How are you dosing SS-31 alongside NAD+? I've put in orders for both. MOTS-C is already part of my routine — 966 mcg injected each day ahead of training — and it leaves me with boundless energy plus a huge boost to metabolism. My hope is that adding SS-31 and NAD+ will push that energy to work even more efficiently.
Ss31
- Thread starter TeresaHip
- Start date
AlexSilver
Explorer
That's not possible. Methylene Blue works as an MAOI, and frequent use puts a strain on your liver.
reta-stacker
Explorer
You're not getting any sex!Gr33dyOctopus said:
if I mentioned doing that to my girl, she'd have a stroke
ceeboo
Explorer
Just so you know, I'm 40. Two days back I began SS-31. Up to now I haven't noticed that "tired" effect... possibly since before starting I'm generally worn out 
. (kidding). Still, my starting amount is 1mg for each pin. Since the cost is pretty high, how did you all begin and then ramp up? Also, what's the usual length for a single cycle? I've been learning from tiktok university and Youtube college of medicine, yet every source tells me something different.
. (kidding). Still, my starting amount is 1mg for each pin. Since the cost is pretty high, how did you all begin and then ramp up? Also, what's the usual length for a single cycle? I've been learning from tiktok university and Youtube college of medicine, yet every source tells me something different.
My starting dose was 5 mg, and skipping the smaller amounts made sense to me since my mitochondria were already trashed beyond repair. From my early twenties onward, I've lived in that exhausted-yet-wired state: downing 2~3 venti Americanos with added shots while putting in 18+ hour workdays, 7 days a week.ceeboo said:
Just so you know, I'm 40. Two days back I began SS-31. Up to now I haven't noticed that "tired" effect... possibly since before starting I'm generally worn out
For me, SS-31 has been absolutely god tier. No matter what, I'll figure out how to get my hands on it. Whenever GBs pop up with solid deals, I do my best to load up.
ceeboo
Explorer
I get it... what's the length of your cycle?miameow said:
My starting dose was 5 mg, and skipping the smaller amounts made sense to me since my mitochondria were already trashed beyond repair. From my early twenties onward, I've lived in that exhausted-yet-wired state: downing 2~3 venti Americanos with added shots while putting in 18+ hour workdays, 7 days a week.ceeboo said:
Just so you know, I'm 40. Two days back I began SS-31. Up to now I haven't noticed that "tired" effect... possibly since before starting I'm generally worn out
For me, SS-31 has been absolutely god tier. No matter what, I'll figure out how to get my hands on it. Whenever GBs pop up with solid deals, I do my best to load up.
as for me, I begin with a small dose - it's just what I prefer.
There's nothing incorrect about beginning at a lower dose. That's likely the smarter way to do it. I simply tend to be the all-in type.ceeboo said:
I get it... what's the length of your cycle?miameow said:
My starting dose was 5 mg, and skipping the smaller amounts made sense to me since my mitochondria were already trashed beyond repair. From my early twenties onward, I've lived in that exhausted-yet-wired state: downing 2~3 venti Americanos with added shots while putting in 18+ hour workdays, 7 days a week.ceeboo said:
Just so you know, I'm 40. Two days back I began SS-31. Up to now I haven't noticed that "tired" effect... possibly since before starting I'm generally worn out
For me, SS-31 has been absolutely god tier. No matter what, I'll figure out how to get my hands on it. Whenever GBs pop up with solid deals, I do my best to load up.
as for me, I begin with a small dose - it's just what I prefer.
I completed 2 cycles, each lasting 4 weeks. The upcoming one is going to run 8 weeks.
When mitochondria are the target of repair work, my view is that this creates a temporary extra draw on energy reserves, which shows up as short-term tiredness. Across several dose and timing arrangements, I have run SS31 alongside MOTS-C and NAD+, and in my experience the combination is a pretty forgiving stack. My cycle is 10-12 weeks on, then 4 weeks off, using:
Either way, daily or every 3 days, I have found that a good energy boost shows up throughout the day. NAD+ I tend to take daily purely because that MF is spicy and a small 25mg stinger daily is what I prefer.
One more thing worth mentioning: I staggered when each part of the stack was introduced and titrated uo to the doses above, so any adverse reaction would tell me which peptide is the culrpit. For me, that meant a few days of NAD+ first, then SS31, then MOTS-C.
- SS31 3mg daily or 9mg every 3 days
- MOTS-C 1.5mg daily or 5mg every 3 days
- NAD+ 25mg daily or 75mg every 3 days.
Either way, daily or every 3 days, I have found that a good energy boost shows up throughout the day. NAD+ I tend to take daily purely because that MF is spicy and a small 25mg stinger daily is what I prefer.
One more thing worth mentioning: I staggered when each part of the stack was introduced and titrated uo to the doses above, so any adverse reaction would tell me which peptide is the culrpit. For me, that meant a few days of NAD+ first, then SS31, then MOTS-C.
I'm inclined to see it the same way. As far as I know, there isn't a straightforward way to measure Mitochondrial Output—you mostly rely on vague signs that you're not at your peak. After you've ruled out other causes (sleep, diet, vitamins/minerals, exercise, and so on) and you still feel "flat," that's when you should start looking into it
Neurogroot
Explorer
Given that Elamipretide (SS-31) holds FDA approval for Barth Syndrome, my guess is you'd begin by looking at the screening approach used for that condition. Cardiolipin markers and TAZ can be checked through blood work and genetic testing. I'm certain there's additional nuance, but that's a reasonable starting point.
If not that, then the rationale becomes something like "I'm 40, and ROS, chemicals, and so on have undoubtedly taken a toll on me by this point."
On the protocol I follow: 5 mg SS-31 on Mon/Weds/Fri (3x/week), paired with 5 mg MOTS-c 3x/week on Sun/Tues/Thurs (which lines up with when I train), plus 100 mg NAD+ administered 2 hrs ahead of MOTS-c. The SS-31/MOTS-c combo runs 8 weeks on, then 4 weeks off. Cycle 2 is almost finished for me. Anecdotally, some individuals use SS-31 ALONE for anywhere between 2-6 weeks to repair mitochondria before introducing MOTS-c, though that isn't necessarily backed to a reliable degree yet.
Regarding what OP asked: during my first week on SS-31 I did experience mild fatigue, which slowly faded, and by week 3 my energy was above baseline.
pughster25
Explorer
I put together a piece about SS31 https://humanupgradeai.com/ss-31-peptide/ it contains some useful details