Twelve months on: before-and-after data on my subject

jw717us

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New year, so here's the progress check. Now that the calendar has flipped I decided to pull before-and-after data on my subject. Tirzepatide plus a fresh training routine started in June. NAD and Semorelin and how got layered in a few weeks later for support. Below is what I'm weighing next. Plenty of people have been asking about BPC/KLOW/etc….. so here's the protocol I'm considering for anyone interested…

Where things stand now:

THE STARTING POINT: May 2025 (238 lbs)

- Class I Obese, BMI 32.8 — 238 lbs

- Visceral fat 5 (high risk), body fat 28.3%

- 69.5% of body weight was muscle (166.8/238 lbs, baseline-adjusted)

- 5h49 of sleep a night, chronic deprivation

- 10.8k steps of casual walking; no structured training at all

  • Pulse: 81bpm awake, 71bpm asleep (elevated)
  • Metabolic age 57 (6 years ahead of his actual age
Conditions:

  • Apnea: CPAP in place after a midgrade OSA diagnosis, ~18AHI
  • Arterial Fibrillation: meds every day and 12-15 episodes each month
Verdict: textbook 53yo American male path — diabetes/CVD risk rising fast.

NOW: Jan 2026 (194 lbs)

- 194 lbs on the scale (−44 lbs, −18.5%)

- BMI 26.9 (healthy overweight)

- Body fat 20.3% (−8 points, -28%)

- Visceral fat 3.5 (−30%)

- 76.5% muscle share of body weight (149.2/194 lbs)

- 7h11 of sleep a night (+1h22, with 53% of nights >7h)

- 8.4k steps plus weights/cycling

- Pulse: 72bpm awake (−9), 62bpm asleep (−9)

- Metabolic age 51 (−6 years reset!)

Ongoing conditions:

  • Apnea: sorted, off CPAP, 5mins of snoring a night
  • Arterial Fibrillation: food-triggered only, roughly 1 episode a month, medicated reactively as needed
This is the part I find striking: lean mass held at 156.9 lbs on the Withings scale even with −44 lb gone overall. Muscle share climbed from ~69.5% (baseline-adjusted) → 76.5%, which is not too shabby at all.

THE PROTOCOL IN USE

Zepbound 10mg each week (the fat-loss engine)

Sermorelin 30u at night (restoring GH)

-NAD+ 50u every day → moving to oral soon (mito/energy)

boswellia, CoQ10+Shilajit, magnesium glycinate 400mg

WHAT COMES NEXT

Knee injuries piled up for the subject through his 30s and 40s. A meniscectomy 3-4 years back, and osteoarthritis setting in now. Pain and weakness have both shown up in that knee. Two separate consults, and both doctors pushed back on the surgery. The only route offered: cortisone shots for a few years, then a knee replacement.

KLOW blend went in a few weeks ago and range of motion plus stability have improved a lot already. Wanting more still, so extra study is on the table now.

What the daily looks like

  • KLOW
  • UC-II collagen, 40mg supplement
  • 10g collagen powder stirred into the morning coffee
  • hyaluronic acid supplement, 250 mg
  • Progressive resistance training 5x/week
AOD injection and VIP nasal are both being considered on top of that.
 
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