Sudden Tirz intolerance — did anyone else hit this?

[Mara_aa]

Ascojoerg said:

Mara_aa said:

Ascojoerg said:

Yes — I went through this myself last summer while using standard prescription Mounjaro. Right after the injection, out of nowhere, I got hit with nausea worse than anything I'd had before, plus severe diarrhea. Staying hydrated was a real fight because of the nausea, and eating was completely off the table for an entire week. My dose at the time was higher (7,5mg), but I'd already been sitting at 7,5mg for 5 weeks, and it was the very same pen I'd used during the 2 weeks before that.

The reassuring part (based only on my own experience) is that it doesn't stick around forever. I quit abruptly because I was terrified of a repeat, and stayed off for roughly 4 months. Eventually curiosity about grey got the better of me, so I restarted at a low dose (Tirz 2,5mg) purely for maintenance and to quiet food noise. Once I'd been on that low dose for a while, I chose to go up again, since I'd never reached my goal weight and was still obese. Since then, by titrating up gradually, I've dropped another 5kg.

Reading your response has genuinely helped calm me down, so thank you for taking the time to write it.

The part that rattled me most is that nothing changed beforehand — same dose for weeks, then out of nowhere this reaction.

From what you describe, our situations line up closely, though my symptoms leaned more toward nausea and feeling weak rather than diarrhea. That bit about struggling to keep fluids down? That has been my exact reality.

Hearing that it eventually resolved for you means a lot. My head keeps spiraling right now, telling me my body has written off Tirz permanently as something toxic…

I'm on day 12 as of today and things have only eased slightly, so injecting again is completely off the table for me at this point

Did you ever think about switching over to Reta? Honestly, the thought of returning to how loud the food noise used to be long term is something I can't picture.

It's great that you were able to start up again without issues and keep losing by going back up on the dose gradually.

Yes I have, and honestly the only thing stopping me is that I'd already bought several kits of Tirz. Once those are gone, or if I can't reach my goal weight, I'll likely revisit the idea.

To be honest, that's a completely reasonable justification lol

Plus, if Tirz continues to do its job for you in general, deciding against switching too soon is entirely logical. That was precisely what I intended as well, until my body chose to throw this theatrical tantrum.

 

[desinr-gal]

Mara_aa said:

desinr-gal said:

Antivirals aren't exactly a walk in the park either... which one did you begin with first?

The reaction and symptoms from Tirz were clearly the first thing to appear. A few days afterward, the antivirals were begun due to what was suspected to be shingles/herpes zoster.

And you're right that antivirals can be harsh too, which, honestly, only makes this whole situation harder to sort out

That sounds terrible! I'm sorry this is happening to you.

 

[BNLFL]

Mara_aa said:

DragonOfTheSea said:

Mara_aa said:

CandyCap said:

That prickling, sore skin reaction can occur with either Tirz or Reta.....though it appears to show up more often with Reta. It sounds a lot like a Reta overdose. Are you certain it is the same vial and the same dosing etc? Nothing else new has been introduced?

Yes, I’m certain: the vial is the same, the concentration is the same, my dosing routine is the same, and I’m confident no dosing error occurred.

No Reta and no other new peptide has been introduced. There’s nothing new in the mix at all, apart from the antivirals, and those only began once the skin symptoms had already shown up, since my doctor suspected shingles/herpes zoster.

I did already know that Reta can bring on the “needle skin” sensation, but I hadn’t heard of it with Tirz. Now I’m beginning to question whether that was Tirz as well. What’s odd is that it showed up only on my left side, which is exactly why shingles/herpes zoster was suspected from the start, given that it wasn’t bilateral.

A fairly nasty cold and a stretch of heavy stress were definitely part of the picture, yet the reaction still came across as wildly out of proportion.

So that’s why I’m left so puzzled: it genuinely resembled an overdose, but I can’t come up with any real-world reason why one would have happened.

That "allodynia" feeling—like needles or sunburn—doesn't have to show up on both sides to be caused by Tirz (or Reta). I've had it with both peptides, and it pops up wherever it feels like it: ankles, tops of the feet, upper thighs, glutes, back, stomach, and even my cheek/face (right side only). Before blaming shingles, I'd pin it (pun intended) on the Tirz.

… because I didn't know any better, the only “needles/allodynia/sunburn skin” reports I'd come across were tied to Reta, never Tirz. So once it showed up on just 1 side, I fully bought into the shingles/herpes zoster theory.

“I would pin it on the Tirz” — that line deserves an award lol

On a serious note, thank you so much Tomorrow morning I'm definitely bringing this up with my doctor… though I doubt I'll be thanking him for the 7 days of antivirals that might have knocked me down even harder.

Mara_aa said:

MsGizmo said:

Mara_aa said:

After 5 weeks at 3 mg, it all landed on me in one go, as though I'd injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math errors on my part.

My stomach more or less factory-reset itself. Nausea hit me like nothing I've ever been through, along with extreme weakness and a general sense that everything was doomed.

Over the last 10 days I've hardly managed to stand up straight. Even small movements leave me short of breath and tachycardic, as if every trip to the kitchen were Olympic training. Blood sugar on the low side (not dangerously so), blood pressure low as well.

And to make it stranger still, I came down with a monster cold at the same time and ended up on antivirals for suspected shingles/herpes zoster, thanks to this awful “needles in the skin” sensation I had.

Except… there was no rash. No blisters. Nothing. So it seems even my maybe-shingles wanted to stay mysterious and dramatic.

The doctor essentially shrugged and told me to skip last Thursday's dose. Bloodwork comes back May 20th.

Today Shotsy puts my level at 1.48 mg and I'm marginally better, which means I've graduated from “barely functioning houseplant” to “weak but technically alive.” I still hardly eat or drink, mind you.

What worries me now is that I somehow turned suddenly and permanently intolerant to Tirz overnight. I can't really find stories like this anywhere, so I'm asking: has anyone had a sudden hypersensitivity or reaction like this after tolerating the dose perfectly well before? Any theories, experiences or reassuring stories are welcome.

For context: Tirz has always been a real struggle for me, and I came close to quitting outright. Then you guys pointed me at microdosing, and that made everything much easier to handle.

Even so, it has never been an “easy” medication in my case — but the results justified putting up with a bit of suffering.

What makes us think tirz is the culprit here, rather than the virus?

What keeps making me think Tirz is the culprit: alongside the crushing fatigue, the symptoms are extremely particular — intense nausea, acid reflux, profound gastric stalling and fullness, and being unable to eat or drink in a normal way.

These line up almost exactly with what hit me when I began Tirz in the first place — only now they've been dialed up to an extreme degree

Mara_aa said:

WLBLD said:

Mara_aa said:

WLBLD said:

I realize you said it isn't a fresh vial, but could it have accumulated in your body by now? Is this a new kit from another supplier you've never tried? I've come across reports of people experiencing sides with certain ones but not others.

To be honest, right now the idea that it built up or accumulated over time seems like the most plausible explanation to me, particularly when you factor in stress and illness happening at the same time.

And to be clear, I hadn't switched to a different vendor or a different batch. It was the exact same source I'd been using and handling fine before this all started.

What confused me the most was how abrupt and out of proportion this reaction was next to the Tirz side effects I normally get.

It could also be related to the antiviral combination. I hope you start feeling better soon!!

Yeah, I think it's possible the antivirals piled on and amplified what was already going on lol

Thanks a ton I'm really hoping this nightmare begins to lift before long as well

Mara_aa said:

Ascojoerg said:

Mara_aa said:

Ascojoerg said:

Yes — I went through this myself last summer while using standard prescription Mounjaro. Right after the injection, out of nowhere, I got hit with nausea worse than anything I'd had before, plus severe diarrhea. Staying hydrated was a real fight because of the nausea, and eating was completely off the table for an entire week. My dose at the time was higher (7,5mg), but I'd already been sitting at 7,5mg for 5 weeks, and it was the very same pen I'd used during the 2 weeks before that.

The reassuring part (based only on my own experience) is that it doesn't stick around forever. I quit abruptly because I was terrified of a repeat, and stayed off for roughly 4 months. Eventually curiosity about grey got the better of me, so I restarted at a low dose (Tirz 2,5mg) purely for maintenance and to quiet food noise. Once I'd been on that low dose for a while, I chose to go up again, since I'd never reached my goal weight and was still obese. Since then, by titrating up gradually, I've dropped another 5kg.

Reading your response has genuinely helped calm me down, so thank you for taking the time to write it.

The part that rattled me most is that nothing changed beforehand — same dose for weeks, then out of nowhere this reaction.

From what you describe, our situations line up closely, though my symptoms leaned more toward nausea and feeling weak rather than diarrhea. That bit about struggling to keep fluids down? That has been my exact reality.

Hearing that it eventually resolved for you means a lot. My head keeps spiraling right now, telling me my body has written off Tirz permanently as something toxic…

I'm on day 12 as of today and things have only eased slightly, so injecting again is completely off the table for me at this point

Did you ever think about switching over to Reta? Honestly, the thought of returning to how loud the food noise used to be long term is something I can't picture.

It's great that you were able to start up again without issues and keep losing by going back up on the dose gradually.

Yes I have, and honestly the only thing stopping me is that I'd already bought several kits of Tirz. Once those are gone, or if I can't reach my goal weight, I'll likely revisit the idea.

To be honest, that's a completely reasonable justification lol

Plus, if Tirz continues to do its job for you in general, deciding against switching too soon is entirely logical. That was precisely what I intended as well, until my body chose to throw this theatrical tantrum.

Just so you're aware, it's possible to quote multiple posts and answer each one on its own.

 

[Mara_aa]

desinr-gal said:

Mara_aa said:

desinr-gal said:

Antivirals aren't exactly a walk in the park either... which one did you begin with first?

The reaction and symptoms from Tirz were clearly the first thing to appear. A few days afterward, the antivirals were begun due to what was suspected to be shingles/herpes zoster.

And you're right that antivirals can be harsh too, which, honestly, only makes this whole situation harder to sort out

That sounds terrible! I'm sorry this is happening to you.

I really appreciate it

Things are getting better bit by bit, so I’m holding onto hope!

 

[Mara_aa]

BNLFL said:

Mara_aa said:

DragonOfTheSea said:

Mara_aa said:

CandyCap said:

That prickling, sore skin reaction can occur with either Tirz or Reta.....though it appears to show up more often with Reta. It sounds a lot like a Reta overdose. Are you certain it is the same vial and the same dosing etc? Nothing else new has been introduced?

Yes, I’m certain: the vial is the same, the concentration is the same, my dosing routine is the same, and I’m confident no dosing error occurred.

No Reta and no other new peptide has been introduced. There’s nothing new in the mix at all, apart from the antivirals, and those only began once the skin symptoms had already shown up, since my doctor suspected shingles/herpes zoster.

I did already know that Reta can bring on the “needle skin” sensation, but I hadn’t heard of it with Tirz. Now I’m beginning to question whether that was Tirz as well. What’s odd is that it showed up only on my left side, which is exactly why shingles/herpes zoster was suspected from the start, given that it wasn’t bilateral.

A fairly nasty cold and a stretch of heavy stress were definitely part of the picture, yet the reaction still came across as wildly out of proportion.

So that’s why I’m left so puzzled: it genuinely resembled an overdose, but I can’t come up with any real-world reason why one would have happened.

That "allodynia" feeling—like needles or sunburn—doesn't have to show up on both sides to be caused by Tirz (or Reta). I've had it with both peptides, and it pops up wherever it feels like it: ankles, tops of the feet, upper thighs, glutes, back, stomach, and even my cheek/face (right side only). Before blaming shingles, I'd pin it (pun intended) on the Tirz.

… because I didn't know any better, the only “needles/allodynia/sunburn skin” reports I'd come across were tied to Reta, never Tirz. So once it showed up on just 1 side, I fully bought into the shingles/herpes zoster theory.

“I would pin it on the Tirz” — that line deserves an award lol

On a serious note, thank you so much Tomorrow morning I'm definitely bringing this up with my doctor… though I doubt I'll be thanking him for the 7 days of antivirals that might have knocked me down even harder.

Mara_aa said:

MsGizmo said:

Mara_aa said:

After 5 weeks at 3 mg, it all landed on me in one go, as though I'd injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math errors on my part.

My stomach more or less factory-reset itself. Nausea hit me like nothing I've ever been through, along with extreme weakness and a general sense that everything was doomed.

Over the last 10 days I've hardly managed to stand up straight. Even small movements leave me short of breath and tachycardic, as if every trip to the kitchen were Olympic training. Blood sugar on the low side (not dangerously so), blood pressure low as well.

And to make it stranger still, I came down with a monster cold at the same time and ended up on antivirals for suspected shingles/herpes zoster, thanks to this awful “needles in the skin” sensation I had.

Except… there was no rash. No blisters. Nothing. So it seems even my maybe-shingles wanted to stay mysterious and dramatic.

The doctor essentially shrugged and told me to skip last Thursday's dose. Bloodwork comes back May 20th.

Today Shotsy puts my level at 1.48 mg and I'm marginally better, which means I've graduated from “barely functioning houseplant” to “weak but technically alive.” I still hardly eat or drink, mind you.

What worries me now is that I somehow turned suddenly and permanently intolerant to Tirz overnight. I can't really find stories like this anywhere, so I'm asking: has anyone had a sudden hypersensitivity or reaction like this after tolerating the dose perfectly well before? Any theories, experiences or reassuring stories are welcome.

For context: Tirz has always been a real struggle for me, and I came close to quitting outright. Then you guys pointed me at microdosing, and that made everything much easier to handle.

Even so, it has never been an “easy” medication in my case — but the results justified putting up with a bit of suffering.

What makes us think tirz is the culprit here, rather than the virus?

What keeps making me think Tirz is the culprit: alongside the crushing fatigue, the symptoms are extremely particular — intense nausea, acid reflux, profound gastric stalling and fullness, and being unable to eat or drink in a normal way.

These line up almost exactly with what hit me when I began Tirz in the first place — only now they've been dialed up to an extreme degree

Mara_aa said:

WLBLD said:

Mara_aa said:

WLBLD said:

I realize you said it isn't a fresh vial, but could it have accumulated in your body by now? Is this a new kit from another supplier you've never tried? I've come across reports of people experiencing sides with certain ones but not others.

To be honest, right now the idea that it built up or accumulated over time seems like the most plausible explanation to me, particularly when you factor in stress and illness happening at the same time.

And to be clear, I hadn't switched to a different vendor or a different batch. It was the exact same source I'd been using and handling fine before this all started.

What confused me the most was how abrupt and out of proportion this reaction was next to the Tirz side effects I normally get.

It could also be related to the antiviral combination. I hope you start feeling better soon!!

Yeah, I think it's possible the antivirals piled on and amplified what was already going on lol

Thanks a ton I'm really hoping this nightmare begins to lift before long as well

Mara_aa said:

Ascojoerg said:

Mara_aa said:

Ascojoerg said:

Yes — I went through this myself last summer while using standard prescription Mounjaro. Right after the injection, out of nowhere, I got hit with nausea worse than anything I'd had before, plus severe diarrhea. Staying hydrated was a real fight because of the nausea, and eating was completely off the table for an entire week. My dose at the time was higher (7,5mg), but I'd already been sitting at 7,5mg for 5 weeks, and it was the very same pen I'd used during the 2 weeks before that.

The reassuring part (based only on my own experience) is that it doesn't stick around forever. I quit abruptly because I was terrified of a repeat, and stayed off for roughly 4 months. Eventually curiosity about grey got the better of me, so I restarted at a low dose (Tirz 2,5mg) purely for maintenance and to quiet food noise. Once I'd been on that low dose for a while, I chose to go up again, since I'd never reached my goal weight and was still obese. Since then, by titrating up gradually, I've dropped another 5kg.

Reading your response has genuinely helped calm me down, so thank you for taking the time to write it.

The part that rattled me most is that nothing changed beforehand — same dose for weeks, then out of nowhere this reaction.

From what you describe, our situations line up closely, though my symptoms leaned more toward nausea and feeling weak rather than diarrhea. That bit about struggling to keep fluids down? That has been my exact reality.

Hearing that it eventually resolved for you means a lot. My head keeps spiraling right now, telling me my body has written off Tirz permanently as something toxic…

I'm on day 12 as of today and things have only eased slightly, so injecting again is completely off the table for me at this point

Did you ever think about switching over to Reta? Honestly, the thought of returning to how loud the food noise used to be long term is something I can't picture.

It's great that you were able to start up again without issues and keep losing by going back up on the dose gradually.

Yes I have, and honestly the only thing stopping me is that I'd already bought several kits of Tirz. Once those are gone, or if I can't reach my goal weight, I'll likely revisit the idea.

To be honest, that's a completely reasonable justification lol

Plus, if Tirz continues to do its job for you in general, deciding against switching too soon is entirely logical. That was precisely what I intended as well, until my body chose to throw this theatrical tantrum.

Just so you're aware, it's possible to quote multiple posts and answer each one on its own.

I should admit that the feature isn’t unfamiliar to me—I’ve watched others use it. But when I’m on my phone, every attempt turns into a mess, and then I can no longer locate all the quotes I meant to respond to.

On a PC, that issue doesn’t really happen for me, though I hardly touch it once work hours are over.

I hope responding to each post separately doesn’t come across as annoying.

Even so, thanks for teaching me.

 

[BNLFL]

Mara_aa said:

BNLFL said:

Mara_aa said:

DragonOfTheSea said:

Mara_aa said:

CandyCap said:

That prickling, sore skin reaction can occur with either Tirz or Reta.....though it appears to show up more often with Reta. It sounds a lot like a Reta overdose. Are you certain it is the same vial and the same dosing etc? Nothing else new has been introduced?

Yes, I’m certain: the vial is the same, the concentration is the same, my dosing routine is the same, and I’m confident no dosing error occurred.

No Reta and no other new peptide has been introduced. There’s nothing new in the mix at all, apart from the antivirals, and those only began once the skin symptoms had already shown up, since my doctor suspected shingles/herpes zoster.

I did already know that Reta can bring on the “needle skin” sensation, but I hadn’t heard of it with Tirz. Now I’m beginning to question whether that was Tirz as well. What’s odd is that it showed up only on my left side, which is exactly why shingles/herpes zoster was suspected from the start, given that it wasn’t bilateral.

A fairly nasty cold and a stretch of heavy stress were definitely part of the picture, yet the reaction still came across as wildly out of proportion.

So that’s why I’m left so puzzled: it genuinely resembled an overdose, but I can’t come up with any real-world reason why one would have happened.

That "allodynia" feeling—like needles or sunburn—doesn't have to show up on both sides to be caused by Tirz (or Reta). I've had it with both peptides, and it pops up wherever it feels like it: ankles, tops of the feet, upper thighs, glutes, back, stomach, and even my cheek/face (right side only). Before blaming shingles, I'd pin it (pun intended) on the Tirz.

… because I didn't know any better, the only “needles/allodynia/sunburn skin” reports I'd come across were tied to Reta, never Tirz. So once it showed up on just 1 side, I fully bought into the shingles/herpes zoster theory.

“I would pin it on the Tirz” — that line deserves an award lol

On a serious note, thank you so much Tomorrow morning I'm definitely bringing this up with my doctor… though I doubt I'll be thanking him for the 7 days of antivirals that might have knocked me down even harder.

Mara_aa said:

MsGizmo said:

Mara_aa said:

After 5 weeks at 3 mg, it all landed on me in one go, as though I'd injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math errors on my part.

My stomach more or less factory-reset itself. Nausea hit me like nothing I've ever been through, along with extreme weakness and a general sense that everything was doomed.

Over the last 10 days I've hardly managed to stand up straight. Even small movements leave me short of breath and tachycardic, as if every trip to the kitchen were Olympic training. Blood sugar on the low side (not dangerously so), blood pressure low as well.

And to make it stranger still, I came down with a monster cold at the same time and ended up on antivirals for suspected shingles/herpes zoster, thanks to this awful “needles in the skin” sensation I had.

Except… there was no rash. No blisters. Nothing. So it seems even my maybe-shingles wanted to stay mysterious and dramatic.

The doctor essentially shrugged and told me to skip last Thursday's dose. Bloodwork comes back May 20th.

Today Shotsy puts my level at 1.48 mg and I'm marginally better, which means I've graduated from “barely functioning houseplant” to “weak but technically alive.” I still hardly eat or drink, mind you.

What worries me now is that I somehow turned suddenly and permanently intolerant to Tirz overnight. I can't really find stories like this anywhere, so I'm asking: has anyone had a sudden hypersensitivity or reaction like this after tolerating the dose perfectly well before? Any theories, experiences or reassuring stories are welcome.

For context: Tirz has always been a real struggle for me, and I came close to quitting outright. Then you guys pointed me at microdosing, and that made everything much easier to handle.

Even so, it has never been an “easy” medication in my case — but the results justified putting up with a bit of suffering.

What makes us think tirz is the culprit here, rather than the virus?

What keeps making me think Tirz is the culprit: alongside the crushing fatigue, the symptoms are extremely particular — intense nausea, acid reflux, profound gastric stalling and fullness, and being unable to eat or drink in a normal way.

These line up almost exactly with what hit me when I began Tirz in the first place — only now they've been dialed up to an extreme degree

Mara_aa said:

WLBLD said:

Mara_aa said:

WLBLD said:

I realize you said it isn't a fresh vial, but could it have accumulated in your body by now? Is this a new kit from another supplier you've never tried? I've come across reports of people experiencing sides with certain ones but not others.

To be honest, right now the idea that it built up or accumulated over time seems like the most plausible explanation to me, particularly when you factor in stress and illness happening at the same time.

And to be clear, I hadn't switched to a different vendor or a different batch. It was the exact same source I'd been using and handling fine before this all started.

What confused me the most was how abrupt and out of proportion this reaction was next to the Tirz side effects I normally get.

It could also be related to the antiviral combination. I hope you start feeling better soon!!

Yeah, I think it's possible the antivirals piled on and amplified what was already going on lol

Thanks a ton I'm really hoping this nightmare begins to lift before long as well

Mara_aa said:

Ascojoerg said:

Mara_aa said:

Ascojoerg said:

Yes — I went through this myself last summer while using standard prescription Mounjaro. Right after the injection, out of nowhere, I got hit with nausea worse than anything I'd had before, plus severe diarrhea. Staying hydrated was a real fight because of the nausea, and eating was completely off the table for an entire week. My dose at the time was higher (7,5mg), but I'd already been sitting at 7,5mg for 5 weeks, and it was the very same pen I'd used during the 2 weeks before that.

The reassuring part (based only on my own experience) is that it doesn't stick around forever. I quit abruptly because I was terrified of a repeat, and stayed off for roughly 4 months. Eventually curiosity about grey got the better of me, so I restarted at a low dose (Tirz 2,5mg) purely for maintenance and to quiet food noise. Once I'd been on that low dose for a while, I chose to go up again, since I'd never reached my goal weight and was still obese. Since then, by titrating up gradually, I've dropped another 5kg.

Reading your response has genuinely helped calm me down, so thank you for taking the time to write it.

The part that rattled me most is that nothing changed beforehand — same dose for weeks, then out of nowhere this reaction.

From what you describe, our situations line up closely, though my symptoms leaned more toward nausea and feeling weak rather than diarrhea. That bit about struggling to keep fluids down? That has been my exact reality.

Hearing that it eventually resolved for you means a lot. My head keeps spiraling right now, telling me my body has written off Tirz permanently as something toxic…

I'm on day 12 as of today and things have only eased slightly, so injecting again is completely off the table for me at this point

Did you ever think about switching over to Reta? Honestly, the thought of returning to how loud the food noise used to be long term is something I can't picture.

It's great that you were able to start up again without issues and keep losing by going back up on the dose gradually.

Yes I have, and honestly the only thing stopping me is that I'd already bought several kits of Tirz. Once those are gone, or if I can't reach my goal weight, I'll likely revisit the idea.

To be honest, that's a completely reasonable justification lol

Plus, if Tirz continues to do its job for you in general, deciding against switching too soon is entirely logical. That was precisely what I intended as well, until my body chose to throw this theatrical tantrum.

Just so you're aware, it's possible to quote multiple posts and answer each one on its own.

I should admit that the feature isn’t unfamiliar to me—I’ve watched others use it. But when I’m on my phone, every attempt turns into a mess, and then I can no longer locate all the quotes I meant to respond to.

On a PC, that issue doesn’t really happen for me, though I hardly touch it once work hours are over.

I hope responding to each post separately doesn’t come across as annoying.

Even so, thanks for teaching me.

No, I just didn't know if you were aware.

 

[Mara_aa]

BNLFL said:

Mara_aa said:

BNLFL said:

Mara_aa said:

DragonOfTheSea said:

Mara_aa said:

CandyCap said:

That prickling, sore skin reaction can occur with either Tirz or Reta.....though it appears to show up more often with Reta. It sounds a lot like a Reta overdose. Are you certain it is the same vial and the same dosing etc? Nothing else new has been introduced?

Yes, I’m certain: the vial is the same, the concentration is the same, my dosing routine is the same, and I’m confident no dosing error occurred.

No Reta and no other new peptide has been introduced. There’s nothing new in the mix at all, apart from the antivirals, and those only began once the skin symptoms had already shown up, since my doctor suspected shingles/herpes zoster.

I did already know that Reta can bring on the “needle skin” sensation, but I hadn’t heard of it with Tirz. Now I’m beginning to question whether that was Tirz as well. What’s odd is that it showed up only on my left side, which is exactly why shingles/herpes zoster was suspected from the start, given that it wasn’t bilateral.

A fairly nasty cold and a stretch of heavy stress were definitely part of the picture, yet the reaction still came across as wildly out of proportion.

So that’s why I’m left so puzzled: it genuinely resembled an overdose, but I can’t come up with any real-world reason why one would have happened.

That "allodynia" feeling—like needles or sunburn—doesn't have to show up on both sides to be caused by Tirz (or Reta). I've had it with both peptides, and it pops up wherever it feels like it: ankles, tops of the feet, upper thighs, glutes, back, stomach, and even my cheek/face (right side only). Before blaming shingles, I'd pin it (pun intended) on the Tirz.

… because I didn't know any better, the only “needles/allodynia/sunburn skin” reports I'd come across were tied to Reta, never Tirz. So once it showed up on just 1 side, I fully bought into the shingles/herpes zoster theory.

“I would pin it on the Tirz” — that line deserves an award lol

On a serious note, thank you so much Tomorrow morning I'm definitely bringing this up with my doctor… though I doubt I'll be thanking him for the 7 days of antivirals that might have knocked me down even harder.

Mara_aa said:

MsGizmo said:

Mara_aa said:

After 5 weeks at 3 mg, it all landed on me in one go, as though I'd injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math errors on my part.

My stomach more or less factory-reset itself. Nausea hit me like nothing I've ever been through, along with extreme weakness and a general sense that everything was doomed.

Over the last 10 days I've hardly managed to stand up straight. Even small movements leave me short of breath and tachycardic, as if every trip to the kitchen were Olympic training. Blood sugar on the low side (not dangerously so), blood pressure low as well.

And to make it stranger still, I came down with a monster cold at the same time and ended up on antivirals for suspected shingles/herpes zoster, thanks to this awful “needles in the skin” sensation I had.

Except… there was no rash. No blisters. Nothing. So it seems even my maybe-shingles wanted to stay mysterious and dramatic.

The doctor essentially shrugged and told me to skip last Thursday's dose. Bloodwork comes back May 20th.

Today Shotsy puts my level at 1.48 mg and I'm marginally better, which means I've graduated from “barely functioning houseplant” to “weak but technically alive.” I still hardly eat or drink, mind you.

What worries me now is that I somehow turned suddenly and permanently intolerant to Tirz overnight. I can't really find stories like this anywhere, so I'm asking: has anyone had a sudden hypersensitivity or reaction like this after tolerating the dose perfectly well before? Any theories, experiences or reassuring stories are welcome.

For context: Tirz has always been a real struggle for me, and I came close to quitting outright. Then you guys pointed me at microdosing, and that made everything much easier to handle.

Even so, it has never been an “easy” medication in my case — but the results justified putting up with a bit of suffering.

What makes us think tirz is the culprit here, rather than the virus?

What keeps making me think Tirz is the culprit: alongside the crushing fatigue, the symptoms are extremely particular — intense nausea, acid reflux, profound gastric stalling and fullness, and being unable to eat or drink in a normal way.

These line up almost exactly with what hit me when I began Tirz in the first place — only now they've been dialed up to an extreme degree

Mara_aa said:

WLBLD said:

Mara_aa said:

WLBLD said:

I realize you said it isn't a fresh vial, but could it have accumulated in your body by now? Is this a new kit from another supplier you've never tried? I've come across reports of people experiencing sides with certain ones but not others.

To be honest, right now the idea that it built up or accumulated over time seems like the most plausible explanation to me, particularly when you factor in stress and illness happening at the same time.

And to be clear, I hadn't switched to a different vendor or a different batch. It was the exact same source I'd been using and handling fine before this all started.

What confused me the most was how abrupt and out of proportion this reaction was next to the Tirz side effects I normally get.

It could also be related to the antiviral combination. I hope you start feeling better soon!!

Yeah, I think it's possible the antivirals piled on and amplified what was already going on lol

Thanks a ton I'm really hoping this nightmare begins to lift before long as well

Mara_aa said:

Ascojoerg said:

Mara_aa said:

Ascojoerg said:

Yes — I went through this myself last summer while using standard prescription Mounjaro. Right after the injection, out of nowhere, I got hit with nausea worse than anything I'd had before, plus severe diarrhea. Staying hydrated was a real fight because of the nausea, and eating was completely off the table for an entire week. My dose at the time was higher (7,5mg), but I'd already been sitting at 7,5mg for 5 weeks, and it was the very same pen I'd used during the 2 weeks before that.

The reassuring part (based only on my own experience) is that it doesn't stick around forever. I quit abruptly because I was terrified of a repeat, and stayed off for roughly 4 months. Eventually curiosity about grey got the better of me, so I restarted at a low dose (Tirz 2,5mg) purely for maintenance and to quiet food noise. Once I'd been on that low dose for a while, I chose to go up again, since I'd never reached my goal weight and was still obese. Since then, by titrating up gradually, I've dropped another 5kg.

Reading your response has genuinely helped calm me down, so thank you for taking the time to write it.

The part that rattled me most is that nothing changed beforehand — same dose for weeks, then out of nowhere this reaction.

From what you describe, our situations line up closely, though my symptoms leaned more toward nausea and feeling weak rather than diarrhea. That bit about struggling to keep fluids down? That has been my exact reality.

Hearing that it eventually resolved for you means a lot. My head keeps spiraling right now, telling me my body has written off Tirz permanently as something toxic…

I'm on day 12 as of today and things have only eased slightly, so injecting again is completely off the table for me at this point

Did you ever think about switching over to Reta? Honestly, the thought of returning to how loud the food noise used to be long term is something I can't picture.

It's great that you were able to start up again without issues and keep losing by going back up on the dose gradually.

Yes I have, and honestly the only thing stopping me is that I'd already bought several kits of Tirz. Once those are gone, or if I can't reach my goal weight, I'll likely revisit the idea.

To be honest, that's a completely reasonable justification lol

Plus, if Tirz continues to do its job for you in general, deciding against switching too soon is entirely logical. That was precisely what I intended as well, until my body chose to throw this theatrical tantrum.

Just so you're aware, it's possible to quote multiple posts and answer each one on its own.

I should admit that the feature isn’t unfamiliar to me—I’ve watched others use it. But when I’m on my phone, every attempt turns into a mess, and then I can no longer locate all the quotes I meant to respond to.

On a PC, that issue doesn’t really happen for me, though I hardly touch it once work hours are over.

I hope responding to each post separately doesn’t come across as annoying.

Even so, thanks for teaching me.

No, I just didn't know if you were aware.

Understood! The main thing is that I'm not getting on anyone's nerves, haha

Either way, thank you for being patient and for explaining things. I'm genuinely grateful.

 

[lessthanhalf]

Tirz gives me skin sensitivity and odd sensations too. It started back when I was titrating up, and these days, since I'm stacking tirz with reta, even a minuscule bump in either reta or tirz makes it noticeably worse.

What's strange is how spotty it is. My left shoulder tends to take the brunt, sometimes both arms, and every so often a nerve in my leg gets zapped. Fortunately it stays fairly gentle unless I slip and take a bit too much.

I've dug around trying to find answers and honestly there's barely anything out there, aside from it showing up as a side effect in a handful of studies. What stands out is that reta seems to trigger it more often, and it was uncommon in the semaglutide trials, yet in the high dose semaglutide trials at 7.2 and 16 mg it turned up frequently, as high as 20%. Since sema only acts on GLP-1, that pretty much forces the conclusion that it's a GLP-1 driven effect, which leaves the reta pattern completely unexplained. I ran this by chatgpt, and it doesn't appear to believe there's any risk of real long term nerve damage from it, and to my knowledge nobody has reported nerve damage from GLP drugs, which I suppose is somewhat comforting.

As for why your side effects abruptly ramped up so much, there's no clear pharmacological answer. One possibility is that some of them got aggravated by a concurrent virus. The only real move is to hold off on dosing until things calm down substantially, then restart considerably lower, and splitting the dose in half while taking it twice as frequently will make it simpler to nudge doses up or down when necessary.

 

[sheilarae74]

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

 

[Mara_aa]

lessthanhalf said:

Tirz gives me skin sensitivity and odd sensations too. It started back when I was titrating up, and these days, since I'm stacking tirz with reta, even a minuscule bump in either reta or tirz makes it noticeably worse.

What's strange is how spotty it is. My left shoulder tends to take the brunt, sometimes both arms, and every so often a nerve in my leg gets zapped. Fortunately it stays fairly gentle unless I slip and take a bit too much.

I've dug around trying to find answers and honestly there's barely anything out there, aside from it showing up as a side effect in a handful of studies. What stands out is that reta seems to trigger it more often, and it was uncommon in the semaglutide trials, yet in the high dose semaglutide trials at 7.2 and 16 mg it turned up frequently, as high as 20%. Since sema only acts on GLP-1, that pretty much forces the conclusion that it's a GLP-1 driven effect, which leaves the reta pattern completely unexplained. I ran this by chatgpt, and it doesn't appear to believe there's any risk of real long term nerve damage from it, and to my knowledge nobody has reported nerve damage from GLP drugs, which I suppose is somewhat comforting.

As for why your side effects abruptly ramped up so much, there's no clear pharmacological answer. One possibility is that some of them got aggravated by a concurrent virus. The only real move is to hold off on dosing until things calm down substantially, then restart considerably lower, and splitting the dose in half while taking it twice as frequently will make it simpler to nudge doses up or down when necessary.

I really appreciate you putting together such a thorough answer — it genuinely helped and made me feel calmer about all this.

Your description of skin sensitivity showing up in random patches and getting noticeably worse as the dose goes up lines up almost exactly with what multiple people in this thread have been reporting, and I honestly never realized this particular side effect could feel this “real” while remaining so poorly understood.

It’s also fascinating that you went through the studies and found it shows up even on high-dose semaglutide. Of course, none of us can pin down the actual mechanism, but it does make me feel a little less like I’m going crazy

A special thank you as well for bringing up the absence of evidence around long-term nerve damage. I’m aware ChatGPT isn’t a medical authority, but learning that there don’t appear to be reports of permanent nerve injury from GLP drugs still gives real psychological relief when your skin suddenly starts acting strange.

Your point about a virus possibly magnifying GLP side effects that were already there also rings very true to me. Maybe my body simply crossed some temporary “too much at once” line.

For the time being I’m absolutely not taking another dose until things settle down a lot. And if I do ever start again, I suspect smaller, more frequent split doses would be the safest route for me as well.

Truly, thank you once more for such a considered and even-handed reply

 

[Mara_aa]

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

That sense of having to push yourself just to get through the day like an ordinary person has ranked among the most frightening parts for me as well. It’s a weird sort of unwellness, since it goes far past what you’d call standard nausea or tiredness.

What you suggested about the vial holds up well, particularly when you factor in the idea of buildup. If a vial were a bit stronger than labeled and the effects kept accumulating later on, that would fit why it hit so hard all at once after you’d been fine with it before.

Knowing you’re already doing noticeably better today makes me hopeful, since I’m on the mend too… only at an annoyingly slow pace haha

To me, your plan to split the dose comes across as sensible and careful. Let me know how it turns out, because at this point syringes feel like they’ve personally wronged me and I could use some good outcomes…

And congrats on being just 12 lbs away from your goal — honestly, easing along carefully at that stage seems like the smart move.

 

[sheilarae74]

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

That sense of having to push yourself just to get through the day like an ordinary person has ranked among the most frightening parts for me as well. It’s a weird sort of unwellness, since it goes far past what you’d call standard nausea or tiredness.

What you suggested about the vial holds up well, particularly when you factor in the idea of buildup. If a vial were a bit stronger than labeled and the effects kept accumulating later on, that would fit why it hit so hard all at once after you’d been fine with it before.

Knowing you’re already doing noticeably better today makes me hopeful, since I’m on the mend too… only at an annoyingly slow pace haha

To me, your plan to split the dose comes across as sensible and careful. Let me know how it turns out, because at this point syringes feel like they’ve personally wronged me and I could use some good outcomes…

And congrats on being just 12 lbs away from your goal — honestly, easing along carefully at that stage seems like the smart move.

Last night I injected 2mg, and so far no issues. For the time being, I'll stick to that amount every 3.5 days and monitor what happens.

 

[chipsandsalsayall]

Yep, that exact thing hit me once. I'd spent roughly 6 months on Zepbound before switching over to a compounded version (not gr*y). Somewhere around 2 months into the compounded stuff — 7.5 mg, if I'm remembering right — I got slammed with horrible nausea, diarrhea, plus every kind of stomach noise and burping you can imagine. And I mean horrible. I hadn't eaten anything heavy or oily. Nothing had changed. Then roughly 2 - 3 days later it faded out and hasn't come back since. I came close to seeing a doctor, but I'm stubborn. It never repeated. Strange.

 

[lessthanhalf]

Feeling unwell or having what seems like a sickness reaction is something GLP-1 drugs can cause, and it frequently comes alongside queasiness and/or an aversion to food. The whole point is to make you stay down, rest, and recuperate, while feeling awful enough that you don't want to get up and do anything. On ozempic, I absolutely experienced every one of those, including at low doses. The brain pathways handling that sick feeling and queasiness are connected, and they switch on in response to illness, poisons, or GLP-1 activity. Fortunately, that unwell side effect doesn't appear to happen very often, and it clearly scales with dose. In tirz and reta, the GIP agonism works in the opposite direction, which reduces how much of a problem it becomes.

 

[lil ghost]

Mara_aa said:

After 5 weeks at 3 mg, it all landed on me in one go, as though I'd injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math errors on my part.

My stomach more or less factory-reset itself. Nausea hit me like nothing I've ever been through, along with extreme weakness and a general sense that everything was doomed.

Over the last 10 days I've hardly managed to stand up straight. Even small movements leave me short of breath and tachycardic, as if every trip to the kitchen were Olympic training. Blood sugar on the low side (not dangerously so), blood pressure low as well.

And to make it stranger still, I came down with a monster cold at the same time and ended up on antivirals for suspected shingles/herpes zoster, thanks to this awful “needles in the skin” sensation I had.

Except… there was no rash. No blisters. Nothing. So it seems even my maybe-shingles wanted to stay mysterious and dramatic.

The doctor essentially shrugged and told me to skip last Thursday's dose. Bloodwork comes back May 20th.

Today Shotsy puts my level at 1.48 mg and I'm marginally better, which means I've graduated from “barely functioning houseplant” to “weak but technically alive.” I still hardly eat or drink, mind you.

What worries me now is that I somehow turned suddenly and permanently intolerant to Tirz overnight. I can't really find stories like this anywhere, so I'm asking: has anyone had a sudden hypersensitivity or reaction like this after tolerating the dose perfectly well before? Any theories, experiences or reassuring stories are welcome.

For context: Tirz has always been a real struggle for me, and I came close to quitting outright. Then you guys pointed me at microdosing, and that made everything much easier to handle.

Even so, it has never been an “easy” medication in my case — but the results justified putting up with a bit of suffering.

I went through this too! I injected my usual 2.5 mg of tirz on Friday, and by Saturday morning I had intense nausea and couldn't get any food or fluids down. After attempting to eat on Sunday, I threw up, and ever since then I've felt weak, shaky, and completely exhausted. There's no question I'm not taking my next dose, and when I do start again, it'll be at a lower amount.

 

[Mara_aa]

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

That sense of having to push yourself just to get through the day like an ordinary person has ranked among the most frightening parts for me as well. It’s a weird sort of unwellness, since it goes far past what you’d call standard nausea or tiredness.

What you suggested about the vial holds up well, particularly when you factor in the idea of buildup. If a vial were a bit stronger than labeled and the effects kept accumulating later on, that would fit why it hit so hard all at once after you’d been fine with it before.

Knowing you’re already doing noticeably better today makes me hopeful, since I’m on the mend too… only at an annoyingly slow pace haha

To me, your plan to split the dose comes across as sensible and careful. Let me know how it turns out, because at this point syringes feel like they’ve personally wronged me and I could use some good outcomes…

And congrats on being just 12 lbs away from your goal — honestly, easing along carefully at that stage seems like the smart move.

Last night I injected 2mg, and so far no issues. For the time being, I'll stick to that amount every 3.5 days and monitor what happens.

If you're able, please keep sharing updates — I've gotten way too invested in your nervous system now lol

 

[Mara_aa]

chipsandsalsayall said:

Yep, that exact thing hit me once. I'd spent roughly 6 months on Zepbound before switching over to a compounded version (not gr*y). Somewhere around 2 months into the compounded stuff — 7.5 mg, if I'm remembering right — I got slammed with horrible nausea, diarrhea, plus every kind of stomach noise and burping you can imagine. And I mean horrible. I hadn't eaten anything heavy or oily. Nothing had changed. Then roughly 2 - 3 days later it faded out and hasn't come back since. I came close to seeing a doctor, but I'm stubborn. It never repeated. Strange.

Reading that it never came back after that is a huge relief for me at this moment.

The way you put it matches this odd pattern a number of folks in this thread have described — getting slammed out of nowhere after months of steady sailing.

Fingers crossed that what I'm dealing with is also nothing more than short-lived GLP turbulence

 

[sheilarae74]

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

That sense of having to push yourself just to get through the day like an ordinary person has ranked among the most frightening parts for me as well. It’s a weird sort of unwellness, since it goes far past what you’d call standard nausea or tiredness.

What you suggested about the vial holds up well, particularly when you factor in the idea of buildup. If a vial were a bit stronger than labeled and the effects kept accumulating later on, that would fit why it hit so hard all at once after you’d been fine with it before.

Knowing you’re already doing noticeably better today makes me hopeful, since I’m on the mend too… only at an annoyingly slow pace haha

To me, your plan to split the dose comes across as sensible and careful. Let me know how it turns out, because at this point syringes feel like they’ve personally wronged me and I could use some good outcomes…

And congrats on being just 12 lbs away from your goal — honestly, easing along carefully at that stage seems like the smart move.

Last night I injected 2mg, and so far no issues. For the time being, I'll stick to that amount every 3.5 days and monitor what happens.

If you're able, please keep sharing updates — I've gotten way too invested in your nervous system now lol

Next week I'll do it, I give you my word.

 

[sheilarae74]

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

That sense of having to push yourself just to get through the day like an ordinary person has ranked among the most frightening parts for me as well. It’s a weird sort of unwellness, since it goes far past what you’d call standard nausea or tiredness.

What you suggested about the vial holds up well, particularly when you factor in the idea of buildup. If a vial were a bit stronger than labeled and the effects kept accumulating later on, that would fit why it hit so hard all at once after you’d been fine with it before.

Knowing you’re already doing noticeably better today makes me hopeful, since I’m on the mend too… only at an annoyingly slow pace haha

To me, your plan to split the dose comes across as sensible and careful. Let me know how it turns out, because at this point syringes feel like they’ve personally wronged me and I could use some good outcomes…

And congrats on being just 12 lbs away from your goal — honestly, easing along carefully at that stage seems like the smart move.

Last night I injected 2mg, and so far no issues. For the time being, I'll stick to that amount every 3.5 days and monitor what happens.

If you're able, please keep sharing updates — I've gotten way too invested in your nervous system now lol

Since then I've settled into a routine of 2.5mg taken every 3.5 days, and the results have been really good. Nausea only shows up for me when I let my hydration slip, and as long as I get enough protein I never crash with extreme tiredness. On top of that, I started taking Nicotinamide Riboside and methylene blue as part of my supplements, and my energy has improved noticeably. Each weekend I've managed to get a fair amount done around the house, which makes me feel like splitting the dose into 2x weekly was the correct call.

 

[Mara_aa]

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

THIS IS EXACTLY HOW I FELT! For the past 10 days, I had to push myself through everything.

Mara_aa said:

sheilarae74 said:

For the last 10 days I've been dealing with the same situation, only with reta. My dose went up to 5mg 2 weeks back, and within a few days nausea set in and I've had zero motivation to do anything all week. Malaise, I think that's the term. Eating has become something I have to make myself do. Across all 17 weeks of using it, I've never experienced anything like this. At first I assumed it was dehydration, since that's normally how dehydration hits me, so I pushed my fluid intake way up. I went heavy on hydration drinks and took in so much salt that my hands are now puffy. Since last week I've dropped every supplement except magnesium and potassium, and this weekend I even cut out the GHK-cu, yet I still feel awful.

A month ago I began a new kit, and during the first 2 weeks it seemed to do almost nothing, which is exactly why I raised my dose in the first place.

Today I'm feeling a little bit better, but my plan once this passes is to divide the dose and do 2.5mg every 3.5 days to find out whether that makes a difference.

Honestly, what you're describing lines up almost exactly with my own situation — particularly how it crept in late and left me thinking "what on earth is my body doing right now."

The whole malaise and apathy thing hits home hard for me as well. Nausea alone doesn't cover it; there's this bizarre whole-body sense that I'm barely able to get through basic human tasks.

At the start I figured dehydration and electrolytes were probably the culprit, so I went hard on fluids, yet that still couldn't account for how bad things got.

Your point about going up because earlier weeks seemed "too mild" is fascinating as well. It genuinely has me questioning if these peptides can produce some sort of lagging buildup or saturation effect.

If I do start again, maybe I'd try splitting my microdose right from the beginning.

And also: I kind of adore you for describing such a close match to what I've been through, and I truly respect that you got through this without missing a single dose, since at this point I'm so rattled I can't even bring myself to glance at a syringe.

The accumulation theory could be onto something. My last 5mg dose, taken last sunday, came from a fresh vial, since the previous one didn't even make it to 4 weeks. I suspect this new vial might contain more than the 20mg it was supposed to. Also, this time I set aside some of the BAC to prime the filter and rinse the remaining reta out after filtering. A guy showed me the COA from a vial he tested from that same batch, and it had 22mg. That's the only explanation I can come up with. I was meant to dose last night but decided it was smarter to hold off until I'm feeling well.

Because I feel much better today, I plan to pin 2mg tonight, then another 2mg Friday morning if all goes smoothly.

I don't blame you for being hesitant to start again. I never want to experience that again, and I'm sure you feel the same. I suppose that's the risk we take doing these China peps. I'm 12lbs from my goal and not rushing, so I'll split for a while and see how it goes.

That sense of having to push yourself just to get through the day like an ordinary person has ranked among the most frightening parts for me as well. It’s a weird sort of unwellness, since it goes far past what you’d call standard nausea or tiredness.

What you suggested about the vial holds up well, particularly when you factor in the idea of buildup. If a vial were a bit stronger than labeled and the effects kept accumulating later on, that would fit why it hit so hard all at once after you’d been fine with it before.

Knowing you’re already doing noticeably better today makes me hopeful, since I’m on the mend too… only at an annoyingly slow pace haha

To me, your plan to split the dose comes across as sensible and careful. Let me know how it turns out, because at this point syringes feel like they’ve personally wronged me and I could use some good outcomes…

And congrats on being just 12 lbs away from your goal — honestly, easing along carefully at that stage seems like the smart move.

Last night I injected 2mg, and so far no issues. For the time being, I'll stick to that amount every 3.5 days and monitor what happens.

If you're able, please keep sharing updates — I've gotten way too invested in your nervous system now lol

Since then I've settled into a routine of 2.5mg taken every 3.5 days, and the results have been really good. Nausea only shows up for me when I let my hydration slip, and as long as I get enough protein I never crash with extreme tiredness. On top of that, I started taking Nicotinamide Riboside and methylene blue as part of my supplements, and my energy has improved noticeably. Each weekend I've managed to get a fair amount done around the house, which makes me feel like splitting the dose into 2x weekly was the correct call.

That’s genuinely great news — it sounds like you’ve landed on a routine your body is responding well to.

What you mentioned about Nicotinamide Riboside and methylene blue is also pretty fascinating. When energy and motivation come back, it can ripple into so many areas. Honestly, being able to tackle chores around the house again says a lot about how much your balance is recovering.

On my end, things are still rough. I’ve been off Tirz for 4 weeks now, and overall I can’t say I’ve noticed any big shift — except that hunger is back and the food noise never stops. Which makes me wonder whether Tirz was ever really the thing making me feel so awful.

There are a few tiny upsides that show up now and then, but they come and go… it’s like moving forward one step, then sliding back one. And if I’m being honest, I think I need to go back on Tirz, because dealing with the food noise again has been really hard for me.