Is there anyone in this group who has experienced a seizure while taking a GLP1? I have a classmate who has been using MJ for what I believe is around 2 years, and she is currently hospitalized after having a few seizures. The doctors are suggesting her GLP1 might be the cause. She mentioned too that her blood pressure was quite low, and she was still taking medication for blood pressure. It strikes me as strange that after losing over 200#, she would still need her BP meds. That said, I am not familiar with her full medical background.
Seizures and GLP1 Use
- Thread starter fatty33
- Start date
rkbleddyn
Explorer
That's awful, I'm really sorry. From my own experience, Tirz brought my BP down further than any blood pressure medication I've ever used. It's dropped enough that I'm hoping to stop taking my BP med if the trend continues.
This is the first I've come across a seizure tied to a GLP-1. Is your classmate being taken off it for that reason?
Flash-BCR
Explorer
Yep, since beginning tirz my BP has dropped to around 115 over 70...I assumed that was from working out more and dropping 20lbs....The tirz angle hadn't crossed my mind...
On their own, glp-1 medications don't seem to be a frequent cause of seizures. The authors of this study use a very large dataset to chart the benefits and risks of glp-1s, and in the abstract seizures are named specifically as having a lower risk while taking glp-1s.
Mapping the effectiveness and risks of GLP-1 receptor agonists - Nature Medicine
An atlas of the associations between the use of GLP-1 receptor agonists (GLP-1RAs) and 175 health outcomes reports the effectiveness and risks of GLP-1RAs compared with other antihyperglycemic medications, such as sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors.
www.nature.com
Could it have been your classmate fainting rather than a seizure? Fainting is extremely common and can be mistaken for a seizure. Very low blood pressure can bring on a seizure, though I suspect fainting would be the more likely event.
Low blood sugar is also conceivable and could trigger a seizure, particularly if your classmate takes a sulfonylurea.
Wishing your friend a speedy recovery!
Mapping the effectiveness and risks of GLP-1 receptor agonists - Nature Medicine
An atlas of the associations between the use of GLP-1 receptor agonists (GLP-1RAs) and 175 health outcomes reports the effectiveness and risks of GLP-1RAs compared with other antihyperglycemic medications, such as sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors.
www.nature.com
Could it have been your classmate fainting rather than a seizure? Fainting is extremely common and can be mistaken for a seizure. Very low blood pressure can bring on a seizure, though I suspect fainting would be the more likely event.
Low blood sugar is also conceivable and could trigger a seizure, particularly if your classmate takes a sulfonylurea.
Wishing your friend a speedy recovery!
rkbleddyn
Explorer
According to my doctor, the explanation lies in how Tirz favorably influences kidney function, specifically the manner in which sodium is processed by them.
aRareUnicorn
Explorer
My electrolytes may be affected by GLP. A few months back, when my GLP dose was raised to 9mg, my sodium fell to 125-126 mEq/L, close to the danger zone. No matter what I try, I can't get it to rise.
Seizures and even brain swelling can result from low sodium (hyponatremia), so monitoring it is really important.
Seizures and even brain swelling can result from low sodium (hyponatremia), so monitoring it is really important.
CNCCurrency
Explorer
I figured this would be about seizures at customs. Hmm? haven't really come across that with glp1's.
Gt3294a
Explorer
That's exactly what drew me in as well—problems with seizures at the border. I find it hard to accept that doctors would pin this on GLP. Sure, super low blood sugar can bring on seizures, but GLP would only be a very minor piece of the puzzle in dropping that low. Still, there's truth to the idea that people taking GLP along with blood pressure meds need to keep a close eye, since I know plenty who had to stop or at least reduce their medication once they lost weight on GLP.
Mine can get pretty severe around the point when my medication gets switched. Since beginning medical marijuana roughly 12 months back, I haven't experienced any. GLP never intensified them beyond how they already were.
That is something of a flaw in the GLP-1 telehealth model. These drugs touch overall health in profound ways, yet those outfits only care about shifting a weight loss script and turn a blind eye to the consequences. Needing to retune blood pressure medication while on a GLP-1 is routine, and it may not get done when the prescriber of the GLP-1 acts as though nothing outside the number on the scale deserves their attention.
The gray market crowd obviously runs into the same thing, though plenty of them take a far more hands-on approach to their own care instead of trusting that a doctor is on top of it, when in reality the doctor is not even watching.
chest rockwell
Explorer
usually, to get a refill you have to complete a questionnaire, and it asks directly about heart rate, blood pressure, other side effects, and so on. That was the case with the one I used, anyway.
Whether they truly check for anything out of the ordinary, or simply overlook it, I can't say.
I don't have any answers. We aren't in touch, and the only details I have come from what she shared on her Facebook page. It struck me as odd that her BP wasn't being monitored, especially given how much weight she has dropped.
Fainting could bring on a seizure — that angle hadn't crossed my mind.
Could electrolytes be part of her routine? Honestly, I have no idea.
Then again, it's possible the doctors are in the dark too, and they simply ordered a bunch of tests to turn a profit.....
Attachments
BNLFL
Explorer
My last 2 BT came back on the low side, but not at a risky level. What fixed it was Liquid IV. I put half a packet into each of 2 Gatorade bottles, then have 1 bottle per day. Each Liquid IV has 500G sodium. When I used 2 every day, my BP went up too high. Now I'm down to 1 again. There's a BP test coming up this month, so I'll see what happens.
That's the same thing I was wondering about. Once I'd been on Tirz for roughly 4 months and had dropped 40lbs, I developed pronounced Orthostatic Hypotension (a big BP drop when going from sitting to standing). It got to the point that I quit 1 of my BP meds completely and halved the other one.
When I finally saw my Cardiologist a few weeks afterward, he was on board with what I'd done.
The left reading is sitting, the right one is standing, taken only 1 minute after. (edit this is the right photo; the previous one was some Metoprolol and VIP experiments I'd been messing with).
If I lose another 10 lbs, I might drop the BP meds entirely. The way they make me feel is something I really dislike.
Before I switched medications, that occurred around 5 or 6 times. There were multiple instances where I came very close—if I hadn't instantly halted and bent over the car hood, the dining room table, or whatever was nearby, I believe I would have passed out.
Speedy
Explorer
In theory, GLP1s have the potential to reduce blood sugar levels. When blood sugar falls far enough, a seizure may occur.
Still, it is uncommon for glucose to decrease to that extent — despite the fact that these drugs were originally created for diabetes treatment.
Still, it is uncommon for glucose to decrease to that extent — despite the fact that these drugs were originally created for diabetes treatment.