Will things improve? Seeking personal stories

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johncena12

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I'm in week 5 at 5mg right now, and my food noise and binge urges haven't gone away—if anything, they've ramped up. I'm really counting on 7.5 or 10 to make a big difference. Has anyone else gone through this?
 
You still have a lot of room before reaching the highest dose that was studied. My own path was different - I began on Sema, went all the way up on it, then made a switch. Still, in your position, after 4 weeks at 5mg, I would move up to the next dose.
 
I was on 3.5mg of branded tirz.

After I made the change to grey, the effect didn't feel the same for me until I reached 5mg.

I hope you're able to find your sweet spot!
 
at 2.5 i noticed a powerful effect right away, then moved up slowly to 5 (spent a few weeks at 3.3 before that), yet after a few weeks on 5 mg the food cravings came back much harder. increasing to 7.5 made a difference.

from my own experience, it seems like after a couple of months i became accustomed to the tirz feeling and had to actively decide to make healthy choices again, rather than simply relying on the medication to steer me. though i might just be telling myself that.
 
Certain individuals notice both benefits and adverse reactions even at small doses, while others notice nothing at all. How each person reacts to these medications varies quite a bit. Where you are now, the only conclusion available is that you aren't among the strong responders, so the sensible move is to keep stepping the dose up, and it will very likely kick in at higher amounts. A small unlucky minority, perhaps 5-10%, barely shed pounds on GLP's, but short of reaching 15mg with nothing happening, there's no way to tell whether you're in that group.

My own experience went the other direction: low dose ozempic hit me hard and left me horribly nauseous, yet when I switched to tirz I barely had any side effects and only mild hunger reduction, and I pushed the dose up to 15mg ( very carefully ) in roughly a month before it matched the hunger control I'd gotten from low dose ozempic.
 
johncena12 said:

I'm in week 5 at 5mg right now, and my food noise and binge urges haven't gone away—if anything, they've ramped up. I'm really counting on 7.5 or 10 to make a big difference. Has anyone else gone through this?
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I'd stay the course and keep titrating up until you hit at least 10mg, since that's where clinical trials demonstrate solid efficacy.

Separately, I've run tirz, reta, sema, and cagri, and tirzepatide is by far the strongest of the bunch when it comes to quieting food noise and appetite. Nothing else comes close.

So hang in there, go up gradually, and reassess somewhere between 10-15mg. There's no reason this won't pan out for you.
 
Other replies have said the same thing — to get the full effect from tirzepatide, you frequently have to move to larger doses. Still, I want to ask whether you're certain about how much you're actually injecting. I bring this up only because a dosing mix-up is a possibility. People who are new to this can easily get confused, and I'm not trying to be rude. Not long ago, someone on the forum believed they were on roughly 28mg of tirz plus 15mg of cagri. The arithmetic, it turned out, was off.

Another thing to remember: a sizable share of people simply don't respond, maybe around 10-15%. It's possible you're in that unlucky group. Even so, don't jump to that conclusion yet — keep increasing the dose, particularly if the side effects aren't bothering you. Continue titrating upward until you notice something. And double-check your dosing.
 
Grogu said:

Other replies have said the same thing — to get the full effect from tirzepatide, you frequently have to move to larger doses. Still, I want to ask whether you're certain about how much you're actually injecting. I bring this up only because a dosing mix-up is a possibility. People who are new to this can easily get confused, and I'm not trying to be rude. Not long ago, someone on the forum believed they were on roughly 28mg of tirz plus 15mg of cagri. The arithmetic, it turned out, was off.

Another thing to remember: a sizable share of people simply don't respond, maybe around 10-15%. It's possible you're in that unlucky group. Even so, don't jump to that conclusion yet — keep increasing the dose, particularly if the side effects aren't bothering you. Continue titrating upward until you notice something. And double-check your dosing.
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At the moment, the pharmacy supplies my 5mg dose. Once I go past that, I'll switch to the gray market. During 2.5, I did notice something for about 1 or 2 weeks, so my guess is that a larger dose is what's needed.
 
I had good fortune. At 2.5mg, I saw results immediately. It appears that every few months, some effectiveness fades, so right now I'm on 10mg and have been for the past 3 months, with no intention of increasing. For me, 10 turned out to be the ideal dose.
 
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