Semax vs Adamax vs P021

koffea

koffea

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Semax vs Adamax vs P021

these seem to be the big heavy hitters. I am curious if anyone has actually tried all three and could share their various experiences.

Semax has a lot of russian based research, and a long history of use. Its safety profile seems ok.

Adamax, I couldnt find any research on this at all. Basically it is all theoretical. “Should be stronger,” “Should bemore bioavailable,” “Should provide better blood-brain barrier penetration”. Nothing that has been proven clinically in human or animals. Would love to be proven wrong here.

P021 has a mouse study. It increased markers such as BDNF and reduced some Alzheimer markers. I guess that is something, but nothing in humans.

Im looking for qualitative stories, because the price difference is substantial.
 
koffea said:


Semax vs Adamax vs P021

these seem to be the big heavy hitters. I am curious if anyone has actually tried all three and could share their various experiences.

Semax has a lot of russian based research, and a long history of use. Its safety profile seems ok.

Adamax, I couldnt find any research on this at all. Basically it is all theoretical. “Should be stronger,” “Should bemore bioavailable,” “Should provide better blood-brain barrier penetration”. Nothing that has been proven clinically in human or animals. Would love to be proven wrong here.

P021 has a mouse study. It increased markers such as BDNF and reduced some Alzheimer markers. I guess that is something, but nothing in humans.

Im looking for qualitative stories, because the price difference is substantial.

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Check here,


https://pep-pedia.org/peptides/adamax
 
I've done multiple cycles of Semax, NA, Semax and Adamax and just started P21 a week ago. Start with Semax first, like suggested above and see how you respond. Those three are all Semax based, where P21 is a different animal. It's related to Cerebrolysin (an amino group subset) and is used to rebuild brain signalling pathways by stimulating neurogenesis and to increase cognitive ability. Both real Adamax and P21 have an Adamantane group attached and need to have it for increased bioavailability and duration. P21 without Adamantane is sludge, a technical term, but it is available from vendors.
 
Chili777 said:


I've done multiple cycles of Semax, NA, Semax and Adamax and just started P21 a week ago. Start with Semax first, like suggested above and see how you respond. Those three are all Semax based, where P21 is a different animal. It's related to Cerebrolysin (an amino group subset) and is used to rebuild brain signalling pathways by stimulating neurogenesis and to increase cognitive ability. Both real Adamax and P21 have an Adamantane group attached and need to have it for increased bioavailability and duration. P21 without Adamantane is sludge, a technical term, but it is available from vendors.

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interesting

so none of the vendors are selling P21 that will be bioavailable? or did I misunderstand that

and could you tell the difference between Semax, NA, Semax and Adamax?
 
koffea said:


interesting

so none of the vendors are selling P21 that will be bioavailable? or did I misunderstand that

and could you tell the difference between Semax, NA, Semax and Adamax?

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Most vendors sell P21 and some sell P21 with Adamantane. P21 without Adamantane is useless. It won't penetrate the BBB and most of it will be destroyed my enzymatic action even if used IN. The difference is between $80 and $300 a kit because it's more expensive to produce with Adamantane.

Yes, I can tell the difference between all the Semax version. Regular lasts 2-3 hours, NA lasts 3-5 hours and Adamax lasts 8-10 hours. I like to use the base and NA versions at 1 mg via IN and Adamax 300-500 mcg via SQ.
 
koffea said:


interesting

so none of the vendors are selling P21 that will be bioavailable? or did I misunderstand that

and could you tell the difference between Semax, NA, Semax and Adamax?

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You can research them further here: https://pep-pedia.org/browse

There are also several threads here on the forum with more RS experiences.
 
Ada (subQ) gave me very vivid dreams & sharp memory. I ended up nailing all of my schoolwork.

If you're not in school or prepping for a licensing exam etc. I don't see the point of semax v ada IMO the promises of long-term structural brain benefits isn't convincing to me. p21 I haven't look into it since it's so cost prohibitive for me and was thinking of trying cerebrolysin (not the name brand the protein mix ofc) since it's cheaper as a trial run.

I think the first question you need to ask yourself is what are your goals? What is your current brain/mental situation you're trying to address?
 
Chili777 said:


Most vendors sell P21 and some sell P21 with Adamantane. P21 without Adamantane is useless. It won't penetrate the BBB and most of it will be destroyed my enzymatic action even if used IN. The difference is between $80 and $300 a kit because it's more expensive to produce with Adamantane.

Yes, I can tell the difference between all the Semax version. Regular lasts 2-3 hours, NA lasts 3-5 hours and Adamax lasts 8-10 hours. I like to use the base and NA versions at 1 mg via IN and Adamax 300-500 mcg via SQ.

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I bought a kit of P-21 from Uther for $240. It doesn't mention Adamantane and the test report just says P-21. Hmmm.
 
yeddie said:


I bought a kit of P-21 from Uther for $240. It doesn't mention Adamantane and the test report just says P-21. Hmmm.

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My understanding is that Jano will only list it as P-21 if it has the adamante group on it. I believe he will show “not P21” or something like that on the COA if it doesn’t have adamante because it has a different molecular weight without it and he doesn’t consider it to be P21 if it isn’t the right MW/doesn’t have the adamante group.
 
koffea said:


How about impact on sleep with Semax, NA, Semax and Adamax?

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I don't take any Semax after 2pm. I don't take Adamax after 10 am. Count on 8-10 hours with it, but it's never affected my sleep and it just wears off gracefully. No crash or anything.
 
Lear00 said:


Related question - what are people’s thoughts and experiences of IN vs SubQ Adamax?

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I haven't run IN with Adamax yet. As I'm a good responder to Semax, I would think the immediate onset would be like riding a rocket for me. It intensifies much quicker. I use it for concentration and focus for work and SQ works well for that. Some RSs do use it via IN, and I may try it next cycle at 200-250 mcg.
 
I got nothing on out of semax or adamax, tbh form what I'm reading adamax is a real mixed bag, and for that price is it really worth trying . I just can't help myself, which I could with this one. 🤔 p21 sitting in my freezer for a run after Pinealon. And yes what the other said, if Jano marks as p21, it should mean it's the correct weight.
 
Chili777 said:


I've done multiple cycles of Semax, NA, Semax and Adamax and just started P21 a week ago. Start with Semax first, like suggested above and see how you respond. Those three are all Semax based, where P21 is a different animal. It's related to Cerebrolysin (an amino group subset) and is used to rebuild brain signalling pathways by stimulating neurogenesis and to increase cognitive ability. Both real Adamax and P21 have an Adamantane group attached and need to have it for increased bioavailability and duration. P21 without Adamantane is sludge, a technical term, but it is available from vendors.

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HI how is the p21 going? I am looking to try more nootropic peptides. Ive been using semax plain, with some good sometimes meh results. Adamax is on the list, and P21 and p22, and the rest. I'd love to hear if this is something that's worth trying. TIA
 
Lear00 said:


Related question - what are people’s thoughts and experiences of IN vs SubQ Adamax?

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I am team subq with these. Main reason, my line of work, I want to have longer lasting, more systemic results. IN hits hard, but falls off. In WWF (or very early WWE terms), IN is like sweet chin music (HBK). Subq is a long Kurt Angle ankle lock. One hits hard and messes someone up for a short time, the other is very effective and lasts longer, and affects more for me. Little long term mood bump, mental stamina, recall, and weirdly, quicker vocabulary recall when speaking. And my speaking skills, especially at work or in a group are trash.

Also, this is purely anecdotal... I experienced a bit of hair shedding/thinning on IN. I don't know if it was BDNF spikes, or something... It might have been something else, stress, poor diet at that time. It might not happen to you either. It got me though. I can't find any proof or definitive science about it though for you. I didn't get the shedding on subq.
 
desinr-gal said:


HI how is the p21 going? I am looking to try more nootropic peptides. Ive been using semax plain, with some good sometimes meh results. Adamax is on the list, and P21 and p22, and the rest. I'd love to hear if this is something that's worth trying. TIA

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I just finished my first week of P21. I going to put together a post of what I've experienced so far, together with my research links. I like it. It's very different from any other peptide I've tried so far the cognitive benefits. I just bought a second kit so I'll have it for a while. It's also supposed to be synergistic with Adamax, and I can see how it would be. I just finished a Adamax cycle so I'm in a washout right now.

I just ordered so PE-22-28 and I'm looking forward to that one also. It was in a GB though, so it will be a while.
 
Chili777 said:


I just finished my first week of P21. I going to put together a post of what I've experienced so far, together with my research links. I like it. It's very different from any other peptide I've tried so far the cognitive benefits. I just bought a second kit so I'll have it for a while. It's also supposed to be synergistic with Adamax, and I can see how it would be. I just finished a Adamax cycle so I'm in a washout right now.

I just ordered so PE-22-28 and I'm looking forward to that one also. It was in a GB though, so it will be a while.

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What protocol are you doing for p21 and plan for pe22?
 
how

Chili777 said:


I just finished my first week of P21. I going to put together a post of what I've experienced so far, together with my research links. I like it. It's very different from any other peptide I've tried so far the cognitive benefits. I just bought a second kit so I'll have it for a while. It's also supposed to be synergistic with Adamax, and I can see how it would be. I just finished a Adamax cycle so I'm in a washout right now.

I just ordered so PE-22-28 and I'm looking forward to that one also. It was in a GB though, so it will be a while.

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looking forward to hearing your experience, anecdotal experiences for p21 are far and few between
 
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