Tirz was fine, Lost 60 lb, Tried reta...

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J Arbey

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Tirz worked well for me (doses reached 15mg/week), and I dropped 60 lb over a bit more than 12 months; then I gave Reta a 1-month trial --> sleep quality fell apart.

After my last Tirz shot, I held off for 10 days before injecting 1mg Reta, then paused 3 days and injected another 1mg Reta.

Over 2.5 weeks I injected 5mg total in divided doses, then took 4mg in 1 go... Food noise clearly quieted, and nausea hit me a little harder than with Tirz...

Sleep, though, was poor: I'd jolt awake around 2-3AM feeling wired, and I cap my coffee at 2 cups in the morning, nothing more.

So I concluded Reta wasn't a good fit for me; 2 weeks after my final Reta dose I resumed Tirz at 8mg. Sleep has improved a lot over the past few days. Just a few pounds left to lose.

This is research. Some experiments pan out, others don't. Responses can vary from person to person.

YMMV

Be safe all.
 
That's rough. Reta is my favorite by far. It's on another level. I still take a bit of Tirz as well. The vascularity Reta gives me is amazing, particularly when I'm lifting. Insane.

Bill
 
Both are fine by me — every week I use 10 mg of each. ;-)

My sleep got better once I'd been on Reta for 2 months.
 
I'm on both. During the initial 2 months of reta, my sleep was poor. Once that phase passed, sleep got better, and it stayed that way even as the doses went up.
 
My doctor mentioned that Reta can increase your resting heart rate. I believe Tirz has a similar effect, though it's milder. Might that be the reason behind your sleep problem?
 
On YouTube I came across someone who mentioned that eating carbs right before sleeping solved his Reta-related sleep problems.

Now, whenever I wake up during the night, I grab a bite. I go for pumpkin seeds plus peanut butter spread on bread.

A bit of carbs, a bit of magnesium.

Up to this point, it's working well.
 
My compounded sema supply ran dry in December, and Februaray is when the first gray reta arrived. During the 2 years on official wegovy and zepbound, and later compounded, I was shedding hair. These days it's coming back in a big way.

On the sleep front: I'm wired as a night owl, hitting the pillow near 2am, and I used to wake up whenever I pleased. Noon wake-ups suited me perfectly.

But now, between 6-8am, something jolts me awake, and going back to sleep is impossible.

My galaxy watch reports solid sleep quality, yet it's only 4-5 hours.

Even when bedtime rolls around, I have zero tiredness.
 
rkbleddyn said:

My doctor mentioned that Reta can increase your resting heart rate. I believe Tirz has a similar effect, though it's milder. Might that be the reason behind your sleep problem?
Click to expand...
A higher HR ought not to have any impact on sleep.
 
I figure the glucagon agonism in reta ramps up sympathetic nervous system activity overall; that drives the higher heart rate and, I'd guess, also explains why people report insomnia on it. The insomnia isn't coming from the faster heartbeat itself—it's the elevated adrenaline and noradrenaline activity behind it.
 
Reta has completely wrecked my sleep. It took me far too long to put the pieces together. On top of that, my mood tanked and I had that skin issue too. It was wild. I went nearly 20 days without pinning anything, then came back at a lower dose. That was 2 days ago.

Hoping I can stick with it (together with daily GHK-cu & KPV). Aside from all that, the way it works really agrees with me. A lot.
 
lessthanhalf said:

I figure the glucagon agonism in reta ramps up sympathetic nervous system activity overall; that drives the higher heart rate and, I'd guess, also explains why people report insomnia on it. The insomnia isn't coming from the faster heartbeat itself—it's the elevated adrenaline and noradrenaline activity behind it.
Click to expand...

I'm beginning to suspect the explanation might just be hunger. Your body rouses itself because it wants carbs. Since we aren't experiencing hunger and have no desire to eat at 2 am, we end up blaming countless other causes.

At least, that's what I figure
 
eidos said:

Both are fine by me — every week I use 10 mg of each. ;-)

My sleep got better once I'd been on Reta for 2 months.
Click to expand...
Are you dosing them on the same day? Does combining them give any advantage? Tirz is what I'm on right now and it's doing the job for me, but I've also got rheta sitting here and I can't decide whether to give it a go.
 
HappyBear said:

eidos said:

Both are fine by me — every week I use 10 mg of each. ;-)

My sleep got better once I'd been on Reta for 2 months.
Click to expand...
Are you dosing them on the same day? Does combining them give any advantage? Tirz is what I'm on right now and it's doing the job for me, but I've also got rheta sitting here and I can't decide whether to give it a go.
Click to expand...
Nope, I don't take them on the same day.

There is an upside, though. I came across info that (official) labs are exploring analog combos, plus I've seen accounts from folks using both, so I dug deeper.

The thing that tipped me toward giving it a shot was a research paper covering how differently Tirz and Reta bind to the GLP-1 receptor. They complement each other, it seems — or at least that's how it's played out for me. These days my glycemia is under better control, and I've shed a fair amount of visceral fat.
 
eidos said:

HappyBear said:

eidos said:

Both are fine by me — every week I use 10 mg of each. ;-)

My sleep got better once I'd been on Reta for 2 months.
Click to expand...
Are you dosing them on the same day? Does combining them give any advantage? Tirz is what I'm on right now and it's doing the job for me, but I've also got rheta sitting here and I can't decide whether to give it a go.
Click to expand...
Nope, I don't take them on the same day.

There is an upside, though. I came across info that (official) labs are exploring analog combos, plus I've seen accounts from folks using both, so I dug deeper.

The thing that tipped me toward giving it a shot was a research paper covering how differently Tirz and Reta bind to the GLP-1 receptor. They complement each other, it seems — or at least that's how it's played out for me. These days my glycemia is under better control, and I've shed a fair amount of visceral fat.
Click to expand...
I appreciate you passing this along—it's a real boost for me on my own path.
 
HappyBear said:

eidos said:

HappyBear said:

eidos said:

Both are fine by me — every week I use 10 mg of each. ;-)

My sleep got better once I'd been on Reta for 2 months.
Click to expand...
Are you dosing them on the same day? Does combining them give any advantage? Tirz is what I'm on right now and it's doing the job for me, but I've also got rheta sitting here and I can't decide whether to give it a go.
Click to expand...
Nope, I don't take them on the same day.

There is an upside, though. I came across info that (official) labs are exploring analog combos, plus I've seen accounts from folks using both, so I dug deeper.

The thing that tipped me toward giving it a shot was a research paper covering how differently Tirz and Reta bind to the GLP-1 receptor. They complement each other, it seems — or at least that's how it's played out for me. These days my glycemia is under better control, and I've shed a fair amount of visceral fat.
Click to expand...
I appreciate you passing this along—it's a real boost for me on my own path.
Click to expand...
If you don't mind, one more question: in a week, how many days apart do you take them?
 
rkbleddyn said:

My doctor mentioned that Reta can increase your resting heart rate. I believe Tirz has a similar effect, though it's milder. Might that be the reason behind your sleep problem?
Click to expand...
At rest my heart rate sits around 60-62BPM... pretty much the same as before... Though I did notice feeling WIRED..

It has now been 10 days since my final Reta dose and I'm sleeping well...

I might give it another go eventually since I've still got some left, but given how much I'm loving my sleep, that could be quite a while off.. Plus I'm nearing the Maint Phase..
 
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