On Tirz I dealt with awful sulfur burps. Right now I'm thinking about making the change to Reta. Based on what I've come across, tirz does a better job at suppressing appetite. A bit of help there would be good, but what I really need is whatever works best for losing weight and easing joint pain. My joints are the main reason I want to drop weight. I broke my patella and it healed improperly. Even a short walk hurts. My hope is that losing some weight will relieve pressure on the knee and let me move around more. I'm not expecting a miracle. I've already done the work to change poor eating patterns. I have PCOS and insulin resistance. Has anyone here moved from tirz to reta over side effects? Are your side effects now the same, different, or gone?