Starting tirzepatide, my reta journey, and seeking new options

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bokonon

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I've spent 2 years on a low dose of tirzepatide, and I've just moved to reta. Half of my excess fat is gone. Now I'm thinking about trying other peptides that focus on longevity and getting back on my feet quickly after an upcoming surgery.
 
A number of my friends have used tirz for some time now. I'm hoping to convince them to give the reta I've got a try (a glp isn't something I need, though ipa is what I'm on) -

When you made the change, did any differences in side effects show up? Was the dosing adjusted at all?
 
bokonon said:

I've spent 2 years on a low dose of tirzepatide, and I've just moved to reta. Half of my excess fat is gone. Now I'm thinking about trying other peptides that focus on longevity and getting back on my feet quickly after an upcoming surgery.
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I've been using Reta, and honestly the results have been wild. Dieting is something I can handle, though it's never easy. Food cravings constantly occupy my thoughts. With Reta, that struggle becomes lighter.

After that, I started reading up on other peptides. They look interesting, but nothing compares to Reta.
 
I'm in the same boat as you. Glad to be on this forum, together we can pick up more than we would by ourselves. Welcome!
 
kobeanbry24 said:

OP, it seems the tirz worked well for you. What made you decide to move to reta?
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The results have been positive for me, but both published data on reta and anecdotal reports suggest Reta packs more of a punch. So far it has performed at least as well as the tirz, while causing fewer side effects. For instance, on 5mg of tirz my blood glucose would sometimes drop too low. That hasn't occurred at the same dose of reta.
 
anonpep said:

A number of my friends have used tirz for some time now. I'm hoping to convince them to give the reta I've got a try (a glp isn't something I need, though ipa is what I'm on) -

When you made the change, did any differences in side effects show up? Was the dosing adjusted at all?
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The dosage remains identical: 5mg. From what I can tell, reta comes out ahead, though I haven't been using it long enough to say for sure.
 
Waterheater said:

Are the side effects more severe with tirzepatide? What dose of Reta are you taking at the moment?
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Switched from 5mg tirz to 5mg reta. I also sent the tirz for testing through janoshik (99.80). My reta hasn't been tested—it came in the same shipment. Finnrisk isn't very favorable toward the lab I purchased from, given the scammers who tweak test results for profit.
 
7 months ago, I began tirz (mounjaro) at 2.5 mg via prescription. Back then, I weighed 101 kg. During month 1, I dropped 7 kg, and the doctor increased the dose to 5mg. By the close of month 2, the overall loss reached 12 kg. At that point, the doctor ordered blood work. All results were fine. My pancreas showed no problems, cholestrol was reduced, and she had no concerns about continuing threatment. I stayed on 5mg up until 2 weeks ago. Over 6.5 months, I lost 21 kg in total. No health problems came up. However, at the end of month 5, my musscles felt overly soft. So after gethering enough information, I began low dosis ipamoreline and working out. Progress is good. Yet gradually, hunger noise started coming back. Two weeks ago, I moved to Reta 6 mg. Here's the interesting bit. I noticed no difference from tirz 5mg. After reading how others here experience reta, I chose to reduce the dose to 3mg. Still, nothing shifted. I continue to hear hunger noise just as much as with tirz 5mg or reta 6 mg. But I can ignore it without trouble, and after a while, it fades for a few hours. I'm unsure if it returned due to Ipamoreline or if I've become resitant to tirz and reta. In the last 2 weeks, I lost 1 kg. But I don't count that as weight loss. It's one kg up one day and one down the next. My goal is simply to hold this weight, lower my dose, and if possible, eventually stop. Any suggestions? Would dropping to 1 mg and, if it gets too hard, injecting 1 mg more after a few days, be a wise approach?
 
skaylife said:

7 months ago, I began tirz (mounjaro) at 2.5 mg via prescription. Back then, I weighed 101 kg. During month 1, I dropped 7 kg, and the doctor increased the dose to 5mg. By the close of month 2, the overall loss reached 12 kg. At that point, the doctor ordered blood work. All results were fine. My pancreas showed no problems, cholestrol was reduced, and she had no concerns about continuing threatment. I stayed on 5mg up until 2 weeks ago. Over 6.5 months, I lost 21 kg in total. No health problems came up. However, at the end of month 5, my musscles felt overly soft. So after gethering enough information, I began low dosis ipamoreline and working out. Progress is good. Yet gradually, hunger noise started coming back. Two weeks ago, I moved to Reta 6 mg. Here's the interesting bit. I noticed no difference from tirz 5mg. After reading how others here experience reta, I chose to reduce the dose to 3mg. Still, nothing shifted. I continue to hear hunger noise just as much as with tirz 5mg or reta 6 mg. But I can ignore it without trouble, and after a while, it fades for a few hours. I'm unsure if it returned due to Ipamoreline or if I've become resitant to tirz and reta. In the last 2 weeks, I lost 1 kg. But I don't count that as weight loss. It's one kg up one day and one down the next. My goal is simply to hold this weight, lower my dose, and if possible, eventually stop. Any suggestions? Would dropping to 1 mg and, if it gets too hard, injecting 1 mg more after a few days, be a wise approach?
Click to expand...
There's a belief among some that lifting weights while on GLP-1 is a must. Plus, tracking waist measurements rather than the scale gives a clearer picture of whether you're losing fat or muscle.
 
bokonon said:

skaylife said:

7 months ago, I began tirz (mounjaro) at 2.5 mg via prescription. Back then, I weighed 101 kg. During month 1, I dropped 7 kg, and the doctor increased the dose to 5mg. By the close of month 2, the overall loss reached 12 kg. At that point, the doctor ordered blood work. All results were fine. My pancreas showed no problems, cholestrol was reduced, and she had no concerns about continuing threatment. I stayed on 5mg up until 2 weeks ago. Over 6.5 months, I lost 21 kg in total. No health problems came up. However, at the end of month 5, my musscles felt overly soft. So after gethering enough information, I began low dosis ipamoreline and working out. Progress is good. Yet gradually, hunger noise started coming back. Two weeks ago, I moved to Reta 6 mg. Here's the interesting bit. I noticed no difference from tirz 5mg. After reading how others here experience reta, I chose to reduce the dose to 3mg. Still, nothing shifted. I continue to hear hunger noise just as much as with tirz 5mg or reta 6 mg. But I can ignore it without trouble, and after a while, it fades for a few hours. I'm unsure if it returned due to Ipamoreline or if I've become resitant to tirz and reta. In the last 2 weeks, I lost 1 kg. But I don't count that as weight loss. It's one kg up one day and one down the next. My goal is simply to hold this weight, lower my dose, and if possible, eventually stop. Any suggestions? Would dropping to 1 mg and, if it gets too hard, injecting 1 mg more after a few days, be a wise approach?
Click to expand...
There's a belief among some that lifting weights while on GLP-1 is a must. Plus, tracking waist measurements rather than the scale gives a clearer picture of whether you're losing fat or muscle.
Click to expand...
Friend, allow me to lay out my circumstances more clearly so you can grasp where I stand. To start with, weightlifting is not part of what I do. What I do instead are bodyweight movements — push-ups, crunches, single leg bridges, squats with no added weight. I run a transportation company and I drive a truck myself as well. The job is passive, and I am 58 years old. Muscle loss does concern me, though I have no serious problem with it so far. It simply struck me that doing nothing to head it off ought to be an issue. My appetite has shifted in a positive direction. Previously I ate pastries, chocolate, french fries, snacks, butter croissants and the like. These days sugar no longer appeals to me. In the morning I have a few slices of grainbread with some cheese and a few olives; for dinner, salads with salmon, shrimps, grilled chicken... and steak, fish, chicken... alongside some salade. When hunger shows up between meals, a few nuts are enough to handle it. The only trouble right now is that I cannot tell which choices I need to make in order to hold my body condition where it currently is. I am not very tuned in to my body. In the past it would ask for sugar, snacks, meat or whatever else in a clear voice. Now I can no longer hear what my body is saying. Either the GLP-1 agonists made me deaf or they made my body dumb. I feel better than I ever have. Yet I do not know what to do next to keep it that way
 
skaylife said:

bokonon said:

skaylife said:

7 months ago, I began tirz (mounjaro) at 2.5 mg via prescription. Back then, I weighed 101 kg. During month 1, I dropped 7 kg, and the doctor increased the dose to 5mg. By the close of month 2, the overall loss reached 12 kg. At that point, the doctor ordered blood work. All results were fine. My pancreas showed no problems, cholestrol was reduced, and she had no concerns about continuing threatment. I stayed on 5mg up until 2 weeks ago. Over 6.5 months, I lost 21 kg in total. No health problems came up. However, at the end of month 5, my musscles felt overly soft. So after gethering enough information, I began low dosis ipamoreline and working out. Progress is good. Yet gradually, hunger noise started coming back. Two weeks ago, I moved to Reta 6 mg. Here's the interesting bit. I noticed no difference from tirz 5mg. After reading how others here experience reta, I chose to reduce the dose to 3mg. Still, nothing shifted. I continue to hear hunger noise just as much as with tirz 5mg or reta 6 mg. But I can ignore it without trouble, and after a while, it fades for a few hours. I'm unsure if it returned due to Ipamoreline or if I've become resitant to tirz and reta. In the last 2 weeks, I lost 1 kg. But I don't count that as weight loss. It's one kg up one day and one down the next. My goal is simply to hold this weight, lower my dose, and if possible, eventually stop. Any suggestions? Would dropping to 1 mg and, if it gets too hard, injecting 1 mg more after a few days, be a wise approach?
Click to expand...
There's a belief among some that lifting weights while on GLP-1 is a must. Plus, tracking waist measurements rather than the scale gives a clearer picture of whether you're losing fat or muscle.
Click to expand...
Friend, allow me to lay out my circumstances more clearly so you can grasp where I stand. To start with, weightlifting is not part of what I do. What I do instead are bodyweight movements — push-ups, crunches, single leg bridges, squats with no added weight. I run a transportation company and I drive a truck myself as well. The job is passive, and I am 58 years old. Muscle loss does concern me, though I have no serious problem with it so far. It simply struck me that doing nothing to head it off ought to be an issue. My appetite has shifted in a positive direction. Previously I ate pastries, chocolate, french fries, snacks, butter croissants and the like. These days sugar no longer appeals to me. In the morning I have a few slices of grainbread with some cheese and a few olives; for dinner, salads with salmon, shrimps, grilled chicken... and steak, fish, chicken... alongside some salade. When hunger shows up between meals, a few nuts are enough to handle it. The only trouble right now is that I cannot tell which choices I need to make in order to hold my body condition where it currently is. I am not very tuned in to my body. In the past it would ask for sugar, snacks, meat or whatever else in a clear voice. Now I can no longer hear what my body is saying. Either the GLP-1 agonists made me deaf or they made my body dumb. I feel better than I ever have. Yet I do not know what to do next to keep it that way
Click to expand...

To be honest, this territory is largely unmapped, and each person's response differs too. Provided it stays manageable and your physique continues to improve or at minimum holds steady—I would certainly try tapering down and/or stopping altogether, just to find out!

A friend of mine is on DSIP to get off some very potent painkillers, and it has worked really well. She is now gradually lowering the DSIP to check whether every painkiller side effect and withdrawal disappears completely with no DSIP at all.

In a perfect world none of us would require these compounds, but it looks like an excellent method to speed up the body's signals to change!
 
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