Reta vs Tirz

Last night I ate a bowl of Cinnamon Toast Crunch — milk and cereal were things I hadn't had in quite a while. Around 700 calories, and it tasted good. The difference from when I last picked up a box: this morning I have no craving for a second bowl. Back then I could finish a whole box in a single day, which is why I almost never bought it.
 
Seeing the recent posts in this thread has left me feeling sorrow for my dad, who has passed away. From start to finish, his days revolved around the question of where his next meal would come from. While we were eating breakfast, he'd turn to my mom and ask what lunch would be. I doubt a single day went by for him without food noise.

He rarely discussed it, but he was raised on a farm in the rural south, and at times I believe food was in short supply, which certainly played a part in what he went through.

I find myself wishing he could have tried GLP1s. My sense is that his final years would have been easier. He had Type 2 diabetes and high cholesterol, eventually required a quadruple bypass, and later developed renal failure that put him on dialysis. With GLP1s, I believe much of that could have been prevented.
 
derekmarc said:

If someone claims Reta silences food noise, are they referring to something like unwanted urges to binge and purge? That’s a major issue for me. I realize it’s an eating disorder, but could Reta put a stop to it?
With reta, food barely crosses my mind anymore. Back when I was dieting before reta, I'd already be planning my next meal long before hunger hit, and I'd sit around watching keto channels on YouTube and similar stuff. These days, though, I don't give food a thought until my body actually signals hunger. It's been months since I last opened a recipe. The other day I was out when dinnertime came around, so I started figuring out where to eat. Usually a whole list of spots would pop into my head, but this time I genuinely had no desire for any of them. Nothing appealed to me. I only knew I needed to eat, because skipping it would leave me feeling awful later. Hopefully that comes across clearly.
 
Last night I had rice. In the past, even a basic thing like that would trigger a whole spiral of obsessive thoughts about food. This week I took 2mg of Reta (week 1), and it’s fascinating how much quieter everything is, just like a lot of you have described. It feels incredibly freeing.
 
FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.
Same here. When it comes to quieting appetite, Tirz comes out ahead of Reta. Someone who has never taken Tirz might not pick up on it, but for me the gap in appetite control with Reta was obvious. On top of that, I found Tirz gave stronger anti-inflammatory effects than Reta.
 
derekmarc said:

If someone claims Reta silences food noise, are they referring to something like unwanted urges to binge and purge? That’s a major issue for me. I realize it’s an eating disorder, but could Reta put a stop to it?
For anyone dealing with serious food noise and binge eating — by that I mean food is on your mind nonstop and you eat even without hunger — Tirz wins hands down. I gave Reta a shot and honestly the hype baffles me. Sure, it might do the job for people whose food noise isn't as intense, but for me the appetite suppression was noticeably weaker, and instead of losing I gained weight and started craving sweets. Before that I'd never had a sweet tooth at all; my cravings were always for carbs and savoury stuff, so suddenly wanting sugary treats was an unwelcome side effect. Even after titrating up to a high dose, I still put on weight with Reta. The whole experience was negative enough that I switched back to Tirz. The only reason I stack Reta with Tirz is that I've got a stockpile of Reta sitting around and I'm too stingy to toss it — but Tirz is doing the real work, and I'm already on quite a high dose of Tirz. Speaking for myself, Tirz is clearly the most effective, and if something is working, why switch to Reta?

Good luck on your weight loss journey 🙂
 
MrZardoz said:

Tirz has been my go-to from the very beginning of my weight loss journey — I went from 322 pounds down to 226 pounds, where I've now hit a standstill. I gave Reta a shot, but no matter how I approached it — whether I eased into it over many months or jumped straight to a massive dose (20mg at the high end) — it produced zero results for me. Why that happens, I honestly can't say. So Tirz is what I'm left with, and I keep wondering what it would feel like to actually drop weight while on Reta...
I'm with you! Reta really didn't work for me. While taking it, my weight went up, plus I had nonstop food noise and out of nowhere started craving sweets — it left me puzzled about why others get such great results from it. For me, Tirz is clearly the better choice; when it comes to suppressing appetite, Reta simply can't compete with Tirz. On top of that, I noticed Reta's anti-inflammatory benefits aren't as strong as what Tirz provides.
 
If someone hits a plateau on Tirz, might reta assist in breaking that plateau, allowing them to return to tirz alone?
 
JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.
Tirz works for me, while a colleague of mine prefers Reta. As far as I know, another coworker is also on Reta. Switching isn't something I've done yet, though the idea has crossed my mind. They're big fans of it and are anxious about running out. 😀
 
Grogu said:

woundcarping said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too 🤣

A genuine friend would've given you a heads-up about that result...

People kept telling me, again and again — I guess I'm just a bit slow on the uptake at times 🤣.

For anyone trying to figure out how many peptides to buy: there's no such thing as having too much cash, being too young, or keeping too many peptides in your freezer!
That's how it's done,
 
sheilarae74 said:

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.
With any luck, reta will give you a better energy boost. For most of my time using it, I've dealt with really heavy tiredness. If that weren't an issue, I'd surely be exercising more. If tirz is even harder on fatigue, there's just no chance I could use it.
At 4mg of reta, around week 3 or 4, I ran into a stall. Whenever I sense that starting, I make a point of eating something so my blood sugar rises for a while. That's my guess for why lethargy hits most people. On top of that, I've seen all of my sides getting milder too. I'm 3 months in. Right now I take 6mg reta plus 1mg tirz
 
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