ToeMittens said:
I’d like to jump into this thread too, because I’m after similar guidance.
My details:
47/F
Beginning weight: 235 lbs
Now holding steady near 145 lbs
I began Tirz in December ‘23, and by June ‘24 I had increased step by step to 15 mg each week.
In March ‘26 I went up to 20 mg weekly.
My weight loss had already flattened roughly 12 months ago. Given my starting point, I mostly accepted that, but more recently the food noise has started returning and I’ve noticed myself choosing poorer options. If possible, I’d like to lose another 10-15 lbs. I recently raised my dose to 20 mg per week, which gave me some improvement. Last week I began dividing the dose into 10 mg twice weekly (Tuesday PM and Saturday AM), and that has helped further. Still, I worry that this peptide may be close to the limit of what it can do for me, so I’m exploring other options.
A few months back I came across the whole Grey market world. At first I only went that route to cut costs (thinking about how much I’ve wasted at Mochi across the last 30 months… /cry), but reading all this research has shown me possibilities I hadn’t considered.
One idea is possibly changing to a Reta/Cagri stack. My thinking is that I’d want to gradually replace Tirz with Reta and finish that change before attempting to add Cagri, but I can’t decide what amount to begin with. Nearly every post I’ve seen comes from people using 10/mg or less of Tirz weekly. At my current Tirz dose, would a Reta dose of 2 mg/week even register for me? Should I test that for several weeks while keeping my Tirz dose unchanged? Should I reduce my Tirz dose once I begin Reta?
Has anyone else transitioned away from such a high Tirz dose as it stops working as well? Any ideas, suggestions, or guidance? Am I over- or under-thinking this? Are there other peps you’d suggest for someone like me who is in the early stages of Peri?
If you got through all of that, thanks for reading! I’m so grateful for this community!
