Tirze+Reta+Cagri stack

BLASIUS · Sep 8, 2026

Hi everyone,

I’ve resumed GLP-1 use following a washout that lasted 4 weeks.

Weeks 1–4: Tirze 2.5 mg

Weeks 5–7: Tirze 2.5 mg alongside Cagri 0.25 mg

Appetite control has been solid so far: nothing in the way of side effects, and food noise has dropped noticeably. Weight loss, though, hasn’t really shown up yet.

A decision is coming in the next few weeks: either push the Tirze and Cagri doses higher while keeping the 10:1 ratio, or bring Reta into the mix, possibly at a T:R:C ratio of 10:5:1.

Has anyone here run a similar stack? If so, what results are you getting? Or would you say this is better left alone?

My background:

Between August 2025 and June 2026 I dropped 16 kg, with roughly 5 months on Tirze and 6 months on Reta. For both Tirze and Reta I got up to 6 mg/week, and at that level diarrhea wouldn’t let up on either one.

That led me to pause GLP-1s and other peptides for a month. I’ve since restarted, easing in with Tirze and Cagri as outlined above.

At least another 20 kg still has to come off, so I’m after a route that keeps appetite in check and weight coming down without the GI problems returning.

I’d especially like to hear from anyone with experience on Tirze + Cagri or Tirze + Reta + Cagri, particularly on weight-loss outcomes and side effects.

lessthanhalf · Sep 8, 2026

On 15mg tirz, 7mg reta, and 0.5mg cagri weekly, though I break it into every-other-day shots for reta and tirz, and every 4th day for cagri—so the ratio is pretty similar to yours.

Ozempic at 0.22mg every other day was my previous regimen; anything past 0.5mg brought on severe nausea and malaise, and even on the alternate-day schedule it wasn't great, though it did take the edge off hunger. I'd already dropped 70kg before starting it, a year prior, hoping to feel less hungry.

My doctor talked me into tirzepatide, so I paid $690 for a legit pen. After plenty of research and math, I figured an equivalent dose sat around 3-5mg, meaning if it stretched 5 months the cost wouldn't be unbearable. What I discovered fast was that side effects were almost nil, I could titrate up without trouble, and hunger dropped much further. That's when I came across this website and put in an order for the grey version—I hadn't known such a thing existed before. Within a month I'd pushed tirz to 15mg using every-other-day shots, with only occasional mild nausea and the rare bout of skin sensitivity. I'd also grabbed some reta as a backup.

Since tirz at 15mg was doing well and side effects were minimal, I chose not to disturb that, so when hunger lingered I simply stacked reta on top, running tirz15/reta 5-6mg for a year, and shed another 14kg very gradually. A few months back I wanted to see if hunger could come down a touch more, so my strict diet wouldn't have to be quite so strict. I bumped reta to 7mg and brought in cagri at 0.25mg every 4 days. Weight loss didn't budge, but my weight seems to hold steady even when I eat some far less healthy foods, while protein intake stays very high.

I can't raise reta or tirz by even a hair—my skin goes really strange. And cagri beyond 0.5 brings mild nausea. Aside from that, the three together give me maybe a tenth of the side effects I had on low-dose ozempic: some nausea here and there, skin sensations often odd particularly on my arms, but usually not annoying enough to matter. Possibly more anhedonia/amotivation, though it's genuinely hard to judge since I had plenty of that before any GLP drug. Hunger and craving control is beyond what I'd have believed possible—I think my appetite system now works close to how it does in a not fat person, so eating when hungry seems to land on the right calorie amount to keep weight stable, and even more surprising, it doesn't demand the extreme low calorie density, low fat, low carb, zero high glycemic index/rich foods rules. Previously, especially after weight loss, a tiny bit of rich high calorie food would set off extreme uncontrollable hunger an hour or two later, and I could put on a kilo a week or more because I couldn't stop. And 56% down to 64kg.

How much of this applies to anyone else is very hard to say—there are many receptors in play plus ten times as many downstream targets affected, so all the different variants people have probably explains why effects and side effects vary so much between individuals. Add to that how obese you were at the start, and how damaged the neurological appetite regulation system is or was. And likely diet and exercise too.

If tirz and or reta give you diarrhoea, things to try are more tirz than reta, since it generally has less gastrointestinal side effects than reta; those sort of side effects do often improve with time, but usually very slowly over months, so you just have to drop the doses if that happens. You might find that with just tirz you might get more effect than from reta if you can tolerate it better. You did not mention what dose of tirz you got to when you were only on tirz. Did you get side effects from cagri? I think its side effects are quite different on its own versus when you add it to a decent dose or reta or tirz, which is how nearly everyone on here uses it. But it can also cause gi side effects not just nausea and fatigue. If you never got much above 6mg with tirz originally maybe just try increasing it to 15mg if you can without the reta, if it does not cause the same diarrhoea, then it might have just been the reta causing it.

At least you are not trying to lose as much as I was, 36 kg is still a lot but if you cannot tolerate standard maximum doses of tirz or reta or a combo of them, then not having vast amounts to lose might be pretty important, as they are the most effective drugs. You probably just have to increase the tirz and or reta doses until you start getting GI side effects then drop the dose a bit, so maybe total dose of 8-10mg or so given 12mg caused problems last time and then add cagri if needed, if you get problematic side effects before getting to your target, then swapping the cagri for Elora is the next move, as it generally has less GI side effects and more weight loss than cagri. Or dont bother with cagri and go stright to elora. If you got GI side effects and had to drop the dose generally you need to wait a few months for tolerance to develop before trying to increase the dose again.

BLASIUS · Sep 8, 2026

lessthanhalf said:

On 15mg tirz, 7mg reta, and 0.5mg cagri weekly, though I break it into every-other-day shots for reta and tirz, and every 4th day for cagri—so the ratio is pretty similar to yours.

Ozempic at 0.22mg every other day was my previous regimen; anything past 0.5mg brought on severe nausea and malaise, and even on the alternate-day schedule it wasn't great, though it did take the edge off hunger. I'd already dropped 70kg before starting it, a year prior, hoping to feel less hungry.

My doctor talked me into tirzepatide, so I paid $690 for a legit pen. After plenty of research and math, I figured an equivalent dose sat around 3-5mg, meaning if it stretched 5 months the cost wouldn't be unbearable. What I discovered fast was that side effects were almost nil, I could titrate up without trouble, and hunger dropped much further. That's when I came across this website and put in an order for the grey version—I hadn't known such a thing existed before. Within a month I'd pushed tirz to 15mg using every-other-day shots, with only occasional mild nausea and the rare bout of skin sensitivity. I'd also grabbed some reta as a backup.

Since tirz at 15mg was doing well and side effects were minimal, I chose not to disturb that, so when hunger lingered I simply stacked reta on top, running tirz15/reta 5-6mg for a year, and shed another 14kg very gradually. A few months back I wanted to see if hunger could come down a touch more, so my strict diet wouldn't have to be quite so strict. I bumped reta to 7mg and brought in cagri at 0.25mg every 4 days. Weight loss didn't budge, but my weight seems to hold steady even when I eat some far less healthy foods, while protein intake stays very high.

I can't raise reta or tirz by even a hair—my skin goes really strange. And cagri beyond 0.5 brings mild nausea. Aside from that, the three together give me maybe a tenth of the side effects I had on low-dose ozempic: some nausea here and there, skin sensations often odd particularly on my arms, but usually not annoying enough to matter. Possibly more anhedonia/amotivation, though it's genuinely hard to judge since I had plenty of that before any GLP drug. Hunger and craving control is beyond what I'd have believed possible—I think my appetite system now works close to how it does in a not fat person, so eating when hungry seems to land on the right calorie amount to keep weight stable, and even more surprising, it doesn't demand the extreme low calorie density, low fat, low carb, zero high glycemic index/rich foods rules. Previously, especially after weight loss, a tiny bit of rich high calorie food would set off extreme uncontrollable hunger an hour or two later, and I could put on a kilo a week or more because I couldn't stop. And 56% down to 64kg.

How much of this applies to anyone else is very hard to say—there are many receptors in play plus ten times as many downstream targets affected, so all the different variants people have probably explains why effects and side effects vary so much between individuals. Add to that how obese you were at the start, and how damaged the neurological appetite regulation system is or was. And likely diet and exercise too.

If tirz and or reta give you diarrhoea, things to try are more tirz than reta, since it generally has less gastrointestinal side effects than reta; those sort of side effects do often improve with time, but usually very slowly over months, so you just have to drop the doses if that happens. You might find that with just tirz you might get more effect than from reta if you can tolerate it better. You did not mention what dose of tirz you got to when you were only on tirz. Did you get side effects from cagri? I think its side effects are quite different on its own versus when you add it to a decent dose or reta or tirz, which is how nearly everyone on here uses it. But it can also cause gi side effects not just nausea and fatigue. If you never got much above 6mg with tirz originally maybe just try increasing it to 15mg if you can without the reta, if it does not cause the same diarrhoea, then it might have just been the reta causing it.

At least you are not trying to lose as much as I was, 36 kg is still a lot but if you cannot tolerate standard maximum doses of tirz or reta or a combo of them, then not having vast amounts to lose might be pretty important, as they are the most effective drugs. You probably just have to increase the tirz and or reta doses until you start getting GI side effects then drop the dose a bit, so maybe total dose of 8-10mg or so given 12mg caused problems last time and then add cagri if needed, if you get problematic side effects before getting to your target, then swapping the cagri for Elora is the next move, as it generally has less GI side effects and more weight loss than cagri. Or dont bother with cagri and go stright to elora. If you got GI side effects and had to drop the dose generally you need to wait a few months for tolerance to develop before trying to increase the dose again.

Appreciate you putting together such a thorough write-up.

With Tirze, the highest weekly amount I reached was 7.5 mg. Diarrhea showed up at that point, though it stayed fairly mild. That pushed me to move over to Reta, tapering Tirze down while bumping Reta up by 1 mg each week.

At one stage I ran Reta at 7.5 mg/week for a single week, and it went badly: cramps in my stomach lasted all night alongside explosive diarrhea. I dropped back to 6 mg/week as a result. The explosive diarrhea stopped happening—maybe helped by adding things like psyllium husk to my diet—yet loose stools kept lingering.

Because of that, I paused every peptide for a month. Back then Ipa + CJC was also part of my routine.

Once the washout was done, the diarrhea cleared up entirely, so I chose to begin again roughly the way I had around a year earlier. This time, however, my plan is to bring Tirze up far more gradually, adding only 1 mg per 8 weeks.

Cagri went in after 4 weeks, and up to now it has done a great job curbing appetite, with zero side effects at all.

Your point is completely valid—responses to a given dose, or even to the same GLP-1, can differ from person to person. So I fully realize that the right combo and amount for me has to come from paying close attention to how my body reacts as time goes on.

As for Reta + Cagri, I have barely come across any posts from people running that pairing. It left me wondering if some kind of interaction or clash could exist between glucagon receptor activation and amylin receptor activation.

Perhaps later on, if Elora shows up at a fair price, I might think about moving from Cagri over to Elora. Still, I have enough Cagri on hand to last at least another 5 months, and because I am handling it so well with no side effects, sticking with it for now suits me fine.

frizzle-fry · Sep 8, 2026

BLASIUS said:

Hi everyone,

I’ve resumed GLP-1 use following a washout that lasted 4 weeks.

Weeks 1–4: Tirze 2.5 mg

Weeks 5–7: Tirze 2.5 mg alongside Cagri 0.25 mg

Appetite control has been solid so far: nothing in the way of side effects, and food noise has dropped noticeably. Weight loss, though, hasn’t really shown up yet.

A decision is coming in the next few weeks: either push the Tirze and Cagri doses higher while keeping the 10:1 ratio, or bring Reta into the mix, possibly at a T:R:C ratio of 10:5:1.

Has anyone here run a similar stack? If so, what results are you getting? Or would you say this is better left alone?

My background:

Between August 2025 and June 2026 I dropped 16 kg, with roughly 5 months on Tirze and 6 months on Reta. For both Tirze and Reta I got up to 6 mg/week, and at that level diarrhea wouldn’t let up on either one.

That led me to pause GLP-1s and other peptides for a month. I’ve since restarted, easing in with Tirze and Cagri as outlined above.

At least another 20 kg still has to come off, so I’m after a route that keeps appetite in check and weight coming down without the GI problems returning.

I’d especially like to hear from anyone with experience on Tirze + Cagri or Tirze + Reta + Cagri, particularly on weight-loss outcomes and side effects.

I’m running this same combination personally: 2.5mg tirz, .25mg cag, 1mg Reta. Since tirz brings on awful heartburn and nausea for me, I added the other two rather than raising the dose. Results are still unknown because I’ve only just begun this stack, but my guess is it will work about as well as a big solo tirz dose while causing fewer side effects

woundcarping · Sep 8, 2026

Right now my regimen is Reta, Tirz, and Elora at a 12mg/2.5mg/1mg split.

On 8/5 I hit my initial milestone — 200lb, which is 82lb lost — after slightly under 34 weeks. My peak doses were 20mg Reta alongside .375mg Sema. I paused dosing for 11 days to give my body a rest and to watch whether food noise and appetite would come back. Appetite remained suppressed and food noise didn't surge back. 13 days later (8/14) I resumed at 8mg Reta and .25mg Sema.

That experiment meant I dropped only 5lb over the past month, compared with the roughly 9lb I had been pacing toward. I'm not sorry about the slower pace; I feel more relaxed, sleep is better, and my RHR has come down… quality of life improvements. I figure my ultimate goal lands near 180lb. The plan: be in the 180's this month, and essentially finish losing before I hit the one year mark (3 months to shed 15-20lb).

I have Cagri sitting unused. All the praise about how smooth Elora is convinced me to hold off until my trial supply arrives. (If I intend to use something long term, I prefer keeping at least a year's worth on hand.)

Flash-BCR · Sep 8, 2026

woundcarping said:

Right now my regimen is Reta, Tirz, and Elora at a 12mg/2.5mg/1mg split.

On 8/5 I hit my initial milestone — 200lb, which is 82lb lost — after slightly under 34 weeks. My peak doses were 20mg Reta alongside .375mg Sema. I paused dosing for 11 days to give my body a rest and to watch whether food noise and appetite would come back. Appetite remained suppressed and food noise didn't surge back. 13 days later (8/14) I resumed at 8mg Reta and .25mg Sema.

That experiment meant I dropped only 5lb over the past month, compared with the roughly 9lb I had been pacing toward. I'm not sorry about the slower pace; I feel more relaxed, sleep is better, and my RHR has come down… quality of life improvements. I figure my ultimate goal lands near 180lb. The plan: be in the 180's this month, and essentially finish losing before I hit the one year mark (3 months to shed 15-20lb).

I have Cagri sitting unused. All the praise about how smooth Elora is convinced me to hold off until my trial supply arrives. (If I intend to use something long term, I prefer keeping at least a year's worth on hand.)

This past weekend I got down to 189...my goal was 185, so that's 34lbs remaining to reach it...though I might aim for 180 instead and then begin strength/resistance work, throw in tesa and so on...

156now · Sep 8, 2026

lessthanhalf said:

On 15mg tirz, 7mg reta, and 0.5mg cagri weekly, though I break it into every-other-day shots for reta and tirz, and every 4th day for cagri—so the ratio is pretty similar to yours.

Ozempic at 0.22mg every other day was my previous regimen; anything past 0.5mg brought on severe nausea and malaise, and even on the alternate-day schedule it wasn't great, though it did take the edge off hunger. I'd already dropped 70kg before starting it, a year prior, hoping to feel less hungry.

My doctor talked me into tirzepatide, so I paid $690 for a legit pen. After plenty of research and math, I figured an equivalent dose sat around 3-5mg, meaning if it stretched 5 months the cost wouldn't be unbearable. What I discovered fast was that side effects were almost nil, I could titrate up without trouble, and hunger dropped much further. That's when I came across this website and put in an order for the grey version—I hadn't known such a thing existed before. Within a month I'd pushed tirz to 15mg using every-other-day shots, with only occasional mild nausea and the rare bout of skin sensitivity. I'd also grabbed some reta as a backup.

Since tirz at 15mg was doing well and side effects were minimal, I chose not to disturb that, so when hunger lingered I simply stacked reta on top, running tirz15/reta 5-6mg for a year, and shed another 14kg very gradually. A few months back I wanted to see if hunger could come down a touch more, so my strict diet wouldn't have to be quite so strict. I bumped reta to 7mg and brought in cagri at 0.25mg every 4 days. Weight loss didn't budge, but my weight seems to hold steady even when I eat some far less healthy foods, while protein intake stays very high.

I can't raise reta or tirz by even a hair—my skin goes really strange. And cagri beyond 0.5 brings mild nausea. Aside from that, the three together give me maybe a tenth of the side effects I had on low-dose ozempic: some nausea here and there, skin sensations often odd particularly on my arms, but usually not annoying enough to matter. Possibly more anhedonia/amotivation, though it's genuinely hard to judge since I had plenty of that before any GLP drug. Hunger and craving control is beyond what I'd have believed possible—I think my appetite system now works close to how it does in a not fat person, so eating when hungry seems to land on the right calorie amount to keep weight stable, and even more surprising, it doesn't demand the extreme low calorie density, low fat, low carb, zero high glycemic index/rich foods rules. Previously, especially after weight loss, a tiny bit of rich high calorie food would set off extreme uncontrollable hunger an hour or two later, and I could put on a kilo a week or more because I couldn't stop. And 56% down to 64kg.

How much of this applies to anyone else is very hard to say—there are many receptors in play plus ten times as many downstream targets affected, so all the different variants people have probably explains why effects and side effects vary so much between individuals. Add to that how obese you were at the start, and how damaged the neurological appetite regulation system is or was. And likely diet and exercise too.

If tirz and or reta give you diarrhoea, things to try are more tirz than reta, since it generally has less gastrointestinal side effects than reta; those sort of side effects do often improve with time, but usually very slowly over months, so you just have to drop the doses if that happens. You might find that with just tirz you might get more effect than from reta if you can tolerate it better. You did not mention what dose of tirz you got to when you were only on tirz. Did you get side effects from cagri? I think its side effects are quite different on its own versus when you add it to a decent dose or reta or tirz, which is how nearly everyone on here uses it. But it can also cause gi side effects not just nausea and fatigue. If you never got much above 6mg with tirz originally maybe just try increasing it to 15mg if you can without the reta, if it does not cause the same diarrhoea, then it might have just been the reta causing it.

At least you are not trying to lose as much as I was, 36 kg is still a lot but if you cannot tolerate standard maximum doses of tirz or reta or a combo of them, then not having vast amounts to lose might be pretty important, as they are the most effective drugs. You probably just have to increase the tirz and or reta doses until you start getting GI side effects then drop the dose a bit, so maybe total dose of 8-10mg or so given 12mg caused problems last time and then add cagri if needed, if you get problematic side effects before getting to your target, then swapping the cagri for Elora is the next move, as it generally has less GI side effects and more weight loss than cagri. Or dont bother with cagri and go stright to elora. If you got GI side effects and had to drop the dose generally you need to wait a few months for tolerance to develop before trying to increase the dose again.

Has your skin become very sensitive? I believe I'm dealing with the same problem.

lessthanhalf · Sep 9, 2026

With standard dosing, it only happens now and then: my arms in particular feel chilly, prickly, and overly reactive. When the dose goes up—or occasionally for no clear reason—I notice little areas of skin pain, where even a light brush hurts, or the pain appears on its own. This closely resembles the cold allodynia I have in my toes from obesity-related small sensory fiber peripheral neuropathy (they feel freezing and painful even with 2 pairs of merino socks on), yet all the information I have come across regarding skin sensitivity from GLP medications points to it being simply a medication side effect, not nerve damage of any sort. That it resolves so quickly when I stop or lower the dose supports this. Actual damage would not clear up that fast.

Tirze+Reta+Cagri stack

BLASIUS

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lessthanhalf

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BLASIUS

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frizzle-fry

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woundcarping

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Flash-BCR

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156now

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lessthanhalf

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