Sema progress so far

O

ottozStrategy

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A few weeks into sema, I figured I'd write some of this down instead of only watching the number on the scale.

During the first 2 weeks, the main thing was feeling full a bit earlier, nothing else really stood out. Once week 3 came around, I realized I was passing on snacks almost automatically. My meals are still about the same, but that nagging pull to eat something in between meals has clearly eased up.

The scale is dropping gradually, and that's okay with me. For anyone who's been on sema for a longer stretch, did your appetite shift continue intensifying as time went on, or did things settle down once the first few weeks passed?
 
Welcome to the forum!! Sema worked really well for me. At last I could get some kind of handle on what I was eating. I'd done Keto for years with results that went back and forth, so having the food noise disappear was truly a relief. My one regret is that I raised my dose too quickly. I was impatient to drop all the weight right away!! Losing 2 or 3 lbs a week felt too slow, so I climbed to the max dose too soon. Once I'd been on the max dose for roughly 6 months, I stalled out. Had I only increased the dose when I stopped losing 2 to 3 lbs per week, I could have remained on it longer and shed even more weight with it. In the end I made the switch to tirzepatide and reached my goal weight and then some. I've just reduced my maintenance dose once more so I can put a little back on.
 
swimmer said:

Welcome to the forum!! Sema worked really well for me. At last I could get some kind of handle on what I was eating. I'd done Keto for years with results that went back and forth, so having the food noise disappear was truly a relief. My one regret is that I raised my dose too quickly. I was impatient to drop all the weight right away!! Losing 2 or 3 lbs a week felt too slow, so I climbed to the max dose too soon. Once I'd been on the max dose for roughly 6 months, I stalled out. Had I only increased the dose when I stopped losing 2 to 3 lbs per week, I could have remained on it longer and shed even more weight with it. In the end I made the switch to tirzepatide and reached my goal weight and then some. I've just reduced my maintenance dose once more so I can put a little back on.
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That genuinely helps a lot. It’s clear how tempting it would be to just keep raising the dose whenever the scale stalls more than you’d like. And the idea of leaving yourself room down the line really lands.
 
gooterp0t said:

Ties or Reta are the better drugs—make the switch.
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Jumping straight to Reta is overkill, like nuking one guy instead of just taking him out. There's no reason to hit all 3 receptors at once when starting with 1 delivers the same health perks and avoids the extra danger.
 
swimmer said:

gooterp0t said:

Ties or Reta are the better drugs—make the switch.
Click to expand...
Jumping straight to Reta is overkill, like nuking one guy instead of just taking him out. There's no reason to hit all 3 receptors at once when starting with 1 delivers the same health perks and avoids the extra danger.
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Just so you know, none of the big three have shown any signs of receptor burnout.
 
ladyj779 said:

swimmer said:

gooterp0t said:

Ties or Reta are the better drugs—make the switch.
Click to expand...
Jumping straight to Reta is overkill, like nuking one guy instead of just taking him out. There's no reason to hit all 3 receptors at once when starting with 1 delivers the same health perks and avoids the extra danger.
Click to expand...
Just so you know, none of the big three have shown any signs of receptor burnout.
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I suppose it comes down to how you define receptor burnout. A tolerance does build up, and to me that counts as a form of burnout. That tolerance is exactly why titration exists, and it's also why a plateau tends to show up eventually. It's well documented that once you stop a GLP1 medication and then start again, it isn't nearly as effective. I'd call that a kind of receptor burnout too.
 
gooterp0t said:

Ties or Reta are the better drugs—make the switch.
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Semaglutide works well and is a completely reasonable choice. Just because something is newer doesn't mean it's the better pick.

As for our OP: Sema treated me well until my coverage ended and I had a gap without it. After that, when I tried grey Sema, it didn't do anything for me, so I made a switch. I stuck with grey sema for 4 months with zero effect. I would have been perfectly happy staying on it.

The starting dose of 0.25mg exists so the body can get used to the medication. Even at 0.25mg, I felt some appetite suppression. Watch the official dosing guidelines closely. Research has gone beyond the original 2.4mg maximum. Whether it's been approved above that number, I can't remember.

Good luck!
 
ottozStrategy said:

gooterp0t said:

Ties or Reta are the better drugs—make the switch.
Click to expand...
Since I'm still at an early stage with sema, I'd prefer to first observe how my body reacts before I consider making a change.
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你连初始剂量都还没稳定下来。

它需要 4 周才能在体内累积起来，所以在滴定之前，你应该会持续看到不错的效果。

有些人非常推崇 sema，并且更偏爱它。

我们试着把 @chmuse 叫进来传道……
 
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