Would oral sema dampen the sides?

Foggy-Hollow

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It’s anhedonia from GLP-1s in general that I’m trying work around.

The liver gets a first pass with oral sema - that's what oral means.

Potentially dampened sides - could that be the result? And the extra pass: would crossing the blood brain barrier get more difficult?

Hearing from anyone who had taken both would interest me.
 
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