Age is likely the biggest factor in whether this makes sense. If someone is past 40 or 50 and has problems with blood sugars, lipids, blood pressure, excess weight, and so on, a GLP is probably the better route — although right now that remains speculation, not something the research has established. For a younger person who is basically healthy, the calculus is far less clear. GLP drugs carry adverse effects that are quite rare but serious, including pancreatitis and NAION. When baseline risk is already elevated because of obesity, those risks are acceptable; whether that still holds for someone younger, healthier, and not obese is simply not known at this point.
Possibly last month. I've only recently begun tracking it once more. Reta has been part of my routine for 32 weeks now, and for roughly 4 weeks I've been experimenting with maintenance dosing in the 6-8mg range. Before that I was on 10mg. When I sit in the morning, my RHR comes in at low 70's. At a doctor's visit a couple months back, my HR was 75 and my BP read 110/68.