Those who barely respond to GLP — what’s your background?

[TurnipMate]

I hardly get results from GLP/appetite-control peptides, and I’m curious whether others are in the same boat. Did you simply raise your dosage? Did side effects hit you? Has anything actually helped? Any theories about why this happens? I’m hoping to hear from more folks who’ve been through this too!

 

[cloratheshadow]

Medical professionals have mentioned a connection between insufficient vitamin d and people who don’t respond. Once I began supplementing with vitamin d and magnesium, my earlier impression of being a slow responder changed—now my response looks quite strong! Might be something to check out!

 

[TurnipMate]

cloratheshadow said:

Medical professionals have mentioned a connection between insufficient vitamin d and people who don’t respond. Once I began supplementing with vitamin d and magnesium, my earlier impression of being a slow responder changed—now my response looks quite strong! Might be something to check out!

Thanks, I was already planning to start vitamin D regardless! I’m just wondering, if you’re okay with saying, what dose were you taking before you introduced vitamin D?

 

[cloratheshadow]

TurnipMate said:

cloratheshadow said:

Medical professionals have mentioned a connection between insufficient vitamin d and people who don’t respond. Once I began supplementing with vitamin d and magnesium, my earlier impression of being a slow responder changed—now my response looks quite strong! Might be something to check out!

Thanks, I was already planning to start vitamin D regardless! I’m just wondering, if you’re okay with saying, what dose were you taking before you introduced vitamin D?

At 5 mg, suppression was minimal for me — perhaps lasting just a day or 2. I’m now in week 4 at 7.5 mg, and getting past 800 calories daily is a struggle. I’ve thought about reducing the dose or switching entirely to Reta. I do add roughly 2-3mg of Reta weekly, though suppression from it is limited. Cagri is another addition I’d say is worth a shot! Even on days I skip pinning Cagri, I feel pronounced suppression!

 

[cloratheshadow]

TurnipMate said:

cloratheshadow said:

Medical professionals have mentioned a connection between insufficient vitamin d and people who don’t respond. Once I began supplementing with vitamin d and magnesium, my earlier impression of being a slow responder changed—now my response looks quite strong! Might be something to check out!

Thanks, I was already planning to start vitamin D regardless! I’m just wondering, if you’re okay with saying, what dose were you taking before you introduced vitamin D?

On top of that, my suggestion is to take d3 together with k2, since k2 assists with d3 uptake. A magnesium supplement can further support absorption too. It's also best to take it alongside some fat—I simply pair it with a fish oil. That way you're getting the full benefits!

 

[lastresort]

cloratheshadow said:

Medical professionals have mentioned a connection between insufficient vitamin d and people who don’t respond. Once I began supplementing with vitamin d and magnesium, my earlier impression of being a slow responder changed—now my response looks quite strong! Might be something to check out!

It’s quite striking how many different processes vitamin D plays a role in.

 

[Kique03]

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

 

[TurnipMate]

Kique03 said:

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

what results have you seen from 10 mg? right now i’m on 10 mg tirz plus 10 mg reta along with 1 mg cagril. i’m satisfied with where i’m at, i can still eat, and side effects are very minimal!

 

[Kique03]

TurnipMate said:

Kique03 said:

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

what results have you seen from 10 mg? right now i’m on 10 mg tirz plus 10 mg reta along with 1 mg cagril. i’m satisfied with where i’m at, i can still eat, and side effects are very minimal!

Things are moving along fine, though the appetite blunting isn't what it was back when I began at 5mg and 7.5mg. On the plus side, I've built better routines since starting this in March. That's the reason I'm looking to add Reta now and find out whether it'll do anything for me — even though I've heard appetite suppression on Reta isn't common.

I'm still working on sorting all of this out haha.

And 10mg tirz plus 10mg reta? That's impressive.

 

[aepower2016]

Right now I take reta at 5mg each week. My starting dose was 1mg, and I pretty fast realized I was able to go far longer stretches without any hunger. Prior to reta, roughly 3 hours after finishing a meal I would feel hungry, or at minimum have the pull to eat another large meal. While on reta, skipping a meal was fine and I still felt alright. Appetite suppression didn't truly begin for me until 4mg, and even then it was slight. I could still manage to at least clear the proteins off my plate. At 5mg, though, that full feeling comes on really fast now. These days I even get slightly nauseous as I eat. The nausea goes away as soon as I stop eating the meal, so for me it's not much of a worry, if any.

Food noise has been an issue and at 5mg it still is to some degree. What I notice at 5mg is that the noise has become tolerable, though it does still hang around sometimes. In fairness, I also quit eating 3 hours before bed, because at bedtime I take tesa/ipa. It's easy to argue that I've developed a new "will" to battle the noise so my bedtime protocol stays as optimized as possible. So whether reta at 5mg is the main thing lowering my food noise right now is genuinely hard to say.

 

[TurnipMate]

Kique03 said:

TurnipMate said:

Kique03 said:

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

what results have you seen from 10 mg? right now i’m on 10 mg tirz plus 10 mg reta along with 1 mg cagril. i’m satisfied with where i’m at, i can still eat, and side effects are very minimal!

Things are moving along fine, though the appetite blunting isn't what it was back when I began at 5mg and 7.5mg. On the plus side, I've built better routines since starting this in March. That's the reason I'm looking to add Reta now and find out whether it'll do anything for me — even though I've heard appetite suppression on Reta isn't common.

I'm still working on sorting all of this out haha.

And 10mg tirz plus 10mg reta? That's impressive.

My first peptide was reta, and later I stacked tirz on top. If your goal is simply stronger appetite suppression, cagril is worth checking out. That said, cagril won’t do anything for the glucagon receptor, so it won’t replace what reta brings on that front. Best of luck!

 

[jusmypullup]

Kique03 said:

TurnipMate said:

Kique03 said:

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

what results have you seen from 10 mg? right now i’m on 10 mg tirz plus 10 mg reta along with 1 mg cagril. i’m satisfied with where i’m at, i can still eat, and side effects are very minimal!

Things are moving along fine, though the appetite blunting isn't what it was back when I began at 5mg and 7.5mg. On the plus side, I've built better routines since starting this in March. That's the reason I'm looking to add Reta now and find out whether it'll do anything for me — even though I've heard appetite suppression on Reta isn't common.

I'm still working on sorting all of this out haha.

And 10mg tirz plus 10mg reta? That's impressive.

cloratheshadow said:

TurnipMate said:

cloratheshadow said:

Medical professionals have mentioned a connection between insufficient vitamin d and people who don’t respond. Once I began supplementing with vitamin d and magnesium, my earlier impression of being a slow responder changed—now my response looks quite strong! Might be something to check out!

Thanks, I was already planning to start vitamin D regardless! I’m just wondering, if you’re okay with saying, what dose were you taking before you introduced vitamin D?

At 5 mg, suppression was minimal for me — perhaps lasting just a day or 2. I’m now in week 4 at 7.5 mg, and getting past 800 calories daily is a struggle. I’ve thought about reducing the dose or switching entirely to Reta. I do add roughly 2-3mg of Reta weekly, though suppression from it is limited. Cagri is another addition I’d say is worth a shot! Even on days I skip pinning Cagri, I feel pronounced suppression!

Even without strong appetite suppression, do you notice reta boosting your metabolism? I'm new to it and 3 mg hasn't done much for my appetite, so I'm hoping it won't take an absurd dose before I notice anything.

 

[AngieHolmes]

Kique03 said:

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

Even though a standard tirz dose didn't do anything for your appetite, you're thinking about microdosing reta — that's what I'm wondering about. Is your reasoning that reta works through another pathway? Or?

 

[Kique03]

AngieHolmes said:

Kique03 said:

At 2.5mg, my appetite was completely unaffected, yet the anti-inflammatory effects showed up right away. It seems like each dose increase is necessary for me to get any appetite suppression—right now I’m at 10mg and just took my 2nd injection yesterday.

I’ve also been thinking about microdosing Reta.

Even though a standard tirz dose didn't do anything for your appetite, you're thinking about microdosing reta — that's what I'm wondering about. Is your reasoning that reta works through another pathway? Or?

My goal is better metabolic health, and I'm pairing that with the diet and exercise I already do. On the plus side, my eating habits are much better now, and Tirz does give me some appetite suppression—though in my opinion it's less than what other people seem to get.

For me, the appeal of Reta is its glucagon receptor activity, which should support greater fat loss through thermogenesis, and that's exactly what I'm after.

From what I've experienced, building muscle while also trying to lose fat makes the weight come off more slowly. That's why I'm considering Reta—to give fat loss a boost. I'm also trying to pay attention to lean mass rather than just lbs on the scale, but as a woman I can't help noticing that the weight loss is slowing down

 

[miameow]

TurnipMate said:

I hardly get results from GLP/appetite-control peptides, and I’m curious whether others are in the same boat. Did you simply raise your dosage? Did side effects hit you? Has anything actually helped? Any theories about why this happens? I’m hoping to hear from more folks who’ve been through this too!

Honestly, I’m happy this thread exists. Any time I say reta didn’t do anything for me, the reta police show up demanding to know where I got it and telling me I just can’t stop eating.

Here’s what you asked:

Did you simply push your dose higher?

I did, but it took 6 months. Every 4 weeks I went up by 1 mg without skipping. In the final month I went from 6 mg straight to 8 mg, mostly because I figured YOLO.

Did you get side effects?

They were brutal. The worst was the gastrointestinal stuff, and it never let up across all 6 months. On top of that, I had hunger so extreme it was unlike anything in my whole life, plus nonstop food fantasies during the day.

Have you landed on anything that helps?

Nothing in the GLP family. I gave Cagri a 1-week trial, but it was just as intolerable, so I quit and I’m now waiting on my Elora.

Any theory about why this happens?

I don’t have one. My only guess is some form of insulin resistance. Diabetes isn’t my diagnosis, but blood sugar problems run through my whole family. I’m the one who’s more or less normal, and that’s only because I have the discipline of a German soldier. If I gave my cravings free rein, I’d be dead already — others in my family have died from complications, some before they turned 40.

 

[TurnipMate]

What stands out to me is that my own side effects stay quite mild, which got me wondering whether people who respond poorly to these peptides also tend to have a muted reaction on the side effect front. A friend of mine splits a kit with me, and 3 mg of reta per week leaves him completely drained; any bump beyond that and he cannot hold down food. My own past includes a long stretch of losing weight successfully through natural dieting, but since I stopped weighing every meal, I have noticed that keeping from overeating takes fairly high doses. Elora is new to me — what is it supposed to do? In the end I landed on a mix of peptides and doses that gives me adequate appetite suppression, though I suspect the same side effects would flatten someone with a normal response.

 

[diplomat]

TurnipMate said:

What stands out to me is that my own side effects stay quite mild, which got me wondering whether people who respond poorly to these peptides also tend to have a muted reaction on the side effect front. A friend of mine splits a kit with me, and 3 mg of reta per week leaves him completely drained; any bump beyond that and he cannot hold down food. My own past includes a long stretch of losing weight successfully through natural dieting, but since I stopped weighing every meal, I have noticed that keeping from overeating takes fairly high doses. Elora is new to me — what is it supposed to do? In the end I landed on a mix of peptides and doses that gives me adequate appetite suppression, though I suspect the same side effects would flatten someone with a normal response.

I’m in the low responder group too, though my path looked different — I’d known about GLP1s for some time, but didn’t actually start until last year.

I bypassed Sema/Tirz, the “old school” options, and jumped straight to Reta, the newer/shiny one. Over 16 weeks I slowly titrated up to 12mg.

Right away I got stomach fullness and terrible acid reflux. Sadly, appetite suppression was completely absent — I was extremely hungry. It wasn’t even “food noise” — I was ravenous!

The reflux happened 24/7 and got worse when I tried to sleep. Avoiding food for 8 hours before bed changed nothing. My gut was miserable, and from my starting weight I had only dropped 4 pounds total.

I drastically reduced the Reta and introduced 2mg of Cagri for its (supposed) appetite benefits… After 2 months, that myth was dead as well.

Now I’m at 4mg of Survodutide. 2 months in, I’ve lost 9 pounds, have no reflux at all, sleep great, and my heartbeat is mostly normal.

Clearly a completely different outcome from yours, TurnipGuy, since all I got were side effects!