Combining Cagrilintide With Tirzepatide

[cythehun]

I'd like to hear from people who have stacked Cagrilintide on top of Tirzepatide. What drove you to try it? What dosing protocol did you use? And what kind of results did you get?

Right now my Tirzepatide dose sits at 10mg/week. It's largely doing its job, but the persistent "food noise" keeps wrecking my attempts to stay disciplined with eating. Rather than keep pushing my TZ dose higher, I want to find out whether bringing Cagrilintide into the mix can deliver the appetite suppression I need to hit my intake targets.

 

[Mayostardayonnaise]

I've worked my way up to 6 mg of Tirz (began in July '25 at 2.125mg), and 6 weeks back I introduced Cagri. My goal is to stretch my time at 6 mg and create a 2 day bridge leading into shot day.

For me at least, this stuff is too effective. I've seen others sitting at 1 or 2 mg without any trouble.

For roughly 3 days afterward, eating becomes a genuine chore. It isn't nausea in the slightest, but going through the motions of eating just feels blah. After that, it appears to fade sooner than Tirz does, yet it still MORE than gets me through to Tirz shot day. Nausea never hit me, and I had no added fatigue. My titration wasn't the standard one; the anecdotes I kept reading scared me too much, so mine went .10, .25, .25, .39, .5, and on Sunday I took .67. Last week I dropped 4 lbs, but the week before that, nothing? If I can't eat enough, I'm unsure how much Cag is actually doing for me. Split dosing might be something I'll try. Weigh in is tomorrow, so we'll see

 

[cythehun]

Mayostardayonnaise said:

I've worked my way up to 6 mg of Tirz (began in July '25 at 2.125mg), and 6 weeks back I introduced Cagri. My goal is to stretch my time at 6 mg and create a 2 day bridge leading into shot day.

For me at least, this stuff is too effective. I've seen others sitting at 1 or 2 mg without any trouble.

For roughly 3 days afterward, eating becomes a genuine chore. It isn't nausea in the slightest, but going through the motions of eating just feels blah. After that, it appears to fade sooner than Tirz does, yet it still MORE than gets me through to Tirz shot day. Nausea never hit me, and I had no added fatigue. My titration wasn't the standard one; the anecdotes I kept reading scared me too much, so mine went .10, .25, .25, .39, .5, and on Sunday I took .67. Last week I dropped 4 lbs, but the week before that, nothing? If I can't eat enough, I'm unsure how much Cag is actually doing for me. Split dosing might be something I'll try. Weigh in is tomorrow, so we'll see

A recommendation I came across on a website suggests 0.6mg of Cag when it is introduced alongside a Tirz schedule already at 10mg. My plan is to begin at that amount. Up to this point, fatigue has been the sole side-effect I have noticed from Tirz by itself.

 

[Devilseye]

I followed that same path. When my tirz was at 10mg, I brought cagri into the mix. My cagri approach was gradual: 0.25, then 0.5, and at this point 2.4. At the start it felt remarkable, particularly the day following the shot, yet the benefits faded pretty fast. That is why I kept increasing the dose, landing at 2.4, and I will remain there until my stack runs out. I do not intend to order more, though.

 

[beamero]

Sunday is T- 12.5mg, and Wednesday is Cagri (right now 1.2mg). Week 6 is coming up. It works great, but during week 1 and 2 the fatigue was palpable. Cagri went 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. Moving to 1.7mg this week.

 

[Mara_aa]

Devilseye said:

I followed that same path. When my tirz was at 10mg, I brought cagri into the mix. My cagri approach was gradual: 0.25, then 0.5, and at this point 2.4. At the start it felt remarkable, particularly the day following the shot, yet the benefits faded pretty fast. That is why I kept increasing the dose, landing at 2.4, and I will remain there until my stack runs out. I do not intend to order more, though.

Is it because the effect fades fast that you wouldn't order it again, or is there another reason?

 

[Mara_aa]

Mayostardayonnaise said:

I've worked my way up to 6 mg of Tirz (began in July '25 at 2.125mg), and 6 weeks back I introduced Cagri. My goal is to stretch my time at 6 mg and create a 2 day bridge leading into shot day.

For me at least, this stuff is too effective. I've seen others sitting at 1 or 2 mg without any trouble.

For roughly 3 days afterward, eating becomes a genuine chore. It isn't nausea in the slightest, but going through the motions of eating just feels blah. After that, it appears to fade sooner than Tirz does, yet it still MORE than gets me through to Tirz shot day. Nausea never hit me, and I had no added fatigue. My titration wasn't the standard one; the anecdotes I kept reading scared me too much, so mine went .10, .25, .25, .39, .5, and on Sunday I took .67. Last week I dropped 4 lbs, but the week before that, nothing? If I can't eat enough, I'm unsure how much Cag is actually doing for me. Split dosing might be something I'll try. Weigh in is tomorrow, so we'll see

Absolutely, do keep me in the loop — I'm genuinely curious. Also, I'd like to hear if you belong to the crowd that sticks with Bac water exclusively, or to the group that goes the extra mile with AA for pH reasons.

 

[Mara_aa]

beamero said:

Sunday is T- 12.5mg, and Wednesday is Cagri (right now 1.2mg). Week 6 is coming up. It works great, but during week 1 and 2 the fatigue was palpable. Cagri went 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. Moving to 1.7mg this week.

Is the fatigue gone at this point? Also, I'd like to hear about your reconstitution method — is BAC water your only choice, or do you include AA as well?

 

[Mayostardayonnaise]

Mara_aa said:

Mayostardayonnaise said:

I've worked my way up to 6 mg of Tirz (began in July '25 at 2.125mg), and 6 weeks back I introduced Cagri. My goal is to stretch my time at 6 mg and create a 2 day bridge leading into shot day.

For me at least, this stuff is too effective. I've seen others sitting at 1 or 2 mg without any trouble.

For roughly 3 days afterward, eating becomes a genuine chore. It isn't nausea in the slightest, but going through the motions of eating just feels blah. After that, it appears to fade sooner than Tirz does, yet it still MORE than gets me through to Tirz shot day. Nausea never hit me, and I had no added fatigue. My titration wasn't the standard one; the anecdotes I kept reading scared me too much, so mine went .10, .25, .25, .39, .5, and on Sunday I took .67. Last week I dropped 4 lbs, but the week before that, nothing? If I can't eat enough, I'm unsure how much Cag is actually doing for me. Split dosing might be something I'll try. Weigh in is tomorrow, so we'll see

Absolutely, do keep me in the loop — I'm genuinely curious. Also, I'd like to hear if you belong to the crowd that sticks with Bac water exclusively, or to the group that goes the extra mile with AA for pH reasons.

Look, my stance is basically this: I go with bac. Part of that is just being lazy — that accounts for about 70% of it — and the other 30% is that I don't buy into the idea that it creates fibrils capable of causing damage that sticks around. No doubt somebody will show up to call me reckless, and maybe they're right, since there's no way to actually know. My approach to risk is pretty…layered? Lol

 

[beamero]

Mara_aa said:

beamero said:

Sunday is T- 12.5mg, and Wednesday is Cagri (right now 1.2mg). Week 6 is coming up. It works great, but during week 1 and 2 the fatigue was palpable. Cagri went 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. Moving to 1.7mg this week.

Is the fatigue gone at this point? Also, I'd like to hear about your reconstitution method — is BAC water your only choice, or do you include AA as well?

Yep, the tiredness has improved a lot. I mix it using Hospira and nothing else.

 

[Devilseye]

Mara_aa said:

Devilseye said:

I followed that same path. When my tirz was at 10mg, I brought cagri into the mix. My cagri approach was gradual: 0.25, then 0.5, and at this point 2.4. At the start it felt remarkable, particularly the day following the shot, yet the benefits faded pretty fast. That is why I kept increasing the dose, landing at 2.4, and I will remain there until my stack runs out. I do not intend to order more, though.

Is it because the effect fades fast that you wouldn't order it again, or is there another reason?

After some time passes, it seems to have no effect at all. Even at a full dose, I wake up hungry. Skipping a dose makes no noticeable difference. Tirzepatide, by contrast, clearly blunts my hunger, and missing a dose brings the hunger creeping back. So no, I won't be ordering it again—for weight loss over the long haul it simply doesn't deliver. Over the short term, though, that's another matter.

 

[Devilseye]

beamero said:

Mara_aa said:

beamero said:

Sunday is T- 12.5mg, and Wednesday is Cagri (right now 1.2mg). Week 6 is coming up. It works great, but during week 1 and 2 the fatigue was palpable. Cagri went 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. Moving to 1.7mg this week.

Is the fatigue gone at this point? Also, I'd like to hear about your reconstitution method — is BAC water your only choice, or do you include AA as well?

Yep, the tiredness has improved a lot. I mix it using Hospira and nothing else.

x2. Fatigue tends to be a short-lived cagri effect and clears up once you've had a few doses. I only ever reconned with hospira BAC as well, and never ran into gelling, though I use it inside 2-3 weeks at most.

 

[arborealtrout]

Roughly 8 months back, I introduced cagrilintide into my tirzepatide regimen. My current approach splits each peptide's dose into 2 weekly administrations on separate days, resulting in 4 shots per week overall. The outcome has left me quite pleased. Yesterday's weigh-in showed a total loss of 100 pounds/45 Kg across the year since I began, with the initial 4 months being tirzepatide by itself. Prior to starting cagrilintide, I felt constant hunger. These days, eating sometimes slips my mind entirely. The trigger for embarking on this was a T2D diagnosis. Whether I'd still satisfy any diagnostic criteria now is unclear, as my glycohemoglobin has stayed comfortably in the normal range for several months. Still, that diagnosis led me to wear a continuous glucose monitor. Its low blood sugar alerts frequently serve as the cue that I've gone without food. I haven't noticed any negative reactions.

 

[cythehun]

arborealtrout said:

Roughly 8 months back, I introduced cagrilintide into my tirzepatide regimen. My current approach splits each peptide's dose into 2 weekly administrations on separate days, resulting in 4 shots per week overall. The outcome has left me quite pleased. Yesterday's weigh-in showed a total loss of 100 pounds/45 Kg across the year since I began, with the initial 4 months being tirzepatide by itself. Prior to starting cagrilintide, I felt constant hunger. These days, eating sometimes slips my mind entirely. The trigger for embarking on this was a T2D diagnosis. Whether I'd still satisfy any diagnostic criteria now is unclear, as my glycohemoglobin has stayed comfortably in the normal range for several months. Still, that diagnosis led me to wear a continuous glucose monitor. Its low blood sugar alerts frequently serve as the cue that I've gone without food. I haven't noticed any negative reactions.

That's amazing! Exactly the kind of outcome I'm aiming for. Would you mind detailing how you dosed over the past 4 months? Thank you!

 

[Mayostardayonnaise]

This morning the scale read 179, which means a drop of 3.6 lbs - the Cag clearly gave the weight loss a push Though honestly! I'm leaning toward stopping it and perhaps trying to taper the Tirz down, since I've only got roughly 20-30 lbs remaining to shed. If the need arose I'd purchase it again, but not an entire kit (unless somebody out there has a 5 mg kit for 60 or less ).

 

[Mara_aa]

Mayostardayonnaise said:

Mara_aa said:

Mayostardayonnaise said:

I've worked my way up to 6 mg of Tirz (began in July '25 at 2.125mg), and 6 weeks back I introduced Cagri. My goal is to stretch my time at 6 mg and create a 2 day bridge leading into shot day.

For me at least, this stuff is too effective. I've seen others sitting at 1 or 2 mg without any trouble.

For roughly 3 days afterward, eating becomes a genuine chore. It isn't nausea in the slightest, but going through the motions of eating just feels blah. After that, it appears to fade sooner than Tirz does, yet it still MORE than gets me through to Tirz shot day. Nausea never hit me, and I had no added fatigue. My titration wasn't the standard one; the anecdotes I kept reading scared me too much, so mine went .10, .25, .25, .39, .5, and on Sunday I took .67. Last week I dropped 4 lbs, but the week before that, nothing? If I can't eat enough, I'm unsure how much Cag is actually doing for me. Split dosing might be something I'll try. Weigh in is tomorrow, so we'll see

Absolutely, do keep me in the loop — I'm genuinely curious. Also, I'd like to hear if you belong to the crowd that sticks with Bac water exclusively, or to the group that goes the extra mile with AA for pH reasons.

Look, my stance is basically this: I go with bac. Part of that is just being lazy — that accounts for about 70% of it — and the other 30% is that I don't buy into the idea that it creates fibrils capable of causing damage that sticks around. No doubt somebody will show up to call me reckless, and maybe they're right, since there's no way to actually know. My approach to risk is pretty…layered? Lol

“nuanced risk tolerance” — that’s honestly where a lot of us land.

My reason for asking: I’m looking into cagrilintide and trying to follow the pH conversation in a way that goes past just the theory.

When it comes to the fibrils angle (the idea of permanent damage), I’m not fully convinced. But breakdown of the peptide as time passes feels like a separate issue.

What I’m trying to pin down: among people who’ve run it for a while, has there been a real, noticeable decline in how well it works after several weeks — or is this mostly still speculation based on extrapolation?

In practical terms, the difference between “holds up for 3–4 weeks” and “no more than 2 weeks” matters a lot.

If actual user experience tends to land nearer the 2-week mark, that would shift my thinking considerably.

And practically speaking, if a vial has to be thrown out after only a few shots, that’s tough to rationalize for the way I’d be using it.

 

[Calm Logic]

Yeah, the drop in effectiveness doesn't line up with the CagriSema studies — one of which ran 68 weeks — so I don't buy it.

https://www.medicalnewstoday.com/ar...-more-effective-than-wegovy-in-clinical-trial

A separate study also looked at cagri on its own :https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01751-7/abstract

 

[Mara_aa]

beamero said:

Mara_aa said:

beamero said:

Sunday is T- 12.5mg, and Wednesday is Cagri (right now 1.2mg). Week 6 is coming up. It works great, but during week 1 and 2 the fatigue was palpable. Cagri went 400mcg, 750mcg, 750mcg, 1.2mg, 1.2mg. Moving to 1.7mg this week.

Is the fatigue gone at this point? Also, I'd like to hear about your reconstitution method — is BAC water your only choice, or do you include AA as well?

Yep, the tiredness has improved a lot. I mix it using Hospira and nothing else.

Good to hear the fatigue has eased up.

Typically, how many days do you get out of a single vial, and does its strength hold steady for you throughout that time?

 

[Mara_aa]

Mayostardayonnaise said:

This morning the scale read 179, which means a drop of 3.6 lbs - the Cag clearly gave the weight loss a push Though honestly! I'm leaning toward stopping it and perhaps trying to taper the Tirz down, since I've only got roughly 20-30 lbs remaining to shed. If the need arose I'd purchase it again, but not an entire kit (unless somebody out there has a 5 mg kit for 60 or less ).

I want a 5 mg kit too, simply to give it a try.

 

[Mayostardayonnaise]

Mara_aa said:

Mayostardayonnaise said:

Mara_aa said:

Mayostardayonnaise said:

I've worked my way up to 6 mg of Tirz (began in July '25 at 2.125mg), and 6 weeks back I introduced Cagri. My goal is to stretch my time at 6 mg and create a 2 day bridge leading into shot day.

For me at least, this stuff is too effective. I've seen others sitting at 1 or 2 mg without any trouble.

For roughly 3 days afterward, eating becomes a genuine chore. It isn't nausea in the slightest, but going through the motions of eating just feels blah. After that, it appears to fade sooner than Tirz does, yet it still MORE than gets me through to Tirz shot day. Nausea never hit me, and I had no added fatigue. My titration wasn't the standard one; the anecdotes I kept reading scared me too much, so mine went .10, .25, .25, .39, .5, and on Sunday I took .67. Last week I dropped 4 lbs, but the week before that, nothing? If I can't eat enough, I'm unsure how much Cag is actually doing for me. Split dosing might be something I'll try. Weigh in is tomorrow, so we'll see

Absolutely, do keep me in the loop — I'm genuinely curious. Also, I'd like to hear if you belong to the crowd that sticks with Bac water exclusively, or to the group that goes the extra mile with AA for pH reasons.

Look, my stance is basically this: I go with bac. Part of that is just being lazy — that accounts for about 70% of it — and the other 30% is that I don't buy into the idea that it creates fibrils capable of causing damage that sticks around. No doubt somebody will show up to call me reckless, and maybe they're right, since there's no way to actually know. My approach to risk is pretty…layered? Lol

“nuanced risk tolerance” — that’s honestly where a lot of us land.

My reason for asking: I’m looking into cagrilintide and trying to follow the pH conversation in a way that goes past just the theory.

When it comes to the fibrils angle (the idea of permanent damage), I’m not fully convinced. But breakdown of the peptide as time passes feels like a separate issue.

What I’m trying to pin down: among people who’ve run it for a while, has there been a real, noticeable decline in how well it works after several weeks — or is this mostly still speculation based on extrapolation?

In practical terms, the difference between “holds up for 3–4 weeks” and “no more than 2 weeks” matters a lot.

If actual user experience tends to land nearer the 2-week mark, that would shift my thinking considerably.

And practically speaking, if a vial has to be thrown out after only a few shots, that’s tough to rationalize for the way I’d be using it.

Anyone feeling wary about Cagri — I get it, no judgment here. In my case, though, I can be a bit absurd, and wanting to give it a shot won out over my worries about that fibrils situation I hadn't gotten any AA beforehand, and my curiosity was just too strong to resist. After that, I simply continued with bac. My so-called nuanced risk tolerance genuinely doesn't add up, I'll admit lol. A month ago on here I was saying things like “I think I’ll stick with only FDA approved stuff,” and I've already moved away from that.