pretty much, that's exactly what I did. 50mg could hit a bit hard, so after injecting, be ready to lie down or stay seated. And afterward, be sure to back up your methylation pathways with tmg/methyl B.
Hmm, is there really an NAD+ 'pool' that 'leaks' as we get older? And that 'pool' can be topped back up? I'd really like to see the research that scientifically established those claims.
Strange — the AL I got came in an amber vial. It only arrived yesterday.
Amino Lair was also where mine came from.
I was just trying to put a picture in my head into words — the idea being that our bodies hold NAD reserves that shrink with age as normal metabolism keeps burning through more of it, while our ability to use or replenish it as efficiently as when we were younger drops off lol. That said, "pools" isn't something I made up; it's an actual term you'll find in NAD research haha
I didn’t want to open every single link that was posted here one by one, and honestly I’m not going to pretend I grasp all the jargon or the way it works either haha. Still, for whatever it’s worth, in my opinion there’s enough material in this thread for me to accept that NAD+ breaks down a lot when it gets hit by light and/or sits around at room temperature. If you look at what degraded NAD+ is reported to cause, things like stinging and short-term fatigue, that might also account for what you went through, rather than it coming down to the product being unbuffered. That said, I’m definitely no kind of authority on this. I just figured I’d pass along at least the info that swayed me and shapes how I keep and use mine personally.
Yeah, that's odd. I haven't bought from them myself, but they've clearly been operating long enough that they should know the norm or what buyers expect. What's even weirder is that the person posting right after you got amber vials just days ago — I can't think of any good reason the same seller would ship it both ways, and definitely not without telling the buyer or giving some kind of notice. Obviously it's your call, but if it were me, I'd say that's enough to ask for a refund or a replacement.
Not long ago, someone on this forum shared a study that caught my attention — unfortunately I can't locate it anymore. What I remember is that this person, or perhaps an acquaintance, mixed a vial of NAD+ and stored it in the refrigerator. When a lab checked the NAD+ concentration 15 days later, the result showed 50% degradation. So I'm with you: after reconstitution, NAD+ doesn't last very long.
Yeah, same here — especially since I've got a ton of powder chilling in the fridge as we speak lol. And if that's what goes down once it's mixed, even with cold storage, then I'm probably better off going with the 500mg vials rather than the 1000 lol
