For general health purposes, I use 1.5mg of Tirzepatide each week. In my case, that amount counts as a microdose. When it comes to Retatrutide for the same goal, I would hesitate — I'm not convinced that sustained glucagon receptor activation is beneficial over the long run.
Could you say more about that final point? What kind of problems could come up with glucagon agonism over the long term?
Are you sure there aren't superior options for this goal? After your research, does Reta really come across as the perfect compound for your needs?
I’ll be honest—I’m still getting up to speed, so if Reta isn’t the ideal option, I’m happy to hear other recommendations.
My weight is in the normal range, I follow a fitness-focused lifestyle, and for years I've taken Tirz at 1-2.5mg weekly. Being neither overweight nor diabetic has always been my situation, yet I can sit 5lbs lighter @ 123lbs, whereas my body's natural setpoint appeared to hover around 127-130lbs. At my crossfit gym, nearly everyone uses glps to get leaner overall, and the majority have never carried excess weight.
I've begun microdosing at 1mg. What makes you decide to adjust your dosage? Are you keeping the same dose at this point, or do you still make changes?
Planning to, the moment I'm down at goal.
My situation matches yours: neither weight nor glucose is a problem for me. I went through a ret cycle aiming to lose 25 pounds, and I've now lost 35. At this point I'm tapering off—or more accurately, reducing to a dose I can stay at long term.
Everything I've come across regarding how tirz and reta compare in their relative affinities for the GLP-1 and GIP receptors contradicts that claim. U/runningFNP, who wrote The Incretin Space, put together a really detailed side-by-side of these two incretins' receptor affinities, drawing on every research paper available at the time. At comparable doses, retatrutide acts considerably more strongly than tirzepatide at the GIP receptor, and somewhat more strongly at the GLP-1 receptor as well.
I've gone below my goal and I'm on 6mg as a microdose for maintenance. Things look stable to me, though I'd like to put on 5lbs. Over 32 weeks I've dropped 60lbs.
From what I've come across, the glucagon agonist component may raise heart rate by as much as 10 beats per minute. For long term health, that could be a downside. When it comes to weight loss, though, reta really stands out.
Tirz makes sense as the pick, I'm with you there — but wouldn't Reta likely deliver a lot of the same upsides?
Over time it does calm down, in my experience. My resting heart rate used to sit around 72 BPM, then it climbed to roughly 82 once I began Reta. More recently it's been back at 72-73 BPM. The nice part is that blood pressure falls quite a bit after a while. Could be tied to the weight loss, though.
What was the timeframe for yours to level out? I've been on it 7 months now, at 8mg/wk, and my RHR has stayed 10 BPM above what it was before I began.