Weekly peptides for chronic pain relief?

amosmylove said:


Has she had a lupus/ANA blood panel done? I'd look for a rheumatologist.

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She's had so much done that I'm actually not sure.

lessthanhalf said:


Glps are probably the peptide with by far the best actual evidence they work to improve chronic pain, but she is already on those. The actual human clinical trial evidence is absent or minimal for the others unfortunately, except a study of ara-290 for neuropathy in humans, but you really need an accurate clinical diagnosis from an experienced expert clinician, if tests do not come up with answers, even if the best they can do is say is the symptoms or results are not specific enough to give a definitive diagnosis at this point in time, which is unfortunately sometimes the case. Trying to research or treat symptoms in the absence of a definite diagnosis is far from ideal.

A well prompted chatgpt being fed information from a medically experienced person can be surprisingly good at diagnosing less common conditions. Possibly better than doctors in some studies ( but it can get a bit carried away with some ideas, I had it tell me it thought my rash I was trying to diagnose was an early t-cell lymphoma for quite a while ) ,, but it can be very useful for coming up with things you had not thought of.

As a non peptide but with very unusually solid human clinical trial evidence for effectiveness for a supplement, and with good supporting preclinical data, PEA palmitoylethanolamide can be very useful for chronic pain, and has no known side effects which is very unusual, but be careful what you buy if you try it. Nearly all the ones on amazon US are majorly underdosed from what is advertised, one I bought advertised 1400mg of ingredients but weighed only 300mg per pill.

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She has put a lot of info into ChatGPT and it comes back with Lupus, EDS, and a few other things I don't recall at the moment. But doctors have told her it's not Lupus or EDS, although genetic testing did suggest hypermobile EDS. I'm not familiar with PEA. I'll have to take a look at it.
 
trey915 said:


I know it’s still daily on a cycle but the KLOW stack has both BOC-157 and TB500 along with KPV and GHKCU. It would just be a single injection. And you could use a re-useable pen that is a much smaller needle. I don’t have near what she has but I’ve been dealing with chronic hip and back pain for several years. I’ve been on KLOW for 3 weeks and the pain went from a 7 out of 10 to a 1. I’m super happy with it. Either way I hope she finds relief.

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I hadn't looked at the premixed stacks. That's a really good idea! Thank you.
 
Calm Logic said:


For neuropathy, ARA-290 (typically 4 mg daily subq for 28+ days) is the go-to, but it is a finicky peptide that likes to gel, even when pre-buffered. So people are more selective with ARA vendors or may add something during recon for the pH.

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My ARA-290 would gel instantly with BAC water (i believe it is not buffered), but the addition of Sodium Bicarb 8.4% solution resolved all gelling problems that I had. I just use 20IU sodium bicard, to 80IU BAC water during reconstition.
 
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