Titration plan and coping with the burn

[trey915]

Skidude said:

trey915 said:

I've been stepping my NAD+ injections up gradually. The schedule I keep reading about calls for 100-300mcg while loading, taken daily, then 2-3x per week, and finally tapering to once a week and then once every 2 weeks. My problem is that even at 80mcg the shot stings - or as we'd put it around here, it's seriously spicy. Anyone else pinning NAD+ suba in that range: how do you cope with the burn, or how do you tone it down? I'm mixing at 100mg/ml at the moment. A couple of days from now I'll move from my current 80 up to 100 units, and eventually to 200 units at that same strength. A site I found through google suggests adding a little lidocaine. Any thoughts?

Make sure you don't confuse mcg with mg.

1000 mcg makes 1mg

1000 mg comes to 1 gram

On the stinging side, after several NAD+ cycles I simply topped up with enough BAC.

My own run was 100mg daily (m-f) across 6 weeks, scheduled 5 on 2 off

EDIT

and yes, the vial was 500mg/5ml with injections at 100mg/1ml

Correct. That was badly worded on my part - what I'm doing is 80mg and titrating upward. The stuff is just so spicy.

 

[trey915]

Glenn said:

Mine burned at the start too, as I recall. Moving the shot to my thigh appeared to make the difference. These days 115 units goes in and I don't even think about it. Stick with it for a while and it should settle down.

This morning's shot did go into my thigh and it was noticeably easier than the abdomen. My habit has been to rotate between abdomen (left and right) and thighs (left and right). Perhaps I should simply keep it to the thighs and swap left to right.

 

[trey915]

Pocket said:

Is the NAD+ you're using buffered, or not? Mine comes from a 500mg vial of buffered NAD+ reconstituted with NaCl BAC and I get no sting from it at all. YMMV - a lot of the peps people call spicy seem to do nothing to me.

What's your source for the NaCl BAC water? That could be the variable. Mine is pure NAD+ and it gets reconstituted with ordinary BAC.

 

[Pocket]

I'm fairly sure it came from Goodies. Nothing special - plain Hospira NaCl Bac water.

 

[ktg123]

trey915 said:

ktg123 said:

After running it for a good while I suspect I have simply adapted. My mix is 500mg/mL and shots run 20-22 units. These days there is hardly any sting left. Anything above roughly 110mg in a day gets broken up into 100mg/hr portions for me.

Meaning it simply became normal for you over time?

Looks like it. My dose is 100mg drawn in 20 units of bac and there's almost nothing to feel at the injection site. The 'rush' still shows up. Every NAD+ I've used has been the buffered kind.

 

[trey915]

Follow up....today I moved up to 120mg. I use refillable pens - or did. Wednesday's shot came from a 3ml syringe, yesterday's from a 1ml syringe. With the pen I was on a 32g/4mm needle. Switching down to a 31g/4mm needle and moving from abdomen to thigh made a huge difference. It is still a bit spicy, but the new needle plus the thigh location at least brought it into tolerable territory.

One other thing....the convipen I had been using is easier, but it gives me less control over how slowly I push. Since switching to a RefillPen I can advance it 1 unit at a time, which I did, and that helped too. Overall a much better experience.

 

[CNCCurrency]

trey915 said:

Pocket said:

Is the NAD+ you're using buffered, or not? Mine comes from a 500mg vial of buffered NAD+ reconstituted with NaCl BAC and I get no sting from it at all. YMMV - a lot of the peps people call spicy seem to do nothing to me.

What's your source for the NaCl BAC water? That could be the variable. Mine is pure NAD+ and it gets reconstituted with ordinary BAC.

Mine has been coming from the site below.

https://injectionshop.com/solutions.html/

 

[T.Bird]

ktg123 said:

trey915 said:

ktg123 said:

After running it for a good while I suspect I have simply adapted. My mix is 500mg/mL and shots run 20-22 units. These days there is hardly any sting left. Anything above roughly 110mg in a day gets broken up into 100mg/hr portions for me.

Meaning it simply became normal for you over time?

View attachment 172

Looks like it. My dose is 100mg drawn in 20 units of bac and there's almost nothing to feel at the injection site. The 'rush' still shows up. Every NAD+ I've used has been the buffered kind.

My setup is 100mg in 20 units, alongside MOTS-c and the 5amino-1mq. There are one or two itchy spots, though I put that down to pinning it cold, straight out of the fridge.

For workouts and all-day energy, this stack has been outstanding for me.

 

[Flash-BCR]

CNCCurrency said:

trey915 said:

Pocket said:

Is the NAD+ you're using buffered, or not? Mine comes from a 500mg vial of buffered NAD+ reconstituted with NaCl BAC and I get no sting from it at all. YMMV - a lot of the peps people call spicy seem to do nothing to me.

What's your source for the NaCl BAC water? That could be the variable. Mine is pure NAD+ and it gets reconstituted with ordinary BAC.

Mine has been coming from the site below.

https://injectionshop.com/solutions.html/

NaCL BAC from Hospira has been turning up at PeptideTest...

 

[nitetrak]

Flash-BCR said:

CNCCurrency said:

trey915 said:

Pocket said:

Is the NAD+ you're using buffered, or not? Mine comes from a 500mg vial of buffered NAD+ reconstituted with NaCl BAC and I get no sting from it at all. YMMV - a lot of the peps people call spicy seem to do nothing to me.

What's your source for the NaCl BAC water? That could be the variable. Mine is pure NAD+ and it gets reconstituted with ordinary BAC.

Mine has been coming from the site below.

https://injectionshop.com/solutions.html/

NaCL BAC from Hospira has been turning up at PeptideTest...

Underground supply undercuts them both.

I picked up a case for the things I know are BAC NaCl compatible, and the regular Hospira BAC stays reserved for my Reta.

Everything I have run on BAC NaCl so far has not stung the way some of it did with ordinary BAC water.

Last week I wrapped up my 14 week mitochondrial repair protocol.

Somewhat disappointing that without NAD+ anything strenuous leaves me feeling wrecked. Yesterday's heavy yard work wiped me out, so today I went back to the 100mg dose and tore through it - I could have carried on afterwards.

Now I suppose the task is working out my own minimum dose.

 

[spamberler]

I'm on 50mg right now mixed 166mg/mL. A little spicy but switched to 1/2 needles and don't notice it a little deeper.

Hi I'm new and I'm just interested where you pin using this size needle please? I'm waiting for my first order to arrive so I'm gathering information before I start!

Pam