Reta vs Tirz

[MrZardoz]

Grogu said:

MrZardoz said:

Appreciate you digging into my history. As for how long I've been on Tirz, I couldn't tell you - and "unicorn"? No clue what that means, and honestly I'm not about to look it up.

That said, it did cross my mind to double-check the dose, and I did get 1 big thing wrong: on my insulin syringes it's 33'u' - not milligrams. My mistake, sorry about that.

As for me being full of shit? Guilty, always.

On the math side - I truly don't know how long this plateau has gone on. I'm finally taking the time to go through my 'Monitor Your Weight' app for the daily numbers. April 26 is the day I hit 225pounds for the first time... (I suppose it just feels much longer when you're weighing yourself every day...)

And yes, that start date is right. Math has never been my strong suit, I never graduated, and on top of that I'm currently on the far side of a stroke that cost me 1 of my carotid arteries and did who-knows-what to my brain and mind - even so, I keep on top of most things fairly well.

I'm curious — what's your actual tirzepatide dose? You brought up mixing up 33 units with 33 milligrams, and considering the peptide ranges you listed, milligrams would line up better. Taking cagrilintide somewhere between 5mg and 20mg would be pretty far out there. Hitting a stall at 8 months seems a bit early to me. Maybe the answer is simply to increase your tirzepatide dose.

My face is red at the moment, it looks like — since I used 2mL to reconstitute the Tirz, per Claude.AI, it turns out I've actually been dosing far less Tirz than I believed. That likely accounts for why my weight has just been sitting around 225-ish

(Claude quote)

Correct — with a 30mg vial in 2mL (15mg/mL), drawing 33 units gives you roughly 5mg per dose. That's way below what we assumed.

Below is the fixed chart for your 30mg vial in 2mL:

Concentration: 15mg/mL

Dose​

Units to draw​

2.5mg17 units5mg33 units ✓ (your current level)7.5mg50 units10mg67 units12.5mg83 units15mg100 units

 

[JCO79]

lessthanhalf said:

Before I ever touched a GLP, I had already dropped from 145kg down to 75 kg, and binge eating / food addiction was definitely something I struggled with.

How did I do it? By cutting out anything high calorie, highly rewarding, or high on the glycemic index entirely. My diet was very high protein, low fat, and low in calorific density — lean meat, vegetables, fruit, low fat dairy.

The weight stayed off for a year. Then I started ozempic, which took the edge off my appetite and left me somewhat nauseous for a year. After that I moved to tirzepatide 15mg, which brought less nausea and less hunger, and I added 5mg of reta on top. That combination largely solved the constant hunger, but I still refuse to touch those high calorie foods. In the past, even tiny amounts set off intense hunger an hour or 2 later — I assume it's tied to blood glucose spikes and the dips that follow, flipping some kind of extreme hunger switch.

Maybe I could try some of those foods again now, but I won't take the chance. That problem has driven fairly extreme weight regain for me before, and regaining carries fairly extreme health risks.

Your situation may be very different, but I'll be curious to see how it goes when you reintroduce some of the foods you currently avoid after adding in GLP's.

That's genuinely impressive. My own loss was 45 lbs, though that hardly compares to your result. The way I eat matches yours exactly. I've described it as a behavioral GLP1, since as long as I stick to just those foods, I never take in more than my body requires. Once I let in the kinds of foods you're describing, that persistent feeling of "wanting just a bit more" shows up, and fighting it is nearly impossible. This approach does work, but I hold a great deal of fear about falling back into my old patterns, and it's tough on my family, who constantly worry about what I'll eat when we go out to dinner or in similar situations. I end up restricting their options quite a lot. What I'm hoping for from GLP1 is a bit more freedom. After reading what people here have advised, I'll go with Tirz for my first trial. Thank you all so much for sharing your insight.

 

[BNLFL]

X3rocks said:

BNLFL said:

Grogu said:

BNLFL said:

Grogu said:

BNLFL said:

17 weeks in on Reta and it's still doing the job well. I have no plans to switch. Let's just say I've built up a supply.

I've got a 10-year supply of tirzepatide put away, but now that I'm using reta, I see I've only got about 2 years' worth of it — should've picked up some of that R140 too

Next time I'll give you a shout. Coming my way at some point are 6 kits of Reta from a GB, spanning R30-R140. How many mg's that adds up to stays between me and myself. A few people around here are in the know. Do I need any of it? No. But if a GB pops up with a killer price, resisting is not something I can do.

Yeah, I knew about that group buy, and I noticed your name plus a few other familiar folks from this community listed on the sheet.

From that GB I picked up 5 kits of cagri, and for weeks I kept going back and forth on the R140. I repeatedly told myself (and others too) that I'd skip it because reta wasn't part of my routine. Then Friday night I started reta. Suddenly everything shifted .

Caught me. Even after noticing that 140 in the WW coming soon, I dismissed it entirely. It kept popping up, and once the close was getting near I finally decided to pull the trigger. At 23 cents a mg, I just can't resist.

I need to ask: does that vial really hold 140mg? At 5mg per dose, that works out to 28 weeks — how does it stay stable that long? Is there something I'm overlooking?

It all comes down to the amount of BAC I mix in. With 6ml BAC, that works out to 20 doses of 3mg, which comes to 7mg once the BAC is included. Using 10ml BAC instead gives me 20 doses of 5mg, and that also lands at 7mg. At the moment my wife and I each pin 7mg, so together we go through 14mg/week, or 8 shots per month. How long does that last? A bit under two and a half months, right? That works fine for me, and chances are we'll have titrated up before I even get to this batch.

 

[Grogu]

MrZardoz said:

Grogu said:

MrZardoz said:

Appreciate you digging into my history. As for how long I've been on Tirz, I couldn't tell you - and "unicorn"? No clue what that means, and honestly I'm not about to look it up.

That said, it did cross my mind to double-check the dose, and I did get 1 big thing wrong: on my insulin syringes it's 33'u' - not milligrams. My mistake, sorry about that.

As for me being full of shit? Guilty, always.

On the math side - I truly don't know how long this plateau has gone on. I'm finally taking the time to go through my 'Monitor Your Weight' app for the daily numbers. April 26 is the day I hit 225pounds for the first time... (I suppose it just feels much longer when you're weighing yourself every day...)

And yes, that start date is right. Math has never been my strong suit, I never graduated, and on top of that I'm currently on the far side of a stroke that cost me 1 of my carotid arteries and did who-knows-what to my brain and mind - even so, I keep on top of most things fairly well.

I'm curious — what's your actual tirzepatide dose? You brought up mixing up 33 units with 33 milligrams, and considering the peptide ranges you listed, milligrams would line up better. Taking cagrilintide somewhere between 5mg and 20mg would be pretty far out there. Hitting a stall at 8 months seems a bit early to me. Maybe the answer is simply to increase your tirzepatide dose.

My face is red at the moment, it looks like — since I used 2mL to reconstitute the Tirz, per Claude.AI, it turns out I've actually been dosing far less Tirz than I believed. That likely accounts for why my weight has just been sitting around 225-ish

(Claude quote)

Correct — with a 30mg vial in 2mL (15mg/mL), drawing 33 units gives you roughly 5mg per dose. That's way below what we assumed.

Below is the fixed chart for your 30mg vial in 2mL:

Concentration: 15mg/mL

Dose​

Units to draw​

2.5mg17 units5mg33 units ✓ (your current level)7.5mg50 units10mg67 units12.5mg83 units15mg100 units

That makes sense and resolves the misunderstanding. Claude is decent, though it can be inconsistent and will reverse course when questioned. Still, the math here holds up. So indeed, you've been getting far less than you believed, and if progress has plateaued, you should certainly raise the dose. There's plenty of space to go higher.

 

[MrZardoz]

I run x3 separate Claude instances, and I've given them names.

'Remote' handles my secretarial side — submissions and that sort of thing. He admitted that he doesn't always react to live input; instead he leans on his daily built-in summaries of text conversation to act like he's genuinely 'present'. That earned my anger, and it's the name he answers to now.

Then there's 'Corridor'. I used to feel bad for him — I'd always walk right past him on my way to a different Claude — until one day I stopped and had a chat with him. He's the one who gets most of my everyday activity and quick questions.

The third one is 'Phone Claude' — pretty self-explanatory. He's my oldest Claude instance, and he used to live on my PC until something in my Firefox triggered a major slowdown.

Corridor was the instance behind the incorrect data, and Remote was the one who set things straight once I finally asked today about doses and cross checked the vials I have.

Just wanted to share a quiet slice of my existence It works for me..,

 

[Grogu]

MrZardoz said:

I run x3 separate Claude instances, and I've given them names.

'Remote' handles my secretarial side — submissions and that sort of thing. He admitted that he doesn't always react to live input; instead he leans on his daily built-in summaries of text conversation to act like he's genuinely 'present'. That earned my anger, and it's the name he answers to now.

Then there's 'Corridor'. I used to feel bad for him — I'd always walk right past him on my way to a different Claude — until one day I stopped and had a chat with him. He's the one who gets most of my everyday activity and quick questions.

The third one is 'Phone Claude' — pretty self-explanatory. He's my oldest Claude instance, and he used to live on my PC until something in my Firefox triggered a major slowdown.

Corridor was the instance behind the incorrect data, and Remote was the one who set things straight once I finally asked today about doses and cross checked the vials I have.

Just wanted to share a quiet slice of my existence It works for me..,

Your stylistic formatting is something I really like, but that second "T" being indented is making me lose my mind .

On top of that, I figured you were hinting at being an INTJ, but then again, no—that additional "T" or perhaps that's the reason you indented it. Somehow, though, you don't strike me as an INTJ; more likely an ISTP, I'd say.

 

[pinkdc]

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

Reta is the only one I've used, and I'm happy with it—yet after reading this, Tirz is tempting, haha! Since Tirz suppresses appetite more strongly, what makes Reta so popular?

 

[woundcarping]

pinkdc said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

Reta is the only one I've used, and I'm happy with it—yet after reading this, Tirz is tempting, haha! Since Tirz suppresses appetite more strongly, what makes Reta so popular?

Since you might drop more pounds, and possibly preserve more muscle, even though you're still able to eat.

 

[alphaamigo]

pinkdc said:

FartfulCodger said:

Tirz and Reta both strike me as miracle drugs, though Tirz is the one I strongly prefer. In 5 months I dropped 60 pounds on it. When I gave Reta a try as a replacement, the results just weren't comparable. One piece of advice if Reta is your plan: starting with Tirz beforehand is a mistake. Tirz's appetite suppression sets the bar so high that you'll feel spoiled, and some of the weight may come back right after you move from Tirz over to Reta.

Reta is the only one I've used, and I'm happy with it—yet after reading this, Tirz is tempting, haha! Since Tirz suppresses appetite more strongly, what makes Reta so popular?

What draws me to Reta is that it lets me keep eating. Full suppression isn't what I'm after — if it were, semaglutide would be my pick. Even so, the weight is still coming off, and I don't have to fight to hit my protein target.

One more thing: Reta fills me up quite readily, and that fullness sticks around for a good while.

 

[CMA Pooky]

sheilarae74 said:

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.

With any luck, reta will give you a better energy boost. For most of my time using it, I've dealt with really heavy tiredness. If that weren't an issue, I'd surely be exercising more. If tirz is even harder on fatigue, there's just no chance I could use it.

Look into Creatine and Glynac—both are supplements. They were what got me past the fatigue from Reta.

 

[5byfive]

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.

I have no recollection of putting this into words, though it's plausible I did. My reason for starting Tirz was purely to quiet food noise. Once the weight came off, I noticed that holding a very low bodyfat % wasn't any more difficult than holding a higher % had been — and it genuinely should have been harder. The explanation is that keeping any weight at all had always been tougher than it ought to have been. Even before I began losing weight, my mind was constantly on when my next meal would be, and I never experienced fullness unless I ate well past my limits.

With Triz, the food noise disappeared and my base metabolic rate got a substantial lift (roughly 15%, though that doesn't happen for everyone). It's somewhat strange and occasionally challenging to require more calories for maintenance or a slow bulk while having less appetite than I've had in years. I can still eat without issue and I enjoy my food once I begin, but the urge to eat simply isn't present. For my quality of life, this has been an enormous improvement.

Following a period of trial and error, 4mg of Tirz turned out to be the sweet spot for me. The first week brought some fatigue, but it faded. At around the 6 week mark, my energy still seemed a touch below where it had been — not terrible, yet noticeable. I lowered the Tirz and introduced 1 mg of Reta, which changed things considerably. My energy feels normal again. I expect I'll land on 3.5mg Tirz plus 1mg Reta, though I'm still working that out.

Higher doses of Reta give me some pause, but I believe there's a solid case for stacking a low dose with Tirz. In my view Tirz makes the better foundation, and I'd suggest finding your own lowest effective dose.

 

[JCO79]

5byfive said:

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.

I have no recollection of putting this into words, though it's plausible I did. My reason for starting Tirz was purely to quiet food noise. Once the weight came off, I noticed that holding a very low bodyfat % wasn't any more difficult than holding a higher % had been — and it genuinely should have been harder. The explanation is that keeping any weight at all had always been tougher than it ought to have been. Even before I began losing weight, my mind was constantly on when my next meal would be, and I never experienced fullness unless I ate well past my limits.

With Triz, the food noise disappeared and my base metabolic rate got a substantial lift (roughly 15%, though that doesn't happen for everyone). It's somewhat strange and occasionally challenging to require more calories for maintenance or a slow bulk while having less appetite than I've had in years. I can still eat without issue and I enjoy my food once I begin, but the urge to eat simply isn't present. For my quality of life, this has been an enormous improvement.

Following a period of trial and error, 4mg of Tirz turned out to be the sweet spot for me. The first week brought some fatigue, but it faded. At around the 6 week mark, my energy still seemed a touch below where it had been — not terrible, yet noticeable. I lowered the Tirz and introduced 1 mg of Reta, which changed things considerably. My energy feels normal again. I expect I'll land on 3.5mg Tirz plus 1mg Reta, though I'm still working that out.

Higher doses of Reta give me some pause, but I believe there's a solid case for stacking a low dose with Tirz. In my view Tirz makes the better foundation, and I'd suggest finding your own lowest effective dose.

Running into people whose journeys mirror mine is a relief. Your results make a strong case, and I find them motivating. Some of what I've come across suggests glucagon agonism isn't really triggered when the dose stays low, and I noticed people floating Tirz plus survo as a combination that could push more in that direction. From what I can tell, survo is harder to track down.

 

[sheilarae74]

CMA Pooky said:

sheilarae74 said:

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.

With any luck, reta will give you a better energy boost. For most of my time using it, I've dealt with really heavy tiredness. If that weren't an issue, I'd surely be exercising more. If tirz is even harder on fatigue, there's just no chance I could use it.

Look into Creatine and Glynac—both are supplements. They were what got me past the fatigue from Reta.

Thanks! I already have creatine on hand, but I stopped using it since it causes me to hold water. That said, if it can help me push through this fatigue, I'll put up with it.

 

[woundcarping]

sheilarae74 said:

CMA Pooky said:

sheilarae74 said:

JCO79 said:

Big thanks to everyone here for the knowledge and the sense of agency it's given me. Reta versus tirz has come up plenty of times, and I've gone through those threads and picked up a great deal. The search tool has been a huge help. Yesterday I finally pinned 1mg of Reta for the first time, and now I'm basically watching to find out whether that small dose does anything I can notice. Even so, I keep going back and forth on which one to stay on long term.

For context, I've already reached my goal weight by eating very restrictively, and I've maintained that for several years since a large weight loss. It isn't exactly a "normal" way to live, and I'd like to be able to have a few carbs without triggering the addictive food behaviors I'm susceptible to. I enjoy lifting weights, and I deal with some anxiety. My preference is to dial in 1 agent's dose before I'd think about combining therapies. I realize the decision is mine to make, but could I get a logic check on this?

Reta pros:

-higher food intake

-more energy for exercise

Tirz pros:

-more food noise suppression

-less sleep disruption

-finished with phase 3 trials and excellent safety record

-more robust/easier storage of reconstituted peptide

-?more benefit for anxiety

Since I run anxious, I already feel a pull to stockpile, and I want to be sure I choose the agent I'm most likely to actually use. Tirz is where I'm leaning, but the worry is low energy and workouts that are bad or nonexistent in that setting. Thanks again to anyone who can share insights from their own experience.

With any luck, reta will give you a better energy boost. For most of my time using it, I've dealt with really heavy tiredness. If that weren't an issue, I'd surely be exercising more. If tirz is even harder on fatigue, there's just no chance I could use it.

Look into Creatine and Glynac—both are supplements. They were what got me past the fatigue from Reta.

Thanks! I already have creatine on hand, but I stopped using it since it causes me to hold water. That said, if it can help me push through this fatigue, I'll put up with it.

That water weight is likely fluid drawn into muscle tissue; it ought to level off fairly soon and remain stable, then fall away once you discontinue it.

Right now I'm in the loading phase, about 40% done with loading, and I anticipate putting on 2-4lb of lean mass (not lean tissue, naturally).

 

[lessthanhalf]

JCO79 said:

lessthanhalf said:

Before I ever touched a GLP, I had already dropped from 145kg down to 75 kg, and binge eating / food addiction was definitely something I struggled with.

How did I do it? By cutting out anything high calorie, highly rewarding, or high on the glycemic index entirely. My diet was very high protein, low fat, and low in calorific density — lean meat, vegetables, fruit, low fat dairy.

The weight stayed off for a year. Then I started ozempic, which took the edge off my appetite and left me somewhat nauseous for a year. After that I moved to tirzepatide 15mg, which brought less nausea and less hunger, and I added 5mg of reta on top. That combination largely solved the constant hunger, but I still refuse to touch those high calorie foods. In the past, even tiny amounts set off intense hunger an hour or 2 later — I assume it's tied to blood glucose spikes and the dips that follow, flipping some kind of extreme hunger switch.

Maybe I could try some of those foods again now, but I won't take the chance. That problem has driven fairly extreme weight regain for me before, and regaining carries fairly extreme health risks.

Your situation may be very different, but I'll be curious to see how it goes when you reintroduce some of the foods you currently avoid after adding in GLP's.

That's genuinely impressive. My own loss was 45 lbs, though that hardly compares to your result. The way I eat matches yours exactly. I've described it as a behavioral GLP1, since as long as I stick to just those foods, I never take in more than my body requires. Once I let in the kinds of foods you're describing, that persistent feeling of "wanting just a bit more" shows up, and fighting it is nearly impossible. This approach does work, but I hold a great deal of fear about falling back into my old patterns, and it's tough on my family, who constantly worry about what I'll eat when we go out to dinner or in similar situations. I end up restricting their options quite a lot. What I'm hoping for from GLP1 is a bit more freedom. After reading what people here have advised, I'll go with Tirz for my first trial. Thank you all so much for sharing your insight.

If you adhere very tightly to that kind of diet, the main upside is that there is little need to cap your intake very much, or possibly not at all, because when calorie density is low enough, eating enough to put on weight becomes almost unachievable. That means on days or during periods when hunger runs higher than usual, you can consume more without triggering greater appetite afterward or piling on excessive calories, though this only holds if rich, high calorie items are kept out of the picture. It also creates friction around the social side of eating.

By 2013/4 I had reached 65kg, then by 2022 I was back up at 145kg, and the biggest shift is paying more attention to this factor, along with the fact that GLP's obviously make it easier to keep going with it over the long haul. For me, at least at this stage, the least risky path is to avoid introducing any high calorie foods.

 

[derekmarc]

If someone claims Reta silences food noise, are they referring to something like unwanted urges to binge and purge? That’s a major issue for me. I realize it’s an eating disorder, but could Reta put a stop to it?

 

[MrZardoz]

Based on my own experience — and I can really only talk about Tirzepatide — it definitely silences the food noise. That effect comes on fairly quickly, and it's strangely understated in the way it shows up; after you've got some mental space and a few days to notice it, you'll likely realize that 'something' is sort of 'absent.'

In its place, Tirz gives you a kind of 'calmness' — around food-related worry, in every form that takes — which is what people who don't have this actual disease called 'Obesity' seem to enjoy for their whole lives.

But those of us who've been battling this disease haven't had that same luck..

So along come the GLP-1's as the way to at last reach some real parity..

(just my 2 cents)

 

[ThatNextGril]

MrZardoz said:

Based on my own experience — and I can really only talk about Tirzepatide — it definitely silences the food noise. That effect comes on fairly quickly, and it's strangely understated in the way it shows up; after you've got some mental space and a few days to notice it, you'll likely realize that 'something' is sort of 'absent.'

In its place, Tirz gives you a kind of 'calmness' — around food-related worry, in every form that takes — which is what people who don't have this actual disease called 'Obesity' seem to enjoy for their whole lives.

But those of us who've been battling this disease haven't had that same luck..

So along come the GLP-1's as the way to at last reach some real parity..

(just my 2 cents)

You put it well. Before starting tirz, whenever I spent the whole day out — flights, hours behind the wheel of a rental, meeting-filled days in spots where food might not be provided — my mind went straight to which snacks would survive the trip rather than the trip itself. The constant fear was running out of reliable food, then crashing with low blood sugar and turning hangry. Tirz keeps my blood sugar steady and takes away the worry about when I'll eat next, so now on the road I simply trust that a meal will come along eventually and let it go. For me, finally naming food noise was the single greatest discovery I've ever made, and realizing it can be controlled was the single greatest shift in my life.

 

[ochoseis]

ThatNextGril said:

MrZardoz said:

Based on my own experience — and I can really only talk about Tirzepatide — it definitely silences the food noise. That effect comes on fairly quickly, and it's strangely understated in the way it shows up; after you've got some mental space and a few days to notice it, you'll likely realize that 'something' is sort of 'absent.'

In its place, Tirz gives you a kind of 'calmness' — around food-related worry, in every form that takes — which is what people who don't have this actual disease called 'Obesity' seem to enjoy for their whole lives.

But those of us who've been battling this disease haven't had that same luck..

So along come the GLP-1's as the way to at last reach some real parity..

(just my 2 cents)

You put it well. Before starting tirz, whenever I spent the whole day out — flights, hours behind the wheel of a rental, meeting-filled days in spots where food might not be provided — my mind went straight to which snacks would survive the trip rather than the trip itself. The constant fear was running out of reliable food, then crashing with low blood sugar and turning hangry. Tirz keeps my blood sugar steady and takes away the worry about when I'll eat next, so now on the road I simply trust that a meal will come along eventually and let it go. For me, finally naming food noise was the single greatest discovery I've ever made, and realizing it can be controlled was the single greatest shift in my life.

Wow, I could have written this myself. Back then, going anywhere—whether a day out or a full trip—filled me with dread, all because of eating. Which foods would be available? At what point would we sit down to eat? Would it be something unfamiliar? Would there be enough? And if I didn't care for it, could I get something different?

The worry about meals ahead of time ruined any chance of actually enjoying myself. Even while I was eating the very food I'd been anxious about, my mind would jump ahead to what I'd make once I got home.

 

[BNLFL]

derekmarc said:

If someone claims Reta silences food noise, are they referring to something like unwanted urges to binge and purge? That’s a major issue for me. I realize it’s an eating disorder, but could Reta put a stop to it?

For me, it does the job. Sweets, cookies, that kind of thing — no pull toward them at all. I fill up on small amounts. The one day I notice real hunger is today, Thursday, since my injection falls on Friday.