Vomited 2 times in the past week

Nausea and vomiting show up at fairly high rates for both reta and cagri — roughly 50% of users experience them to some degree with either compound. The sole trial that paired cagri with another agent was cagrisema, and that combination produced very high rates of nausea and vomiting. So bumping up reta could be the cause, though layering cagri on top makes it even more probable. What you're describing sits at the very mild end of the side-effect range. If lifestyle adjustments don't solve it — for example, smaller meals at once and cutting back on fluids alongside food so the stomach doesn't get too full — then you may need to lower doses somewhat for a period, but this kind of side effect usually improves gradually with time. I'm curious why cagri was added while the reta dose was still so low, instead of simply raising reta?
 
lessthanhalf said:

Nausea and vomiting show up at fairly high rates for both reta and cagri — roughly 50% of users experience them to some degree with either compound. The sole trial that paired cagri with another agent was cagrisema, and that combination produced very high rates of nausea and vomiting. So bumping up reta could be the cause, though layering cagri on top makes it even more probable. What you're describing sits at the very mild end of the side-effect range. If lifestyle adjustments don't solve it — for example, smaller meals at once and cutting back on fluids alongside food so the stomach doesn't get too full — then you may need to lower doses somewhat for a period, but this kind of side effect usually improves gradually with time. I'm curious why cagri was added while the reta dose was still so low, instead of simply raising reta?
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At 14 weeks, I had no clue my Reta dosage was on the low side. Seeing posts from folks running 3x what I take makes me want to keep every mg as low as I can get away with. Since Cagri runs at much smaller amounts (particularly next to Reta), it looked like a solid pick, and I believe I got the ratio almost right — the problem was ramping up too quickly, purely out of not knowing any better. On the same stack, .25mg of cagri worked perfectly; I never imagined that another .25mg would hit like a nuclear bomb, all the more so given that I run a huge number of peptides every day and week with absolutely no side effects — right up until this one.

Logically, dropping back to .2 cagri ought to put me straight back to feeling completely fine, and after that I can give it time and check where my hunger lands.
 
Peps-Enthusiast said:

lessthanhalf said:

Nausea and vomiting show up at fairly high rates for both reta and cagri — roughly 50% of users experience them to some degree with either compound. The sole trial that paired cagri with another agent was cagrisema, and that combination produced very high rates of nausea and vomiting. So bumping up reta could be the cause, though layering cagri on top makes it even more probable. What you're describing sits at the very mild end of the side-effect range. If lifestyle adjustments don't solve it — for example, smaller meals at once and cutting back on fluids alongside food so the stomach doesn't get too full — then you may need to lower doses somewhat for a period, but this kind of side effect usually improves gradually with time. I'm curious why cagri was added while the reta dose was still so low, instead of simply raising reta?
Click to expand...
At 14 weeks, I had no clue my Reta dosage was on the low side. Seeing posts from folks running 3x what I take makes me want to keep every mg as low as I can get away with. Since Cagri runs at much smaller amounts (particularly next to Reta), it looked like a solid pick, and I believe I got the ratio almost right — the problem was ramping up too quickly, purely out of not knowing any better. On the same stack, .25mg of cagri worked perfectly; I never imagined that another .25mg would hit like a nuclear bomb, all the more so given that I run a huge number of peptides every day and week with absolutely no side effects — right up until this one.

Logically, dropping back to .2 cagri ought to put me straight back to feeling completely fine, and after that I can give it time and check where my hunger lands.
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I picked up some Cagril 10 simply so I'd have it around...a 10mg vial felt like a big amount given the doses I'd be taking, but it'll sit in the tool box until I figure it could help push past a hump or something...That said, I agree with you, 250mcg might be too much...😳
 
With every other peptide I've tried, messing up the dose—whether too high or too low—doesn't really matter. But Cag is a completely different story: it will wreck several days of your life with its merciless nature. Overdoing klow, bpc, AD5, Mots, kpv, kp, or dsip? No problem at all.
 
Curious about the thinking behind stacking both instead of simply pushing reta higher. To me there are decent theoretical grounds for pairing a modest dose of reta or tirz with cagri or elora — it may be the sweet spot for maximum weight loss at minimum side effects. The numbers: reta 1mg 9% and elora 1mg 9% loss; reta 4mg 19% with elora 3mg 13% — if those effects stack, the result would be remarkable. personally I run cagri 0.25 mg every 4 days alongside tirz15/reta5mg, and every attempt at going up in dose brings clearly more nausea. I couldn't locate the full cagri trials — only abstracts — when I went looking for solid side-effect rates.
 
Flash-BCR said:

Peps-Enthusiast said:

Fifty-five years. In that time, roughly ten instances of throwing up come to mind, and 7 of them happened back when I was young and overdid it with alcohol. Throwing up just isn't something I do — yet this week it happened 2 times. My digestion and the peptides I'm using seem like the likely culprit, most likely RETA and Cagri. Nothing out of the ordinary went into my mouth. All day long, my wife and kid consumed the identical meals I did. The only deviations from my routine were eating at a slightly later hour than usual and taking in a somewhat bigger serving than usual — nothing extreme, just above my norm.

When you're on peptides that delay digestion, I figure this kind of thing probably isn't rare. Curious whether anyone else has dealt with the same. For reference: week 14 of reta at 2.5mg/2x week, cagri .5mg/2x week was added a couple weeks back, plus klow AD5 mots and tesa.
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During my first week on tirz at 2.5mg, I vomited (I'm sensitive to medications)...hiccups were awful...acid reflux too...For the first 2-3 weeks, the acid reflux lingered, mainly during the night. Tums were something I used frequently. After 4 weeks I moved up to 5mg, and after 12 weeks to 7.5mg. These days I have zero stomach problems. Your body does adapt, though I also began BPC-157 and KPV, which I believe made a big difference for my digestion issues...Either way, those symptoms improve fairly fast....GL!
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I'm curious about how you're using KPV and BPC-157 to address digestive issues. Could you tell me what doses you take?
 
I use nausea as my gauge for whether my GLP1 dose is working. When I feel a bit queasy 2-3 days after dosing, that tells me the amount is right. No queasiness at all means the dose is too small. Intense queasiness means it's too high.

Feeling sick really stops me from eating.
 
tul9033 said:

I use nausea as my gauge for whether my GLP1 dose is working. When I feel a bit queasy 2-3 days after dosing, that tells me the amount is right. No queasiness at all means the dose is too small. Intense queasiness means it's too high.

Feeling sick really stops me from eating.
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During the 12 months I was on ozempic, this rings painfully true — I settled at 0.22mg taken every other day, since that amount cut my appetite somewhat while keeping nausea manageable. Luckily, other glp medications have worked out better for me, causing less nausea. I believe the underlying principle about finding the correct dose is basically right, though it would be best to reduce it by ten percent, aiming to preserve most of the hunger reduction while minimizing nausea, or alternatively move to dosing two times per week.
 
lessthanhalf said:

tul9033 said:

I use nausea as my gauge for whether my GLP1 dose is working. When I feel a bit queasy 2-3 days after dosing, that tells me the amount is right. No queasiness at all means the dose is too small. Intense queasiness means it's too high.

Feeling sick really stops me from eating.
Click to expand...
During the 12 months I was on ozempic, this rings painfully true — I settled at 0.22mg taken every other day, since that amount cut my appetite somewhat while keeping nausea manageable. Luckily, other glp medications have worked out better for me, causing less nausea. I believe the underlying principle about finding the correct dose is basically right, though it would be best to reduce it by ten percent, aiming to preserve most of the hunger reduction while minimizing nausea, or alternatively move to dosing two times per week.
Click to expand...
That's pretty much how things go with my tirz schedule...on day 2 and day 3 following the shot, I burp a little more and feel somewhat 'urpy' come nighttime. A Tums or 2 and I'm able to fall back asleep, reassured that my dose level is where it should be. Through the daytime, food noise stays at a faint hum. I do feel hunger, though it isn't yelling at me, and a few baby carrots or a small handful of nuts leaves me satisfied. My pins fall on Friday and Monday...the Friday one gets me through the weekend with barely any interest in food, and the Monday one stacks on top of Friday's, giving me a boost that lasts the rest of the week...then I do it all over again...
 
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