Vibegron, β3, and brown fat

D

diogenes

Explorer
Joined
Jul 4, 2025
Messages
1
Reaction score
0
Location
Berkeley, CA
How does everyone view the idea of hitting β3 to turn on brown fat and thereby raise RMR as an obesity strategy?

From what I gather, mirabegron was the earlier attempt, yet a useful RMR increase only showed up at doses as high as 200mg. At that level there was excessive norepinephrine cross-talk and β1/β2 spillover (hypertension, tachycardia, and so on). Still, it did produce results: patients gained a 200kcal/day boost, which is substantial.

I noticed a trial now running with vibegron, described as a (patented) β3 agonist with greater selectivity: https://clinicaltrials.gov/study/NCT06987383. Presumably the hope is an RMR increase minus those side effects.

Should that pan out, it looks like it might serve as a helpful add-on to GLP-1 drugs. Thoughts?
 
diogenes said:

How does everyone view the idea of hitting β3 to turn on brown fat and thereby raise RMR as an obesity strategy?

From what I gather, mirabegron was the earlier attempt, yet a useful RMR increase only showed up at doses as high as 200mg. At that level there was excessive norepinephrine cross-talk and β1/β2 spillover (hypertension, tachycardia, and so on). Still, it did produce results: patients gained a 200kcal/day boost, which is substantial.

I noticed a trial now running with vibegron, described as a (patented) β3 agonist with greater selectivity: https://clinicaltrials.gov/study/NCT06987383. Presumably the hope is an RMR increase minus those side effects.

Should that pan out, it looks like it might serve as a helpful add-on to GLP-1 drugs. Thoughts?
Click to expand...
A GLP-2 or retatrutide (since "GLP-3" does not exist) can deliver solid results while avoiding side effects tied to other drugs. Throw in some Mots-C plus 5 amino 1mq and you may see even greater benefits. Dropping weight isn't a sprint you have to win quickly; actually, going fast tends to backfire in most situations. Losing lean mass and regaining weight both occur when you overdo it and fail to pair the process with resistance training and a high-protein intake.
 
Back
Top