Tesamorelin causing large welts and allergic reactions, resembling insect bite responses.

[breefree31]

Hello,

I'm hoping to hear from others about histamine reactions linked to Tesamorelin.

Context: Today marks week 5 of my Tesa+IPA protocol. I inject 2mg Tesa plus 300mcg IPA, following a 5 days on, 2 days off schedule each week. During the initial 3 weeks, subQ shots caused only minor itching right after injection, typically fading within 10-15 minutes. Since the past 2 weeks, though, the shot itself is okay, but roughly 12 hours post-dose, the itching intensifies, and swelling with welts keeps growing, often worst at about 48 hours.

To give you an idea, my reactions to insect bites are not like the usual histamine response others get—my wife, for instance. Mine turn into big, super itchy welts that are 2 inches across or larger.

What I've tried so far to control the itching: I attempted adjusting the concentration by adding more BAC water; I used 3ML BAC with the 10mg Tesa, but it made little difference. I also divided the dose into 2 shots in different sites—thigh and abdomen—and that didn't work either, though the thigh one itches a bit less, it's still very itchy, warm, and welted. OTC antihistamines such as Ceterizine and Fomatidine have helped the itch for a few hours. I've also warmed the syringe to room temperature before injecting, with no improvement. Topical anti-itch creams and Triamcinalone can reduce it somewhat, but the welts and itching remain.

I'm also using other compounds: "Klow," Semax and Selank, plus Reta at 2mg once weekly, and none of those cause any ISR.

Given that I also have severe bite reactions and seasonal allergies to various plants and weeds that trigger similar responses, I'm thinking about getting tests to check if my tryptase levels are off.

Has anyone with comparable allergic reactions discovered treatments that helped? I was considering options like Ketotifen or perhaps short-term oral steroids.

Thanks for any input!

 

[Mr. Blonde]

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

 

[Rickcaps]

I've come across a few comparable patterns; it seems fairly unpredictable and, in my view, relates to how warm the solution is along with the gap after the workout.

Do you switch to a fresh syringe for each injection?

breefree31 said:

Hello,

I'm hoping to hear from others about histamine reactions linked to Tesamorelin.

Context: Today marks week 5 of my Tesa+IPA protocol. I inject 2mg Tesa plus 300mcg IPA, following a 5 days on, 2 days off schedule each week. During the initial 3 weeks, subQ shots caused only minor itching right after injection, typically fading within 10-15 minutes. Since the past 2 weeks, though, the shot itself is okay, but roughly 12 hours post-dose, the itching intensifies, and swelling with welts keeps growing, often worst at about 48 hours.

To give you an idea, my reactions to insect bites are not like the usual histamine response others get—my wife, for instance. Mine turn into big, super itchy welts that are 2 inches across or larger.

What I've tried so far to control the itching: I attempted adjusting the concentration by adding more BAC water; I used 3ML BAC with the 10mg Tesa, but it made little difference. I also divided the dose into 2 shots in different sites—thigh and abdomen—and that didn't work either, though the thigh one itches a bit less, it's still very itchy, warm, and welted. OTC antihistamines such as Ceterizine and Fomatidine have helped the itch for a few hours. I've also warmed the syringe to room temperature before injecting, with no improvement. Topical anti-itch creams and Triamcinalone can reduce it somewhat, but the welts and itching remain.

I'm also using other compounds: "Klow," Semax and Selank, plus Reta at 2mg once weekly, and none of those cause any ISR.

Given that I also have severe bite reactions and seasonal allergies to various plants and weeds that trigger similar responses, I'm thinking about getting tests to check if my tryptase levels are off.

Has anyone with comparable allergic reactions discovered treatments that helped? I was considering options like Ketotifen or perhaps short-term oral steroids.

Thanks for any input!

 

[breefree31]

Rickcaps said:

I've come across a few comparable patterns; it seems fairly unpredictable and, in my view, relates to how warm the solution is along with the gap after the workout.

Do you switch to a fresh syringe for each injection?

breefree31 said:

Hello,

I'm hoping to hear from others about histamine reactions linked to Tesamorelin.

Context: Today marks week 5 of my Tesa+IPA protocol. I inject 2mg Tesa plus 300mcg IPA, following a 5 days on, 2 days off schedule each week. During the initial 3 weeks, subQ shots caused only minor itching right after injection, typically fading within 10-15 minutes. Since the past 2 weeks, though, the shot itself is okay, but roughly 12 hours post-dose, the itching intensifies, and swelling with welts keeps growing, often worst at about 48 hours.

To give you an idea, my reactions to insect bites are not like the usual histamine response others get—my wife, for instance. Mine turn into big, super itchy welts that are 2 inches across or larger.

What I've tried so far to control the itching: I attempted adjusting the concentration by adding more BAC water; I used 3ML BAC with the 10mg Tesa, but it made little difference. I also divided the dose into 2 shots in different sites—thigh and abdomen—and that didn't work either, though the thigh one itches a bit less, it's still very itchy, warm, and welted. OTC antihistamines such as Ceterizine and Fomatidine have helped the itch for a few hours. I've also warmed the syringe to room temperature before injecting, with no improvement. Topical anti-itch creams and Triamcinalone can reduce it somewhat, but the welts and itching remain.

I'm also using other compounds: "Klow," Semax and Selank, plus Reta at 2mg once weekly, and none of those cause any ISR.

Given that I also have severe bite reactions and seasonal allergies to various plants and weeds that trigger similar responses, I'm thinking about getting tests to check if my tryptase levels are off.

Has anyone with comparable allergic reactions discovered treatments that helped? I was considering options like Ketotifen or perhaps short-term oral steroids.

Thanks for any input!

Yes, definitely....I always switch to a fresh syringe when injecting a second site, and as I mentioned earlier, even after letting it reach room temperature the reaction remains severe. It's awful.

 

[breefree31]

Mr. Blonde said:

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

What was the severity of your reaction? I checked how others responded to similar peptides, and theirs are mild next to what I experienced. The spots where I inject balloon to the size of golf balls — it's rough!

 

[Rickcaps]

breefree31 said:

Mr. Blonde said:

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

What was the severity of your reaction? I checked how others responded to similar peptides, and theirs are mild next to what I experienced. The spots where I inject balloon to the size of golf balls — it's rough!

That size is clearly excessive. Have you considered switching injection sites to the fat on the lower back or the inner thighs?

 

[breefree31]

Rickcaps said:

breefree31 said:

Mr. Blonde said:

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

What was the severity of your reaction? I checked how others responded to similar peptides, and theirs are mild next to what I experienced. The spots where I inject balloon to the size of golf balls — it's rough!

That size is clearly excessive. Have you considered switching injection sites to the fat on the lower back or the inner thighs?

Last night I injected into the glute using a 1/2" needle, and I'll report back on the outcome.

 

[RubbaDubba1]

Perhaps others here can confirm whether Thymosin Alpha-1 might be useful for this situation? Shellfish is an allergen for me, yet I have no other allergy background. Across 100s & 100s of injections, just 2 very mild histamine reactions to pins have occurred. My impression is that TA-1 is assisting with that, since it supports immune balance and prevents it from becoming dysregulated. My WBC count has been gradually increasing, as it had been on the lower side, and I intend to continue taking it through the remainder of the year.

AI version: TA1 is an immunomodulating peptide that may help manage histamine reactions by balancing the immune system, particularly by modulating Th2-dominant responses that drive allergy symptoms. While often used for immune support in chronic infections, its ability to reduce inflammation makes it a potential tool for managing histamine-driven conditions.

 

[ltjltj]

Anaphylaxis has been documented as a possible effect of GH secretagogues. Were I in your position, I would stop using this — your system appears to be mounting an allergic response that is growing more intense each time.

 

[breefree31]

Rickcaps said:

breefree31 said:

Mr. Blonde said:

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

What was the severity of your reaction? I checked how others responded to similar peptides, and theirs are mild next to what I experienced. The spots where I inject balloon to the size of golf balls — it's rough!

That size is clearly excessive. Have you considered switching injection sites to the fat on the lower back or the inner thighs?

Update: glute showed no response!

 

[Rickcaps]

breefree31 said:

Rickcaps said:

breefree31 said:

Mr. Blonde said:

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

What was the severity of your reaction? I checked how others responded to similar peptides, and theirs are mild next to what I experienced. The spots where I inject balloon to the size of golf balls — it's rough!

That size is clearly excessive. Have you considered switching injection sites to the fat on the lower back or the inner thighs?

Update: glute showed no response!

That solves it — we got to the bottom of this.

 

[chewonmysac]

breefree31 said:

Rickcaps said:

breefree31 said:

Mr. Blonde said:

With cjc 1295, I experienced the very same thing. From what I understand, this kind of reaction is fairly typical when using ghrp and ghs peptides. My impression is that it happens in around 50% of users.

What was the severity of your reaction? I checked how others responded to similar peptides, and theirs are mild next to what I experienced. The spots where I inject balloon to the size of golf balls — it's rough!

That size is clearly excessive. Have you considered switching injection sites to the fat on the lower back or the inner thighs?

Update: glute showed no response!

That's the approach I take with my GHK-cu, and I appreciate the suggestion—I'll start doing the same with my Tesa. It's not as severe as what the original poster described, but it can still be irritating. Somewhat lumpy as well. I figured I'd be reaching for the 1/2" Easy Touch once more.

 

[CNCCurrency]

RubbaDubba1 said:

Perhaps others here can confirm whether Thymosin Alpha-1 might be useful for this situation? Shellfish is an allergen for me, yet I have no other allergy background. Across 100s & 100s of injections, just 2 very mild histamine reactions to pins have occurred. My impression is that TA-1 is assisting with that, since it supports immune balance and prevents it from becoming dysregulated. My WBC count has been gradually increasing, as it had been on the lower side, and I intend to continue taking it through the remainder of the year.

AI version: TA1 is an immunomodulating peptide that may help manage histamine reactions by balancing the immune system, particularly by modulating Th2-dominant responses that drive allergy symptoms. While often used for immune support in chronic infections, its ability to reduce inflammation makes it a potential tool for managing histamine-driven conditions.

Numerous people in this community recommend kpv when it comes to immune reactions, from what I've noticed.

 

[RubbaDubba1]

CNCCurrency said:

RubbaDubba1 said:

Perhaps others here can confirm whether Thymosin Alpha-1 might be useful for this situation? Shellfish is an allergen for me, yet I have no other allergy background. Across 100s & 100s of injections, just 2 very mild histamine reactions to pins have occurred. My impression is that TA-1 is assisting with that, since it supports immune balance and prevents it from becoming dysregulated. My WBC count has been gradually increasing, as it had been on the lower side, and I intend to continue taking it through the remainder of the year.

AI version: TA1 is an immunomodulating peptide that may help manage histamine reactions by balancing the immune system, particularly by modulating Th2-dominant responses that drive allergy symptoms. While often used for immune support in chronic infections, its ability to reduce inflammation makes it a potential tool for managing histamine-driven conditions.

Numerous people in this community recommend kpv when it comes to immune reactions, from what I've noticed.

As for KPV on its own, I have no experience with that, so I can't say whether it would do anything for me solo. From what I understand, it does have anti-inflammatory action and supports the digestive tract. Same as you, I've come across positive reports, and right now I'm on KLOW, which gives me 500mcg of KPV daily. With this shoulder surgery, I'm using every tool available to recover.

TA1 is sold as a prescription medication (Zadaxin) in more than 35 countries, and it's even given to cancer patients to support their immune system. That's the reason I want to run it for a year, since it may help raise WBC count. I also have some LL-37 on hand that I'd like to try, though I'm not sure whether using it while healthy would just be wasted. I'll ask my Dr about that next month.

 

[Radxpro43]

Around the injection spot I notice a short-lived histamine reaction: a little lump plus some itchiness, though it clears up before morning arrives. What I actually watch for is several lumps at once or swelling that points to something serious. Tesa does have a bit of a sting to it. Should the reaction lean more toward histamine rather than a true allergy, one option might be to add extra bac.

 

[foffspam111]

I experienced this across all 3: Sermorelin, CJC/IPA, and Tesa. Once I'd completed 2 cycles of tesa at 90 days each, the welts started easing up after the first month of the initial cycle, and at this point they've stopped entirely. My injection site is the love handles. My take is that if the reaction stays mild, it might fade on its own the way it did in my case.

 

[breefree31]

foffspam111 said:

I experienced this across all 3: Sermorelin, CJC/IPA, and Tesa. Once I'd completed 2 cycles of tesa at 90 days each, the welts started easing up after the first month of the initial cycle, and at this point they've stopped entirely. My injection site is the love handles. My take is that if the reaction stays mild, it might fade on its own the way it did in my case.

For me, the reaction was by far the most severe around the love handles. Right after that injection, the welt covered the entire region and stuck around for 4 days; the itching only let up yesterday.

 

[foffspam111]

Wow, 4 days seems really intense! For me the discomfort only hung around for roughly a couple of hours—though honestly it might have gone on longer, since I head straight to sleep right after injecting. Either way, the irritation has completely cleared up at this point.

Perhaps try taking a bit of an antihistamine alongside your injection?

I recall a woman posting here who reacted so severely to tesa that she ended up in the hospital because of the allergic reaction. Should things escalate, it might be worth exploring other options.

What dosage are you using? Have you tried reducing it slightly to check whether that makes a difference?