eidos said:
What would be the effect if it were a nasal spray?
Assuming there would be 20 doses, that would be an amount of ~1,300 endotoxin units per spray.
I can't find any documentation on this. Does anyone have any ref?
Click to expand...
The calculation doesn't cover IN administration as it's based on the FDA/USP pyrogenic dose threshold of 5.0 EU/kg/hour for parenteral (IV/SC/IM) administration, but you're dosing directly into the mucosa, so the onset of fever is even more rapid. And with that Endo load, I think you're talking about an eventual major infection. The table is wrapped, but you get the gist of it.
Per LLM-
Effects of Intranasal Administration of Pyrogens
Rapid Onset of Fever
Intranasal administration of pyrogens can lead to a rapid onset of fever. This is due to their ability to stimulate the immune system directly through the nasal mucosa, allowing for quicker absorption into the bloodstream.
Inflammatory Responses
The introduction of pyrogens via the intranasal route can also trigger inflammatory responses. This occurs as the immune system reacts to the pyrogens, which are substances that induce fever and inflammation.
Comparison with Other Routes
The intranasal route offers advantages over traditional methods of administration, such as oral or injectable forms, particularly in terms of speed and efficiency. Here’s a comparison:
Attribute Intranasal Administration Other Routes
Onset of Action Rapid Slower
Absorption Efficiency High Variable
Invasiveness Non-invasive Invasive (injections)
Patient Comfort Higher Lower (especially with needles)
Summary
Overall, intranasal administration of pyrogens is effective for inducing rapid fever and inflammatory responses, making it a valuable method for certain therapeutic applications.
