Validating my single-vial mix plan for 20mg Tesa + 5mg Ipa

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venkacelnor

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Hi all,

I'm getting ready for a first run with Tesamorelin/Ipamorelin and I'd like a sanity check on both the arithmetic and the way I plan to reconstitute. To keep physical shear stress off the fragile Tesa, I'd rather skip the "double-transfer" approach.

Since the vials already sit at the exact 4:1 ratio I'm targeting, my idea is to move the whole Ipa solution over into the Tesa vial in one go.

What I'm working with:

  • Tesamorelin vial: 20mg
  • Ipamorelin vial: 5mg
  • Target Dose: 1mg Tesa / 250mcg Ipa
How I'd do it:

  1. Put 2mL BAC into the 5mg Ipa vial.
  2. Pull out all 2mL of the mixed Ipa.
  3. Push that full 2mL straight into the dry 20mg Tesa vial.
The Draw:On a U-100 syringe, 10 units (0.1mL) ought to deliver exactly 1mg Tesa and 250mcg Ipa.

Where I need input:

  1. Did I get the 10-unit draw math right?
  2. Compared with adding plain BAC first, does this "single-pass" transfer actually do a better job of keeping the Tesa from gelling?
  3. Will all 20mg of Tesa dissolve cleanly in the already-mixed Ipa/BAC solution?
Any thoughts?

TIA 🙏
 
The unit conversion is fine: putting 5 mg ipa in 2 mL into the 20 mg tesa vial gives 10 mg/mL tesa and 2.5 mg/mL ipa, so 10 units (0.1 mL) equals 1 mg tesa + 250 mcg ipa. The real issue is concentration — 20 mg in just 2 mL is where tesa frequently turns thick or gel-like; many people target closer to 5 mg/mL or lower by adding more BAC, and still inject slowly down the side and roll, never shake. Whether mixing the ipa first genuinely prevents gelling better than plain BAC is more myth than proven — if it remains cloudy or gelled after gentle rolling, don't force it.
 
When my head is too foggy to handle the calculations, I simply hand it over to AI...and it gives me the answer straight away...

Still, if I were putting Tesa and IPA together, I'd follow your exact methodology...
 
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