Switching from Tirz to Reta? Dealing with Anhedonia

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notalittlegiddy

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New York here, F/33. I came across compounded tirz and went from 230 down to 200, losing 30lbs over the past 6 months at roughly 4-5mg.

That said, the past 2 years I've been dealing with severe depression, which made everything messier. I do suspect the tirz made my anhedonia worse, and it was genuinely hard to cope with. A month ago I quit cold turkey to see if the anhedonia would let up - I'm still depressed now, though maybe with slightly more energy and interest returning, but I gained 20 lbs in 30 days. jfc. I broke down crying today. Feels like there's no way to win.

Now I'm trying to work out my next move. Could Reta be an improvement or a downgrade? Should I restart tirz at a micro/mini dose? Has anyone managed to keep anhedonia/depressive side effects from GLPs under control?
 
Reta has been part of my routine for 4 months and I'm still going, keeping the doses low since there's no rush on my end. Anhedonia comes up a lot in what I've read, though whether I've truly gone through it is something I can't say for certain. One thing is clear: I'm noticeably calmer than I normally am. What does seem to make a difference with GLP-1s across the board is having your day and your activities mapped out ahead of time. When there's something on the schedule I'm eager about, like time with family or friends, that anticipation really does lift me. In my view, the social piece matters a great deal for getting past Anhedonia, and it can't be left to chance — it has to be deliberate. I realize you said depression is something you're dealing with, and I hope you find your way through it, but my belief is that the more we connect with other people, the better our lives become. Wishing you the best on your journey, and I hope this is of some help!
 
Social ties matter when it comes to pushing through anhedonia — that's something I'd back @Taz90 on. While moving up through Reta doses, I hit it during a few different titration steps, and each time it faded within a few weeks.

Still, being on your own makes anhedonia way heavier. That's a tough spot for me since my job is at home, in my own office, with just a handful of remote coworkers. So the social side has to come from somewhere beyond work.
 
Last night I put together a spreadsheet tracking my mood, and it looks like my lowest points line up closely with when I was on GLP, getting worse as the dose went up. It hurts to admit it, but I believe stopping them is what I actually need to do. Looking back, cycling on and off GLPs seems to have wrecked my mental health and the past 3 years of my life… wanting to be thin is such a powerful pull that I'm stunned I kept going until now
 
Hey — I'm really glad you shared this. It sounds deeply frustrating, and you're definitely not irrational for feeling trapped by it.

To start with some perspective:

  • 30 lbs lost over 6 months is genuine progress
  • putting weight back on quickly once you stop is sadly extremely typical (it isn't a personal failing — it's just your body's biology rebounding)
About the emotional side — the anhedonia on tirz you're describing does get mentioned. It doesn't happen for everyone, but certain people notice:

  • feeling more numb
  • getting less pleasure from activities
  • reduced motivation
And after you stop:

  • hunger comes roaring back
  • pounds return rapidly
That combination can be really rough.

A few approaches that people in similar spots often look into:

1. Lower / “maintenance-style” dosing

Rather than aiming for total appetite suppression, some find it works better to use:

  • smaller, more consistent doses
  • just enough to quiet the food noise
  • without going so high that emotions get flattened
2. Reta vs Tirz

Experiences vary:

  • some report more energy / feeling less flat on Reta
  • others say it's comparable or even more stimulating
It isn't a sure fix for mood, but it can feel different.

3. Addressing the mental health part on its own

This is equally important:

  • sleep
  • sunlight / movement (even gentle)
  • real depression care (therapy, medication if necessary)
GLPs may affect mood, but they aren't the entire story.

Also — putting on 20 lbs that quickly after stopping isn't “you losing control.”

It's:

👉 hunger hormones + rebound + water + glycogen

It feels terrible, but it won't last forever.

You aren't stuck in a no-win situation, even if it seems that way at this moment.

Many people eventually land on a middle path where:

  • weight stays managed
  • mood stays tolerable
It just requires some fine-tuning.

You're asking the right things — truly. Hang in there. 💛
 
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