Which holds maintenance better, Reta or Tirz?

bbvvin

bbvvin

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Setting aside everything else — for people at target weight who are now maintaining, which one does the job better; Reta or Tirz?

Is the glucagon agonist part of Reta the right choice for very long-term use, or does Tirz's GLP/GIP alone serve better, considering Reta's raised resting heart rate, allodynia and dopamine blunting against Tirz's cleaner profile?

My plan is to stash several grams of whichever one wins😄 and stay on it for 2-3 years at minimum, tapering down to zero at the end.
 
Both do the job for most people, though Reta brings side affects for some. Above 4mg, in my own case.

You have to find out for yourself whether you get the side effects and whether you can live with them.
 
Something worth weighing up is Reta's ability to hold fatty liver in check while also cutting visceral fat. If a dose low enough to take the sides down, or away entirely, still maintains you, then the extra metabolic benefits of Reta could make it the better option. And plenty of people on maintenance appear to be on really low 1-2 mg, so very much may not be needed.
 
bbvvin said:

Setting aside everything else — for people at target weight who are now maintaining, which one does the job better; Reta or Tirz?

Is the glucagon agonist part of Reta the right choice for very long-term use, or does Tirz's GLP/GIP alone serve better, considering Reta's raised resting heart rate, allodynia and dopamine blunting against Tirz's cleaner profile?

My plan is to stash several grams of whichever one wins😄 and stay on it for 2-3 years at minimum, tapering down to zero at the end.
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I had tirz at 10mg/week for maintenance, and it wasn't sufficient. So I titrated reta in and pulled the tirz back. These days it's 5T and 6R weekly. It's going very well. The glucagon effect was what I was after from reta. Once the tirz supply is gone I'll most likely move to reta alone.
 
Holding steady since 5/25. Reta at 3mg, once a week. Weight hasn't moved, and food is still enjoyable.
 
Picking a compound matters less for maintenance than the dose does.

What I can't work out is where in the studies you found that retatrutide blunts dopamine
 
Habibibi said:

Picking a compound matters less for maintenance than the dose does.

What I can't work out is where in the studies you found that retatrutide blunts dopamine
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Reta is no dopamine antagonist, but it does activate incretin receptors, and that dampens the dopamine bursts that hedonic stimuli (food, here) set off.
 
Reward circuitry and dopamine effects come largely through GLP-1, which means they apply to every GLP drug , not reta alone.
 
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