CNCCurrency
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Bingo, I say
Finally happened. my Tesa Gelled up on me.
- Thread starter Gr33dyOctopus
- Start date
Typical AI slop. Pharma tesamorelin has different excipients, and is stored differently. No one here is using Pharma tesamorelin.Zelmar702 said:
Chat says:
Tesamorelin is notorious for turning into a gel. It is a long, highly complex 44-amino-acid peptide chain. Its length and unique electrical charge make it significantly more prone to self-assembling into a thick, gelatinous matrix than almost any other compound on the market. [1, 2]
Even though you used Hospira bacteriostatic water—which is generally the highest industry standard—the combination of a tight 2ml volume, the acidic nature of the preservative water, and the immediate drop in temperature from your refrigerator caused the remaining molecules to bind together into a "jelly mess" overnight. [1, 2]
How to Salvage Your Tesamorelin
Because this is a physical clumping of molecules (aggregation) and not immediate chemical destruction, you can usually melt it back down into a usable liquid. [1]
- Dilute it Further: Tesamorelin rarely tolerates high concentrations well. Add another 1.0ml of Hospira water into the vial to thin it out. [, 2]
- Warm to Room Temperature: Take the vial out of the refrigerator. Let it naturally warm up to standard room temperature (around 68°F to 75°F). [1]
- Roll and Swirl Gently: Place the vial between the palms of your hands and roll it back and forth. The ambient body warmth breaks the physical bonds holding the gel grid together. Do not shake it, as shaking adds microbubbles that lock the gel structure in place. [1, 2, 3]
- Give it Time: Let it sit at room temperature for 30 to 45 minutes. In most cases, it will smoothly liquefy back into a perfectly clear, colorless solution. [1, 2]
Future Storage Warning for Tesamorelin
The official prescription guidelines for brand-name Tesamorelin (Egrifta) actually advise storing the reconstituted solution at room temperature (68°F to 77°F / 20°C to 25°C) rather than in the refrigerator, explicitly to prevent this cold-induced gelling process. [1, 2]
If your room environment is stable and protected from light, keeping it out of the fridge can prevent this from happening again. However, if you do choose to refrigerate it for stability, you must expect to warm it up in your hands to melt the gel before every subsequent use. [1, 2]
Dosing Adjustment After Correction
If you add an extra 1.0ml of water to salvage the vial, your total liquid volume will increase from 2ml to 3ml. To pull your exact intended milligram dose, you will need to increase your syringe pull volume by exactly 1.5 times.
- If you were previously pulling 10 units on your syringe, you must now pull 15 units.
- If you were previously pulling 20 units on your syringe, you must now pull 30 units.
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Gr33dyOctopus
Explorer
so i did add another ml of bac, and let it hit room temp, and it does seem ok now.
if tomorrow morning it draws up like a liquid and shoots into my 31g syringe like a miniature fire hose ill shoot it, otherwise tossing that shit.
Does that sound like a plan? I honestly dont mind tossing it, im 4 vials in to two kits Tesa10mg. but if its still good, why waste it????
if tomorrow morning it draws up like a liquid and shoots into my 31g syringe like a miniature fire hose ill shoot it, otherwise tossing that shit.
Does that sound like a plan? I honestly dont mind tossing it, im 4 vials in to two kits Tesa10mg. but if its still good, why waste it????
Gr33dyOctopus
Explorer
sooooo, someone help me get this straight. tesa should have more than 2ml bac per 3ml vial, it can be left out at room temp, or stashed in fridge and warmed up slightly to use, I should jist drink it or boof it?
amosmylove
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Glug glug, baby!
...for science.
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https://www.mayoclinic.org/drugs-supplements/tesamorelin-subcutaneous-route/description/drg-20074632
/community-link/thread/11074/
Gr33dyOctopus
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ty! after reading that its going back in the fridge.Zelmar702 said:
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https://www.mayoclinic.org/drugs-supplements/tesamorelin-subcutaneous-route/description/drg-20074632
/community-link/thread/11074/
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Merk1986
Explorer
This just happened to TWO vials of Mots-C. Tossed one and mixed another. Same. Same
Not sure what to do. Used hospira to reconstitue both. Could my refrigerator be too cold?Johnny D
Explorer
The only way to test that is to leave the vial at RT for an hour or soMerk1986 said:
This just happened to TWO vials of Mots-C. Tossed one and mixed another. Same. Same
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Merk1986
Explorer
Seems like a common sense approach, right? Lol. I'll give it a try. Thanks.
It's not uncommon I see it all over Reddit... though I would say probably over 15 years I maybe had three or four vials that did that otherwise it's a very very rare in my experience but absolutely something that happens to people.
So don't blame the batch or the vendor or the quality of the peptide.. just luck of the draw or user ever with regards to reconstitution amount.
Also...never ..never ...never (did I say never?) Use sodium chloride (NaCl) sterile water for Tesamorelin. Instant gel.
So don't blame the batch or the vendor or the quality of the peptide.. just luck of the draw or user ever with regards to reconstitution amount.
Also...never ..never ...never (did I say never?) Use sodium chloride (NaCl) sterile water for Tesamorelin. Instant gel.
If you have 20 mg Tesa coming, 3 mL BAC will probably not be enough to prevent aggregation. You might want to get some 10 mL sterile vials and try 5 or 6 mL BAC. Just a thought.sheilarae74 said:
Damn.Thanks for the warning. I will definitely keep them separate then.
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Ultra Spec 10ML Clear Sealed Sterile Glass Vials, Qty 1
Ultra Spec Sterile Clear Sealed Glass Vials - 10ML (20mm Neck) made of SCHOTT FIOLAX® glass tubing. In order to receive vials in sealed shrink wrap boxes, please order in multiples of 25.
www.medical-and-lab-supplies.com
sheilarae74
Explorer
Thanks for the tip. I do have some 10mL vials and I definitely will put 6mL of bac in it just to be safe.Chili777 said:
If you have 20 mg Tesa coming, 3 mL BAC will probably not be enough to prevent aggregation. You might want to get some 10 mL sterile vials and try 5 or 6 mL BAC. Just a thought.
Ultra Spec 10ML Clear Sealed Sterile Glass Vials, Qty 1
Ultra Spec Sterile Clear Sealed Glass Vials - 10ML (20mm Neck) made of SCHOTT FIOLAX® glass tubing. In order to receive vials in sealed shrink wrap boxes, please order in multiples of 25.
www.medical-and-lab-supplies.com
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Gr33dyOctopus
Explorer
Just to drop a pin in this. i added an extra ml to the tesa, in the fridge over the weekend, brought it out to draw. and it looked fine, back to a true liquid consistency but after seeing it all gelled up the last time, noped out and just tossed it in the trash. fuck that. I know its likely good but id rather just set up a freshie this evening. ty everyone for all the insight and advice on this one.
venkacelnor
Explorer
Ugh, I just came across this and it's making me rethink everything. I've already ordered 20mg of Tesa plus 5mg of Ipa, and the plan was to dump the Ipa right into the Tesa vial so there's only 1 shot to do at bedtime. What happened with your remaining vials afterward? Did you keep experimenting with combining them to find what works, or did you give up and split them into separate pins, and what does your current routine look like? I'd really like to stick with just 1 pin, but losing a fresh 20mg Tesa vial immediately is not something I want. :/Gr33dyOctopus said:
yes, I mixed mine with ipamorelin. and it didn't keep it from happening, in fact I wonder if it contributed!!!sheilarae74 said:
Damn, that sucks. I have tesa 20mg coming soon. I am for sure going to reconstitute it with at least 3mL of hospira. I wonder if mixing in the ipa I plan on taking with it will keep that from happening? I really wanted to keep them separate but oh well.Gr33dyOctopus said:
Well that sucks. Darn, I had just reconstituted 10mg w 2ml of Hospira, used once and then this morning the whole thing was a jelly mess.
I’ll be injecting tesa and ipa in separate shots. My tesa vial contains 10mg, and since I’ll be dosing 1mg 5x per week, I intend to leave the reconstituted tesa out at room temperature and use it within 2 weeks.
On one of the testing servers, I saw a degradation study comparing tesa stored at room temperature against tesa kept in the fridge, with mass and purity checked on days 0, 7, 14, 21, and 28. The room-temperature vial’s purity matched the reference vial through day 14, after which it dropped off. Purity was 99.157% at 14 days and declined to 97.969% by 21 days.
On one of the testing servers, I saw a degradation study comparing tesa stored at room temperature against tesa kept in the fridge, with mass and purity checked on days 0, 7, 14, 21, and 28. The room-temperature vial’s purity matched the reference vial through day 14, after which it dropped off. Purity was 99.157% at 14 days and declined to 97.969% by 21 days.
Johnny D
Explorer
Haha....that was really just me failing to read the original poster's message carefully
Symmetry
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My orthopedic Dr. instructed me to keep my tesa at room temp inside a dark cabinet. Last month, one of them gelled up.