When Weight-Loss Drugs Don’t Work

[sfkid]

https://share.google/jTyQpIy8C6fxuSXq5

According to this article, it appears that 1 out of 10 people have no response whatsoever to GLP1s.

Is there anyone here who knows a person that experienced absolutely no effect?

 

[DjJoshua]

sfkid said:


https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Click to expand...

Is it only happening on my end, or does that link require signing up for an account before the article can be viewed? Could someone share another link?

 

[sfkid]

DjJoshua said:

sfkid said:


https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Click to expand...

Is it only happening on my end, or does that link require signing up for an account before the article can be viewed? Could someone share another link?

No subscription was needed on my end—it went through fine.

Give this a shot

https://share.google/jTyQpIy8C6fxuSXq5

 

[DjJoshua]

sfkid said:

DjJoshua said:

sfkid said:


https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Click to expand...

Is it only happening on my end, or does that link require signing up for an account before the article can be viewed? Could someone share another link?

No subscription was needed on my end—it went through fine.

Give this a shot

https://share.google/jTyQpIy8C6fxuSXq5

That second attempt gave me the same result.

I'm pretty sure the NY times isn't your only news source (wink wink)

 

[CNCCurrency]

DjJoshua said:

sfkid said:

DjJoshua said:

sfkid said:


https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Click to expand...

Is it only happening on my end, or does that link require signing up for an account before the article can be viewed? Could someone share another link?

No subscription was needed on my end—it went through fine.

Give this a shot

https://share.google/jTyQpIy8C6fxuSXq5

That second attempt gave me the same result.

I'm pretty sure the NY times isn't your only news source (wink wink)

It did the job in my case — could an ad blocker or VPN be the issue on your end? For me, those tools occasionally cut off access to some sites.

 

[FortySeven]

To be more precise, 1 in 10 people who made it into a clinical trial got labeled "non-responders" -- and that label didn't even require zero response, only a smaller one. That's a different thing from the punchy subhead's assertion: 'But one in 10 people are what scientists call “non-responders.”' The implication there is that 1 in 10 people across the entire global population fall into what they'd term "non-responders".

Sloppy science journalism like this keeps bogus claims alive, though I suppose it moves copies.

Consider this: folks enrolled in a clinical trial aren't automatically "average" people. They presumably had to clear various criteria. Those criteria mean the trial group likely contained a larger share than the general public of individuals who were a) obese and b) had attempted weight loss through other means/possibly other medications and not succeeded. (I'm not using 'failed' as a judgment here, to be clear.)

Still, it's a worthwhile article, and it points to other worthwhile articles (such as the one about retatrutide clinical study participants quitting because they were shedding "too much" weight). It's just that science reporting which tosses out easy-breezy claims with seemingly little critical thought really gets under my skin.

 

[randompersonrandom]

The link wouldn’t open on my end. Even so, I doubt it would contain much that’s new to me; some share of people either barely notice the effect or manage to out-eat it. My guess is that years down the line we’ll learn this comes down to why someone overeats in the first place: for 90% of them, the reasons line up with the 2 receptors tirz targets, while for the remaining 10%, the reasons will turn out to respond to hitting a different receptor.

 

[DjJoshua]

CNCCurrency said:

DjJoshua said:

sfkid said:

DjJoshua said:

sfkid said:


https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Click to expand...

Is it only happening on my end, or does that link require signing up for an account before the article can be viewed? Could someone share another link?

No subscription was needed on my end—it went through fine.

Give this a shot

https://share.google/jTyQpIy8C6fxuSXq5

That second attempt gave me the same result.

I'm pretty sure the NY times isn't your only news source (wink wink)

It did the job in my case — could an ad blocker or VPN be the issue on your end? For me, those tools occasionally cut off access to some sites.

I've got every tool there is. VPN, ad blocker — whatever you can think of, I'm running it! lol... My e-mail is even a ghost e-mail.

 

[tubby]

To give some context, the reta phase 2 trial data supplement includes these waterfall plots.

Looking at 1mg, a fair number of people remained quite near the 0% mark at 48 weeks.

Yet I'd venture that in the 12mg arm, nobody had failed to drop substantial weight by 48 weeks.

My guess is that other GLPs would produce comparable patterns when comparing low and high doses.

Like always, a NY Times piece (or honestly any "news" piece) trying to tackle a scientific subject shouldn't be taken too seriously, unless what you want is a shallow (and usually wrong) grasp of it.

 

[tubby]

Hmm.... the 12mg data point on the chart seems to be missing. I'll give it another shot.

 

[Rolltide61]

sfkid said:

https://share.google/jTyQpIy8C6fxuSXq5

According to this article, it appears that 1 out of 10 people have no response whatsoever to GLP1s.

Is there anyone here who knows a person that experienced absolutely no effect?

Reta gave me no results at all. I climbed all the way to 10mg. Tirz did nothing either. Even combining Cagri with Reta, I felt absolutely no reduction in hunger.

But here's the strange part. I started Melanotan ll. No appetite whatsoever.

Go figure.

 

[sfkid]

DjJoshua said:

CNCCurrency said:

DjJoshua said:

sfkid said:

DjJoshua said:

sfkid said:


https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Click to expand...

Is it only happening on my end, or does that link require signing up for an account before the article can be viewed? Could someone share another link?

No subscription was needed on my end—it went through fine.

Give this a shot

https://share.google/jTyQpIy8C6fxuSXq5

That second attempt gave me the same result.

I'm pretty sure the NY times isn't your only news source (wink wink)

It did the job in my case — could an ad blocker or VPN be the issue on your end? For me, those tools occasionally cut off access to some sites.

I've got every tool there is. VPN, ad blocker — whatever you can think of, I'm running it! lol... My e-mail is even a ghost e-mail.

The NY Times is after nothing but your cash

 

[lessthanhalf]

tubby said:

To give some context, the reta phase 2 trial data supplement includes these waterfall plots.

Looking at 1mg, a fair number of people remained quite near the 0% mark at 48 weeks.





View attachment 10046

Yet I'd venture that in the 12mg arm, nobody had failed to drop substantial weight by 48 weeks.

My guess is that other GLPs would produce comparable patterns when comparing low and high doses.

Like always, a NY Times piece (or honestly any "news" piece) trying to tackle a scientific subject shouldn't be taken too seriously, unless what you want is a shallow (and usually wrong) grasp of it.

Those graphs are great — hadn’t come across them before. What’s happening at the opposite end is equally fascinating: roughly 20% managed to drop 15% or more while on 1mg, and close to 10% shed nearly 30% at that same 1mg dose. Clearly, some people are extreme responders.

When you get to 12mg, even the poorest responders still achieved a 5% loss — that’s around 5% — while another 10% only reached 10%. Meanwhile, about 40% lost weight in the high 20% range. And since 48 weeks is likely too soon for everyone to have plateaued, the results might look a little stronger a few months down the line.

 

[WLBLD]

Wasn’t 2mg where the trials began?

 

[lessthanhalf]

A particularly notable finding is that taking reta at 1mg for a full year delivers results that are unexpectedly strong — the first graph shows roughly 9% average weight reduction. At low doses, no other GLP comes close to that level of effectiveness. For people with mild obesity or who are simply overweight, a low dose of reta is likely a solid choice. I'd bet that once reta gets approved, they may even feature this in their promotional materials. The clear upside is that at 1mg, side effects are usually going to be fairly mild. It's possible it offers the best balance of side effects versus weight loss among all the GLPs, though confirming that would require me to check.

 

[tubby]

lessthanhalf said:

tubby said:

To give some context, the reta phase 2 trial data supplement includes these waterfall plots.

Looking at 1mg, a fair number of people remained quite near the 0% mark at 48 weeks.





View attachment 10046

Yet I'd venture that in the 12mg arm, nobody had failed to drop substantial weight by 48 weeks.

My guess is that other GLPs would produce comparable patterns when comparing low and high doses.

Like always, a NY Times piece (or honestly any "news" piece) trying to tackle a scientific subject shouldn't be taken too seriously, unless what you want is a shallow (and usually wrong) grasp of it.

Those graphs are great — hadn’t come across them before. What’s happening at the opposite end is equally fascinating: roughly 20% managed to drop 15% or more while on 1mg, and close to 10% shed nearly 30% at that same 1mg dose. Clearly, some people are extreme responders.

When you get to 12mg, even the poorest responders still achieved a 5% loss — that’s around 5% — while another 10% only reached 10%. Meanwhile, about 40% lost weight in the high 20% range. And since 48 weeks is likely too soon for everyone to have plateaued, the results might look a little stronger a few months down the line.

There's one more I think you'll get a kick out of.

 

[Vash]

sfkid said:

https://share.google/jTyQpIy8C6fxuSXq5

According to this article, it appears that 1 out of 10 people have no response whatsoever to GLP1s.

Is there anyone here who knows a person that experienced absolutely no effect?

My Reta journey began at 2mg. I pushed the dose all the way to 7.5, but the adverse effects forced me to stop. No weight came off at all.

So while I’m not strictly a non-responder, the outcome wasn’t what the drug is meant to do.

I probably rushed the ramp-up beyond what the studies used, so the fault may be mine. After letting it wash out, I’m restarting at 2mg. This time I’m following the study titration protocol to the letter. It’s been 3 weeks and I’ve actually gained a couple pounds.

Bloodwork is still pending. I’ll commit to a full 8 weeks before judging.

No sides have shown up yet. During the first attempt, nothing registered until I hit 5mg.

I’m also running test, growth, BPC, and TB500. My reasoning: even if it does nothing for fat loss, it ought to counter the side effects from the growth.

 

[sfkid]

Vash_ said:

sfkid said:

https://share.google/jTyQpIy8C6fxuSXq5

According to this article, it appears that 1 out of 10 people have no response whatsoever to GLP1s.

Is there anyone here who knows a person that experienced absolutely no effect?

My Reta journey began at 2mg. I pushed the dose all the way to 7.5, but the adverse effects forced me to stop. No weight came off at all.

So while I’m not strictly a non-responder, the outcome wasn’t what the drug is meant to do.

I probably rushed the ramp-up beyond what the studies used, so the fault may be mine. After letting it wash out, I’m restarting at 2mg. This time I’m following the study titration protocol to the letter. It’s been 3 weeks and I’ve actually gained a couple pounds.

Bloodwork is still pending. I’ll commit to a full 8 weeks before judging.

No sides have shown up yet. During the first attempt, nothing registered until I hit 5mg.

I’m also running test, growth, BPC, and TB500. My reasoning: even if it does nothing for fat loss, it ought to counter the side effects from the growth.

Which one are you on — tirz or reta?

 

[Vash]

sfkid said:


Are you using tirz or reta ?

Click to expand...

Apologies. Retatrutide.

 

[DjJoshua]

Vash_ said:

sfkid said:

https://share.google/jTyQpIy8C6fxuSXq5

According to this article, it appears that 1 out of 10 people have no response whatsoever to GLP1s.

Is there anyone here who knows a person that experienced absolutely no effect?

My Reta journey began at 2mg. I pushed the dose all the way to 7.5, but the adverse effects forced me to stop. No weight came off at all.

So while I’m not strictly a non-responder, the outcome wasn’t what the drug is meant to do.

I probably rushed the ramp-up beyond what the studies used, so the fault may be mine. After letting it wash out, I’m restarting at 2mg. This time I’m following the study titration protocol to the letter. It’s been 3 weeks and I’ve actually gained a couple pounds.

Bloodwork is still pending. I’ll commit to a full 8 weeks before judging.

No sides have shown up yet. During the first attempt, nothing registered until I hit 5mg.

I’m also running test, growth, BPC, and TB500. My reasoning: even if it does nothing for fat loss, it ought to counter the side effects from the growth.

Absolutely, fill us in on how the Teas and that HGH turn out. I've got some Tesa headed my way at the moment.